Aryl-hydrocarbon receptor-dependent pathway and toxic effects of TCDD in humans: a population-based study in Seveso, Italy
Approximately 20 years after the Seveso, Italy accident, we conducted a population-based study to evaluate the impact of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) exposure upon immune and mechanistically based biomarkers of dioxin response in humans. TCDD toxic effects are known to be mediated by...
Saved in:
| Published in | Toxicology letters Vol. 149; no. 1; pp. 287 - 293 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article Conference Proceeding |
| Language | English |
| Published |
Shannon
Elsevier Ireland Ltd
01.04.2004
Amsterdam Elsevier Science |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0378-4274 1879-3169 |
| DOI | 10.1016/j.toxlet.2003.12.062 |
Cover
| Abstract | Approximately 20 years after the Seveso, Italy accident, we conducted a population-based study to evaluate the impact of 2,3,7,8-tetrachlorodibenzo-
p-dioxin (TCDD) exposure upon immune and mechanistically based biomarkers of dioxin response in humans. TCDD toxic effects are known to be mediated by the aryl-hydrocarbon receptor (AhR). We randomly selected 62 study subjects from the highest exposed zones and 59 from the surrounding non-contaminated area. Current lipid-adjusted plasma TCDD concentrations in these subjects ranged from 3.5 to 90
ng/kg (or ppt) and were negatively associated with plasma IgG concentrations (
r=−0.35;
P=0.0002). The expression of genes in the AhR-dependent pathway, including AhR, aryl-hydrocarbon receptor nuclear translocator (ARNT), CYP1A1, and CYP1B1 transcripts, and the CYP1A1-associated 7-ethoxyresorufin-
O-deethylase (EROD) activity was measured in lymphocytes. AhR mRNA levels in uncultured lymphocytes were negatively associated with plasma TCDD (
P=0.03). When mitogen-induced lymphocytes were cultured with 10
nM TCDD, all AhR-dependent genes were induced 1.2- to 13-fold. In these cells, plasma TCDD was associated with decreased EROD activity. Markers within the AhR pathway were correlated with one another.
Our findings suggest the presence of long-term effects in the subjects exposed to TCDD after the Seveso accident. |
|---|---|
| AbstractList | Approximately 20 years after the Seveso, Italy accident, we conducted a population-based study to evaluate the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure upon immune and mechanistically based biomarkers of dioxin response in humans. TCDD toxic effects are known to be mediated by the aryl-hydrocarbon receptor (AhR). We randomly selected 62 study subjects from the highest exposed zones and 59 from the surrounding non-contaminated area. Current lipid-adjusted plasma TCDD concentrations in these subjects ranged from 3.5 to 90 ng/kg (or ppt) and were negatively associated with plasma IgG concentrations (r=-0.35; P = 0.0002). The expression of genes in the AhR-dependent pathway, including AhR, aryl-hydrocarbon receptor nuclear translocator (ARNT), CYP1A1, and CYP1B1 transcripts, and the CYP1A1-associated 7-ethoxyresorufin-O-deethylase (EROD) activity was measured in lymphocytes. AhR mRNA levels in uncultured lymphocytes were negatively associated with plasma TCDD (P=0.03). When mitogen-induced lymphocytes were cultured with 10nM TCDD, all AhR-dependent genes were induced 1.2- to 13-fold. In these cells, plasma TCDD was associated with decreased EROD activity. Markers within the AhR pathway were correlated with one another. Our findings suggest the presence of long-term effects in the subjects exposed to TCDD after the Seveso accident. Approximately 20 years