Valganciclovir in Infants with Hearing Loss and Clinically Inapparent Congenital Cytomegalovirus Infection: A Nonrandomized Controlled Trial

To assess the efficacy of valganciclovir in infants with hearing loss and clinically inapparent congenital cytomegalovirus infection (cCMV), as there is no consensus on treatment of this group. A nationwide, nonrandomized controlled trial, comparing 6 weeks of oral valganciclovir to no treatment in...

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Published inThe Journal of pediatrics Vol. 268; p. 113945
Main Authors Chung, Pui Khi, Schornagel, Fleurtje A.J., Soede, Wim, van Zwet, Erik W., Kroes, Aloys C.M., Oudesluys-Murphy, Anne Marie, Vossen, Ann C.T.M.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2024
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Online AccessGet full text
ISSN0022-3476
1097-6833
1085-8695
1097-6833
DOI10.1016/j.jpeds.2024.113945

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Abstract To assess the efficacy of valganciclovir in infants with hearing loss and clinically inapparent congenital cytomegalovirus infection (cCMV), as there is no consensus on treatment of this group. A nationwide, nonrandomized controlled trial, comparing 6 weeks of oral valganciclovir to no treatment in infants with cCMV, recruited after newborn hearing screening resulted in referral to an audiologist. The choice whether to treat was left to parents of subjects. Eligible subjects were full term infants aged <13 weeks with sensorineural hearing loss and diagnosed with cCMV through dried blood spot testing. The primary outcome, measured by linear and ordinal logistic regression, was change in best-ear hearing from baseline to follow-up at 18-22 months of age. Thirty-seven participants were included in the final analysis, of whom 25 were in the treatment group and 12 in the control group. The majority of subjects in both groups had neuroimaging abnormalities, which were mostly mild. Hearing deterioration was more likely in the control group compared with the treatment group (common OR 0.10, 95% CI 0.02-0.45, P = .003). Mean best-ear hearing deteriorated by 13.7 dB in the control group, compared with improvement of 3.3 dB in the treatment group (difference 17 dB, 95% CI 2.6 – 31.4, P = .02). We investigated treatment in children with hearing loss and clinically inapparent cCMV. Although our study was nonrandomized, it is the first prospective and controlled trial in this population. Valganciclovir-treated children with hearing loss and inapparent cCMV had less hearing deterioration at 18 through 22 months of age than control subjects. 2013-003068-30.
AbstractList To assess the efficacy of valganciclovir in infants with hearing loss and clinically inapparent congenital cytomegalovirus infection (cCMV), as there is no consensus on treatment of this group.OBJECTIVETo assess the efficacy of valganciclovir in infants with hearing loss and clinically inapparent congenital cytomegalovirus infection (cCMV), as there is no consensus on treatment of this group.A nationwide, nonrandomized controlled trial, comparing 6 weeks of oral valganciclovir to no treatment in infants with cCMV, recruited after newborn hearing screening resulted in referral to an audiologist. The choice whether to treat was left to parents of subjects. Eligible subjects were full term infants aged <13 weeks with sensorineural hearing loss and diagnosed with cCMV through dried blood spot testing. The primary outcome, measured by linear and ordinal logistic regression, was change in best-ear hearing from baseline to follow-up at 18-22 months of age.STUDY DESIGNA nationwide, nonrandomized controlled trial, comparing 6 weeks of oral valganciclovir to no treatment in infants with cCMV, recruited after newborn hearing screening resulted in referral to an audiologist. The choice whether to treat was left to parents of subjects. Eligible subjects were full term infants aged <13 weeks with sensorineural hearing loss and diagnosed with cCMV through dried blood spot testing. The primary outcome, measured by linear and ordinal logistic regression, was change in best-ear hearing from baseline to follow-up at 18-22 months of age.Thirty-seven participants were included in the final analysis, of whom 25 were in the treatment group and 12 in the control group. The majority of subjects in both groups had neuroimaging abnormalities, which were mostly mild. Hearing deterioration was more likely in the control group compared with the treatment group (common OR 0.10, 95% CI 0.02-0.45, P = .003). Mean best-ear hearing deteriorated by 13.7 dB in the control group, compared with improvement of 3.3 dB in the treatment group (difference 17 dB, 95% CI 2.6 - 31.4, P = .02).RESULTSThirty-seven participants were included in the final analysis, of whom 25 were in the treatment group and 12 in the control group. The majority of subjects in both groups had neuroimaging abnormalities, which were mostly mild. Hearing deterioration was more likely in the control group compared with the treatment group (common OR 0.10, 95% CI 0.02-0.45, P = .003). Mean best-ear hearing deteriorated by 13.7 dB in the control group, compared with improvement of 3.3 dB in the treatment group (difference 17 dB, 95% CI 2.6 - 31.4, P = .02).We investigated treatment in children with hearing loss and clinically inapparent cCMV. Although our study was nonrandomized, it is the first prospective and controlled trial in this population. Valganciclovir-treated children with hearing loss and inapparent cCMV had less hearing deterioration at 18 through 22 months of age than control subjects.CONCLUSIONSWe investigated treatment in children with hearing loss and clinically inapparent cCMV. Although our study was nonrandomized, it is the first prospective and controlled trial in this population. Valganciclovir-treated children with hearing loss and inapparent cCMV had less hearing deterioration at 18 through 22 months of age than control subjects.2013-003068-30.EUDRACT REGISTRY NUMBER2013-003068-30.
