Kinetic analysis of histone acetylation turnover and trichostatin A induced hyper- and hypoacetylation in alfalfa

Dynamic histone acetylation is a characteristic of chromatin transcription. The first estimates for the rate of acetylation turnover of plants are reported, measured in alfalfa cells by pulse, pulse-chase, and steady-state acetylation labeling. Acetylation turnover half-lives of about 0.5 h were obs...

Full description

Saved in:
Bibliographic Details
Published inBiochemistry and cell biology Vol. 80; no. 3; pp. 279 - 293
Main Authors Waterborg, J.H, Kapros, T
Format Journal Article
LanguageEnglish
Published Ottawa, Canada NRC Research Press 2002
Canadian Science Publishing NRC Research Press
Subjects
Online AccessGet full text
ISSN0829-8211
1208-6002
DOI10.1139/o02-021

Cover

Abstract Dynamic histone acetylation is a characteristic of chromatin transcription. The first estimates for the rate of acetylation turnover of plants are reported, measured in alfalfa cells by pulse, pulse-chase, and steady-state acetylation labeling. Acetylation turnover half-lives of about 0.5 h were observed by all methods used for histones H3, H4, and H2B. This is consistent with the rate at which changes in gene expression occur in plants. Treatment with histone deacetylase inhibitor Trichostatin A (TSA) induced hyperacetylation at a similar rate. Replacement histone variant H3.2, preferentially localized in highly acetylated chromatin, displayed faster acetyl turnover. Histone H2A with a low level of acetylation was not subject to rapid turnover or hyperacetylation. Patterns of acetate labeling revealed fundamental differences between histone H3 versus histones H4 and H2B. In H3, acetylation of all molecules, limited by lysine methylation, had similar rates, independent of the level of lysine acetylation. Acetylation of histones H4 and H2B was seen in only a fraction of all molecules and involved multiacetylation. Acetylation turnover rates increased from mono- to penta- and hexaacetylated forms, respectively. TSA was an effective inhibitor of alfalfa histone deacetylases in vivo and caused a doubling in steady-state acetylation levels by 4–6 h after addition. However, hyperacetylation was transient due to loss of TSA inhibition. TSA-induced overexpression of cellular deacetylase activity produced hypoacetylation by 18 h treatment with enhanced acetate turnover labeling of alfalfa histones. Thus, application of TSA to change gene expression in vivo in plants may have unexpected consequences.
AbstractList Dynamic histone acetylation is a characteristic of chromatin transcription. The first estimates for the rate of acetylation turnover of plants are reported, measured in alfalfa cells by pulse, pulse-chase and steady-state acetylation labeling. Application of Trichostatin A to change gene expression in vivo in plants may have unexpected consequences.
Dynamic histone acetylation is a characteristic of chromatin transcription. The first estimates for the rate of acetylation turnover of plants are reported, measured in alfalfa cells by pulse, pulse-chase, and steady-state acetylation labeling. Acetylation turnover half-lives of about 0.5 h were observed by all methods used for histones H3, H4, and H2B. This is consistent with the rate at which changes in gene expression occur in plants. Treatment with histone deacetylase inhibitor Trichostatin A (TSA) induced hyperacetylation at a similar rate. Replacement histone variant H3.2, preferentially localized in highly acetylated chromatin, displayed faster acetyl turnover. Histone H2A with a low level of acetylation was not subject to rapid turnover or hyperacetylation. Patterns of acetate labeling revealed fundamental differences between histone H3 versus histones H4 and H2B. In H3, acetylation of all molecules, limited by lysine methylation, had similar rates, independent of the level of lysine acetylation. Acetylation of histones H4 and H2B was seen in only a fraction of all molecules and involved multiacetylation. Acetylation turnover rates increased from mono- to penta- and hexaacetylated forms, respectively. TSA was an effective inhibitor of alfalfa histone deacetylases in vivo and caused a doubling in steady-state acetylation levels by 4-6 h after addition. However, hyperacetylation was transient due to loss of TSA inhibition. TSA-induced overexpression of cellular deacetylase activity produced hypoacetylation by 18 h treatment with enhanced acetate turnover labeling of alfalfa histones. Thus, application of TSA to change gene expression in vivo in plants may have unexpected consequences.
Dynamic histone acetylation is a characteristic of chromatin transcription. The first estimates for the rate of acetylation turnover of plants are reported, measured in alfalfa cells by pulse, pulse-chase, and steady-state acetylation labeling. Acetylation turnover half-lives of about 0.5 h were observed by all methods used for histones H3, H4, and H2B. This is consistent with the rate at which changes in gene expression occur in plants. Treatment with histone deacetylase inhibitor Trichostatin A (TSA) induced hyperacetylation at a similar rate. Replacement histone variant H3.2, preferentially localized in highly acetylated chromatin, displayed faster acetyl turnover. Histone H2A with a low level of acetylation was not subject to rapid turnover or hyperacetylation. Patterns of acetate labeling revealed fundamental differences between histone H3 versus histones H4 and H2B. In H3, acetylation of all molecules, limited by lysine methylation, had similar rates, independent of the level of lysine acetylation. Acetylation of histones H4 and H2B was seen in only a fraction of all molecules and involved multiacetylation. Acetylation turnover rates increased from mono- to penta- and hexaacetylated forms, respectively. TSA was an effective inhibitor of alfalfa histone deacetylases in vivo and caused a doubling in steady-state acetylation levels by 4–6 h after addition. However, hyperacetylation was transient due to loss of TSA inhibition. TSA-induced overexpression of cellular deacetylase activity produced hypoacetylation by 18 h treatment with enhanced acetate turnover labeling of alfalfa histones. Thus, application of TSA to change gene expression in vivo in plants may have unexpected consequences.