after the Seveso, Italy accident, we conducted a population-based study to evaluate the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure upon immune and mechanistically based biomarkers of dioxin response in humans. TCDD toxic effects are known to be mediated by the aryl-hydrocarbon receptor (AhR). We randomly selected 62 study subjects from the highest exposed zones and 59 from the surrounding non-contaminated area. Current lipid-adjusted plasma TCDD concentrations in these subjects ranged from 3.5 to 90 ng/kg (or ppt) and were negatively associated with plasma IgG concentrations (r=-0.35; P = 0.0002). The expression of genes in the AhR-dependent pathway, including AhR, aryl-hydrocarbon receptor nuclear translocator (ARNT), CYP1A1, and CYP1B1 transcripts, and the CYP1A1-associated 7-ethoxyresorufin-O-deethylase (EROD) activity was measured in lymphocytes. AhR mRNA levels in uncultured lymphocytes were negatively associated with plasma TCDD (P=0.03). When mitogen-induced lymphocytes were cultured with 10nM TCDD, all AhR-dependent genes were induced 1.2- to 13-fold. In these cells, plasma TCDD was associated with decreased EROD activity. Markers within the AhR pathway were correlated with one another. Our findings suggest the presence of long-term effects in the subjects exposed to TCDD after the Seveso accident.Approximately 20 years after the Seveso, Italy accident, we conducted a population-based study to evaluate the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure upon immune and mechanistically based biomarkers of dioxin response in humans. TCDD toxic effects are known to be mediated by the aryl-hydrocarbon receptor (AhR). We randomly selected 62 study subjects from the highest exposed zones and 59 from the surrounding non-contaminated area. Current lipid-adjusted plasma TCDD concentrations in these subjects ranged from 3.5 to 90 ng/kg (or ppt) and were negatively associated with plasma IgG concentrations (r=-0.35; P = 0.0002). The expression of genes in the AhR-dependent pathway, including AhR, aryl-hydrocarbon receptor nuclear translocator (ARNT), CYP1A1, and CYP1B1 transcripts, and the CYP1A1-associated 7-ethoxyresorufin-O-deethylase (EROD) activity was measured in lymphocytes. AhR mRNA levels in uncultured lymphocytes were negatively associated with plasma TCDD (P=0.03). When mitogen-induced lymphocytes were cultured with 10nM TCDD, all AhR-dependent genes were induced 1.2- to 13-fold. In these cells, plasma TCDD was associated with decreased EROD activity. Markers within the AhR pathway were correlated with one another. Our findings suggest the presence of long-term effects in the subjects exposed to TCDD after the Seveso accident. Approximately 20 years after the Seveso, Italy accident, we conducted a population-based study to evaluate the impact of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) exposure upon immune and mechanistically based biomarkers of dioxin response in humans. TCDD toxic effects are known to be mediated by the aryl-hydrocarbon receptor (AhR). We randomly selected 62 study subjects from the highest exposed zones and 59 from the surrounding non-contaminated area. Current lipid-adjusted plasma TCDD concentrations in these subjects ranged from 3.5 to 90 ng/kg (or ppt) and were negatively associated with plasma IgG concentrations ( r=−0.35; P=0.0002). The expression of genes in the AhR-dependent pathway, including AhR, aryl-hydrocarbon receptor nuclear translocator (ARNT), CYP1A1, and CYP1B1 transcripts, and the CYP1A1-associated 7-ethoxyresorufin- O-deethylase (EROD) activity was measured in lymphocytes. AhR mRNA levels in uncultured lymphocytes were negatively associated with plasma TCDD ( P=0.03). When mitogen-induced lymphocytes were cultured with 10 nM TCDD, all AhR-dependent genes were induced 1.2- to 13-fold. In these cells, plasma TCDD was associated with decreased EROD activity. Markers within the AhR pathway were correlated with one another. Our findings suggest the presence of long-term effects in the subjects exposed to TCDD after the Seveso accident. |
