Lipocalin 2 produces insulin resistance and can be upregulated by glucocorticoids in human adipose tissue
The adipokine lipocalin 2 is linked to obesity and metabolic disorders. However, its role in human adipose tissue glucose and lipid metabolism is not explored. Here we show that the synthetic glucocorticoid dexamethasone dose-dependently increased lipocalin 2 gene expression in subcutaneous and omen...
Saved in:
| Published in | Molecular and cellular endocrinology Vol. 427; pp. 124 - 132 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ireland
Elsevier Ireland Ltd
15.05.2016
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0303-7207 1872-8057 1872-8057 |
| DOI | 10.1016/j.mce.2016.03.011 |
Cover
| Abstract | The adipokine lipocalin 2 is linked to obesity and metabolic disorders. However, its role in human adipose tissue glucose and lipid metabolism is not explored. Here we show that the synthetic glucocorticoid dexamethasone dose-dependently increased lipocalin 2 gene expression in subcutaneous and omental adipose tissue from pre-menopausal females, while it had no effect in post-menopausal females or in males. Subcutaneous adipose tissue from both genders treated with recombinant human lipocalin 2 showed a reduction in protein levels of GLUT1 and GLUT4 and in glucose uptake in isolated adipocytes. In subcutaneous adipose tissue, lipocalin 2 increased IL-6 gene expression whereas expression of PPARγ and adiponectin was reduced. Our findings suggest that lipocalin 2 can contribute to insulin resistance in human adipose tissue. In pre-menopausal females, it may partly mediate adverse metabolic effects exerted by glucocorticoid excess.
•This study demonstrates a role of lipocalin 2 in human adipose tissue metabolism.•Dexamethasone induces lipocalin 2 gene expression in pre-menopausal females.•Stromal vascular cells are major contributors of lipocalin 2 expression.•Lipocalin 2 impairs basal and insulin-stimulated glucose uptake in adipocytes.•Lipocalin 2 reduces PPARγ and adiponectin expression. |
|---|---|
| AbstractList | The adipokine lipocalin 2 is linked to obesity and metabolic disorders. However, its role in human adipose tissue glucose and lipid metabolism is not explored. Here we show that the synthetic glucocorticoid dexamethasone dose-dependently increased lipocalin 2 gene expression in subcutaneous and omental adipose tissue from pre-menopausal females, while it had no effect in post-menopausal females or in males. Subcutaneous adipose tissue from both genders treated with recombinant human lipocalin 2 showed a reduction in protein levels of GLUT1 and GLUT4 and in glucose uptake in isolated adipocytes. In subcutaneous adipose tissue, lipocalin 2 increased IL-6 gene expression whereas expression of PPARγ and adiponectin was reduced. Our findings suggest that lipocalin 2 can contribute to insulin resistance in human adipose tissue. In pre-menopausal females, it may partly mediate adverse metabolic effects exerted by glucocorticoid excess. The adipokine lipocalin 2 is linked to obesity and metabolic disorders. However, its role in human adipose tissue glucose and lipid metabolism is not explored. Here we show that the synthetic glucocorticoid dexamethasone dose-dependently increased lipocalin 2 gene expression in subcutaneous and omental adipose tissue from pre-menopausal females, while it had no effect in post-menopausal females or in males. Subcutaneous adipose tissue from both genders treated with recombinant human lipocalin 2 showed a reduction in protein levels of GLUT1 and GLUT4 and in glucose uptake in isolated adipocytes. In subcutaneous adipose tissue, lipocalin 2 increased IL-6 gene expression whereas expression of PPAR gamma and adiponectin was reduced. Our findings suggest that lipocalin 2 can contribute to insulin resistance in human adipose tissue. In pre-menopausal females, it may partly mediate adverse metabolic effects exerted by glucocorticoid excess. The adipokine lipocalin 2 is linked to obesity and metabolic disorders. However, its role in human adipose tissue glucose and lipid metabolism is not explored. Here we show that the synthetic glucocorticoid dexamethasone dose-dependently increased lipocalin 2 gene expression in subcutaneous and omental adipose tissue from pre-menopausal females, while it had no effect in post-menopausal females or in males. Subcutaneous adipose tissue from both genders treated with recombinant human lipocalin 2 showed a reduction in protein levels of GLUT1 and GLUT4 and in glucose uptake in isolated adipocytes. In subcutaneous adipose tissue, lipocalin 2 increased IL-6 gene expression whereas expression of PPARγ and adiponectin was reduced. Our findings suggest that lipocalin 2 can contribute to insulin resistance in human adipose tissue. In pre-menopausal females, it may partly mediate adverse metabolic effects exerted by glucocorticoid excess. •This study demonstrates a role of lipocalin 2 in human adipose tissue metabolism.•Dexamethasone induces lipocalin 2 gene expression in pre-menopausal females.•Stromal vascular cells are major contributors of lipocalin 2 expression.•Lipocalin 2 impairs basal and insulin-stimulated glucose uptake in adipocytes.•Lipocalin 2 reduces PPARγ and adiponectin expression. |
