B-cell receptor reactivity against Rothia mucilaginosa in nodular lymphocyte-predominant Hodgkin lymphoma

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a Hodgkin lymphoma expressing functional B-cell receptors (BCR). Recently, we described a dual stimulation model of IgD+ lymphocyte-predominant cells by Moraxella catarrhalis antigen RpoC and its superantigen MID/hag, associated with extralo...

Full description

Saved in:
Bibliographic Details
Published inHaematologica (Roma) Vol. 108; no. 12; pp. 3347 - 3358
Main Authors Thurner, Lorenz, Fadle, Natalie, Regitz, Evi, Roth, Sophie, Cetin, Onur, Kos, Igor Age, Hess, Simon Mauro, Bein, Julia, Bohle, Rainer Maria, Vornanen, Martine, Sundström, Christer, De Leval, Laurence, Tiacci, Enrico, Borchmann, Peter, Engert, Andreas, Poeschel, Viola, Held, Gerhard, Schwarz, Eva C., Neumann, Frank, Preuss, Klaus-Dieter, Hoth, Markus, Küppers, Ralf, Lehman, Karola, Hansmann, Martin-Leo, Becker, Sören L., Bewarder, Moritz, Hartmann, Sylvia
Format Journal Article
LanguageEnglish
Published Italy Ferrata Storti Foundation 01.12.2023
Subjects
Hodgkin Disease - pathology
Humans
Lymphocytes - pathology
Micrococcaceae
Receptors, Antigen, B-Cell
Online AccessGet full text
ISSN0390-6078
1592-8721
1592-8721
DOI10.3324/haematol.2023.282698

Cover

Abstract Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a Hodgkin lymphoma expressing functional B-cell receptors (BCR). Recently, we described a dual stimulation model of IgD+ lymphocyte-predominant cells by Moraxella catarrhalis antigen RpoC and its superantigen MID/hag, associated with extralong CDR3 and HLA-DRB1*04 or HLADRB1* 07 haplotype. The aim of the present study was to extend the antigen screening to further bacteria and viruses. The fragment antibody-binding (Fab) regions of seven new and 15 previously reported cases were analyzed. The reactivity of non-Moraxella spp.-reactive Fab regions against lysates of Rothia mucilaginosa was observed in 5/22 (22.7%) cases. Galactofuranosyl transferase (Gltf) and 2,3-butanediol dehydrogenase (Bdh) of R. mucilaginosa were identified by comparative silver- and immuno-staining in two-dimensional gels, with subsequent mass spectrometry and validation by western blots and enzyme-linked immunosorbent assay. Both R. mucilaginosa Gltf and Bdh induced BCR pathway activation and proliferation in vitro. Apoptosis was induced by recombinant Gltf/ETA’-immunotoxin conjugates in DEV cells expressing recombinant R. mucilaginosa-reactive BCR. Reactivity against M. catarrhalis RpoC was confirmed in 3/7 newly expressed BCR (total 10/22 reactive to Moraxella spp.), resulting in 15/22 (68.2%) cases with BCR reactivity against defined bacterial antigens. These findings strengthen the hypothesis of bacterial trigger contributing to subsets of NLPHL.