To assess the efficacy of valganciclovir in infants with hearing loss and clinically inapparent congenital cytomegalovirus infection (cCMV), as there is no consensus on treatment of this group. A nationwide, nonrandomized controlled trial, comparing 6 weeks of oral valganciclovir to no treatment in infants with cCMV, recruited after newborn hearing screening resulted in referral to an audiologist. The choice whether to treat was left to parents of subjects. Eligible subjects were full term infants aged <13 weeks with sensorineural hearing loss and diagnosed with cCMV through dried blood spot testing. The primary outcome, measured by linear and ordinal logistic regression, was change in best-ear hearing from baseline to follow-up at 18-22 months of age. Thirty-seven participants were included in the final analysis, of whom 25 were in the treatment group and 12 in the control group. The majority of subjects in both groups had neuroimaging abnormalities, which were mostly mild. Hearing deterioration was more likely in the control group compared with the treatment group (common OR 0.10, 95% CI 0.02-0.45, P = .003). Mean best-ear hearing deteriorated by 13.7 dB in the control group, compared with improvement of 3.3 dB in the treatment group (difference 17 dB, 95% CI 2.6 - 31.4, P = .02). We investigated treatment in children with hearing loss and clinically inapparent cCMV. Although our study was nonrandomized, it is the first prospective and controlled trial in this population. Valganciclovir-treated children with hearing loss and inapparent cCMV had less hearing deterioration at 18 through 22 months of age than control subjects. 2013-003068-30.
ArticleNumber 113945
Author Chung, Pui Khi
Schornagel, Fleurtje A.J.
Kroes, Aloys C.M.
Soede, Wim
van Zwet, Erik W.
Vossen, Ann C.T.M.
Oudesluys-Murphy, Anne Marie
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  givenname: Fleurtje A.J.
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  surname: Vossen
  fullname: Vossen, Ann C.T.M.
  organization: Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
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Cites_doi 10.1002/jmv.10263
10.1002/rmv.544
10.3390/jcm11133582
10.1186/2051-5960-1-63
10.1159/000446690
10.1093/jpids/pix105
10.1136/archdischild-2022-324699
10.1016/j.ijporl.2020.110055
10.1007/s00431-010-1176-9
10.1097/01.mlg.0000154722.55044.fc
10.1542/peds.2018-3095
10.1016/j.jcv.2007.09.004
10.1097/INF.0000000000001763
10.1016/j.jcv.2018.03.006
10.1007/s00431-019-03558-7
10.3109/00016489.2015.1099733
10.1016/j.jcv.2012.10.008
10.1007/s00401-011-0895-y
10.1016/S1473-3099(17)30143-3
10.1056/NEJMoa1404599
10.1136/archdischild-2015-309154
10.1016/j.pediatrneurol.2020.05.006
10.1136/archdischild-2016-311859
10.1016/j.jcv.2005.09.015
10.1177/0009922813510204
10.1002/uog.12377
10.1016/j.jpeds.2018.02.028
10.1136/archdischild-2013-305276
10.1016/S0022-3476(03)00192-6
10.1016/j.jcv.2009.09.001
10.1097/01.mlg.0000149466.80703.55
10.1093/jpids/piu089
10.1002/lary.30027
10.3390/v13061078
10.1016/j.jcv.2012.06.001
10.1136/archdischild-2023-325790
10.1128/JCM.42.4.1498-1504.2004
10.1542/peds.2008-0770
10.1093/cid/ciy1128
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Keywords RCT
congenital infection
targeted screening
cCMV
audiology
CNS
CONCERT 2.0
CMV
BSID-III
antiviral treatment
DBS
virology
pediatrics
NHS
SNHL
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References Luck, Wieringa, Blazquez-Gamero, Henneke, Schuster, Butler (bib12) 2017; 36
Amir, Wolf, Levy (bib18) 2010; 169
Faure-Bardon, Magny, Parodi, Couderc, Garcia, Maillotte (bib23) 2019; 69
Chung, Schornagel, Oudesluys-Murphy, de Vries, Soede, van Zwet (bib9) 2023; 108
del Rosal, Baquero-Artigao, Blazquez, Noguera-Julian, Moreno-Perez, Reyes (bib13) 2012; 55
Haller, Shoup, Park (bib11) 2020; 134
de Vries, Claas, Kroes, Vossen (bib8) 2009; 46