| Author | Sundbom, Magnus Eriksson, Jan W. Kamble, Prasad G. Amini, Sam Sidibeh, Cherno O. Pereira, Maria J. Börjesson, Joey Lau |
| Author_xml | – sequence: 1 givenname: Prasad G. surname: Kamble fullname: Kamble, Prasad G. organization: Department of Medical Sciences, Uppsala University, Uppsala, Sweden – sequence: 2 givenname: Maria J. surname: Pereira fullname: Pereira, Maria J. organization: Department of Medical Sciences, Uppsala University, Uppsala, Sweden – sequence: 3 givenname: Cherno O. surname: Sidibeh fullname: Sidibeh, Cherno O. organization: Department of Medical Sciences, Uppsala University, Uppsala, Sweden – sequence: 4 givenname: Sam surname: Amini fullname: Amini, Sam organization: Department of Medical Sciences, Uppsala University, Uppsala, Sweden – sequence: 5 givenname: Magnus surname: Sundbom fullname: Sundbom, Magnus organization: Department of Surgery, Uppsala University, Uppsala, Sweden – sequence: 6 givenname: Joey Lau surname: Börjesson fullname: Börjesson, Joey Lau organization: Department of Medical Sciences, Uppsala University, Uppsala, Sweden – sequence: 7 givenname: Jan W. surname: Eriksson fullname: Eriksson, Jan W. email: jan.eriksson@medsci.uu.se organization: Department of Medical Sciences, Uppsala University, Uppsala, Sweden |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26973291$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-297263$$DView record from Swedish Publication Index |
| BookMark | eNqNkk1v1DAQhi1URLeFH8AF-ciBBH8ktiNOVSkf0kpcgKvl2JPFqyQOdgzqv6-jbTlwKJxsWc8z8sy8F-hsDjMg9JKSmhIq3h7ryULNyrUmvCaUPkE7qiSrFGnlGdoRTnglGZHn6CKlIyFEtkw9Q-dMdJKzju6Q3_slWDP6GTO8xOCyhYT9nPL2FCH5tJrZAjazw9bMuAeclwiHPJoVHO5v8WHMNtgQV2-Dd5uMf-SpoMaV2gnw6lPK8Bw9HcyY4MX9eYm-fbj5ev2p2n_5-Pn6al_ZphVrJUo3HTVWEdHbVlI5tK1oOymF4kypjkhHjHCg2MCaxnAihq5jQ2-ZcXRghF-iN6e66TcsuddL9JOJtzoYr9_771c6xIPOWbNOMsEL_vqEl-Z_ZkirnnyyMI5mhpCTZmVqTHYNk_9EqaKCKNa1_4FKRVveSLWhr-7R3E_g_vz3YUcFkCfAxpBShEFbv5rVh3mNxo-aEr2lQR91SYPe0qAJ1yUNxaR_mQ_FH3PenRwoO_rlIepkPZQEOB_BrtoF_4h9BzE4y0c |
| CitedBy_id | crossref_primary_10_1038_s41413_021_00142_4 crossref_primary_10_1016_j_coph_2017_08_011 crossref_primary_10_1360_SSV_2024_0261 crossref_primary_10_1016_j_redox_2025_103506 crossref_primary_10_1016_j_neubiorev_2018_09_014 crossref_primary_10_1038_s41598_020_67293_y crossref_primary_10_1016_j_bbrep_2020_100831 crossref_primary_10_1002_ijc_35205 crossref_primary_10_5812_thrita_84879 crossref_primary_10_1038_s41598_020_71249_7 crossref_primary_10_3390_cancers14071679 crossref_primary_10_1210_clinem_dgac042 crossref_primary_10_1055_a_1909_1922 crossref_primary_10_3390_ijerph182413333 crossref_primary_10_1097_MNH_0000000000000804 crossref_primary_10_1016_j_phrs_2021_105486 crossref_primary_10_1146_annurev_nutr_071816_064559 crossref_primary_10_1007_s40618_020_01494_0 crossref_primary_10_13005_bbra_2922 crossref_primary_10_1016_j_molmet_2020_101047 crossref_primary_10_1016_j_arr_2021_101414 crossref_primary_10_1016_j_bios_2016_09_010 crossref_primary_10_1194_jlr_R094060 crossref_primary_10_1038_s41598_025_88115_z crossref_primary_10_32527_2018_101373 crossref_primary_10_1016_j_bcp_2019_113626 crossref_primary_10_1155_2017_6589262 crossref_primary_10_1210_endrev_bnad025 crossref_primary_10_1016_j_bone_2024_117238 crossref_primary_10_1016_j_mce_2019_04_002 crossref_primary_10_3389_fimmu_2023_1229885 crossref_primary_10_1016_j_molmet_2020_101040 crossref_primary_10_1111_bcpt_13332 crossref_primary_10_3390_endocrines6010004 |
| Cites_doi | 10.1210/jcem-67-6-1122 10.1074/mcp.M200006-MCP200 10.1155/2010/802078 10.1016/j.mce.2009.10.004 10.1016/j.metabol.2014.05.015 10.1016/S0026-895X(25)10446-X 10.1016/j.bbadis.2013.05.029 10.1016/S0021-9258(18)82217-7 10.1016/j.jaci.2005.02.023 10.1210/jc.2003-031157 10.1016/S0006-2952(96)00506-0 10.1152/ajpendo.2001.280.5.E745 10.4093/dmj.2014.38.5.356 10.1074/jbc.M107101200 10.1152/ajpendo.00586.2007 10.1007/s001250050807 10.1096/fj.10-165175 10.2337/db07-0007 10.1074/jbc.M113.532234 10.1186/1475-2840-11-11 10.1038/sj.ijo.0800469 10.1186/1475-2840-12-176 10.1007/s00134-014-3468-4 10.1210/en.2011-1642 10.1007/BF03347037 10.1136/ard.2010.132399 10.1210/en.2004-1675 10.1210/jc.2014-1839 10.1373/clinchem.2006.075614 10.1194/jlr.R700005-JLR200 10.1002/oby.20507 10.1210/endo.137.11.8895337 10.1016/j.cmet.2007.03.006 10.1038/oby.2011.61 10.1074/jbc.M114.606459 10.1016/0378-1119(95)00896-9 10.1007/s00109-009-0486-8 10.1016/0026-0495(94)90010-8 10.1210/jc.2005-0354 10.1055/s-0028-1087168 10.1101/gad.948702 10.1016/S0021-9258(18)93981-5 10.1007/s00125-006-0572-1 10.2337/db09-1541 |
| ContentType | Journal Article |
| Copyright | 2016 Elsevier Ireland Ltd Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. |
| Copyright_xml | – notice: 2016 Elsevier Ireland Ltd – notice: Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7U5 8FD L7M 7S9 L.6 ADTPV AOWAS DF2 |
| DOI | 10.1016/j.mce.2016.03.011 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Solid State and Superconductivity Abstracts Technology Research Database Advanced Technologies Database with Aerospace AGRICOLA AGRICOLA - Academic SwePub SwePub Articles SWEPUB Uppsala universitet |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic Technology Research Database Advanced Technologies Database with Aerospace Solid State and Superconductivity Abstracts AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic AGRICOLA Technology Research Database |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1872-8057 |