Dynamic histone acetylation is a characteristic of chromatin transcription. The first estimates for the rate of acetylation turnover of plants are reported, measured in alfalfa cells by pulse, pulse-chase, and steady-state acetylation labeling. Acetylation turnover half-lives of about 0.5 h were observed by all methods used for histones H3, H4, and H2B. This is consistent with the rate at which changes in gene expression occur in plants. Treatment with histone deacetylase inhibitor Trichostatin A (TSA) induced hyperacetylation at a similar rate. Replacement histone variant H3.2, preferentially localized in highly acetylated chromatin, displayed faster acetyl turnover. Histone H2A with a low level of acetylation was not subject to rapid turnover or hyperacetylation. Patterns of acetate labeling revealed fundamental differences between histone H3 versus histones H4 and H2B. In H3, acetylation of all molecules, limited by lysine methylation, had similar rates, independent of the level of lysine acetylation. Acetylation of histones H4 and H2B was seen in only a fraction of all molecules and involved multiacetylation. Acetylation turnover rates increased from mono- to penta- and hexaacetylated forms, respectively. TSA was an effective inhibitor of alfalfa histone deacetylases in vivo and caused a doubling in steady-state acetylation levels by 4-6 h after addition. However, hyperacetylation was transient due to loss of TSA inhibition. TSA-induced overexpression of cellular deacetylase activity produced hypoacetylation by 18 h treatment with enhanced acetate turnover labeling of alfalfa histones. Thus, application of TSA to change gene expression in vivo in plants may have unexpected consequences.Dynamic histone acetylation is a characteristic of chromatin transcription. The first estimates for the rate of acetylation turnover of plants are reported, measured in alfalfa cells by pulse, pulse-chase, and steady-state acetylation labeling. Acetylation turnover half-lives of about 0.5 h were observed by all methods used for histones H3, H4, and H2B. This is consistent with the rate at which changes in gene expression occur in plants. Treatment with histone deacetylase inhibitor Trichostatin A (TSA) induced hyperacetylation at a similar rate. Replacement histone variant H3.2, preferentially localized in highly acetylated chromatin, displayed faster acetyl turnover. Histone H2A with a low level of acetylation was not subject to rapid turnover or hyperacetylation. Patterns of acetate labeling revealed fundamental differences between histone H3 versus histones H4 and H2B. In H3, acetylation of all molecules, limited by lysine methylation, had similar rates, independent of the level of lysine acetylation. Acetylation of histones H4 and H2B was seen in only a fraction of all molecules and involved multiacetylation. Acetylation turnover rates increased from mono- to penta- and hexaacetylated forms, respectively. TSA was an effective inhibitor of alfalfa histone deacetylases in vivo and caused a doubling in steady-state acetylation levels by 4-6 h after addition. However, hyperacetylation was transient due to loss of TSA inhibition. TSA-induced overexpression of cellular deacetylase activity produced hypoacetylation by 18 h treatment with enhanced acetate turnover labeling of alfalfa histones. Thus, application of TSA to change gene expression in vivo in plants may have unexpected consequences.
Abstract_FL L'acétylation dynamique des histones est une caractéristique de la transcription de la chromatine. Cet article présente les premières estimations du taux de renouvellement des groupes acétyle chez les plantes, obtenues en mesurant l'acétylation grâce à un marquage bref, suivi ou non d'une chasse, et à un marquage à l'équilibre de cellules de luzerne. La demi-vie de renouvellement des groupes acétyle des histones H3, H4 et H2B est environ 0,50 h selon toutes les méthodes. Cela concorde avec la vitesse de modification de l'expression des gènes chez les plantes. Une incubation en présence de Trichostatine A (TSA), un inhibiteur des histones désacétylases, induit une hyperacétylation à une vitesse similaire. Le taux de renouvellement des groupes acétyle de l'histone H3.2 de remplacement, qui se trouve préférentiellement dans la chromatine hyperacétylée, est plus rapide. L'histone H2A peu acétylée a un taux de renouvellement des groupes acétyle lent et elle n'est pas sujette à l'hyperacétylation. Le marquage avec l'acétate montre qu'il y a des différences fondamentales entre l'histone H3, d'une part, et les histones H4 et H2B, d'autre part. L'acétylation de toutes les molécules d'histone H3, limitée par la méthylation des résidus lysine, se fait à la même vitesse, indépendamment du niveau d'acétylation des résidus lysine. Par contre, seulement une fraction de toutes les molécules des histones H4 et H2B sont acétylées et cela fait intervenir de multiples acétylations. Les taux de renouvellement des groupes acétyle augmentent en allant des formes mono-acétylées aux formes penta- et hexa-acétylées. La TSA est un bon inhibiteur des histones désacétylases de la luzerne in vivo et le taux d'acétylation à l'équilibre double 4 à 6 h après traitement avec la TSA. Cependant, l'hyperacétylation est transitoire car l'inhibition par la TSA disparaît progressivement. La TSA induit la surexpression des désacétylases cellulaires, ce qui engendre une hypoacétylation, 18 h aprés traitement avec la TSA, et une augmentation du taux de renouvellement des groupes acétyle des histones de la luzerne. Donc, l'application de TSA à des plantes afin de modifier l'expression de leurs gènes in vivo pourrait avoir des conséquences imprévues.[Traduit par la Rédaction]
Author Kapros, T
Waterborg, J.H
Author_xml – sequence: 1
  fullname: Waterborg, J.H
– sequence: 2
  fullname: Kapros, T
BackLink https://www.ncbi.nlm.nih.gov/pubmed/12123281$$D View this record in MEDLINE/PubMed
BookMark eNqF0VFrFDEQB_AgFXut4jfQxYcKwmpmstlNHktpVSz4oH0OuSTrpewl1yRbuG9v2jtFKloITCC_DMz8j8hBiMER8hLoewAmP0SKLUV4QhaAVLQ9pXhAFlSgbAUCHJKjnK8pBeykeEYOAQEZCliQmy8-uOJNo4OettnnJo7NyudS-zfauLKddPExNGVOId66VKFtSvJmFXOpT6E5bXyws3G2WW03LrX3ol7jn9-r09N4d56Tp7Vm92Jfj8nVxfn3s0_t5dePn89OL1vT8b60trcczaCho5aKATijRqKRZuyFY5qLJRUcYbR86EyVvZSj7s0orV4CCM2Oycmu7ybFm9nlotY-GzdNOrg4ZzWABA7IH4WdGBiFoXsUguhYpbLCNw_gdazrq9MqBI5cdgNU9GqP5uXaWbVJfq3TVv3KpoJ2B0yKOSc3KuPL_TZL0n5SQNVd9qpmr2r21b994H-3_Eu-28mQTHLZ6WRW_8En_8Z7pDZ2rPD1Do46Kv0j-ayuviEFRlGikJKznx5N0hI