Hranilovich, Park, Knackstedt, Ostrander, Hedlund, Shi (bib37) 2020; 110
Kimberlin, Lin, Sanchez, Demmler, Dankner, Shelton (bib3) 2003; 143
Pass, Fowler, Boppana, Britt, Stagno (bib22) 2006; 35
Ari-Even Roth, Lubin, Kuint, Teperberg-Oikawa, Mendelson, Strauss (bib40) 2017; 102
Ogawa, Matsui, Baba, Yamada, Suzuki, Suzutani (bib29) 2016; 136
Dorfman, Amir, Attias, Bilavsky (bib15) 2020; 179
Sugiura, Yoshikawa, Nishiyama, Morishita, Sato, Beppu (bib28) 2004; 114
Chen, Holmes, Slifer, Ramachandran, Mackey, Hebson (bib32) 2016; 5
De Cuyper, Acke, Keymeulen, Dhooge (bib6) 2022; 132
Dollard, Grosse, Ross (bib1) 2007; 17
Pasternak, Ziv, Attias, Amir, Bilavsky (bib5) 2018; 199
Grosse, Ross, Dollard (bib2) 2008; 41
Sugiura, Yoshikawa, Nishiyama, Morishita, Sato, Hattori (bib27) 2003; 69
Kalpoe, Kroes, de Jong, Schinkel, de Brouwer, Beersma (bib7) 2004; 42
Amir, Attias, Pardo (bib14) 2014; 53
Rawlinson, Boppana, Fowler, Kimberlin, Lazzarotto, Alain (bib35) 2017; 17
Gabrielli, Bonasoni, Santini, Piccirilli, Chiereghin, Guerra (bib31) 2013; 1
Krstanovic, Britt, Jonjic, Brizic (bib33) 2021; 13
Foulon, Naessens, Foulon, Casteels, Gordts (bib21) 2008; 122
Teissier, Delezoide, Mas, Khung-Savatovsky, Bessieres, Nardelli (bib30) 2011; 122
Rawlinson, Palasanthiran, Hall, Al Yazidi, Cannon, Cottier (bib38) 2018; 102
Lipitz, Yinon, Malinger, Yagel, Levit, Hoffman (bib20) 2013; 41
Foulon, De Brucker, Buyl, Lichtert, Verbruggen, Pierard (bib24) 2019; 144
bib17
Vancor, Shapiro, Loyal (bib41) 2019; 8
Bilavsky, Shahar-Nissan, Pardo, Attias, Amir (bib19) 2016; 101
de Vries, Vesseur, Rotteveel, Korver, Rusman, Wessels (bib25) 2013; 56
Alarcon, Martinez-Biarge, Cabanas, Quero, Garcia-Alix (bib34) 2016; 110
Kimberlin, Aban, Acosta (bib4) 2015; 372
Bauer, Parizi-Robinson, Roland, Yegappan (bib26) 2005; 115
Williams, Kadambari, Berrington, Luck, Atkinson, Walter (bib39) 2014; 99
Morioka, Kakei, Omori, Nozu, Fujioka, Takahashi (bib16) 2022; 11
Alarcon, de Vries, Parodi, Arnaez, Cabanas, Steggerda (bib36) 2024; 109
IBf (bib10) 1996
Chung (10.1016/j.jpeds.2024.113945_bib9) 2023; 108
Williams (10.1016/j.jpeds.2024.113945_bib39) 2014; 99
Teissier (10.1016/j.jpeds.2024.113945_bib30) 2011; 122
Ogawa (10.1016/j.jpeds.2024.113945_bib29) 2016; 136
Krstanovic (10.1016/j.jpeds.2024.113945_bib33) 2021; 13
Pass (10.1016/j.jpeds.2024.113945_bib22) 2006; 35
Gabrielli (10.1016/j.jpeds.2024.113945_bib31) 2013; 1
del Rosal (10.1016/j.jpeds.2024.113945_bib13) 2012; 55
Sugiura (10.1016/j.jpeds.2024.113945_bib28) 2004; 114
Rawlinson (10.1016/j.jpeds.2024.113945_bib38) 2018; 102
Bauer (10.1016/j.jpeds.2024.113945_bib26) 2005; 115
Luck (10.1016/j.jpeds.2024.113945_bib12) 2017; 36
Dorfman (10.1016/j.jpeds.2024.113945_bib15) 2020; 179
Foulon (10.1016/j.jpeds.2024.113945_bib24) 2019; 144
de Vries (10.1016/j.jpeds.2024.113945_bib25) 2013; 56
Vancor (10.1016/j.jpeds.2024.113945_bib41) 2019; 8
Sugiura (10.1016/j.jpeds.2024.113945_bib27) 2003; 69
Dollard (10.1016/j.jpeds.2024.113945_bib1) 2007; 17
Kalpoe (10.1016/j.jpeds.2024.113945_bib7) 2004; 42
De Cuyper (10.1016/j.jpeds.2024.113945_bib6) 2022; 132
Kimberlin (10.1016/j.jpeds.2024.113945_bib4) 2015; 372
Foulon (10.1016/j.jpeds.2024.113945_bib21) 2008; 122
Chen (10.1016/j.jpeds.2024.113945_bib32) 2016; 5
Grosse (10.1016/j.jpeds.2024.113945_bib2) 2008; 41
Amir (10.1016/j.jpeds.2024.113945_bib14) 2014; 53
Faure-Bardon (10.1016/j.jpeds.2024.113945_bib23) 2019; 69
Morioka (10.1016/j.jpeds.2024.113945_bib16) 2022; 11
Amir (10.1016/j.jpeds.2024.113945_bib18) 2010; 169
Kimberlin (10.1016/j.jpeds.2024.113945_bib3) 2003; 143
Alarcon (10.1016/j.jpeds.2024.113945_bib36) 2024; 109
Hranilovich (10.1016/j.jpeds.2024.113945_bib37) 2020; 110
Haller (10.1016/j.jpeds.2024.113945_bib11) 2020; 134
Bilavsky (10.1016/j.jpeds.2024.113945_bib19) 2016; 101
Ari-Even Roth (10.1016/j.jpeds.2024.113945_bib40) 2017; 102
IBf (10.1016/j.jpeds.2024.113945_bib10)