| EndPage | 132 |
| ExternalDocumentID | oai_DiVA_org_uu_297263 26973291 10_1016_j_mce_2016_03_011 S0303720716300594 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M -~X .~1 0R~ 123 1B1 1RT 1~. 1~5 4.4 457 4G. 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAXUO ABBQC ABFRF ABGSF ABJNI ABLVK ABMAC ABMZM ABUDA ABYKQ ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX AXJTR BKOJK BLXMC BNPGV CS3 DOVZS DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IHE J1W KOM LCYCR LX3 LZ1 M29 M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 RIG ROL RPZ SCC SCU SDF SDG SDP SES SPCBC SSH SSU SSZ T5K WH7 ~G- .55 .GJ 29M 3O- 53G AAHBH AAQXK AATTM AAXKI AAYWO AAYXX ABFNM ABWVN ABXDB ACIEU ACLOT ACRPL ACVFH ADCNI ADMUD ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AGRDE AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP ASPBG AVWKF AZFZN CITATION EFKBS FEDTE FGOYB G-2 HDZ HLW HMK HMO HVGLF HZ~ J5H MVM R2- SAE SBG SEW WUQ X7M ZGI ZXP ~HD CGR CUY CVF ECM EIF NPM 7X8 7U5 8FD L7M 7S9 L.6 ADTPV AGCQF AOWAS DF2 |
| ID | FETCH-LOGICAL-c456t-601691ac806bc5717f5565977683288907d0a6de82f244a306f992fbc2ad1f203 |
| IEDL.DBID | .~1 |
| ISSN | 0303-7207 1872-8057 |
| IngestDate | Tue Sep 09 23:58:19 EDT 2025 Sun Sep 28 00:05:30 EDT 2025 Sun Sep 28 08:09:35 EDT 2025 Mon Sep 29 05:59:44 EDT 2025 Wed Feb 19 01:55:28 EST 2025 Wed Oct 01 06:00:03 EDT 2025 Thu Apr 24 23:04:47 EDT 2025 Fri Feb 23 02:20:28 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Lipocalin 2 Type 2 diabetes KRH BCA GLUT1 SVC Glucocorticoids EDTA WST-1 PPARγ IL-6 PBS-T BSA DMEM PEST FBS rhLcn2 Insulin resistance TNF α GLUT4 GAPDH Human adipose tissue BMI Lcn2 |
| Language | English |
| License | Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c456t-601691ac806bc5717f5565977683288907d0a6de82f244a306f992fbc2ad1f203 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 26973291 |
| PQID | 1781534787 |
| PQPubID | 23479 |
| PageCount | 9 |
| ParticipantIDs | swepub_primary_oai_DiVA_org_uu_297263 proquest_miscellaneous_2000279427 proquest_miscellaneous_1816082957 proquest_miscellaneous_1781534787 pubmed_primary_26973291 crossref_citationtrail_10_1016_j_mce_2016_03_011 crossref_primary_10_1016_j_mce_2016_03_011 elsevier_sciencedirect_doi_10_1016_j_mce_2016_03_011 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2016-05-15 |
| PublicationDateYYYYMMDD | 2016-05-15 |
| PublicationDate_xml | – month: 05 year: 2016 text: 2016-05-15 day: 15 |
| PublicationDecade | 2010 |
| PublicationPlace | Ireland |
| PublicationPlace_xml | – name: Ireland |
| PublicationTitle | Molecular and cellular endocrinology |
| PublicationTitleAlternate | Mol Cell Endocrinol |
| PublicationYear | 2016 |
| Publisher | Elsevier Ireland Ltd |
| Publisher_xml | – name: Elsevier Ireland Ltd |
| References | Lundgren (bib24) 2004; 89 Lundgren (bib26) 2008; 40 Auguet (bib1) 2011; 19 Lonn (bib23) 1994; 43 Owen (bib30) 2008; 294 Drew (bib7) 2015; 290 Pereira (bib32) 2014; 63 Conde (bib5) 2011; 70 Kjeldsen (bib18) 1993; 268 Garay-Rojas (bib11) 1996; 170 Huang (bib14) 2012; 11 Cakal (bib3) 2011; 34 Lundgren (bib25) 2007; 50 Yu (bib43) 1997; 40 Munoz (bib27) 1996; 52 Fine, DiGirolamo (bib10) 1997; 21 Huang, Czech (bib13) 2007; 5 Rebuffe-Scrive (bib33) 1988; 67 Paton (bib31) 2013; 21 Fain (bib8) 2010; 315 Fantuzzi (bib9) 2005; 115 Ni (bib29) 2013; 12 Zhao, Elks, Stephens (bib45) 2014; 289 Sethi, Vidal-Puig (bib37) 2007; 48 Kern (bib17) 2001; 280 Tafuri (bib38) 1996; 137 Seth (bib36) 2002; 62 Renstrom, Buren, Eriksson (bib34) 2005; 146 Guo (bib12) 2012; 153 Nakada (bib28) 1987; 31 Yan (bib41) 2007; 56 Dole (bib6) 1961; 236 Yoo (bib42) 2014; 38 Balistreri, Caruso, Candore (bib2) 2010; 2010 Lee (bib21) 2014; 1842 Kratchmarova (bib19) 2002; 1 Widmer (bib40) 2005; 90 Rosen (bib35) 2002; 16 Wang (bib39) 2007; 53 Catalan (bib4) 2009; 87 Law (bib20) 2010; 59 Lin (bib22) 2001; 276 Zhang (bib44) 2014; 40 Jin (bib15) 2011; 25 Karim (bib16) 2015; 100 Law (10.1016/j.mce.2016.03.011_bib20) 2010; 59 Fantuzzi (10.1016/j.mce.2016.03.011_bib9) 2005; 115 Fine (10.1016/j.mce.2016.03.011_bib10) 1997; 21 Lundgren (10.1016/j.mce.2016.03.011_bib25) 2007; 50 Huang (10.1016/j.mce.2016.03.011_bib14) 2012; 11 Lee (10.1016/j.mce.2016.03.011_bib21) 2014; 1842 Kjeldsen (10.1016/j.mce.2016.03.011_bib18) 1993; 268 Auguet (10.1016/j.mce.2016.03.011_bib1) 2011; 19 Catalan (10.1016/j.mce.2016.03.011_bib4) 2009; 87 Drew (10.1016/j.mce.2016.03.011_bib7) 2015; 290 Garay-Rojas (10.1016/j.mce.2016.03.011_bib11) 1996; 170 Renstrom (10.1016/j.mce.2016.03.011_bib34) 2005; 146 Ni (10.1016/j.mce.2016.03.011_bib29) 2013; 12 Wang (10.1016/j.mce.2016.03.011_bib39) 2007; 53 Guo (10.1016/j.mce.2016.03.011_bib12) 2012; 153 Rosen (10.1016/j.mce.2016.03.011_bib35) 2002; 16 Munoz (10.1016/j.mce.2016.03.011_bib27) 1996; 52 Paton (10.1016/j.mce.2016.03.011_bib31) 2013; 21 Tafuri (10.1016/j.mce.2016.03.011_bib38) 1996; 137 Kern (10.1016/j.mce.2016.03.011_bib17) 2001; 280 Huang (10.1016/j.mce.2016.03.011_bib13) 2007; 5 Sethi (10.1016/j.mce.2016.03.011_bib37) 2007; 48 Lin (10.1016/j.mce.2016.03.011_bib22) 2001; 276 Fain (10.1016/j.mce.2016.03.011_bib8) 2010; 315 Yan (10.1016/j.mce.2016.03.011_bib41) 2007; 56 Zhang (10.1016/j.mce.2016.03.011_bib44) 2014; 