CitedBy_id crossref_primary_10_1073_pnas_1119740109
crossref_primary_10_1016_j_bbagrm_2011_02_005
crossref_primary_10_1242_jcs_01293
crossref_primary_10_1002_prca_200600631
crossref_primary_10_1016_j_bioorg_2019_103452
crossref_primary_10_1016_j_gde_2014_06_002
crossref_primary_10_1074_jbc_M111_254383
crossref_primary_10_1586_14789450_4_2_211
crossref_primary_10_1016_j_cell_2020_05_026
crossref_primary_10_1124_mol_107_042838
crossref_primary_10_1080_14789450_2019_1559061
crossref_primary_10_1016_j_nlm_2016_08_009
crossref_primary_10_3390_ijms21228451
crossref_primary_10_1038_s42003_023_05601_8
Cites_doi 10.1104/pp.115.3.1021
10.1126/science.288.5470.1422
10.1074/jbc.M000909200
10.1007/BF00042074
10.1074/jbc.M004830200
10.1042/bj2730753
10.1126/science.289.5488.2290
10.1073/pnas.95.16.9430
10.1104/pp.90.1.237
10.1016/S0092-8674(00)81532-9
10.1016/S0006-3495(98)77990-1
10.1016/S1360-1385(00)01839-2
10.1515/bchm.1998.379.10.1235
10.1093/emboj/19.14.3714
10.1038/47412
10.1074/jbc.273.42.27602
10.1016/S1097-2765(00)80194-X
10.1021/bi9918184
10.1023/A:1009222609581
10.1038/35035000
10.1042/bj2500241
10.1016/S0031-9422(00)00195-3
10.1016/S0968-0004(99)01516-9
10.1016/S0006-3495(98)77989-5
10.1016/S0021-9258(18)53483-9
10.1136/gut.46.4.507
10.1016/S1097-2765(00)80256-7
10.1073/pnas.91.11.4781
10.1016/S0176-1617(88)80266-9
10.1007/BF02524647
10.1016/S0092-8674(00)80217-2
10.1101/sqb.1998.63.435
10.1016/S0021-9258(19)68068-3
10.1104/pp.96.2.453
10.1093/emboj/17.10.2865
10.1073/pnas.96.22.12356
10.1016/S1097-2765(00)80257-9
10.1139/g98-133
10.1128/MCB.20.20.7541-7549.2000
10.1038/20974
10.1128/MCB.19.8.5504
10.1016/B978-0-12-450550-6.50010-5
10.1021/bi00142a006
10.1128/MCB.19.12.8591
10.1016/S0021-9258(17)44882-4
10.1101/gad.12.5.627
10.1111/j.1432-1033.1981.tb05664.x
10.1007/s004120050239
10.1016/S0092-8674(00)80211-1
10.1016/S0021-9258(19)41247-7
10.1016/0167-4838(96)00069-6
10.1016/S0962-8924(99)01536-6
10.1042/bj3030723
10.1038/38444
10.1016/0003-9861(87)90435-8
10.1016/S0021-9258(19)83850-4
10.1007/BF00034947
10.1016/S0168-9525(00)02066-7
10.1016/0167-4781(90)90105-B
10.1083/jcb.93.2.285
10.1074/jbc.275.17.13007
10.1074/jbc.270.2.923
10.1101/gad.14.8.951
10.1074/jbc.271.26.15837
10.1021/bi002480c
10.1073/pnas.180316197
10.1016/S0021-9258(18)53482-7
10.1104/pp.109.2.393
10.1073/pnas.76.1.46
10.1093/emboj/19.8.1839
10.1042/bj2500233
ContentType Journal Article
Copyright Copyright National Research Council of Canada 2002
Copyright_xml – notice: Copyright National Research Council of Canada 2002
DBID FBQ
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QO
7QP
7QR
7TK
7TM
7U7
7U9
7X2
7X7
7XB
88A
88E
88I
8AF
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
8FQ
8FV
8G5
ABJCF
ABUWG
AEUYN
AFKRA
ATCPS
AZQEC
BBNVY
BEC
BENPR
BGLVJ
BHPHI
C1K
CCPQU
D1I
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
GUQSH
H94
HCIFZ
K9.
KB.
LK8
M0K
M0S
M1P
M2O
M2P
M3G
M7P
MBDVC
P64
PADUT
PDBOC
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
RC3
7S9
L.6
7X8
DOI 10.1139/o02-021
DatabaseName AGRIS
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Biotechnology Research Abstracts
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Toxicology Abstracts
Virology and AIDS Abstracts
Agricultural Science Collection
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
STEM Database
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Canadian Business & Current Affairs Database
Canadian Business & Current Affairs Database (Alumni)
Research Library (Alumni)
ProQuest Materials Science & Engineering
ProQuest Central (Alumni)
ProQuest One Sustainability (subscription)
ProQuest Central UK/Ireland
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
eLibrary Curriculum
ProQuest Central
Technology collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Materials Science Collection
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
Research Library Prep
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Materials Science Database
Biological Sciences
Agriculture Science Database
ProQuest Health & Medical Collection
Medical Database
ProQuest Research Library
Science Database
CBCA Reference & Current Events
Biological Science Database
Research Library (Corporate)
Biotechnology and BioEngineering Abstracts
Research Library China
Materials Science Collection
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
Genetics Abstracts
AGRICOLA
AGRICOLA - Academic
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Agricultural Science Database
Research Library Prep
ProQuest Central Student
ProQuest Central Essentials
Nucleic Acids Abstracts
elibrary
ProQuest AP Science
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
CBCA Complete (Alumni Edition)
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
ProQuest Central (New)
Research Library China
ProQuest Medical Library (Alumni)
Virology and AIDS Abstracts
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Agricultural Science Collection
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
Materials Science Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Agricultural & Environmental Science Collection
AIDS and Cancer Research Abstracts
Materials Science Database
CBCA Complete
ProQuest Research Library
ProQuest Materials Science Collection
ProQuest Central Basic
Toxicology Abstracts
ProQuest Science Journals
CBCA Reference & Current Events
ProQuest SciTech Collection
ProQuest Medical Library
Materials Science & Engineering Collection
ProQuest Central (Alumni)
AGRICOLA
AGRICOLA - Academic
MEDLINE - Academic
DatabaseTitleList Agricultural Science Database
Nucleic Acids Abstracts
MEDLINE

CrossRef
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
– sequence: 4
  dbid: FBQ
  name: AGRIS
  url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN
  sourceTypes: Publisher
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
Chemistry
Biology
EISSN 1208-6002
EndPage 293
ExternalDocumentID 135566111
12123281
10_1139_o02_021
US201302928995
Genre Article
Research Support, U.S. Gov't, Non-P.H.S
Journal Article
Feature
Conference Paper
GroupedDBID ---
-~X
.55
.GJ
00T
0R~
23N
36B
3O-
3V.