AbstractList Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a Hodgkin lymphoma expressing functional B-cell receptors (BCR). Recently, we described a dual stimulation model of IgD+ lymphocyte-predominant cells by Moraxella catarrhalis antigen RpoC and its superantigen MID/hag, associated with extralong CDR3 and HLA-DRB1*04 or HLADRB1* 07 haplotype. The aim of the present study was to extend the antigen screening to further bacteria and viruses. The fragment antibody-binding (Fab) regions of seven new and 15 previously reported cases were analyzed. The reactivity of non-Moraxella spp.-reactive Fab regions against lysates of Rothia mucilaginosa was observed in 5/22 (22.7%) cases. Galactofuranosyl transferase (Gltf) and 2,3-butanediol dehydrogenase (Bdh) of R. mucilaginosa were identified by comparative silver- and immuno-staining in two-dimensional gels, with subsequent mass spectrometry and validation by western blots and enzyme-linked immunosorbent assay. Both R. mucilaginosa Gltf and Bdh induced BCR pathway activation and proliferation in vitro. Apoptosis was induced by recombinant Gltf/ETA’-immunotoxin conjugates in DEV cells expressing recombinant R. mucilaginosa-reactive BCR. Reactivity against M. catarrhalis RpoC was confirmed in 3/7 newly expressed BCR (total 10/22 reactive to Moraxella spp.), resulting in 15/22 (68.2%) cases with BCR reactivity against defined bacterial antigens. These findings strengthen the hypothesis of bacterial trigger contributing to subsets of NLPHL.
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a Hodgkin lymphoma expressing functional B-cell receptors (BCR). Recently, we described a dual stimulation model of IgD+ lymphocyte-predominant cells by Moraxella catarrhalis antigen RpoC and its superantigen MID/hag, associated with extralong CDR3 and HLA-DRB1*04 or HLADRB1* 07 haplotype. The aim of the present study was to extend the antigen screening to further bacteria and viruses. The fragment antibody-binding (Fab) regions of seven new and 15 previously reported cases were analyzed. The reactivity of non-Moraxella spp.-reactive Fab regions against lysates of Rothia mucilaginosa was observed in 5/22 (22.7%) cases. Galactofuranosyl transferase (Gltf) and 2,3-butanediol dehydrogenase (Bdh) of R. mucilaginosa were identified by comparative silver- and immuno-staining in two-dimensional gels, with subsequent mass spectrometry and validation by western blots and enzyme-linked immunosorbent assay. Both R. mucilaginosa Gltf and Bdh induced BCR pathway activation and proliferation in vitro. Apoptosis was induced by recombinant Gltf/ETA'-immunotoxin conjugates in DEV cells expressing recombinant R. mucilaginosa-reactive BCR. Reactivity against M. catarrhalis RpoC was confirmed in 3/7 newly expressed BCR (total 10/22 reactive to Moraxella spp.), resulting in 15/22 (68.2%) cases with BCR reactivity against defined bacterial antigens. These findings strengthen the hypothesis of bacterial trigger contributing to subsets of NLPHL.Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a Hodgkin lymphoma expressing functional B-cell receptors (BCR). Recently, we described a dual stimulation model of IgD+ lymphocyte-predominant cells by Moraxella catarrhalis antigen RpoC and its superantigen MID/hag, associated with extralong CDR3 and HLA-DRB1*04 or HLADRB1* 07 haplotype. The aim of the present study was to extend the antigen screening to further bacteria and viruses. The fragment antibody-binding (Fab) regions of seven new and 15 previously reported cases were analyzed. The reactivity of non-Moraxella spp.-reactive Fab regions against lysates of Rothia mucilaginosa was observed in 5/22 (22.7%) cases. Galactofuranosyl transferase (Gltf) and 2,3-butanediol dehydrogenase (Bdh) of R. mucilaginosa were identified by comparative silver- and immuno-staining in two-dimensional gels, with subsequent mass spectrometry and validation by western blots and enzyme-linked immunosorbent assay. Both R. mucilaginosa Gltf and Bdh induced BCR pathway activation and proliferation in vitro. Apoptosis was induced by recombinant Gltf/ETA'-immunotoxin conjugates in DEV cells expressing recombinant R. mucilaginosa-reactive BCR. Reactivity against M. catarrhalis RpoC was confirmed in 3/7 newly expressed BCR (total 10/22 reactive to Moraxella spp.), resulting in 15/22 (68.2%) cases with BCR reactivity against defined bacterial antigens. These findings strengthen the hypothesis of bacterial trigger contributing to subsets of NLPHL.