40 Dole (10.1016/j.mce.2016.03.011_bib6) 1961; 236 Conde (10.1016/j.mce.2016.03.011_bib5) 2011; 70 Rebuffe-Scrive (10.1016/j.mce.2016.03.011_bib33) 1988; 67 Balistreri (10.1016/j.mce.2016.03.011_bib2) 2010; 2010 Jin (10.1016/j.mce.2016.03.011_bib15) 2011; 25 Zhao (10.1016/j.mce.2016.03.011_bib45) 2014; 289 Karim (10.1016/j.mce.2016.03.011_bib16) 2015; 100 Yoo (10.1016/j.mce.2016.03.011_bib42) 2014; 38 Kratchmarova (10.1016/j.mce.2016.03.011_bib19) 2002; 1 Nakada (10.1016/j.mce.2016.03.011_bib28) 1987; 31 Seth (10.1016/j.mce.2016.03.011_bib36) 2002; 62 Yu (10.1016/j.mce.2016.03.011_bib43) 1997; 40 Widmer (10.1016/j.mce.2016.03.011_bib40) 2005; 90 Lonn (10.1016/j.mce.2016.03.011_bib23) 1994; 43 Lundgren (10.1016/j.mce.2016.03.011_bib24) 2004; 89 Owen (10.1016/j.mce.2016.03.011_bib30) 2008; 294 Pereira (10.1016/j.mce.2016.03.011_bib32) 2014; 63 Cakal (10.1016/j.mce.2016.03.011_bib3) 2011; 34 Lundgren (10.1016/j.mce.2016.03.011_bib26) 2008; 40 |
| References_xml | – volume: 137 start-page: 4706 year: 1996 end-page: 4712 ident: bib38 article-title: Troglitazone enhances differentiation, basal glucose uptake, and Glut1 protein levels in 3T3-L1 adipocytes publication-title: Endocrinology – volume: 280 start-page: E745 year: 2001 end-page: E751 ident: bib17 article-title: Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance publication-title: Am. J. Physiol. Endocrinol. Metab. – volume: 62 start-page: 4540 year: 2002 end-page: 4544 ident: bib36 article-title: Cellular and molecular targets of estrogen in normal human breast tissue publication-title: Cancer Res. – volume: 5 start-page: 237 year: 2007 end-page: 252 ident: bib13 article-title: The GLUT4 glucose transporter publication-title: Cell Metab. – volume: 40 start-page: 854 year: 2008 end-page: 860 ident: bib26 article-title: Sex- and depot-specific lipolysis regulation in human adipocytes: interplay between adrenergic stimulation and glucocorticoids publication-title: Horm. Metab. Res. – volume: 100 start-page: 508 year: 2015 end-page: 515 ident: bib16 article-title: Association of endogenous sex hormones with adipokines and ghrelin in postmenopausal women publication-title: J. Clin. Endocrinol. Metab. – volume: 236 start-page: 3121 year: 1961 end-page: 3124 ident: bib6 article-title: The fatty acid pool in adipose tissue publication-title: J. Biol. Chem. – volume: 21 start-page: 764 year: 1997 end-page: 768 ident: bib10 article-title: A simple method to predict cellular density in adipocyte metabolic incubations publication-title: Int. J. Obes. Relat. Metab. Disord. – volume: 52 start-page: 1665 year: 1996 end-page: 1673 ident: bib27 article-title: Evidence for posttranscriptional regulation of GLUT4 expression in muscle and adipose tissue from streptozotocin-induced diabetic and benfluorex-treated rats publication-title: Biochem. Pharmacol. – volume: 289 start-page: 5960 year: 2014 end-page: 5969 ident: bib45 article-title: The induction of lipocalin-2 protein expression in vivo and in vitro publication-title: J. Biol. Chem. – volume: 11 start-page: 11 year: 2012 ident: bib14 article-title: Lipocalin-2, glucose metabolism and chronic low-grade systemic inflammation in Chinese people publication-title: Cardiovasc Diabetol. – volume: 31 start-page: 377 year: 1987 end-page: 384 ident: bib28 article-title: Glucocorticoid regulation of beta-adrenergic receptors in 3T3-L1 preadipocytes publication-title: Mol. Pharmacol. – volume: 70 start-page: 551 year: 2011 end-page: 559 ident: bib5 article-title: Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes publication-title: Ann. Rheum. Dis. – volume: 315 start-page: 292 year: 2010 end-page: 298 ident: bib8 article-title: Dexamethasone and the inflammatory response in explants of human omental adipose tissue publication-title: Mol. Cell Endocrinol. – volume: 290 start-page: 5566 year: 2015 end-page: 5581 ident: bib7 article-title: Estrogen receptor (ER)alpha-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression publication-title: J. Biol. Chem. – volume: 21 start-page: E640 year: 2013 end-page: E648 ident: bib31 article-title: Lipocalin-2 increases fat oxidation in vitro and is correlated with energy expenditure in normal weight but not obese women publication-title: Obesity (Silver Spring) – volume: 115 start-page: 911 year: 2005 end-page: 919 ident: bib9 article-title: Adipose tissue, adipokines, and inflammation publication-title: J. Allergy Clin. Immunol. – volume: 40 start-page: 1197 year: 1997 end-page: 1203 ident: bib43 article-title: Peroxovanadate and insulin action in adipocytes from NIDDM patients. Evidence against a primary defect in tyrosine phosphorylation publication-title: Diabetologia – volume: 153 start-page: 1183 year: 2012 end-page: 1193 ident: bib12 article-title: Lipocalin 2 deficiency alters estradiol production and estrogen receptor signaling in female mice publication-title: Endocrinology – volume: 19 start-page: 2295 year: 2011 end-page: 2300 ident: bib1 article-title: Upregulation of lipocalin 2 in adipose tissues of severely obese women: positive relationship with proinflammatory cytokines publication-title: Obesity (Silver Spring) – volume: 1 start-page: 213 year: 2002 end-page: 222 ident: bib19 article-title: A proteomic approach for identification of secreted proteins during the differentiation