Lipitz (10.1016/j.jpeds.2024.113945_bib20) 2013; 41
Alarcon (10.1016/j.jpeds.2024.113945_bib34) 2016; 110
de Vries (10.1016/j.jpeds.2024.113945_bib8) 2009; 46
Pasternak (10.1016/j.jpeds.2024.113945_bib5) 2018; 199
Rawlinson (10.1016/j.jpeds.2024.113945_bib35) 2017; 17
References_xml – year: 1996
  ident: bib10
  article-title: BIAP recommendation 02/1: audiometric classification of hearing impairments
– volume: 69
  start-page: 72
  year: 2003
  end-page: 75
  ident: bib27
  article-title: Detection of human cytomegalovirus DNA in perilymph of patients with sensorineural hearing loss using real-time PCR
  publication-title: J Med Virol
– volume: 13
  start-page: 1078
  year: 2021
  ident: bib33
  article-title: Cytomegalovirus infection and inflammation in developing brain
  publication-title: Viruses
– ident: bib17
  article-title: Valganciclovir therapy in infants and children with congenital CMV infection and hearing loss
– volume: 42
  start-page: 1498
  year: 2004
  end-page: 1504
  ident: bib7
  article-title: Validation of clinical application of cytomegalovirus plasma DNA load measurement and definition of treatment criteria by analysis of correlation to antigen detection
  publication-title: J Clin Microbiol
– volume: 122
  start-page: e1123
  year: 2008
  end-page: e1127
  ident: bib21
  article-title: Hearing loss in children with congenital cytomegalovirus infection in relation to the maternal trimester in which the maternal primary infection occurred
  publication-title: Pediatrics
– volume: 1
  start-page: 63
  year: 2013
  ident: bib31
  article-title: Human fetal inner ear involvement in congenital cytomegalovirus infection
  publication-title: Acta Neuropathol Commun
– volume: 8
  start-page: 55
  year: 2019
  end-page: 59
  ident: bib41
  article-title: Results of a targeted screening program for congenital cytomegalovirus infection in infants who fail newborn hearing screening
  publication-title: J Pediatric Infect Dis Soc
– volume: 102
  start-page: F519
  year: 2017
  end-page: F524
  ident: bib40
  article-title: Contribution of targeted saliva screening for congenital CMV-related hearing loss in newborns who fail hearing screening
  publication-title: Arch Dis Child Fetal Neonatal Ed
– volume: 110
  start-page: 277
  year: 2016
  end-page: 285
  ident: bib34
  article-title: A prognostic neonatal neuroimaging scale for symptomatic congenital cytomegalovirus infection
  publication-title: Neonatology
– volume: 372
  start-page: 2463
  year: 2015
  ident: bib4
  article-title: Valganciclovir for congenital cytomegalovirus
  publication-title: N Engl J Med
– volume: 53
  start-page: 444
  year: 2014
  end-page: 448
  ident: bib14
  article-title: Treatment of late-onset hearing loss in infants with congenital cytomegalovirus infection
  publication-title: Clin Pediatr (Phila)
– volume: 5
  start-page: 14
  year: 2016
  end-page: 20
  ident: bib32
  article-title: Longitudinal Kinetics of cytomegalovirus-specific T-cell immunity and viral replication in infants with congenital cytomegalovirus infection
  publication-title: J Pediatric Infect Dis Soc
– volume: 35
  start-page: 216
  year: 2006
  end-page: 220
  ident: bib22
  article-title: Congenital cytomegalovirus infection following first trimester maternal infection: symptoms at birth and outcome
  publication-title: J Clin Virol
– volume: 132
  start-page: 2241
  year: 2022
  end-page: 2250
  ident: bib6
  article-title: The effect of (Val)ganciclovir on hearing in congenital cytomegalovirus: a systematic review
  publication-title: Laryngoscope
– volume: 144
  year: 2019
  ident: bib24
  article-title: Hearing loss with congenital cytomegalovirus infection
  publication-title: Pediatrics
– volume: 108
  start-page: 302
  year: 2023
  end-page: 308
  ident: bib9
  article-title: Targeted screening for congenital cytomegalovirus infection: clinical, audiological and neuroimaging findings