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a Hodgkin lymphoma expressing functional B-cell receptors (BCR). Recently, we described a dual stimulation model of IgD+ lymphocyte-predominant cells by Moraxella catarrhalis antigen RpoC and its superantigen MID/hag, associated with extralong CDR3 and HLA-DRB1*04 or HLA-DRB1*07 haplotype. The aim of the present study was to extend the antigen screening to further bacteria and viruses. The fragment antibody-binding (Fab) regions of seven new and 15 previously reported cases were analyzed. The reactivity of non-Moraxella spp.-reactive Fab regions against lysates of Rothia mucilaginosa was observed in 5/22 (22.7%) cases. Galactofuranosyl transferase (Gltf) and 2,3-butanediol dehydrogenase (Bdh) of R. mucilaginosa were identified by comparative silver-and immuno-staining in two-dimensional gels, with subsequent mass spectrometry and validation by western blots and enzyme-linked immunosorbent assay. Both R. mucilaginosa Gltf and Bdh induced BCR pathway activation and proliferation in vitro. Apoptosis was induced by recombinant Gltf/ETA'-immunotoxin conjugates in DEV cells expressing recombinant R. mucilaginosa-reactive BCR. Reactivity against M. catarrhalis RpoC was confirmed in 3/7 newly expressed BCR (total 10/22 reactive to Moraxella spp.), resulting in 15/22 (68.2%) cases with BCR reactivity against defined bacterial antigens. These findings strengthen the hypothesis of bacterial trigger contributing to subsets of NLPHL.
Author Bein, Julia
Tiacci, Enrico
Roth, Sophie
Hartmann, Sylvia
Preuss, Klaus-Dieter
Küppers, Ralf
Held, Gerhard
Bohle, Rainer Maria
Hansmann, Martin-Leo
Hess, Simon Mauro
Poeschel, Viola
Borchmann, Peter
Neumann, Frank
Sundström, Christer
Kos, Igor Age
Thurner, Lorenz
Vornanen, Martine
Schwarz, Eva C.
De Leval, Laurence
Becker, Sören L.
Lehman, Karola
Regitz, Evi
Engert, Andreas
Cetin, Onur
Hoth, Markus
Fadle, Natalie
Bewarder, Moritz
Author_xml – sequence: 1
  givenname: Lorenz
  surname: Thurner
  fullname: Thurner, Lorenz
– sequence: 2
  givenname: Natalie
  surname: Fadle
  fullname: Fadle, Natalie
– sequence: 3
  givenname: Evi
  surname: Regitz
  fullname: Regitz, Evi
– sequence: 4
  givenname: Sophie
  surname: Roth
  fullname: Roth, Sophie
– sequence: 5
  givenname: Onur
  surname: Cetin
  fullname: Cetin, Onur
– sequence: 6
  givenname: Igor Age
  surname: Kos
  fullname: Kos, Igor Age
– sequence: 7
  givenname: Simon Mauro
  surname: Hess
  fullname: Hess, Simon Mauro
– sequence: 8
  givenname: Julia
  surname: Bein
  fullname: Bein, Julia
– sequence: 9
  givenname: Rainer Maria
  surname: Bohle
  fullname: Bohle, Rainer Maria
– sequence: 10
  givenname: Martine
  surname: Vornanen
  fullname: Vornanen, Martine
– sequence: 11
  givenname: Christer
  surname: Sundström
  fullname: Sundström, Christer
– sequence: 12
  givenname: Laurence
  surname: De Leval
  fullname: De Leval, Laurence
– sequence: 13
  givenname: Enrico
  surname: Tiacci
  fullname: Tiacci, Enrico
– sequence: 14
  givenname: Peter
  surname: Borchmann
  fullname: Borchmann, Peter
– sequence: 15
  givenname: Andreas
  surname: Engert
  fullname: Engert, Andreas
– sequence: 16
  givenname: Viola
  surname: Poeschel
  fullname: Poeschel, Viola
– sequence: 17
  givenname: Gerhard
  surname: Held
  fullname: Held, Gerhard
– sequence: 18
  givenname: Eva C.
  surname: Schwarz
  fullname: Schwarz, Eva C.