of 3T3-L1 preadipocytes to adipocytes publication-title: Mol. Cell Proteom. – volume: 87 start-page: 803 year: 2009 end-page: 813 ident: bib4 article-title: Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans publication-title: J. Mol. Med. Berl. – volume: 294 start-page: E1023 year: 2008 end-page: E1034 ident: bib30 article-title: Dexamethasone-induced expression of the glucocorticoid response gene lipocalin 2 in chondrocytes publication-title: Am. J. Physiol. Endocrinol. Metab. – volume: 268 start-page: 10425 year: 1993 end-page: 10432 ident: bib18 article-title: Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase publication-title: J. Biol. Chem. – volume: 1842 start-page: 473 year: 2014 end-page: 481 ident: bib21 article-title: Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity publication-title: Biochim. Biophys. Acta – volume: 12 start-page: 176 year: 2013 ident: bib29 article-title: Serum lipocalin-2 levels positively correlate with coronary artery disease and metabolic syndrome publication-title: Cardiovasc Diabetol. – volume: 146 start-page: 3044 year: 2005 end-page: 3051 ident: bib34 article-title: Insulin receptor substrates-1 and -2 are both depleted but via different mechanisms after down-regulation of glucose transport in rat adipocytes publication-title: Endocrinology – volume: 34 start-page: 97 year: 2011 end-page: 100 ident: bib3 article-title: Serum lipocalin-2 as an insulin resistance marker in patients with polycystic ovary syndrome publication-title: J. Endocrinol. Invest. – volume: 48 start-page: 1253 year: 2007 end-page: 1262 ident: bib37 article-title: Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation publication-title: J. Lipid Res. – volume: 53 start-page: 34 year: 2007 end-page: 41 ident: bib39 article-title: Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans publication-title: Clin. Chem. – volume: 40 start-page: 1499 year: 2014 end-page: 1508 ident: bib44 article-title: Prognostic significance of hypothalamic-pituitary-adrenal axis hormones in early sepsis: a study performed in the emergency department publication-title: Intensive Care Med. – volume: 56 start-page: 2533 year: 2007 end-page: 2540 ident: bib41 article-title: The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance publication-title: Diabetes – volume: 89 start-page: 2989 year: 2004 end-page: 2997 ident: bib24 article-title: Glucocorticoids down-regulate glucose uptake capacity and insulin-signaling proteins in omental but not subcutaneous human adipocytes publication-title: J. Clin. Endocrinol. Metab. – volume: 2010 start-page: 802078 year: 2010 ident: bib2 article-title: The role of adipose tissue and adipokines in obesity-related inflammatory diseases publication-title: Mediat. Inflamm. – volume: 16 start-page: 22 year: 2002 end-page: 26 ident: bib35 article-title: C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway publication-title: Genes Dev. – volume: 63 start-page: 1198 year: 2014 end-page: 1208 ident: bib32 article-title: FKBP5 expression in human adipose tissue increases following dexamethasone exposure and is associated with insulin resistance publication-title: Metabolism – volume: 67 start-page: 1122 year: 1988 end-page: 1128 ident: bib33 article-title: Muscle and adipose tissue morphology and metabolism in Cushing's syndrome publication-title: J. Clin. Endocrinol. Metab. – volume: 90 start-page: 4579 year: 2005 end-page: 4586 ident: bib40 article-title: Cortisol response in relation to the severity of stress and illness publication-title: J. Clin. Endocrinol. Metab. – volume: 276 start-page: 42077 year: 2001 end-page: 42083 ident: bib22 article-title: Hyperglycemia-induced production of acute phase reactants in adipose tissue publication-title: J. Biol. Chem. – volume: 170 start-page: 173 year: 1996 end-page: 180 ident: bib11 article-title: An apparent autocrine mechanism amplifies the dexamethasone- and retinoic acid-induced expression of mouse lipocalin-encoding gene 24p3 publication-title: Gene – volume: 38 start-page: 356 year: 2014 end-page: 365 ident: bib42 article-title: Adipose gene expression profiles related to metabolic syndrome using microarray analyses in two different models publication-title: Diabetes Metab. J. – volume: 50 start-page: 625 year: 2007 end-page: 633 ident: bib25 article-title: Fat cell enlargement is an independent marker of insulin resistance and ‘hyperleptinaemia’ publication-title: Diabetologia – volume: 25 start-page: 754 year: 2011 end-page: 764 ident: bib15 article-title: Lipocalin 2 is a selective modulator of peroxisome proliferator-activated receptor-gamma activation and function in lipid homeostasis and energy expenditure publication-title: FASEB J. – volume: 59 start-page: 872 year: 2010 end-page: 882 ident: bib20 article-title: Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity publication-title: Diabetes – volume: 43 start-page: 1517 year: 1994 end-page: 1522 ident: bib23 article-title: Changes in body composition and adipose tissue distribution after treatment of women with Cushing's syndrome publication-title: Metabolism – volume: 67 start-page: 1122 issue: 6 year: 1988 ident: 10.1016/j.mce.2016.03.011_bib33 article-title: Muscle and adipose tissue morphology and metabolism in Cushing's syndrome publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jcem-67-6-1122 – volume: 1 start-page: 213 issue: 3 year: 2002 ident: 10.1016/j.mce.2016.03.011_bib19 article-title: A proteomic approach for identification of secreted proteins during the differentiation of 3T3-L1 preadipocytes to adipocytes publication-title: Mol. Cell Proteom. doi: 10.1074/mcp.M200006-MCP200 – volume: 2010 start-page: 802078 year: 2010 ident: 10.1016/j.mce.2016.03.011_bib2 article-title: The role of adipose tissue and adipokines in obesity-related inflammatory diseases publication-title: Mediat. Inflamm. doi: 10.1155/2010/802078 – volume: 315 start-page: 292 issue: 1–2 year: 2010 ident: 10.1016/j.mce.2016.03.011_bib8 article-title: Dexamethasone and the inflammatory response in explants of human omental adipose tissue publication-title: Mol. Cell Endocrinol. doi: 10.1016/j.mce.2009.10.004 – volume: 63 start-page: 1198 issue: 9 year: 2014 ident: 10.1016/j.mce.2016.03.011_bib32 article-title: FKBP5 expression in human adipose tissue increases following dexamethasone exposure and is associated with insulin resistance publication-title: Metabolism doi: 10.1016/j.metabol.2014.05.015 – volume: 31 start-page: 377 issue: 4 year: 1987 ident: 10.1016/j.mce.2016.03.011_bib28 article-title: Glucocorticoid regulation of beta-adrenergic receptors in 3T3-L1 preadipocytes publication-title: Mol. Pharmacol. doi: 10.1016/S0026-895X(25)10446-X – volume: 1842 start-page: 473 issue: 3 year: 2014 ident: 10.1016/j.mce.2016.03.011_bib21 article-title: Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbadis.2013.05.029 – volume: 268 start-page: 10425 issue: 14 year: 1993 ident: 10.1016/j.mce.2016.03.011_bib18 article-title: Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)82217-7 – volume: 115 start-page: 911 issue: 5 year: 2005 ident: 10.1016/j.mce.2016.03.011_bib9 article-title: Adipose tissue, adipokines, and inflammation publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2005.02.023 – volume: 89 start-page: 2989 issue: 6 year: 2004 ident: 10.1016/j.mce.2016.03.011_bib24 article-title: Glucocorticoids down-regulate glucose uptake capacity and insulin-signaling proteins in omental but not subcutaneous human adipocytes publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2003-031157 – volume: 52 start-page: 1665 issue: 11 year: 1996 ident: 10.1016/j.mce.2016.03.011_bib27 article-title: Evidence for posttranscriptional regulation of GLUT4 expression in muscle and adipose tissue from streptozotocin-induced diabetic and benfluorex-treated rats publication-title: Biochem. Pharmacol. doi: 10.1016/S0006-2952(96)00506-0 – volume: 280 start-page: E745 issue: 5 year: 2001 ident: 10.1016/j.mce.2016.03.011_bib17 article-title: Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.2001.280.5.E745 – volume: 38 start-page: 356 issue: 5 year: 2014 ident: 10.1016/j.mce.2016.03.011_bib42 article-title: Adipose gene expression profiles related to metabolic syndrome using microarray analyses in two different models publication-title: Diabetes Metab. J. doi: 10.4093/dmj.2014.38.5.356 – volume: 276 start-page: 42077 issue: 45 year: 2001 ident: 10.1016/j.mce.2016.03.011_bib22 article-title: Hyperglycemia-induced production of acute phase reactants in adipose tissue publication-title: J. Biol. Chem. doi: 10.1074/jbc.M107101200 – volume: 294 start-page: E1023 issue: 6 year: 2008 ident: 10.1016/j.mce.2016.03.011_bib30 article-title: Dexamethasone-induced expression of the glucocorticoid response gene lipocalin 2 in chondrocytes publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00586.2007 – volume: 40 start-page: 1197 issue: 10 year: 1997 ident: 10.1016/j.mce.2016.03.011_bib43 article-title: Peroxovanadate and insulin action in adipocytes from NIDDM patients. Evidence against a primary defect in tyrosine phosphorylation publication-title: Diabetologia doi: 10.1007/s001250050807 – volume: 25 start-page: 754 issue: 2 year: 2011 ident: 10.1016/j.mce.2016.03.011_bib15 article-title: Lipocalin 2 is a selective modulator of peroxisome proliferator-activated receptor-gamma activation and function in lipid homeostasis and energy expenditure publication-title: FASEB J. doi: 10.1096/fj.10-165175 – volume: 56 start-page: 2533 issue: 10 year: 2007 ident: 10.1016/j.mce.2016.03.011_bib41 article-title: The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance publication-title: Diabetes doi: 10.2337/db07-0007 – volume: 289 start-page: 5960 issue: 9 year: 2014 ident: 10.1016/j.mce.2016.03.011_bib45 article-title: The induction of lipocalin-2 protein expression in vivo and in vitro publication-title: J. Biol. Chem. doi: 10.1074/jbc.M113.532234 – volume: 11 start-page: 11 year: 2012 ident: 10.1016/j.mce.2016.03.011_bib14 article-title: Lipocalin-2, glucose metabolism and chronic low-grade systemic inflammation in Chinese people publication-title: Cardiovasc Diabetol. doi: 10.1186/1475-2840-11-11 – volume: 21 start-page: 764 issue: 9 year: 1997 ident: 10.1016/j.mce.2016.03.011_bib10 article-title: A simple method to predict cellular density in adipocyte metabolic incubations publication-title: Int. J. Obes. Relat. Metab. Disord. doi: 10.1038/sj.ijo.0800469 – volume: 12 start-page: 176 year: 2013 ident: 10.1016/j.mce.2016.03.011_bib29 article-title: Serum lipocalin-2 levels positively correlate with coronary artery disease and