| Author | Needham, Larry L Caporaso, Neil E Masten, Scott A Patterson, Donald G Pesatori, Angela C Bertazzi, Pier Alberto Grassman, Jean A Consonni, Dario Mocarelli, Paolo Landi, Maria Teresa Baccarelli, Andrea |
| Author_xml | – sequence: 1 givenname: Andrea surname: Baccarelli fullname: Baccarelli, Andrea email: baccarea@mail.nih.gov, andrea.baccarelli@unimi.it organization: Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd. EPS 7110, Bethesda, MD 20892-7236, USA – sequence: 2 givenname: Angela C surname: Pesatori fullname: Pesatori, Angela C organization: EPOCA, Department of Occupational and Environmental Health, Research Center for Occupational, Clinical and Environmental Epidemiology, University of Milan, Milan, Italy – sequence: 3 givenname: Scott A surname: Masten fullname: Masten, Scott A organization: Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA – sequence: 4 givenname: Donald G surname: Patterson fullname: Patterson, Donald G organization: Division of Environmental Health Laboratory Science, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA – sequence: 5 givenname: Larry L surname: Needham fullname: Needham, Larry L organization: Division of Environmental Health Laboratory Science, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA – sequence: 6 givenname: Paolo surname: Mocarelli fullname: Mocarelli, Paolo organization: Department of Laboratory Medicine, University of Milan–Bicocca, Hospital of Desio, Desio, Milan, Italy – sequence: 7 givenname: Neil E surname: Caporaso fullname: Caporaso, Neil E organization: Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd. EPS 7110, Bethesda, MD 20892-7236, USA – sequence: 8 givenname: Dario surname: Consonni fullname: Consonni, Dario organization: Department of Occupational Health and Safety, Epidemiology Unit, Istituti Clinici di Perfezionamento, Milan, Italy – sequence: 9 givenname: Jean A surname: Grassman fullname: Grassman, Jean A organization: Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA – sequence: 10 givenname: Pier Alberto surname: Bertazzi fullname: Bertazzi, Pier Alberto organization: EPOCA, Department of Occupational and Environmental Health, Research Center for Occupational, Clinical and Environmental Epidemiology, University of Milan, Milan, Italy – sequence: 11 givenname: Maria Teresa surname: Landi fullname: Landi, Maria Teresa organization: Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd. EPS 7110, Bethesda, MD 20892-7236, USA |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15678338$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/15093275$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kUtv1DAUhSNURB_wDxDyBlZk8Ctx0kWlasqjUiUWlLV1Y99oPMrYwXYK4deTYQaEWHR1N985VzrfeXHig8eieMnoilFWv9uucvgxYF5xSsWK8RWt-ZPijDWqLQWr25PijArVlJIreVqcp7SllNayrp4Vp6yireCqOit-Xsd5KDezjcFA7IInEQ2OOcTS4ojeos9khLz5DjMBb8ny1BmCfY8mJxJ6cr--uSHOk820A58uCZAxjNMA2QVfdpDQkpQnO--ZL_iAKbwltxmG-XnxtIch4YvjvSi-fnh_v_5U3n3-eLu-viuNrOpc1iCxYUp0HYe2ho51VDHWdlBBI3vRgK2gNYZXUiqsbc8Fb3ohrOqg50A7cVG8OfSOMXybMGW9c8ngMIDHMCWtWCMr1cgFfHUEp26HVo_R7SDO-s9aC_D6CEAyMPQRvHHpH65WjRDNwl0eOBNDShF7bVz-PUiO4AbNqN4r1Ft9UKj3CjXjelG4hOV_4b_9j8euDjFcpnxwGHUyDr1B6xajWdvgHi_4BX_9uRk |