4.4
53G
5GY
5RE
5RP
7X2
7X7
88A
88E
88I
8AF
8AO
8CJ
8FE
8FG
8FH
8FI
8FJ
8FQ
8G5
A8Z
AAIKC
AAMNW
AAYJJ
ABDBF
ABEFU
ABJCF
ABJNI
ABPTK
ABUWG
ACGFO
ACGFS
ACGOD
ACIWK
ACPRK
ACSVP
ADBBV
AEQTP
AFKRA
AFRAH
AHMBA
AIAGR
AIXEN
ALMA_UNASSIGNED_HOLDINGS
APEBS
ATCPS
AZQEC
BBNVY
BCR
BCU
BEC
BENPR
BES
BGLVJ
BHPHI
BLC
BPHCQ
BVXVI
CAG
CCPQU
COF
CS3
D1I
D1J
D8U
DATHI
DWQXO
EAD
EAP
EBC
EBD
EBS
ECC
EJD
EMB
EMK
EMOBN
EPL
ESTFP
ESX
F5P
FBQ
FYUFA
GNUQQ
GUQSH
HCIFZ
HF~
HMCUK
HZ~
H~9
IAG
IAO
ICQ
IEA
IGS
IHR
INH
INR
IOF
IPNFZ
ISN
ISR
ITC
KB.
L7B
LK8
M0K
M0L
M1P
M2O
M2P
M2Q
M3C
M3G
M7P
MV1
MVM
NMEPN
NRXXU
NYCZX
O9-
ONR
OVD
P2P
PADUT
PDBOC
PEA
PQQKQ
PRG
PROAC
PSQYO
PV9
QF4
QM4
QN7
QO4
QRP
RIG
RRCRK
RRP
RZL
SJFOW
SV3
TEORI
TUS
UKHRP
VQG
WH7
X7M
XFK
ZAY
ZGI
ZXP
~KM
ACUHS
AEUYN
ALIPV
PHGZM
PHGZT
AAYXX
CITATION
PJZUB
PPXIY
PQGLB
PUEGO
CGR
CUY
CVF
ECM
EIF
NPM
PKN
7QO
7QP
7QR
7TK
7TM
7U7
7U9
7XB
8FD
8FK
C1K
FR3
H94
K9.
MBDVC
P64
PKEHL
PQEST
PQUKI
PRINS
Q9U
RC3
7S9
L.6
7X8
ID FETCH-LOGICAL-c456t-d6d52c7a140d0871530c92c9cf68e3a58b08521fd574c52c699fa6cf9dab118a3
IEDL.DBID 8FG
ISSN 0829-8211
IngestDate Wed Oct 01 14:04:42 EDT 2025
Mon Sep 08 16:17:03 EDT 2025
Mon Sep 08 13:13:12 EDT 2025
Thu Aug 21 03:50:34 EDT 2025
Wed Feb 19 01:33:45 EST 2025
Wed Oct 01 05:53:01 EDT 2025
Thu Apr 24 23:03:31 EDT 2025
Thu May 23 14:04:14 EDT 2019
Fri Jun 13 18:33:44 EDT 2025
Wed Dec 27 19:03:36 EST 2023
IsPeerReviewed true
IsScholarly true
Issue 3
Language English
License http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c456t-d6d52c7a140d0871530c92c9cf68e3a58b08521fd574c52c699fa6cf9dab118a3
Notes SourceType-Scholarly Journals-1
ObjectType-Conference Paper-2
ObjectType-Feature-1
content type line 14
ObjectType-Article-2
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
PMID 12123281
PQID 215259471
PQPubID 47596
PageCount 15
ParticipantIDs pubmed_primary_12123281
crossref_primary_10_1139_o02_021
nrcresearch_primary_10_1139_o02_021
proquest_miscellaneous_48730174
proquest_miscellaneous_18437309
proquest_journals_215259471
proquest_miscellaneous_71915125
fao_agris_US201302928995
crossref_citationtrail_10_1139_o02_021
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2002-00-00
PublicationDateYYYYMMDD 2002-01-01
PublicationDate_xml – year: 2002
  text: 2002-00-00
PublicationDecade 2000
PublicationPlace Ottawa, Canada
PublicationPlace_xml – name: Ottawa, Canada
– name: Canada
– name: Ottawa
PublicationTitle Biochemistry and cell biology
PublicationTitleAlternate Biochimie et biologie cellulaire
PublicationYear 2002
Publisher NRC Research Press
Canadian Science Publishing NRC Research Press
Publisher_xml – name: NRC Research Press
– name: Canadian Science Publishing NRC Research Press
References Wade P.A. (p_60/p_60_1) 1998; 63
Buzek J. (p_12/p_12_1) 1998; 379
Gilbert S.L. (p_26/p_26_1) 1999; 96
Cheung P. (p_18/p_18_1) 2000; 5
Covault J. (p_20/p_20_1) 1982; 257
Leuba S.H. (p_40/p_40_1) 1998; 74
Nelson D.A. (p_47/p_47_1) 1982; 257
Richon V.M. (p_53/p_53_1) 2000; 97
Kuo M.H. (p_35/p_35_1) 1998; 12
Waterborg J.H. (p_71/p_71_1) 1989; 90
Brown C.E. (p_11/p_11_1) 2000; 25
Carmen A.A. (p_15/p_15_1) 1999; 96
Leuba S.H. (p_39/p_39_1) 1998; 74
Belyaev N.D. (p_8/p_8_1) 1998; 6
Waterborg J.H. (p_73/p_73_1) 1995; 109
Barratt M.J. (p_6/p_6_1) 1994; 91
Selker E.U. (p_56/p_56_1) 1998; 95
Chestier A. (p_17/p_17_1) 1979; 76
Luger K. (p_42/p_42_1) 1997; 389