metabolic syndrome publication-title: Cardiovasc Diabetol. doi: 10.1186/1475-2840-12-176 – volume: 40 start-page: 1499 issue: 10 year: 2014 ident: 10.1016/j.mce.2016.03.011_bib44 article-title: Prognostic significance of hypothalamic-pituitary-adrenal axis hormones in early sepsis: a study performed in the emergency department publication-title: Intensive Care Med. doi: 10.1007/s00134-014-3468-4 – volume: 153 start-page: 1183 issue: 3 year: 2012 ident: 10.1016/j.mce.2016.03.011_bib12 article-title: Lipocalin 2 deficiency alters estradiol production and estrogen receptor signaling in female mice publication-title: Endocrinology doi: 10.1210/en.2011-1642 – volume: 34 start-page: 97 issue: 2 year: 2011 ident: 10.1016/j.mce.2016.03.011_bib3 article-title: Serum lipocalin-2 as an insulin resistance marker in patients with polycystic ovary syndrome publication-title: J. Endocrinol. Invest. doi: 10.1007/BF03347037 – volume: 70 start-page: 551 issue: 3 year: 2011 ident: 10.1016/j.mce.2016.03.011_bib5 article-title: Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes publication-title: Ann. Rheum. Dis. doi: 10.1136/ard.2010.132399 – volume: 146 start-page: 3044 issue: 7 year: 2005 ident: 10.1016/j.mce.2016.03.011_bib34 article-title: Insulin receptor substrates-1 and -2 are both depleted but via different mechanisms after down-regulation of glucose transport in rat adipocytes publication-title: Endocrinology doi: 10.1210/en.2004-1675 – volume: 100 start-page: 508 issue: 2 year: 2015 ident: 10.1016/j.mce.2016.03.011_bib16 article-title: Association of endogenous sex hormones with adipokines and ghrelin in postmenopausal women publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2014-1839 – volume: 53 start-page: 34 issue: 1 year: 2007 ident: 10.1016/j.mce.2016.03.011_bib39 article-title: Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans publication-title: Clin. Chem. doi: 10.1373/clinchem.2006.075614 – volume: 48 start-page: 1253 issue: 6 year: 2007 ident: 10.1016/j.mce.2016.03.011_bib37 article-title: Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation publication-title: J. Lipid Res. doi: 10.1194/jlr.R700005-JLR200 – volume: 21 start-page: E640 issue: 12 year: 2013 ident: 10.1016/j.mce.2016.03.011_bib31 article-title: Lipocalin-2 increases fat oxidation in vitro and is correlated with energy expenditure in normal weight but not obese women publication-title: Obesity (Silver Spring) doi: 10.1002/oby.20507 – volume: 137 start-page: 4706 issue: 11 year: 1996 ident: 10.1016/j.mce.2016.03.011_bib38 article-title: Troglitazone enhances differentiation, basal glucose uptake, and Glut1 protein levels in 3T3-L1 adipocytes publication-title: Endocrinology doi: 10.1210/endo.137.11.8895337 – volume: 5 start-page: 237 issue: 4 year: 2007 ident: 10.1016/j.mce.2016.03.011_bib13 article-title: The GLUT4 glucose transporter publication-title: Cell Metab. doi: 10.1016/j.cmet.2007.03.006 – volume: 19 start-page: 2295 issue: 12 year: 2011 ident: 10.1016/j.mce.2016.03.011_bib1 article-title: Upregulation of lipocalin 2 in adipose tissues of severely obese women: positive relationship with proinflammatory cytokines publication-title: Obesity (Silver Spring) doi: 10.1038/oby.2011.61 – volume: 290 start-page: 5566 issue: 9 year: 2015 ident: 10.1016/j.mce.2016.03.011_bib7 article-title: Estrogen receptor (ER)alpha-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression publication-title: J. Biol. Chem. doi: 10.1074/jbc.M114.606459 – volume: 170 start-page: 173 issue: 2 year: 1996 ident: 10.1016/j.mce.2016.03.011_bib11 article-title: An apparent autocrine mechanism amplifies the dexamethasone- and retinoic acid-induced expression of mouse lipocalin-encoding gene 24p3 publication-title: Gene doi: 10.1016/0378-1119(95)00896-9 – volume: 87 start-page: 803 issue: 8 year: 2009 ident: 10.1016/j.mce.2016.03.011_bib4 article-title: Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans publication-title: J. Mol. Med. Berl. doi: 10.1007/s00109-009-0486-8 – volume: 43 start-page: 1517 issue: 12 year: 1994 ident: 10.1016/j.mce.2016.03.011_bib23 article-title: Changes in body composition and adipose tissue distribution after treatment of women with Cushing's syndrome publication-title: Metabolism doi: 10.1016/0026-0495(94)90010-8 – volume: 90 start-page: 4579 issue: 8 year: 2005 ident: 10.1016/j.mce.2016.03.011_bib40 article-title: Cortisol response in relation to the severity of stress and illness publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2005-0354 – volume: 40 start-page: 854 issue: 12 year: 2008 ident: 10.1016/j.mce.2016.03.011_bib26 article-title: Sex- and depot-specific lipolysis regulation in human adipocytes: interplay between adrenergic stimulation and glucocorticoids publication-title: Horm. Metab. Res. doi: 10.1055/s-0028-1087168 – volume: 62 start-page: 4540 issue: 16 year: 2002 ident: 10.1016/j.mce.2016.03.011_bib36 article-title: Cellular and molecular targets of estrogen in normal human breast tissue publication-title: Cancer Res. – volume: 16 start-page: 22 issue: 1 year: 2002 ident: 10.1016/j.mce.2016.03.011_bib35 article-title: C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway publication-title: Genes Dev. doi: 10.1101/gad.948702 – volume: 236 start-page: 3121 year: 1961 ident: 10.1016/j.mce.2016.03.011_bib6 article-title: The fatty acid pool in adipose tissue publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)93981-5 – volume: 50 start-page: 625 issue: 3 year: 2007 ident: 10.1016/j.mce.2016.03.011_bib25 article-title: Fat cell enlargement is an independent marker of insulin resistance and ‘hyperleptinaemia’ publication-title: Diabetologia doi: 10.1007/s00125-006-0572-1 – volume: 59 start-page: 872 issue: 4 year: 2010 ident: 10.1016/j.mce.2016.03.011_bib20 article-title: Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity publication-title: Diabetes doi: 10.2337/db09-1541 |