  publication-title: Arch Dis Child Fetal Neonatal Ed
– volume: 41
  start-page: 57
  year: 2008
  end-page: 62
  ident: bib2
  article-title: Congenital cytomegalovirus (CMV) infection as a cause of permanent bilateral hearing loss: a quantitative assessment
  publication-title: J Clin Virol
– volume: 110
  start-page: 55
  year: 2020
  end-page: 58
  ident: bib37
  article-title: Brain magnetic resonance imaging in congenital cytomegalovirus with failed newborn hearing screen
  publication-title: Pediatr Neurol
– volume: 179
  start-page: 807
  year: 2020
  end-page: 812
  ident: bib15
  article-title: Treatment of congenital cytomegalovirus beyond the neonatal period: an observational study
  publication-title: Eur J Pediatr
– volume: 169
  start-page: 1061
  year: 2010
  end-page: 1067
  ident: bib18
  article-title: Treatment of symptomatic congenital cytomegalovirus infection with intravenous ganciclovir followed by long-term oral valganciclovir
  publication-title: Eur J Pediatr
– volume: 56
  start-page: 113
  year: 2013
  end-page: 117
  ident: bib25
  article-title: Cytomegalovirus DNA detection in dried blood spots and perilymphatic fluids from pediatric and adult cochlear implant recipients with prelingual deafness
  publication-title: J Clin Virol
– volume: 199
  start-page: 166
  year: 2018
  end-page: 170
  ident: bib5
  article-title: Valganciclovir is beneficial in children with congenital cytomegalovirus and isolated hearing loss
  publication-title: J Pediatr
– volume: 101
  start-page: 433
  year: 2016
  end-page: 438
  ident: bib19
  article-title: Hearing outcome of infants with congenital cytomegalovirus and hearing impairment
  publication-title: Arch Dis Child
– volume: 115
  start-page: 223
  year: 2005
  end-page: 225
  ident: bib26
  article-title: Cytomegalovirus in the perilymphatic fluid
  publication-title: Laryngoscope
– volume: 134
  year: 2020
  ident: bib11
  article-title: Should hearing targeted screening for congenital cytomegalovirus infection be implemented?
  publication-title: Int J Pediatr Otorhi
– volume: 136
  start-page: 132
  year: 2016
  end-page: 135
  ident: bib29
  article-title: Presence of cytomegalovirus in the perilymphatic fluid of patients with profound sensorineural hearing loss caused by congenital cytomegalovirus infection
  publication-title: Acta Otolaryngol
– volume: 55
  start-page: 72
  year: 2012
  end-page: 74
  ident: bib13
  article-title: Treatment of symptomatic congenital cytomegalovirus infection beyond the neonatal period
  publication-title: J Clin Virol
– volume: 46
  start-page: S37
  year: 2009
  end-page: S42
  ident: bib8
  article-title: Evaluation of DNA extraction methods for dried blood spots in the diagnosis of congenital cytomegalovirus infection
  publication-title: J Clin Virol
– volume: 143
  start-page: 16
  year: 2003
  end-page: 25
  ident: bib3
  article-title: Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial
  publication-title: J Pediatr
– volume: 36
  start-page: 1205
  year: 2017
  end-page: 1213
  ident: bib12
  article-title: Congenital cytomegalovirus: a European expert consensus statement on diagnosis and management
  publication-title: Pediatr Infect Dis J
– volume: 122
  start-page: 763
  year: 2011
  end-page: 774
  ident: bib30
  article-title: Inner ear lesions in congenital cytomegalovirus infection of human fetuses
  publication-title: Acta Neuropathol
– volume: 99
  start-page: F230
  year: 2014
  end-page: F236
  ident: bib39
  article-title: Feasibility and acceptability of targeted screening for congenital CMV-related hearing loss
  publication-title: Arch Dis Child Fetal Neonatal Ed
– volume: 69
  start-page: 1526
  year: 2019
  end-page: 1532
  ident: bib23
  article-title: Sequelae of congenital cytomegalovirus following maternal primary infections are limited to those acquired in the first trimester of pregnancy