| CODEN | TOLED5 |
| CitedBy_id | crossref_primary_10_1016_j_envint_2008_07_003 crossref_primary_10_1002_minf_200900064 crossref_primary_10_1007_s00360_005_0483_3 crossref_primary_10_1265_jjh_64_759 crossref_primary_10_1016_j_scitotenv_2018_06_136 crossref_primary_10_1080_10643389_2012_672076 crossref_primary_10_3389_fmicb_2019_02349 crossref_primary_10_1021_jp1099893 crossref_primary_10_1016_j_jhazmat_2013_07_017 crossref_primary_10_1016_j_jes_2015_11_011 crossref_primary_10_1007_s10661_024_12690_3 crossref_primary_10_1080_08923970902756056 crossref_primary_10_1097_MOP_0b013e32832925cc crossref_primary_10_1080_01635581_2012_711419 crossref_primary_10_1177_0748233712440139 crossref_primary_10_1111_ced_14617 crossref_primary_10_1016_j_canlet_2005_09_020 crossref_primary_10_3389_fimmu_2021_624293 crossref_primary_10_1039_C6CP01728B crossref_primary_10_1111_jdv_16835 crossref_primary_10_1016_j_envint_2020_105731 crossref_primary_10_1016_j_fct_2009_04_028 crossref_primary_10_1038_srep38012 crossref_primary_10_1039_C4TX00236A crossref_primary_10_1289_ehp_7219 crossref_primary_10_1007_s11356_014_3799_2 crossref_primary_10_1016_j_tox_2011_01_025 crossref_primary_10_1186_s12940_018_0365_2 crossref_primary_10_1016_j_mrfmmm_2011_05_004 crossref_primary_10_1002_etc_189 crossref_primary_10_1016_j_bcp_2010_10_003 crossref_primary_10_1016_j_envint_2018_08_051 crossref_primary_10_1016_j_toxlet_2005_06_015 crossref_primary_10_1111_j_1742_7843_2007_00201_x crossref_primary_10_1016_j_tox_2020_152646 crossref_primary_10_3390_ijerph16193566 crossref_primary_10_1007_s13530_013_0169_2 crossref_primary_10_1016_j_envint_2016_08_016 crossref_primary_10_1016_j_ecoenv_2022_113344 crossref_primary_10_1134_S0006297913030024 crossref_primary_10_1016_j_envint_2014_06_009 crossref_primary_10_1016_j_cotox_2018_03_001 crossref_primary_10_1007_s13277_012_0413_4 crossref_primary_10_1039_C4CP05466K crossref_primary_10_2903_j_efsa_2018_5333 crossref_primary_10_1039_c0em00730g crossref_primary_10_1007_BF03216482 crossref_primary_10_4049_jimmunol_179_1_247 crossref_primary_10_1007_s00420_005_0049_4 crossref_primary_10_1016_j_etap_2006_03_005 crossref_primary_10_1080_00927870701873214 |
| ContentType | Journal Article Conference Proceeding |
| Copyright | 2004 Elsevier Ireland Ltd 2004 INIST-CNRS |
| Copyright_xml | – notice: 2004 Elsevier Ireland Ltd – notice: 2004 INIST-CNRS |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.toxlet.2003.12.062 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Public Health Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1879-3169 |
| EndPage | 293 |
| ExternalDocumentID | 15093275 15678338 10_1016_j_toxlet_2003_12_062 S0378427403005083 |
| Genre | Journal Article |
| GeographicLocations | Italy Europe |
| GroupedDBID | --- --K --M .GJ .~1 0R~ 123 1B1 1RT 1~. 1~5 29Q 4.4 457 4G. 53G 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXUO ABEFU ABFNM ABFRF ABFYP ABJNI ABLST ABMAC ABXDB ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD AEBSH AEFWE AEKER AENEX AFFNX AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHEUO AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AKIFW ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLECG BLXMC CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMT HVGLF HZ~ IHE J1W KCYFY KOM M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCC SDF SDG SDP SES SEW SPCBC SPT SSJ SSP SSZ T5K WH7 WUQ XPP ZGI ZXP ~G- ~KM AAYWO AAYXX ABWVN ACLOT ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFPUW AIIUN AKBMS AKRWK AKYEP ANKPU CITATION EFKBS ~HD AAXKI AFJKZ IQODW CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c456t-6a4e8173bb2a96ab1b07119ba5a84f38ad5a9cc25447e6df2328f33d7baf2a0b3 |
