Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides - Graham, Mark J; Lee, Richard G; Brandt, Teresa A; Tai, Li-Jung; Fu, Wuxia; Peralta, Raechel; Yu, Rosie; Hurh, Eunju; Paz, Erika; McEvoy, Bradley W; Baker, Brenda F; Pham, Nguyen C; et al. (The New England journal of medicine, 2017)
Keywords: Adult; Aged; Angiopoietin; Angiopoietin-like Proteins; Angiopoietins - antagonists & inhibitors; Angiopoietins - genetics; Animals; Antisense oligonucleotides; Antisense RNA; Apolipoprotein B; Apolipoprotein C-III; Apolipoproteins; Arteriosclerosis; Atherosclerosis; Atherosclerosis - drug therapy; Atherosclerosis - metabolism; Atherosclerosis - prevention & control; Cholesterol; Coronary Artery Disease - genetics; Coronary Artery Disease - metabolism; Disease Models, Animal; Double-Blind Method; Drug dosages; Dyslipidemias - blood; Dyslipidemias - drug therapy; Female; Gene expression; Humans; Lipid Metabolism - drug effects; Lipids; Lipids - blood; Lipoproteins; Low density lipoprotein; Male; Mice; Mice, Inbred Strains; Middle Aged; mRNA; Oligonucleotides - pharmacology; Oligonucleotides - therapeutic use; Oligonucleotides, Antisense - pharmacology; Oligonucleotides, Antisense - therapeutic use; Pharmacodynamics; Plasma; RNA, Messenger - antagonists & inhibitors; Triglycerides