  publication-title: Clin Infect Dis
– volume: 102
  start-page: 110
  year: 2018
  end-page: 115
  ident: bib38
  article-title: Neonates with congenital cytomegalovirus and hearing loss identified via the universal newborn hearing screening program
  publication-title: J Clin Virol
– volume: 109
  start-page: 151
  year: 2024
  end-page: 158
  ident: bib36
  article-title: Neuroimaging in infants with congenital cytomegalovirus infection and its correlation with outcome: emphasis on white matter abnormalities
  publication-title: Arch Dis Child Fetal Neonatal Ed
– volume: 41
  start-page: 508
  year: 2013
  end-page: 514
  ident: bib20
  article-title: Risk of cytomegalovirus-associated sequelae in relation to time of infection and findings on prenatal imaging
  publication-title: Ultrasound Obstet Gynecol
– volume: 114
  start-page: 2235
  year: 2004
  end-page: 2238
  ident: bib28
  article-title: Detection of herpesvirus DNAs in perilymph obtained from patients with sensorineural hearing loss by real-time polymerase chain reaction
  publication-title: Laryngoscope
– volume: 17
  start-page: e177
  year: 2017
  end-page: e188
  ident: bib35
  article-title: Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy
  publication-title: Lancet Infect Dis
– volume: 17
  start-page: 355
  year: 2007
  end-page: 363
  ident: bib1
  article-title: New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection
  publication-title: Rev Med Virol
– volume: 11
  start-page: 3582
  year: 2022
  ident: bib16
  article-title: Oral valganciclovir therapy in infants aged </=2 Months with congenital cytomegalovirus disease: a multicenter, single-arm, open-label clinical trial in Japan
  publication-title: J Clin Med
– volume: 69
  start-page: 72
  year: 2003
  ident: 10.1016/j.jpeds.2024.113945_bib27
  article-title: Detection of human cytomegalovirus DNA in perilymph of patients with sensorineural hearing loss using real-time PCR
  publication-title: J Med Virol
  doi: 10.1002/jmv.10263
– volume: 17
  start-page: 355
  year: 2007
  ident: 10.1016/j.jpeds.2024.113945_bib1
  article-title: New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection
  publication-title: Rev Med Virol
  doi: 10.1002/rmv.544
– volume: 11
  start-page: 3582
  year: 2022
  ident: 10.1016/j.jpeds.2024.113945_bib16
  article-title: Oral valganciclovir therapy in infants aged </=2 Months with congenital cytomegalovirus disease: a multicenter, single-arm, open-label clinical trial in Japan
  publication-title: J Clin Med
  doi: 10.3390/jcm11133582
– volume: 1
  start-page: 63
  year: 2013
  ident: 10.1016/j.jpeds.2024.113945_bib31
  article-title: Human fetal inner ear involvement in congenital cytomegalovirus infection
  publication-title: Acta Neuropathol Commun
  doi: 10.1186/2051-5960-1-63
– volume: 110
  start-page: 277
  year: 2016
  ident: 10.1016/j.jpeds.2024.113945_bib34
  article-title: A prognostic neonatal neuroimaging scale for symptomatic congenital cytomegalovirus infection
  publication-title: Neonatology
  doi: 10.1159/000446690
– volume: 8
  start-page: 55
  year: 2019
  ident: 10.1016/j.jpeds.2024.113945_bib41
  article-title: Results of a targeted screening program for congenital cytomegalovirus infection in infants who fail newborn hearing screening
  publication-title: J Pediatric Infect Dis Soc
  doi: 10.1093/jpids/pix105
– volume: 108
  start-page: 302
  year: 2023
  ident: 10.1016/j.jpeds.2024.113945_bib9
  article-title: Targeted screening for congenital cytomegalovirus infection: clinical, audiological and neuroimaging findings
  publication-title: Arch Dis Child Fetal Neonatal Ed
  doi: 10.1136/archdischild-2022-324699
– volume: 134
  year: 2020
  ident: 10.1016/j.jpeds.2024.113945_bib11
  article-title: Should hearing targeted screening for congenital cytomegalovirus infection be implemented?