Jackson V. (p_31/p_31_1) 1975; 250
p_45/p_45_1
Zhang D.E. (p_75/p_75_1) 1988; 250
Waterborg J.H. (p_67/p_67_1) 1998; 273
Waterborg J.H. (p_63/p_63_1) 1992; 18
Carmen A.A. (p_14/p_14_1) 1996; 271
Ahringer J. (p_1/p_1_1) 2000; 16
Waterborg J.H. (p_64/p_64_1) 1992; 31
Zhang D.E. (p_76/p_76_1) 1988; 250
Garcia-Ramirez M. (p_25/p_25_1) 1995; 270
Hendzel M.J. (p_29/p_29_1) 1991; 273
Dhalluin C. (p_21/p_21_1) 1999; 399
Doetzlhofer A. (p_23/p_23_1) 1999; 19
Pazin M.J. (p_50/p_50_1) 1997; 89
Nightingale K.P. (p_48/p_48_1) 1998; 17
Strahl B.D. (p_58/p_58_1) 2000; 403
Waterborg J.H. (p_70/p_70_1) 1987; 256
p_3/p_3_1
p_32/p_32_1
Ayer D.E. (p_5/p_5_1) 1999; 9
Carruthers L.M. (p_16/p_16_1) 2000; 275
Pedersen T.J. (p_51/p_51_1) 1988; 132
Waterborg J.H. (p_69/p_69_1) 2001; 40
Lechner T. (p_38/p_38_1) 2000; 39
Orphanides G. (p_49/p_49_1) 2000; 407
Wittschieben B.O. (p_74/p_74_1) 1999; 4
Fax P. (p_24/p_24_1) 2000; 275
Arfmann H.A. (p_4/p_4_1) 1981; 21
Brosch G. (p_10/p_10_1) 1995; 7
Schroter H. (p_55/p_55_1) 1981; 120
Ransom R.F. (p_52/p_52_1) 1997; 115
Kurooka H. (p_36/p_36_1) 2000; 275
Sanchez (p_54/p_54_1) 1994; 303
Waterborg J.H. (p_65/p_65_1) 1993; 268
Hebbes T.R. (p_27/p_27_1) 2000; 275
Vyskot B. (p_59/p_59_1) 1999; 42
Waterborg J.H. (p_68/p_68_1) 2000; 275
Matangkasombut O. (p_44/p_44_1) 2000; 14
Lo W.S. (p_41/p_41_1) 2000; 5
Murphy J.P. (p_46/p_46_1) 2000; 55
Belyaev N.D. (p_7/p_7_1) 1997; 106
Allan J. (p_2/p_2_1) 1982; 93
Waterborg J.H. (p_72/p_72_1) 1990; 1049
Bird A.P. (p_9/p_9_1) 1999; 99
Caretti G. (p_13/p_13_1) 1999; 19
Waterborg J.H. (p_66/p_66_1) 1993; 268
Kadosh D. (p_33/p_33_1) 1997; 89
Idei S. (p_30/p_30_1) 1996; 105
Hecht A. (p_28/p_28_1) 2000; 19
Kapros T. (p_34/p_34_1) 1995; 28
Lechner T. (p_37/p_37_1) 1996; 1296
Waterborg J.H. (p_61/p_61_1) 1990; 265
Waterborg J.H. (p_62/p_62_1) 1991; 96
Lusser A. (p_43/p_43_1) 2001; 6
Clayton A.L. (p_19/p_19_1) 2000; 19
Siavoshian S. (p_57/p_57_1) 2000; 46
DiRenzo J. (p_22/p_22_1) 2000; 20
References_xml – volume: 115
  start-page: 1021
  year: 1997
  ident: p_52/p_52_1
  publication-title: Plant Physiol.
  doi: 10.1104/pp.115.3.1021
– ident: p_32/p_32_1
  doi: 10.1126/science.288.5470.1422
– volume: 275
  start-page: 211
  year: 2000
  ident: p_36/p_36_1
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M000909200
– volume: 28
  start-page: 901
  year: 1995
  ident: p_34/p_34_1
  publication-title: Plant Mol. Biol.
  doi: 10.1007/BF00042074
– volume: 275
  start-page: 347
  year: 2000
  ident: p_27/p_27_1
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M004830200
– volume: 273
  start-page: 753
  year: 1991
  ident: p_29/p_29_1
  publication-title: Biochem. J.
  doi: 10.1042/bj2730753
– ident: p_45/p_45_1
  doi: 10.1126/science.289.5488.2290
– volume: 95
  start-page: 9430
  year: 1998
  ident: p_56/p_56_1
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.95.16.9430
– volume: 90
  start-page: 237
  year: 1989
  ident: p_71/p_71_1
  publication-title: Plant Physiol.
  doi: 10.1104/pp.90.1.237
– volume: 99
  start-page: 451
  year: 1999
  ident: p_9/p_9_1
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81532-9
– volume: 74
  start-page: 2830
  year: 1998
  ident: p_40/p_40_1
  publication-title: Biophys. J.
  doi: 10.1016/S0006-3495(98)77990-1
– volume: 6
  start-page: 59
  year: 2001
  ident: p_43/p_43_1
  publication-title: Trends Plant Sci.