– sequence: 19
  givenname: Frank
  surname: Neumann
  fullname: Neumann, Frank
– sequence: 20
  givenname: Klaus-Dieter
  surname: Preuss
  fullname: Preuss, Klaus-Dieter
– sequence: 21
  givenname: Markus
  surname: Hoth
  fullname: Hoth, Markus
– sequence: 22
  givenname: Ralf
  surname: Küppers
  fullname: Küppers, Ralf
– sequence: 23
  givenname: Karola
  surname: Lehman
  fullname: Lehman, Karola
– sequence: 24
  givenname: Martin-Leo
  surname: Hansmann
  fullname: Hansmann, Martin-Leo
– sequence: 25
  givenname: Sören L.
  surname: Becker
  fullname: Becker, Sören L.
– sequence: 26
  givenname: Moritz
  surname: Bewarder
  fullname: Bewarder, Moritz
– sequence: 27
  givenname: Sylvia
  surname: Hartmann
  fullname: Hartmann, Sylvia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37139600$$D View this record in MEDLINE/PubMed
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-525069$$DView record from Swedish Publication Index
BookMark eNp9kkuP1SAYhokZ41z0HxjTpQt7pFBu7sbxMpNMYmLULfmg9BzGFipQzfn39kznmOjCFQSe9_kSeM_RSYjBIfS8wRtKSft6B26EEocNwYRuiCRcyUforGGK1FKQ5gSdYapwzbGQp-g85zuMCVZKPEGnVDRUcYzPkH9bWzcMVXLWTSWmZQO2-J--7CvYgg-5VJ9j2Xmoxtn6AbY-xAyVD1WI3TxAqob9OO2i3RdXT8l1cfQBQqmuY7f9vmDr9QhP0eMehuyePawX6OuH91-uruvbTx9vri5va9syXmppFBO2M5wpTEQvmGG8J4YYJzrRU0cx4cJQjmXbts5xpZRkoCjtlO0so_QC3azeLsKdnpIfIe11BK_vD2LaakjF28Fp1i1RwohtJSzDuWmls6axgBUs7n5xvVpd-ZebZvOX7Z3_dnlvm2fNCMNcLfjLFZ9S_DG7XPTo8-F5Ibg4Z00kVqwlTMoFffGAzmZ03R_z8WcW4M0K2BRzTq7X1hcoPoaSwA-6wfpQA32sgT7UQK81WMLtP-Gj_7-x33TMuqE
CitedBy_id crossref_primary_10_3324_haematol_2023_283392
crossref_primary_10_1111_bjh_20042
crossref_primary_10_1016_j_imlet_2023_08_007
crossref_primary_10_1002_ajh_27459
crossref_primary_10_1016_j_modpat_2024_100441
crossref_primary_10_1016_j_molmed_2024_10_004
Cites_doi 10.1200/JCO.2011.41.4466
10.1182/blood-2007-03-082511
10.1182/blood-2012-08-447904
10.1038/nrc1589
10.1016/S0140-6736(14)61469-0
10.1200/jco.2011.29.15_suppl.8002
10.1007/s00417-015-2950-1
10.1182/blood.V116.21.765.765
10.1074/jbc.274.26.18470
10.1002/eji.200535594
10.1200/JCO.2018.36.15_suppl.7574
10.1093/abt/tbab010
10.1056/NEJM194407132310201
10.1016/0140-6736(93)91409-F
10.3324/haematol.2019.241653
10.1097/00000478-200310000-00007
10.1182/blood.2020008835
10.1182/blood.2022015851
10.1016/0140-6736(91)92035-Z
10.1002/hon.2437_52
10.1007/978-1-62703-269-8_3
10.1002/ajh.25972
10.1038/s41467-020-16375-6
10.1056/NEJM199803123381113
10.1073/pnas.94.17.9337
10.1038/s41375-018-0182-1
10.1097/01.pas.0000194741.87798.45
10.1016/S1470-2045(08)70002-0
10.1074/jbc.274.26.18218
10.1002/path.1984
10.1002/path.1746
10.1056/NEJM199708143370703
10.1182/blood-2018-10-877761
10.1111/bjh.13310
10.3324/haematol.2009.010157
10.1038/leu.2015.328
10.1371/journal.pone.0078812
10.1182/blood.V87.2.465.bloodjournal872465
10.1200/JCO.2012.43.5958
10.1084/jem.20080809
10.1182/blood-2002-05-1592
10.1182/blood-2018-99-112403
10.1097/QCO.0b013e3283298e4e