  publication-title: Int J Pediatr Otorhi
  doi: 10.1016/j.ijporl.2020.110055
– volume: 169
  start-page: 1061
  year: 2010
  ident: 10.1016/j.jpeds.2024.113945_bib18
  article-title: Treatment of symptomatic congenital cytomegalovirus infection with intravenous ganciclovir followed by long-term oral valganciclovir
  publication-title: Eur J Pediatr
  doi: 10.1007/s00431-010-1176-9
– volume: 115
  start-page: 223
  year: 2005
  ident: 10.1016/j.jpeds.2024.113945_bib26
  article-title: Cytomegalovirus in the perilymphatic fluid
  publication-title: Laryngoscope
  doi: 10.1097/01.mlg.0000154722.55044.fc
– volume: 144
  year: 2019
  ident: 10.1016/j.jpeds.2024.113945_bib24
  article-title: Hearing loss with congenital cytomegalovirus infection
  publication-title: Pediatrics
  doi: 10.1542/peds.2018-3095
– volume: 41
  start-page: 57
  year: 2008
  ident: 10.1016/j.jpeds.2024.113945_bib2
  article-title: Congenital cytomegalovirus (CMV) infection as a cause of permanent bilateral hearing loss: a quantitative assessment
  publication-title: J Clin Virol
  doi: 10.1016/j.jcv.2007.09.004
– volume: 36
  start-page: 1205
  year: 2017
  ident: 10.1016/j.jpeds.2024.113945_bib12
  article-title: Congenital cytomegalovirus: a European expert consensus statement on diagnosis and management
  publication-title: Pediatr Infect Dis J
  doi: 10.1097/INF.0000000000001763
– volume: 102
  start-page: 110
  year: 2018
  ident: 10.1016/j.jpeds.2024.113945_bib38
  article-title: Neonates with congenital cytomegalovirus and hearing loss identified via the universal newborn hearing screening program
  publication-title: J Clin Virol
  doi: 10.1016/j.jcv.2018.03.006
– volume: 179
  start-page: 807
  year: 2020
  ident: 10.1016/j.jpeds.2024.113945_bib15
  article-title: Treatment of congenital cytomegalovirus beyond the neonatal period: an observational study
  publication-title: Eur J Pediatr
  doi: 10.1007/s00431-019-03558-7
– volume: 136
  start-page: 132
  year: 2016
  ident: 10.1016/j.jpeds.2024.113945_bib29
  article-title: Presence of cytomegalovirus in the perilymphatic fluid of patients with profound sensorineural hearing loss caused by congenital cytomegalovirus infection
  publication-title: Acta Otolaryngol
  doi: 10.3109/00016489.2015.1099733
– volume: 56
  start-page: 113
  year: 2013
  ident: 10.1016/j.jpeds.2024.113945_bib25
  article-title: Cytomegalovirus DNA detection in dried blood spots and perilymphatic fluids from pediatric and adult cochlear implant recipients with prelingual deafness
  publication-title: J Clin Virol
  doi: 10.1016/j.jcv.2012.10.008
– volume: 122
  start-page: 763
  year: 2011
  ident: 10.1016/j.jpeds.2024.113945_bib30
  article-title: Inner ear lesions in congenital cytomegalovirus infection of human fetuses
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-011-0895-y
– volume: 17
  start-page: e177
  year: 2017
  ident: 10.1016/j.jpeds.2024.113945_bib35
  article-title: Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy
  publication-title: Lancet Infect Dis
  doi: 10.1016/S1473-3099(17)30143-3
– volume: 372
  start-page: 2463
  year: 2015
  ident: 10.1016/j.jpeds.2024.113945_bib4
  article-title: Valganciclovir for congenital cytomegalovirus
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1404599
– volume: 101
  start-page: 433
  year: 2016
  ident: 10.1016/j.jpeds.2024.113945_bib19
  article-title: Hearing outcome of infants with congenital cytomegalovirus and hearing impairment
  publication-title: Arch Dis Child
  doi: 10.1136/archdischild-2015-309154
– volume: 110
  start-page: 55
  year: 2020
  ident: 10.1016/j.jpeds.2024.113945_bib37
  article-title: Brain magnetic resonance imaging in congenital cytomegalovirus with failed newborn hearing screen
  publication-title: Pediatr Neurol
  doi: 10.1016/j.pediatrneurol.2020.05.006
– volume: 102
  start-page: F519
  year: 2017
  ident: 10.1016/j.jpeds.2024.113945_bib40
  article-title: Contribution of targeted saliva screening for congenital CMV-related hearing loss in newborns who fail hearing screening
  publication-title: Arch Dis Child Fetal Neonatal Ed
  doi: 10.1136/archdischild-2016-311859
– volume: 35
  start-page: 216
  year: 2006
  ident: 10.1016/j.jpeds.2024.113945_bib22
  article-title: Congenital cytomegalovirus infection following first trimester maternal infection: symptoms at birth and outcome
  publication-title: J Clin Virol
  doi: 10.1016/j.jcv.2005.09.015
– volume: 53
  start-page: 444
  year: 2014
  ident: 10.1016/j.jpeds.2024.113945_bib14
  article-title: Treatment of late-onset hearing loss in infants with congenital cytomegalovirus infection
  publication-title: Clin Pediatr (Phila)
  doi: 10.1177/0009922813510204
– volume: 41
  start-page: 508
  year: 2013
  ident: 10.1016/j.jpeds.2024.113945_bib20