| SSID | ssj0007528 |
| Score | 2.3358152 |
| Snippet | The adipokine lipocalin 2 is linked to obesity and metabolic disorders. However, its role in human adipose tissue glucose and lipid metabolism is not explored.... |
| SourceID | swepub proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 124 |
| SubjectTerms | adipocytes adiponectin Adiponectin - genetics adipose tissue Adipose Tissue - drug effects Adipose Tissue - metabolism Adipose tissues Adult Aged Cellular dexamethasone Dexamethasone - pharmacology Female Females Gene expression Glucocorticoids Glucocorticoids - chemical synthesis Glucocorticoids - physiology Glucose Glucose - metabolism glucose transporters Human Human adipose tissue Humans Insulin Insulin Resistance interleukin-6 lipid metabolism Lipocalin 2 Lipocalin-2 - metabolism Lipocalin-2 - physiology Male males metabolic diseases Middle Aged obesity postmenopause PPAR gamma PPAR gamma - metabolism PPARγ premenopause Recombinant Proteins - pharmacology Subcutaneous Fat - drug effects Subcutaneous Fat - metabolism Type 2 diabetes Up-Regulation Young Adult |
| Title | Lipocalin 2 produces insulin resistance and can be upregulated by glucocorticoids in human adipose tissue |
| URI | https://dx.doi.org/10.1016/j.mce.2016.03.011 https://www.ncbi.nlm.nih.gov/pubmed/26973291 https://www.proquest.com/docview/1781534787 https://www.proquest.com/docview/1816082957 https://www.proquest.com/docview/2000279427 https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-297263 |
| Volume | 427 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Baden-Württemberg Complete Freedom Collection (Elsevier) customDbUrl: eissn: 1872-8057 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0007528 issn: 0303-7207 databaseCode: GBLVA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection customDbUrl: eissn: 1872-8057 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0007528 issn: 0303-7207 databaseCode: .~1 dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection customDbUrl: eissn: 1872-8057 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0007528 issn: 0303-7207 databaseCode: AIKHN dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection customDbUrl: eissn: 1872-8057 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0007528 issn: 0303-7207 databaseCode: ACRLP dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 1872-8057 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0007528 issn: 0303-7207 databaseCode: AKRWK dateStart: 19740101 isFulltext: true providerName: Library Specific Holdings |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LbxMxELaqIlVcELQ8yqOaSsABacnaazubY1RapYX2AkW9WfbaixbRzSrJHnrhtzPj3Q2Cqjn0mGS8D8-MZyb-_A1jb3Vw0mUCjTf4jFqYoc8pZxPp06wgOhMdz8KcX-jZpTy7Uldb7Gg4C0Owyn7t79b0uFr334z62Rw1VTX6iuZJLVYw4c8i6widYJeaYH0ff_-FeYxV7K9KwglJDzubEeN1XRBTJteR55Tzu2LT7dzzP2LRGIxOHrNHfRYJ0-5Bn7CtUO-yvWmNFfT1DbyHiOuMf5jvsp3zfvt8j1VfqoZiV1WDgCZyvYYl9HB0wMKbkkmcAbC1B5xzcAHaZtG1qw8e3A1EiDtWrHjjeeVpMMQ2f2A9XnsZYBU1-ZRdnhx_O5olfa-FBDWiV0lkZeG2yFPtCoU1Xqkw1cPkUKPL5zmW0D612odclJgQWCw0yslElK4Q1vNSpNkztl3P6_CCQfDSunEplJNeKqznCKnqiScu5Knj6T5Lh1k2RU9ETv0wfpkBcfbToGIMKcakmUHF7LMP6yFNx8KxSVgOqjP_mJLBKLFp2OGgZoMuRvsmtg7zdmn4OMe4QCxGG2RyrumYstogI-I-70QKlHne2dH6bYQm2qQJPsW7zrDWvxD_96fq-9TMFz9M2xqB_qSzl_d7yVfsIX0i-ANXr9n2atGGN5hVrdxBdJsD9mB6-nl28QdpPh6y |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFLdGJwEXBBsfAwZGAg5IUWPHdtNjtTF1rO2FDe1m2bGDglgatc1h_z3vOU4lhuhh1-Q5if2-4-ffI-Sj8lbYjIPwepdhCzPQOWlNIlyaFQhnosJZmPlCTa_Et2t5vUdO-rMwWFYZbX9n04O1jleGcTWHTVUNv4N4YosVCPizgDrygOwLCTZ5QPYn5xfTxdYgj2RosYr0CQ7oNzdDmddNgWCZTAWoU8b-557-DT_vYIsGf3T2lDyJgSSddN_6jOz5-oAcTmpIom9u6WcaSjvDP_MD8nAed9APSTWrGnRfVU05bQLcq1_TWJFOIffGeBIWgZraUVh2aj1tm1XXsd47am9pqHKHpBVevKwcDqah0x81Dp699nQTmPmcXJ19vTyZJrHdQgJMUZskALMwU-SpsoWENK-UEO1BfKhA6_McsmiXGuV8zkuICQzkGuV4zEtbcONYydPsBRnUy9q_ItQ7Yeyo5NIKJySkdFis6hAqzuepZekRSftV1kXEIseWGL91X3T2SwNjNDJGp5kGxhyRL9shTQfEsYtY9KzTf0mTBkexa9iHns0atAy3Tkztl-1as1EOrgGBjHbQ5EzhSWW5g4aHrd6x4EDzspOj7Wy4QuSkMXzFp06wtncQAvy0-jHRy9VP3baag0qp7PX9JvmePJpezmd6dr64eEMe4x2shmDyLRlsVq0_hiBrY99FJfoDGTQhXQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Lipocalin+2+produces+insulin+resistance+and+can+be+upregulated+by+glucocorticoids+in+human+adipose+tissue&rft.jtitle=Molecular+and+cellular+endocrinology&rft.au=Kamble%2C+Prasad+G&rft.au=Pereira%2C+Maria+J&rft.au=Sidibeh%2C+Cherno+O&rft.au=Amini%2C+Sam&rft.date=2016-05-15&rft.issn=0303-7207&rft.volume=427+p.124-132&rft.spage=124&rft.epage=132&rft_id=info:doi/10.1016%2Fj.mce.2016.03.011&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0303-7207&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0303-7207&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0303-7207&client=summon |