  doi: 10.1016/S1360-1385(00)01839-2
– volume: 379
  start-page: 1235
  year: 1998
  ident: p_12/p_12_1
  publication-title: Biol. Chem.
  doi: 10.1515/bchm.1998.379.10.1235
– volume: 19
  start-page: 3714
  year: 2000
  ident: p_19/p_19_1
  publication-title: EMBO J.
  doi: 10.1093/emboj/19.14.3714
– volume: 403
  start-page: 41
  year: 2000
  ident: p_58/p_58_1
  publication-title: Nature (Lond.)
  doi: 10.1038/47412
– volume: 273
  start-page: 602
  year: 1998
  ident: p_67/p_67_1
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.273.42.27602
– volume: 4
  start-page: 123
  year: 1999
  ident: p_74/p_74_1
  publication-title: Mol. Cell.
  doi: 10.1016/S1097-2765(00)80194-X
– volume: 39
  start-page: 1683
  year: 2000
  ident: p_38/p_38_1
  publication-title: Biochemistry
  doi: 10.1021/bi9918184
– volume: 6
  start-page: 59
  year: 1998
  ident: p_8/p_8_1
  publication-title: Chromosome Res.
  doi: 10.1023/A:1009222609581
– volume: 407
  start-page: 471
  year: 2000
  ident: p_49/p_49_1
  publication-title: Nature (Lond.)
  doi: 10.1038/35035000
– volume: 250
  start-page: 241
  year: 1988
  ident: p_76/p_76_1
  publication-title: Biochem. J.
  doi: 10.1042/bj2500241
– volume: 55
  start-page: 11
  year: 2000
  ident: p_46/p_46_1
  publication-title: Phytochemistry
  doi: 10.1016/S0031-9422(00)00195-3
– volume: 25
  start-page: 15
  year: 2000
  ident: p_11/p_11_1
  publication-title: Trends Biochem. Sci.
  doi: 10.1016/S0968-0004(99)01516-9
– volume: 74
  start-page: 2823
  year: 1998
  ident: p_39/p_39_1
  publication-title: Biophys. J.
  doi: 10.1016/S0006-3495(98)77989-5
– volume: 268
  start-page: 4918
  year: 1993
  ident: p_66/p_66_1
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)53483-9
– volume: 46
  start-page: 507
  year: 2000
  ident: p_57/p_57_1
  publication-title: Gut
  doi: 10.1136/gut.46.4.507
– volume: 5
  start-page: 905
  year: 2000
  ident: p_18/p_18_1
  publication-title: Mol. Cell.
  doi: 10.1016/S1097-2765(00)80256-7
– volume: 91
  start-page: 4781
  year: 1994
  ident: p_6/p_6_1
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.91.11.4781
– volume: 132
  start-page: 623
  year: 1988
  ident: p_51/p_51_1
  publication-title: J. Plant Physiol.
  doi: 10.1016/S0176-1617(88)80266-9
– volume: 105
  start-page: 293
  year: 1996
  ident: p_30/p_30_1
  publication-title: Chromosoma
  doi: 10.1007/BF02524647
– volume: 89
  start-page: 365
  year: 1997
  ident: p_33/p_33_1
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80217-2
– volume: 63
  start-page: 435
  year: 1998
  ident: p_60/p_60_1
  publication-title: Cold Spring Harbor Symp. Quant. Biol.
  doi: 10.1101/sqb.1998.63.435
– volume: 257
  start-page: 1565
  year: 1982
  ident: p_47/p_47_1
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(19)68068-3
– volume: 96
  start-page: 453
  year: 1991
  ident: p_62/p_62_1
  publication-title: Plant Physiol.
  doi: 10.1104/pp.96.2.453
– volume: 17
  start-page: 2865
  year: 1998
  ident: p_48/p_48_1
  publication-title: EMBO J.
  doi: 10.1093/emboj/17.10.2865
– volume: 7
  start-page: 1941
  year: 1995
  ident: p_10/p_10_1
  publication-title: Plant Cell
– volume: 96
  start-page: 356
  year: 1999
  ident: p_15/p_15_1
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.96.22.12356
– volume: 5
  start-page: 917
  year: 2000
  ident: p_41/p_41_1
  publication-title: Mol. Cell.
  doi: 10.1016/S1097-2765(00)80257-9
– volume: 42
  start-page: 343
  year: 1999
  ident: p_59/p_59_1
  publication-title: Genome
  doi: 10.1139/g98-133
– volume: 20
  start-page: 7541
  year: 2000
  ident: p_22/p_22_1
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.20.20.7541-7549.2000
– volume: 21
  start-page: 317
  year: 1981
  ident: p_4/p_4_1
  publication-title: Lett.
– volume: 399
  start-page: 491
  year: 1999
  ident: p_21/p_21_1
  publication-title: Nature (Lond.)
  doi: 10.1038/20974
– volume: 19
  start-page: 5504
  year: 1999
  ident: p_23/p_23_1
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.19.8.5504
– ident: p_3/p_3_1
  doi: 10.1016/B978-0-12-450550-6.50010-5
– volume: 96
  start-page: 825
  year: 1999
  ident: p_26/p_26_1
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
– volume: 31
  start-page: 6211
  year: 1992
  ident: p_64/p_64_1
  publication-title: Biochemistry
  doi: 10.1021/bi00142a006
– volume: 19
  start-page: 8591
  year: 1999
  ident: p_13/p_13_1
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.19.12.8591
– volume: 265
  start-page: 157
  year: 1990
  ident: p_61/p_61_1
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(17)44882-4
– volume: 12
  start-page: 627
  year: 1998
  ident: p_35/p_35_1
  publication-title: Genes Dev.
  doi: 10.1101/gad.12.5.627
– volume: 120
  start-page: 21
  year: 1981
  ident: p_55/p_55_1
  publication-title: Eur. J. Biochem.