  article-title: Risk of cytomegalovirus-associated sequelae in relation to time of infection and findings on prenatal imaging
  publication-title: Ultrasound Obstet Gynecol
  doi: 10.1002/uog.12377
– volume: 199
  start-page: 166
  year: 2018
  ident: 10.1016/j.jpeds.2024.113945_bib5
  article-title: Valganciclovir is beneficial in children with congenital cytomegalovirus and isolated hearing loss
  publication-title: J Pediatr
  doi: 10.1016/j.jpeds.2018.02.028
– volume: 99
  start-page: F230
  year: 2014
  ident: 10.1016/j.jpeds.2024.113945_bib39
  article-title: Feasibility and acceptability of targeted screening for congenital CMV-related hearing loss
  publication-title: Arch Dis Child Fetal Neonatal Ed
  doi: 10.1136/archdischild-2013-305276
– volume: 143
  start-page: 16
  year: 2003
  ident: 10.1016/j.jpeds.2024.113945_bib3
  article-title: Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial
  publication-title: J Pediatr
  doi: 10.1016/S0022-3476(03)00192-6
– volume: 46
  start-page: S37
  year: 2009
  ident: 10.1016/j.jpeds.2024.113945_bib8
  article-title: Evaluation of DNA extraction methods for dried blood spots in the diagnosis of congenital cytomegalovirus infection
  publication-title: J Clin Virol
  doi: 10.1016/j.jcv.2009.09.001
– volume: 114
  start-page: 2235
  year: 2004
  ident: 10.1016/j.jpeds.2024.113945_bib28
  article-title: Detection of herpesvirus DNAs in perilymph obtained from patients with sensorineural hearing loss by real-time polymerase chain reaction
  publication-title: Laryngoscope
  doi: 10.1097/01.mlg.0000149466.80703.55
– volume: 5
  start-page: 14
  year: 2016
  ident: 10.1016/j.jpeds.2024.113945_bib32
  article-title: Longitudinal Kinetics of cytomegalovirus-specific T-cell immunity and viral replication in infants with congenital cytomegalovirus infection
  publication-title: J Pediatric Infect Dis Soc
  doi: 10.1093/jpids/piu089
– volume: 132
  start-page: 2241
  year: 2022
  ident: 10.1016/j.jpeds.2024.113945_bib6
  article-title: The effect of (Val)ganciclovir on hearing in congenital cytomegalovirus: a systematic review
  publication-title: Laryngoscope
  doi: 10.1002/lary.30027
– volume: 13
  start-page: 1078
  year: 2021
  ident: 10.1016/j.jpeds.2024.113945_bib33
  article-title: Cytomegalovirus infection and inflammation in developing brain
  publication-title: Viruses
  doi: 10.3390/v13061078
– volume: 55
  start-page: 72
  year: 2012
  ident: 10.1016/j.jpeds.2024.113945_bib13
  article-title: Treatment of symptomatic congenital cytomegalovirus infection beyond the neonatal period
  publication-title: J Clin Virol
  doi: 10.1016/j.jcv.2012.06.001
– ident: 10.1016/j.jpeds.2024.113945_bib10
– volume: 109
  start-page: 151
  year: 2024
  ident: 10.1016/j.jpeds.2024.113945_bib36
  article-title: Neuroimaging in infants with congenital cytomegalovirus infection and its correlation with outcome: emphasis on white matter abnormalities
  publication-title: Arch Dis Child Fetal Neonatal Ed
  doi: 10.1136/archdischild-2023-325790
– volume: 42
  start-page: 1498
  year: 2004
  ident: 10.1016/j.jpeds.2024.113945_bib7
  article-title: Validation of clinical application of cytomegalovirus plasma DNA load measurement and definition of treatment criteria by analysis of correlation to antigen detection
  publication-title: J Clin Microbiol
  doi: 10.1128/JCM.42.4.1498-1504.2004
– volume: 122
  start-page: e1123
  year: 2008
  ident: 10.1016/j.jpeds.2024.113945_bib21
  article-title: Hearing loss in children with congenital cytomegalovirus infection in relation to the maternal trimester in which the maternal primary infection occurred
  publication-title: Pediatrics
  doi: 10.1542/peds.2008-0770
– volume: 69
  start-page: 1526
  year: 2019
  ident: 10.1016/j.jpeds.2024.113945_bib23
  article-title: Sequelae of congenital cytomegalovirus following maternal primary infections are limited to those acquired in the first trimester of pregnancy
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/ciy1128
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Snippet To assess the efficacy of valganciclovir in infants with hearing loss and clinically inapparent congenital cytomegalovirus infection (cCMV), as there is no...
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StartPage 113945
SubjectTerms antiviral treatment
audiology
congenital infection
pediatrics
targeted screening
virology
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Title Valganciclovir in Infants with Hearing Loss and Clinically Inapparent Congenital Cytomegalovirus Infection: A Nonrandomized Controlled Trial
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https://dx.doi.org/10.1016/j.jpeds.2024.113945
https://www.ncbi.nlm.nih.gov/pubmed/38336204
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