Early EEG Features for Outcome Prediction After Cardiac Arrest in Children

• Published in: Journal of clinical neurophysiology Vol. 36; no. 5; p. 349
• Main Authors: Fung, France W, Topjian, Alexis A, Xiao, Rui, Abend, Nicholas S
• Format: Journal Article
• Language: English
• Published: United States 01.09.2019
• Subjects: Child; Child, Preschool; Critical Illness - therapy; Electroencephalography - methods; Electroencephalography - mortality; Electroencephalography - trends; Female; Heart Arrest - diagnosis; Heart Arrest - mortality; Heart Arrest - physiopathology; Humans; Infant; Male; Prognosis; Prospective Studies; Resuscitation - methods; Resuscitation - mortality; Resuscitation - trends; Treatment Outcome
• ISSN: 1537-1603
• DOI: 10.1097/WNP.0000000000000591

We aimed to determine which early EEG features and feature combinations most accurately predicted short-term neurobehavioral outcomes and survival in children resuscitated after cardiac arrest. This was a prospective, single-center observational study of infants and children resuscitated from cardiac arrest who underwent conventional EEG monitoring with standardized EEG scoring. Logistic regression evaluated the marginal effect of each EEG variable or EEG variable combinations on the outcome. The primary outcome was neurobehavioral outcome (Pediatric Cerebral Performance Category score), and the secondary outcome was mortality. The authors identified the models with the highest areas under the receiver operating characteristic curve (AUC), evaluated the optimal models using a 5-fold cross-validation approach, and calculated test characteristics maximizing specificity. Eighty-nine infants and children were evaluated. Unfavorable neurologic outcome (Pediatric Cerebral Performance Category score 4-6) occurred in 44 subjects (49%), including mortality in 30 subjects (34%). A model incorporating a four-level EEG Background Category (normal, slow-disorganized, discontinuous or burst-suppression, or attenuated-flat), stage 2 Sleep Transients (present or absent), and Reactivity-Variability (present or absent) had the highest AUC. Five-fold cross-validation for the optimal model predicting neurologic outcome indicated a mean AUC of 0.75 (range, 0.70-0.81) and for the optimal model predicting mortality indicated a mean AUC of 0.84 (range, 0.76-0.97). The specificity for unfavorable neurologic outcome and mortality were 95% and 97%, respectively. The positive predictive value for unfavorable neurologic outcome and mortality were both 86%. The specificity of the optimal model using a combination of early EEG features was high for unfavorable neurologic outcome and mortality in critically ill children after cardiac arrest. However, the positive predictive value was only 86% for both outcomes. Therefore, EEG data must be considered in overall clinical context when used for neuroprognostication early after cardiac arrest.