  doi: 10.1111/j.1432-1033.1981.tb05664.x
– volume: 106
  start-page: 193
  year: 1997
  ident: p_7/p_7_1
  publication-title: Chromosoma
  doi: 10.1007/s004120050239
– volume: 89
  start-page: 325
  year: 1997
  ident: p_50/p_50_1
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80211-1
– volume: 250
  start-page: 4856
  year: 1975
  ident: p_31/p_31_1
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(19)41247-7
– volume: 1296
  start-page: 181
  year: 1996
  ident: p_37/p_37_1
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/0167-4838(96)00069-6
– volume: 9
  start-page: 193
  year: 1999
  ident: p_5/p_5_1
  publication-title: Trends Cell Biol.
  doi: 10.1016/S0962-8924(99)01536-6
– volume: 303
  start-page: 723
  year: 1994
  ident: p_54/p_54_1
  publication-title: Biochem. J.
  doi: 10.1042/bj3030723
– volume: 389
  start-page: 251
  year: 1997
  ident: p_42/p_42_1
  publication-title: Nature (Lond.)
  doi: 10.1038/38444
– volume: 256
  start-page: 167
  year: 1987
  ident: p_70/p_70_1
  publication-title: Arch. Biochem. Biophys.
  doi: 10.1016/0003-9861(87)90435-8
– volume: 257
  start-page: 5809
  year: 1982
  ident: p_20/p_20_1
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(19)83850-4
– volume: 18
  start-page: 181
  year: 1992
  ident: p_63/p_63_1
  publication-title: Plant Mol. Biol.
  doi: 10.1007/BF00034947
– volume: 16
  start-page: 351
  year: 2000
  ident: p_1/p_1_1
  publication-title: Trends Genet.
  doi: 10.1016/S0168-9525(00)02066-7
– volume: 275
  start-page: 554
  year: 2000
  ident: p_24/p_24_1
  publication-title: J. Biol. Chem.
– volume: 1049
  start-page: 324
  year: 1990
  ident: p_72/p_72_1
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/0167-4781(90)90105-B
– volume: 275
  start-page: 285
  year: 2000
  ident: p_16/p_16_1
  publication-title: J. Biol. Chem.
– volume: 93
  start-page: 285
  year: 1982
  ident: p_2/p_2_1
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.93.2.285
– volume: 275
  start-page: 007
  year: 2000
  ident: p_68/p_68_1
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.275.17.13007
– volume: 270
  start-page: 923
  year: 1995
  ident: p_25/p_25_1
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.270.2.923
– volume: 14
  start-page: 951
  year: 2000
  ident: p_44/p_44_1
  publication-title: Genes Dev.
  doi: 10.1101/gad.14.8.951
– volume: 271
  start-page: 837
  year: 1996
  ident: p_14/p_14_1
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.271.26.15837
– volume: 40
  start-page: 2599
  year: 2001
  ident: p_69/p_69_1
  publication-title: Biochemistry
  doi: 10.1021/bi002480c
– volume: 97
  start-page: 014
  year: 2000
  ident: p_53/p_53_1
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.180316197
– volume: 268
  start-page: 4912
  year: 1993
  ident: p_65/p_65_1
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)53482-7
– volume: 109
  start-page: 393
  year: 1995
  ident: p_73/p_73_1
  publication-title: Plant Physiol.
  doi: 10.1104/pp.109.2.393
– volume: 76
  start-page: 46
  year: 1979
  ident: p_17/p_17_1
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.76.1.46
– volume: 19
  start-page: 1839
  year: 2000
  ident: p_28/p_28_1
  publication-title: EMBO J.
  doi: 10.1093/emboj/19.8.1839
– volume: 250
  start-page: 233
  year: 1988
  ident: p_75/p_75_1
  publication-title: Biochem. J.
  doi: 10.1042/bj2500233
SSID ssj0012498
Score 1.69463
Snippet Dynamic histone acetylation is a characteristic of chromatin transcription. The first estimates for the rate of acetylation turnover of plants are reported,...
SourceID proquest
pubmed
crossref
nrcresearch
fao
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 279
SubjectTerms Acetates
Acetates - metabolism
Acetylation
Alfalfa
Cells
Cellular biology
Chromatin
Enzyme Inhibitors
Enzyme Inhibitors - pharmacology
Flowers & plants
Genetics
Histone Deacetylase Inhibitors
Histone Deacetylases
Histone Deacetylases - metabolism
Histones
Histones - metabolism
Hydroxamic Acids
Hydroxamic Acids - pharmacology
Kinetics
Medicago sativa
Medicago sativa - metabolism
metabolism
methods
pharmacology
plant biochemistry
plant physiology
Staining and Labeling
Staining and Labeling - methods
Title Kinetic analysis of histone acetylation turnover and trichostatin A induced hyper- and hypoacetylation in alfalfa
URI http://www.nrcresearchpress.com/doi/abs/10.1139/o02-021
https://www.ncbi.nlm.nih.gov/pubmed/12123281