10.3324/haematol.2021.278427
10.1038/s41375-022-01625-x
10.1182/blood-2018-03-836932
10.1016/S0140-6736(17)32134-7
10.4049/jimmunol.122.4.1468
10.1016/j.annonc.2019.10.010
ContentType Journal Article
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
ACNBI
ADTPV
AOWAS
D8T
DF2
ZZAVC
DOA
DOI 10.3324/haematol.2023.282698
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
SWEPUB Uppsala universitet full text
SwePub
SwePub Articles
SWEPUB Freely available online
SWEPUB Uppsala universitet
SwePub Articles full text
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList
MEDLINE
MEDLINE - Academic
CrossRef
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Anatomy & Physiology
EISSN 1592-8721
EndPage 3358
ExternalDocumentID oai_doaj_org_article_5d85a252c48a4566b48ecb1ca09a4eef
oai_DiVA_org_uu_525069
37139600
10_3324_haematol_2023_282698
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
29I
2WC
53G
5GY
5RE
5VS
AAFWJ
AAYXX
ADBBV
AENEX
AFPKN
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
BTFSW
CITATION
CS3
DIK
E3Z
EBS
EJD
F5P
FRP
GROUPED_DOAJ
H13
HYE
KQ8
OK1
OVT
P2P
RHI
RNS
RPM
SJN
TFS
TR2
W8F
WOQ
WOW
CGR
CUY
CVF
ECM
EIF
M~E
NPM
RHF
SV3
7X8
ACNBI
ADTPV
AOWAS
C1A
D8T
DF2
UDS
ZZAVC
ID FETCH-LOGICAL-c456t-8b957cdb659027f75b56f2b2be7d7f3e30267b3608444ee699985a933d9cdc533
IEDL.DBID DOA
ISSN 0390-6078
1592-8721
IngestDate Wed Aug 27 01:29:53 EDT 2025
Thu Aug 21 06:52:39 EDT 2025
Fri Jul 11 00:02:29 EDT 2025
Thu Jan 02 22:42:38 EST 2025
Thu Apr 24 23:06:28 EDT 2025
Tue Jul 01 04:22:30 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 12
Language English
License http://creativecommons.org/licenses/by/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c456t-8b957cdb659027f75b56f2b2be7d7f3e30267b3608444ee699985a933d9cdc533
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://doaj.org/article/5d85a252c48a4566b48ecb1ca09a4eef
PMID 37139600
PQID 2809542588
PQPubID 23479
PageCount 12
ParticipantIDs doaj_primary_oai_doaj_org_article_5d85a252c48a4566b48ecb1ca09a4eef
swepub_primary_oai_DiVA_org_uu_525069
proquest_miscellaneous_2809542588
pubmed_primary_37139600
crossref_citationtrail_10_3324_haematol_2023_282698
crossref_primary_10_3324_haematol_2023_282698
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2023-12-01
PublicationDateYYYYMMDD 2023-12-01
PublicationDate_xml – month: 12
  year: 2023
  text: 2023-12-01
  day: 01
PublicationDecade 2020
PublicationPlace Italy
PublicationPlace_xml – name: Italy
PublicationTitle Haematologica (Roma)
PublicationTitleAlternate Haematologica
PublicationYear 2023
Publisher Ferrata Storti Foundation
Publisher_xml – name: Ferrata Storti Foundation
References 55043
55042
55041
55040
55047
55046
55045
55044
55049
55048
55050
55054
55053
55052
55051
55058
55057
55056
55055
55018
55059
55019
55061
55060
55021
55065
55020
55064
55063
55062
55025
55069
55024
55068
55023
55067
55022
55066
55029
55028
55027
55026
55071
55070
55032
55031
55030
55036
55035
55034
55033
55039