| IEDL.DBID | .~1 |
| ISSN | 0378-4274 |
| IngestDate | Sun Sep 28 11:16:04 EDT 2025 Wed Feb 19 01:38:39 EST 2025 Tue Mar 18 02:08:18 EDT 2025 Wed Oct 01 01:23:50 EDT 2025 Thu Apr 24 23:09:26 EDT 2025 Fri Feb 23 02:28:20 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | TCDD Molecular epidemiology Population-based study Dioxin Aryl-hydrocarbon receptor Human Toxicity Biological marker Gene expression Pollutant Ah receptor Chlorine Organic compounds Public health |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0 |
| LinkModel | DirectLink |
| MeetingName | Science for Safety |
| MergedId | FETCHMERGED-LOGICAL-c456t-6a4e8173bb2a96ab1b07119ba5a84f38ad5a9cc25447e6df2328f33d7baf2a0b3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 15093275 |
| PQID | 71845784 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | proquest_miscellaneous_71845784 pubmed_primary_15093275 pascalfrancis_primary_15678338 crossref_citationtrail_10_1016_j_toxlet_2003_12_062 crossref_primary_10_1016_j_toxlet_2003_12_062 elsevier_sciencedirect_doi_10_1016_j_toxlet_2003_12_062 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2004-04-01 |
| PublicationDateYYYYMMDD | 2004-04-01 |
| PublicationDate_xml | – month: 04 year: 2004 text: 2004-04-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Shannon Amsterdam |
| PublicationPlace_xml | – name: Amsterdam – name: Shannon – name: Netherlands |
| PublicationTitle | Toxicology letters |
| PublicationTitleAlternate | Toxicol Lett |
| PublicationYear | 2004 |
| Publisher | Elsevier Ireland Ltd Elsevier Science |
| Publisher_xml | – name: Elsevier Ireland Ltd – name: Elsevier Science |
| References | Patterson, Hampton, Lapeza, Belser, Green, Alexander, Needham (BIB14) 1987; 59 Grassman, Landi, Masten, Spencer, Consonni, Edler, Needham, Caporaso, Mocarelli, Lucier (BIB7) 1999; 44 dioxins and polychlorinated dibenzofurans. IARC Monogr. Eval. Carcinog. Risks Hum. 69. Baccarelli, Mocarelli, Patterson, Bonzini, Pesatori, Caporaso, Landi (BIB1) 2002; 110 Dey, Parmar, Dayal, Dhawan, Seth (BIB6) 2001; 69 Landi, Needham, Lucier, Mocarelli, Bertazzi, Caporaso (BIB10) 1997; 349 Holsapple, Snyder, Wood, Morris (BIB8) 1991; 69 Whitlock (BIB15) 1999; 39 Masten, Grassman, Miller, Spencer, Walker, Jung, Edler, Patterson, Needham, Lucier (BIB13) 1998; 37 Bertazzi, Consonni, Bachetti, Rubagotti, Baccarelli, Zocchetti, Pesatori (BIB3) 2001; 153 Birnbaum, Tuomisto (BIB4) 2000; 17 DeVito, Birnbaum, Farland, Gasiewicz (BIB5) 1995; 103 Landi, Consonni, Patterson, Needham, Lucier, Brambilla, Cazzaniga, Mocarelli, Pesatori, Bertazzi, Caporaso (BIB11) 1998; 106 Landi, Bertazzi, Baccarelli, Consonni, Masten, Lucier, Mocarelli, Needham, Caporaso, Grassman (BIB12) 2003; 24 Bertazzi, Pesatori, Bernucci, Landi, Consonni (BIB2) 1999; 13 IARC, 1997. Polychlorinated dibenzo- |
| References_xml | – volume: 59 start-page: 2000 year: 1987 end-page: 2005 ident: BIB14 article-title: High-resolution gas chromatographic/high-resolution mass spectrometric analysis of human serum on a whole-weight and lipid basis for 2,3,7,8-tetrachlorodibenzo- publication-title: Anal. Chem. – volume: 110 start-page: 1169 year: 2002 end-page: 1173 ident: BIB1 article-title: Immunologic effects of dioxin: new results from Seveso and comparison with other studies publication-title: Environ. Health Perspect. – volume: 24 start-page: 673 year: 2003 end-page: 680 ident: BIB12 article-title: TCDD-mediated alterations in the AhR-dependent pathway in Seveso, Italy, 20 years