https://www.proquest.com/docview/215259471
https://www.proquest.com/docview/18437309
https://www.proquest.com/docview/48730174
https://www.proquest.com/docview/71915125
Volume 80
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVEBS
  databaseName: EBSCOhost Academic Search Ultimate
  customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn
  eissn: 1208-6002
  dateEnd: 20241003
  omitProxy: true
  ssIdentifier: ssj0012498
  issn: 0829-8211
  databaseCode: ABDBF
  dateStart: 20010201
  isFulltext: true
  titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn
  providerName: EBSCOhost
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1208-6002
  dateEnd: 20070630
  omitProxy: true
  ssIdentifier: ssj0012498
  issn: 0829-8211
  databaseCode: 7X7
  dateStart: 19980101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl: http://www.proquest.com/pqcentral?accountid=15518
  eissn: 1208-6002
  dateEnd: 20070630
  omitProxy: true
  ssIdentifier: ssj0012498
  issn: 0829-8211
  databaseCode: BENPR
  dateStart: 19980101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Technology Collection
  customDbUrl:
  eissn: 1208-6002
  dateEnd: 20070630
  omitProxy: true
  ssIdentifier: ssj0012498
  issn: 0829-8211
  databaseCode: 8FG
  dateStart: 19980101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/technologycollection1
  providerName: ProQuest
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fb9MwELboJgR7QLAx1g2KJdDeouWXm_gJtWNlAjEhWKW-WY5_sIeRdG33sP9-nx2nDEGRIiWqz1HSu5y_zz7fEfK-kCYvbF5EGGziKE9jBj9YZlFlmNXc7Xb09VO-XgzPp_nnGZuF2JxlCKvsfKJ31LpRbo78xNVfZRyu9MP8JnJFo9ziaqig0SPbSQpDchvFJ5_WiwhgFt4RlymPShCdds9sAsxz0ri42zT5YzDqWdnskJ16oUKenavNqNOPPpPn5FmAjXTU6vkFeWTqXbI3qkGZf93RY-oDOf0M-S55PO6unpx25dz2yM0X4En0pjKkIaGNpT7bcG2oVGZ110bFUYxBtYvrhKCml3CTbh8Immo6oiDwMAVNr8BeF5GXwGXzsDvk5LV1x0synZxdnp5Hod5CpACjVpEeapaqQoJz6RhEimWx4qniyg5Lk0lWVsBnaWI1K3IFySHnVg6V5VpW4Cky2ydbNR76gNCiMjZmhinj8tOXaFP4xVR5IlOHYPrkuPvjhQrJyF1NjGvhSUnGBTQkoKE-oWvBeZt_42-RA2hOyJ_wimL6I_VrsdwRSdYn7x6oc_MN3v5LKrSKubZ9ctQZggjf-FKsLRL9161QqltxkbVpbpfCFdOBC-WbJcAX4WKLfLNEAUYNVIZ3edVa4O_XcLAjLZPD_z7dEXnqK9j4aaPXZGu1uDVvAKRW1YD0ilkx8B_NgGyPxh_HE5zHZxffvt8DpzofQw
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3fb9MwED5tQ2jsAcHGtrLBLAF7i5Y4cRI_INQNpo5ue6GV-mYc_9iQRtK1nVD_KP5Hzk5ShqC8TepDVJ-jJHc-f599vgN4m0mTZDbJApxswiChIUM_mMdBYZjV3J129PVTLi7T3jD5PGKjFfjZnoVxYZWtT_SOWlfKrZEfufqrjKMr_TC-DVzRKLe52lbQqK2ib-Y_kLFN3599RPW-o_T00-CkFzRFBQKFWGEW6FQzqjKJxEKHyBZYHCpOFVc2zU0sWV4gCKGR1SxLFEqmnFuZKsu1LBCMyxjvuwqPkjhMXKr-bLTgd66Ms3f8OeVBjsSqPqMbIcY6qlycL43-mPxWraw2YKOcqCavz_VylOtnu9Nn8LSBqaRb29VzWDHlJmx1S6To3-fkkPjAUb8ivwmPj9ur9ZO2fNwW3PYRv2JvIpu0J6SyxGc3Lg2RyszmdRQewTmvdHGkKKjJAN2yO3eCTSXpkm-lRtPT5BrZ8iTwEnhZ3e-OcvLGut8LGD6IKrZhrcSH3gWSFcaGzDBlXD78HNsU_mOKJJLUIaYOHLYfXqgm-bmrwXEjPAmKuUANCdRQB8hCcFzn-_hbZBc1J-QVemEx_EL93i93xJV14M09dS6_wcG_pJpWMda2A3utIYjGp0zFYgRg_0UrKtXt8MjSVHdT4Yr3oMvmyyWQn6JLz5LlEhkyeESB-C47tQX-fg0Hc2gevfzv0x3Aem9wcS7Ozy77e_DEV8_xS1b7sDab3JlXCOJmxWs_dAh8feix-gvbgVgG
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1db9MwFLW2IT72gGADVgbMErC3qK0TN_EDQmWj2ihMSKxS3zzHHwxpJF3bCfWn8e84dpIyBOVtUh-i-jpKcq-vz7Gv7yXkVapskrokjTDZdKKEdTj8YBZHueXOCH_aMdRP-XTSOxolH8Z8vEZ-NmdhfFhl4xODozal9mvkbV9_lQu40raroyI-Hw7eTi4jX0DKb7Q21TQqCxnaxQ-wt9mb40Oo-jVjg_enB0dRXWAg0sAN88j0DGc6VSAZpgPmwOOOFkwL7XqZjRXPcgAS1nWGp4mGZE8Ip3raCaNyAHMV477r5FYaJ7GPJkvHS67nSzqHSSBjIspAsqrzul3grXbpY35Z94-JcN2pcpNsFlNd5_g5X414w8w3eEDu15CV9isbe0jWbLFFtvsF6Pr3Bd2nIYg0rM5vkdvvmqu7B00puW1yOQSWRW-q6hQotHQ0ZDouLFXazhdVRB7F_Ff4mFIIGnoKF-3PoKCpoH36rTAwQ0PPwZynUZDAZXm9O-TUhfO_R2R0I6p4TDYKPPQOoWluXYdbrq3PjZ-hTeMfmyddxTx6apH95sNLXSdC9_U4LmQgRLGQ0JCEhlqELgUnVe6Pv0V2oDmpvsIjy9EXFvaBhSexvEVeXlPn6hvs_UuqbpUT41pktzEEWfuXmVyOBvRftkKpfrdHFba8mklfyAfuW6yWAFeFe0-T1RIp2DwQId7lSWWBv1_DQx6WdZ_-9-n2yB2MUvnx-GS4S-6FQjph9eoZ2ZhPr-xz4Ll5_iKMHErObnqo_gL_oFxB
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Kinetic+analysis+of+histone+acetylation+turnover+and+Trichostatin+A+induced+hyper-+and+hypoacetylation+in+alfalfa&rft.jtitle=Biochemistry+and+cell+biology&rft.au=Waterborg%2C+Jakob+H&rft.au=Kapros%2C+Tam%C3%A1s&rft.date=2002&rft.pub=NRC+Research+Press&rft.issn=0829-8211&rft.eissn=1208-6002&rft.volume=80&rft.issue=3&rft.spage=279&rft.epage=293&rft_id=info:doi/10.1139%2Fo02-021
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0829-8211&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0829-8211&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0829-8211&client=summon