55038
55037
37381755 - Haematologica. 2023 Dec 01;108(12):3195-3196. doi: 10.3324/haematol.2023.283392
References_xml – ident: 55070
  doi: 10.1200/JCO.2011.41.4466
– ident: 55027
  doi: 10.1182/blood-2007-03-082511
– ident: 55038
– ident: 55052
  doi: 10.1182/blood-2012-08-447904
– ident: 55055
  doi: 10.1038/nrc1589
– ident: 55041
  doi: 10.1016/S0140-6736(14)61469-0
– ident: 55046
  doi: 10.1200/jco.2011.29.15_suppl.8002
– ident: 55061
  doi: 10.1007/s00417-015-2950-1
– ident: 55042
  doi: 10.1182/blood.V116.21.765.765
– ident: 55031
  doi: 10.1074/jbc.274.26.18470
– ident: 55050
– ident: 55065
  doi: 10.1002/eji.200535594
– ident: 55047
  doi: 10.1200/JCO.2018.36.15_suppl.7574
– ident: 55062
  doi: 10.1093/abt/tbab010
– ident: 55021
  doi: 10.1056/NEJM194407132310201
– ident: 55068
  doi: 10.1016/0140-6736(93)91409-F
– ident: 55056
  doi: 10.3324/haematol.2019.241653
– ident: 55032
  doi: 10.1097/00000478-200310000-00007
– ident: 55058
  doi: 10.1182/blood.2020008835
– ident: 55033
  doi: 10.1182/blood.2022015851
– ident: 55067
  doi: 10.1016/0140-6736(91)92035-Z
– ident: 55043
  doi: 10.1002/hon.2437_52
– ident: 55049
  doi: 10.1007/978-1-62703-269-8_3
– ident: 55036
  doi: 10.1002/ajh.25972
– ident: 55039
  doi: 10.1038/s41467-020-16375-6
– ident: 55024
  doi: 10.1056/NEJM199803123381113
– ident: 55028
  doi: 10.1073/pnas.94.17.9337
– ident: 55053
  doi: 10.1038/s41375-018-0182-1
– ident: 55037
  doi: 10.1097/01.pas.0000194741.87798.45
– ident: 55057
  doi: 10.1038/s41375-018-0182-1
– ident: 55045
  doi: 10.1016/S1470-2045(08)70002-0
– ident: 55051
  doi: 10.1074/jbc.274.26.18218
– ident: 55069
  doi: 10.1002/path.1984
– ident: 55030
  doi: 10.1002/path.1746
– ident: 55025
  doi: 10.1056/NEJM199708143370703
– ident: 55071
  doi: 10.1182/blood-2018-10-877761
– ident: 55060
  doi: 10.1111/bjh.13310
– ident: 55035
  doi: 10.3324/haematol.2009.010157
– ident: 55023
  doi: 10.1038/leu.2015.328
– ident: 55059
  doi: 10.1371/journal.pone.0078812
– ident: 55029
  doi: 10.1182/blood.V87.2.465.bloodjournal872465
– ident: 55018
  doi: 10.1200/JCO.2012.43.5958
– ident: 55019
  doi: 10.1084/jem.20080809
– ident: 55026
  doi: 10.1182/blood-2002-05-1592
– ident: 55048
  doi: 10.1182/blood-2018-99-112403
– ident: 55064
  doi: 10.1097/QCO.0b013e3283298e4e
– ident: 55020
  doi: 10.1371/journal.pone.0078812
– ident: 55022
– ident: 55040
  doi: 10.3324/haematol.2021.278427
– ident: 55034
  doi: 10.1038/s41375-022-01625-x
– ident: 55054
  doi: 10.1182/blood-2018-03-836932
– ident: 55044
  doi: 10.1016/S0140-6736(17)32134-7
– ident: 55063
  doi: 10.4049/jimmunol.122.4.1468
– ident: 55066
  doi: 10.1016/j.annonc.2019.10.010
– reference: 37381755 - Haematologica. 2023 Dec 01;108(12):3195-3196. doi: 10.3324/haematol.2023.283392
SSID ssj0020997
Score 2.4724388
Snippet Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a Hodgkin lymphoma expressing functional B-cell receptors (BCR). Recently, we described a dual...