after the accident publication-title: Carcinogenesis – volume: 44 start-page: 375 year: 1999 end-page: 379 ident: BIB7 article-title: Determinants of ethoxyresorufin- publication-title: Organohalogen Comp. – volume: 13 start-page: S72 year: 1999 end-page: S74 ident: BIB2 article-title: Dioxin exposure and human leukemias and lymphomas. Lessons from the Seveso accident and studies on industrial workers publication-title: Leukemia – volume: 69 start-page: 383 year: 2001 end-page: 393 ident: BIB6 article-title: Cytochrome P450 1A1 (CYP1A1) in blood lymphocytes evidence for catalytic activity and mRNA expression publication-title: Life Sci. – reference: -dioxins and polychlorinated dibenzofurans. IARC Monogr. Eval. Carcinog. Risks Hum. 69. – reference: IARC, 1997. Polychlorinated dibenzo- – volume: 106 start-page: 273 year: 1998 end-page: 277 ident: BIB11 article-title: 2,3,7,8-Tetrachlorodibenzo- publication-title: Environ. Health Perspect. – volume: 349 start-page: 1811 year: 1997 ident: BIB10 article-title: Concentrations of dioxin 20 years after Seveso publication-title: Lancet – volume: 37 start-page: 13 year: 1998 end-page: 16 ident: BIB13 article-title: Population-based studies of dioxin responsiveness: individual variation in CYP1A1 levels and relationship to dioxin body burden publication-title: Organohalogen Comp. – volume: 17 start-page: 275 year: 2000 end-page: 288 ident: BIB4 article-title: Non-carcinogenic effects of TCDD in animals publication-title: Food Addit. Contam. – volume: 103 start-page: 820 year: 1995 end-page: 831 ident: BIB5 article-title: Comparisons of estimated human body burdens of dioxinlike chemicals and TCDD body burdens in experimentally exposed animals publication-title: Environ. Health Perspect. – volume: 39 start-page: 103 year: 1999 end-page: 125 ident: BIB15 article-title: Induction of cytochrome P4501A1 publication-title: Annu. Rev. Pharmacol. Toxicol. – volume: 153 start-page: 1031 year: 2001 end-page: 1044 ident: BIB3 article-title: Health effects of dioxin exposure: a 20-year mortality study publication-title: Am. J. Epidemiol. – volume: 69 start-page: 219 year: 1991 end-page: 255 ident: BIB8 article-title: A review of 2,3,7,8-tetrachlorodibenzo- publication-title: Toxicology |
| SSID | ssj0006465 |
| Score | 2.0155988 |
| Snippet | Approximately 20 years after the Seveso, Italy accident, we conducted a population-based study to evaluate the impact of 2,3,7,8-tetrachlorodibenzo-
p-dioxin... Approximately 20 years after the Seveso, Italy accident, we conducted a population-based study to evaluate the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin... |
| SourceID | proquest pubmed pascalfrancis crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 287 |
| SubjectTerms | Adult Aged Analysis. Health state Aryl Hydrocarbon Hydroxylases - biosynthesis Aryl Hydrocarbon Receptor Nuclear Translocator Aryl-hydrocarbon receptor Biological and medical sciences Biomarkers Body Burden Chemical and industrial products toxicology. Toxic occupational diseases Complement C3 - analysis Complement C4 - analysis Cytochrome P-450 CYP1A1 - biosynthesis Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 CYP1B1 Dioxin DNA-Binding Proteins Environmental Pollutants - toxicity Epidemiology Female General aspects Humans Immunoglobulins - analysis In Vitro Techniques Italy - epidemiology Lymphocytes - enzymology Male Medical sciences Middle Aged Molecular epidemiology Polychlorinated Dibenzodioxins - toxicity Population Population-based study Public health. Hygiene Public health. Hygiene-occupational medicine Receptors, Aryl Hydrocarbon - biosynthesis Receptors, Aryl Hydrocarbon - physiology RNA, Messenger - analysis RNA, Messenger - biosynthesis TCDD Toxicology Transcription Factors - biosynthesis Various organic compounds |
| Title | Aryl-hydrocarbon receptor-dependent pathway and toxic effects of TCDD in humans: a population-based study in Seveso, Italy |
| URI | https://dx.doi.org/10.1016/j.toxlet.2003.12.062 https://www.ncbi.nlm.nih.gov/pubmed/15093275 https://www.proquest.com/docview/71845784 |
| Volume | 149 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Complete Freedom Collection [SCCMFC] customDbUrl: eissn: 1879-3169 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0006465 issn: 0378-4274 databaseCode: ACRLP dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection customDbUrl: eissn: 1879-3169 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0006465 issn: 0378-4274 databaseCode: .~1 dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals [SCFCJ] customDbUrl: eissn: 1879-3169 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0006465 issn: 0378-4274 databaseCode: AIKHN dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 1879-3169 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0006465 issn: 0378-4274 databaseCode: AKRWK dateStart: 19930101 isFulltext: true providerName: Library Specific Holdings |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pa9swFBaluwzK2Lpf2Y9Mh9FTtDiWLCm7hXQl3aAUmkJvRrJkllJsE7vtvMP-9j1Jdr0eSmH4ZiRblp70PsnvfR9Cn7mkOeUu8zePFGGKcwJ2w4gAbz03mXCUXS7a4oSvztn3i-RiBy37XBgXVtmt_WFN96t1d2fa9ea02mymZxEVksGmKnKM64AkXAY7PBps-sufIcyDMy8n6QoTV7pPn_MxXk35C3rHs4L6Q0EeP-Se9ipVQ6flQe3iYTjq3dLRc_Ssw5N4EZr8Au3YYh8dnAZC6naC10N-VT3BB_h0oKpu99FeOLXDIRnpJfq92LZX5GdrwK2prS4LDJ1jK9iXk14tt8FOxPhWtVgVBsOnQfUuKASXOV4vDw_xpsBe-6_-ihWu7iTCiHOZBntGW1fmzN7YupzgY9gAtK_Q-dG39XJFOnUGkgHoaghXzMqZoFrHas6VnmlAK7O5VomSLKdSmUTNs8xRoAnLTQ7QTeaUGqFVHqtI09dotygL-xZhJmImMqMN55IpbSRcVkSJhP1VpmM9QrQflDTrqMudgsZV2seoXaZhKJ2qJk1ncQpDOULkrlYVqDseKS_68U7vmWAK3uWRmuN75jG8LgEsQKkcoU-9vaQwfd0_GVXY8rpOARowWDTZCL0JZvRP3QiwtUje_Xez3qOnQ5zRB7TbbK_tR4BQjR77OTJGTxbHP1YnfwGw0xyZ |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9swFBZd-rBBGVt3yy6tHkafIuJYsqTsLaQrydqFQlPom5AsmWYU28TuWu_X78iXZH0oheE3o4Nt6ficT_Y534fQVy5pQrnv_E0CTZjmnIDfMCIgW49tLDxll6-2WPDZJftxFV3toGnXC-PLKtvY38T0Olq3Z4btbA7z1Wp4EVAhGWyqAs-4DkjiGdplEcTkHtqdzE9ni01A5qxWlPTjiTfoOujqMq8yu4cJqolB6--CPHwsQ-3luoB5SxrBi8cRaZ2ZTl6hly2kxJPmrl-jHZfuo6PzhpO6GuDltsWqGOAjfL5lq6720V7z4Q43_Uhv0J_Juroh15WFzKbXJksxzI_LYWtOOsHcEnsd4ztdYZ1aDI8G5m1dCM4SvJweH-NVimv5v-Ib1jjfqIQRnzUtrklt_ZgL99sV2QDPYQ9QvUWXJ9-X0xlpBRpIDLirJFwzJ0eCGhPqMddmZACwjMZGR1qyhEptIz2OY8-CJhy3CaA3mVBqhdFJqAND36FemqXuA8JMhEzE1ljOJdPGSjicCCIJW6zYhKaPaLcoKm7Zy72Ixo3qytR-qWYpvbAmVaNQwVL2EdlY5Q17xxPjRbfe6oEXKkgwT1gePHCP7eUigAOUyj467PxFwRvsf8vo1GW3hQJ0wCBusj5637jRP7YBwGsRffzv2zpEz2fLn2fqbL44_YRebMuOPqNeub51XwBRleagfWP-AkUEH0Q |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=proceeding&rft.title=Toxicology+letters&rft.atitle=Aryl-hydrocarbon+receptor-dependent+pathway+and+toxic+effects+of+TCDD+in+humans%3A+a+population-based+study+in+Seveso%2C+Italy&rft.au=BACCARELLI%2C+Andrea&rft.au=PESATORI%2C+Angela+C&rft.au=LANDI%2C+Maria+Teresa&rft.au=MASTEN%2C+Scott+A&rft.date=2004-04-01&rft.pub=Elsevier+Science&rft.issn=0378-4274&rft.volume=149&rft.issue=1-3&rft.spage=287&rft.epage=293&rft_id=info:doi/10.1016%2Fj.toxlet.2003.12.062&rft.externalDBID=n%2Fa&rft.externalDocID=15678338 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0378-4274&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0378-4274&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0378-4274&client=summon |