SourceID doaj
swepub
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 3347
SubjectTerms Hodgkin Disease - pathology
Humans
Lymphocytes - pathology
Micrococcaceae
Receptors, Antigen, B-Cell
Title B-cell receptor reactivity against Rothia mucilaginosa in nodular lymphocyte-predominant Hodgkin lymphoma
URI https://www.ncbi.nlm.nih.gov/pubmed/37139600
https://www.proquest.com/docview/2809542588
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-525069
https://doaj.org/article/5d85a252c48a4566b48ecb1ca09a4eef
Volume 108
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9swDBaGHopehvWxLesDGrDtptWxZFk6pi8EA7rDsA69CXq5M5bYQRsf8u9LWk6wDgV62S1wZFDWR4v8TIok5JOoLIbrAouxskzwYJlS3jHtZNBFwMwaPJx8_V1Ob8S32-L2r1ZfmBOWygOnhTstgipsXuReKAvGXjqhondjbzNtBQjA3TfT2ZpMDVQLz4P28QMN5AisYDo0x8F7OP1tsRhqi2GHnH8FxiG1emKU-tr9zzmc_1QT7S3Q1RvyenAd6SRNeZe8is0e2Z80IGa-ol9on8zZfyXfI9vXQ8x8n9RnDL_OU9ja4gIYNvzAwwzYM4LaO1uDf0h_AF61pfPO1zNsW9Q-WFo3tGkDZqnS2Qowb_1qGdkCC4ym9Bk6bcPdHxiW_p7bA3JzdfnzfMqGBgvMw1IumXK6KH1wEmu4lFVZuEJWuctdLENZ8cixPZXjMlNCwFpLcCYBDM150D54cBTfkq2mbeJ7Qt04Lz2QLyGdElrl1o35WFpfcbCN0ZYjwtcrbPxQfRybYMwMsBDExaxxMYiLSbiMCNvctUjVN14Yf4bgbcZi7ez-AmiUGTTKvKRRI_JxDb2Bdw0hsk1suwcQAg4pbHIKBL1LOrERxYHtAxvMRuRzUpInk7iof036SXSdwUCy1B_-x1QPyQ4-fUqvOSJby_suHoOTtHQn_fvwCJLFEF8
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=B-cell+receptor+reactivity+against+Rothia+mucilaginosa+in+nodular+lymphocyte-predominant+Hodgkin+lymphoma&rft.jtitle=Haematologica+%28Roma%29&rft.au=Thurner%2C+Lorenz&rft.au=Fadle%2C+Natalie&rft.au=Regitz%2C+Evi&rft.au=Roth%2C+Sophie&rft.date=2023-12-01&rft.issn=0390-6078&rft.eissn=1592-8721&rft.volume=108&rft.issue=12&rft.spage=3347&rft.epage=3358&rft_id=info:doi/10.3324%2Fhaematol.2023.282698&rft.externalDBID=n%2Fa&rft.externalDocID=10_3324_haematol_2023_282698
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0390-6078&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0390-6078&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0390-6078&client=summon