Valganciclovir in Infants with Hearing Loss and Clinically Inapparent Congenital Cytomegalovirus Infection: A Nonrandomized Controlled Trial
To assess the efficacy of valganciclovir in infants with hearing loss and clinically inapparent congenital cytomegalovirus infection (cCMV), as there is no consensus on treatment of this group. A nationwide, nonrandomized controlled trial, comparing 6 weeks of oral valganciclovir to no treatment in...
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Published in | The Journal of pediatrics Vol. 268; p. 113945 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.05.2024
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ISSN | 0022-3476 1097-6833 1085-8695 1097-6833 |
DOI | 10.1016/j.jpeds.2024.113945 |
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Abstract | To assess the efficacy of valganciclovir in infants with hearing loss and clinically inapparent congenital cytomegalovirus infection (cCMV), as there is no consensus on treatment of this group.
A nationwide, nonrandomized controlled trial, comparing 6 weeks of oral valganciclovir to no treatment in infants with cCMV, recruited after newborn hearing screening resulted in referral to an audiologist. The choice whether to treat was left to parents of subjects. Eligible subjects were full term infants aged <13 weeks with sensorineural hearing loss and diagnosed with cCMV through dried blood spot testing. The primary outcome, measured by linear and ordinal logistic regression, was change in best-ear hearing from baseline to follow-up at 18-22 months of age.
Thirty-seven participants were included in the final analysis, of whom 25 were in the treatment group and 12 in the control group. The majority of subjects in both groups had neuroimaging abnormalities, which were mostly mild. Hearing deterioration was more likely in the control group compared with the treatment group (common OR 0.10, 95% CI 0.02-0.45, P = .003). Mean best-ear hearing deteriorated by 13.7 dB in the control group, compared with improvement of 3.3 dB in the treatment group (difference 17 dB, 95% CI 2.6 – 31.4, P = .02).
We investigated treatment in children with hearing loss and clinically inapparent cCMV. Although our study was nonrandomized, it is the first prospective and controlled trial in this population. Valganciclovir-treated children with hearing loss and inapparent cCMV had less hearing deterioration at 18 through 22 months of age than control subjects.
2013-003068-30. |
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AbstractList | To assess the efficacy of valganciclovir in infants with hearing loss and clinically inapparent congenital cytomegalovirus infection (cCMV), as there is no consensus on treatment of this group.OBJECTIVETo assess the efficacy of valganciclovir in infants with hearing loss and clinically inapparent congenital cytomegalovirus infection (cCMV), as there is no consensus on treatment of this group.A nationwide, nonrandomized controlled trial, comparing 6 weeks of oral valganciclovir to no treatment in infants with cCMV, recruited after newborn hearing screening resulted in referral to an audiologist. The choice whether to treat was left to parents of subjects. Eligible subjects were full term infants aged <13 weeks with sensorineural hearing loss and diagnosed with cCMV through dried blood spot testing. The primary outcome, measured by linear and ordinal logistic regression, was change in best-ear hearing from baseline to follow-up at 18-22 months of age.STUDY DESIGNA nationwide, nonrandomized controlled trial, comparing 6 weeks of oral valganciclovir to no treatment in infants with cCMV, recruited after newborn hearing screening resulted in referral to an audiologist. The choice whether to treat was left to parents of subjects. Eligible subjects were full term infants aged <13 weeks with sensorineural hearing loss and diagnosed with cCMV through dried blood spot testing. The primary outcome, measured by linear and ordinal logistic regression, was change in best-ear hearing from baseline to follow-up at 18-22 months of age.Thirty-seven participants were included in the final analysis, of whom 25 were in the treatment group and 12 in the control group. The majority of subjects in both groups had neuroimaging abnormalities, which were mostly mild. Hearing deterioration was more likely in the control group compared with the treatment group (common OR 0.10, 95% CI 0.02-0.45, P = .003). Mean best-ear hearing deteriorated by 13.7 dB in the control group, compared with improvement of 3.3 dB in the treatment group (difference 17 dB, 95% CI 2.6 - 31.4, P = .02).RESULTSThirty-seven participants were included in the final analysis, of whom 25 were in the treatment group and 12 in the control group. The majority of subjects in both groups had neuroimaging abnormalities, which were mostly mild. Hearing deterioration was more likely in the control group compared with the treatment group (common OR 0.10, 95% CI 0.02-0.45, P = .003). Mean best-ear hearing deteriorated by 13.7 dB in the control group, compared with improvement of 3.3 dB in the treatment group (difference 17 dB, 95% CI 2.6 - 31.4, P = .02).We investigated treatment in children with hearing loss and clinically inapparent cCMV. Although our study was nonrandomized, it is the first prospective and controlled trial in this population. Valganciclovir-treated children with hearing loss and inapparent cCMV had less hearing deterioration at 18 through 22 months of age than control subjects.CONCLUSIONSWe investigated treatment in children with hearing loss and clinically inapparent cCMV. Although our study was nonrandomized, it is the first prospective and controlled trial in this population. Valganciclovir-treated children with hearing loss and inapparent cCMV had less hearing deterioration at 18 through 22 months of age than control subjects.2013-003068-30.EUDRACT REGISTRY NUMBER2013-003068-30. To assess the efficacy of valganciclovir in infants with hearing loss and clinically inapparent congenital cytomegalovirus infection (cCMV), as there is no consensus on treatment of this group. A nationwide, nonrandomized controlled trial, comparing 6 weeks of oral valganciclovir to no treatment in infants with cCMV, recruited after newborn hearing screening resulted in referral to an audiologist. The choice whether to treat was left to parents of subjects. Eligible subjects were full term infants aged <13 weeks with sensorineural hearing loss and diagnosed with cCMV through dried blood spot testing. The primary outcome, measured by linear and ordinal logistic regression, was change in best-ear hearing from baseline to follow-up at 18-22 months of age. Thirty-seven participants were included in the final analysis, of whom 25 were in the treatment group and 12 in the control group. The majority of subjects in both groups had neuroimaging abnormalities, which were mostly mild. Hearing deterioration was more likely in the control group compared with the treatment group (common OR 0.10, 95% CI 0.02-0.45, P = .003). Mean best-ear hearing deteriorated by 13.7 dB in the control group, compared with improvement of 3.3 dB in the treatment group (difference 17 dB, 95% CI 2.6 - 31.4, P = .02). We investigated treatment in children with hearing loss and clinically inapparent cCMV. Although our study was nonrandomized, it is the first prospective and controlled trial in this population. Valganciclovir-treated children with hearing loss and inapparent cCMV had less hearing deterioration at 18 through 22 months of age than control subjects. 2013-003068-30. |
ArticleNumber | 113945 |
Author | Chung, Pui Khi Schornagel, Fleurtje A.J. Kroes, Aloys C.M. Soede, Wim van Zwet, Erik W. Vossen, Ann C.T.M. Oudesluys-Murphy, Anne Marie |
Author_xml | – sequence: 1 givenname: Pui Khi orcidid: 0000-0002-3176-3233 surname: Chung fullname: Chung, Pui Khi email: p.k.chung@lumc.nl organization: Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands – sequence: 2 givenname: Fleurtje A.J. surname: Schornagel fullname: Schornagel, Fleurtje A.J. organization: Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands – sequence: 3 givenname: Wim surname: Soede fullname: Soede, Wim organization: Department of Otorhinolaryngology and Head & Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands – sequence: 4 givenname: Erik W. surname: van Zwet fullname: van Zwet, Erik W. organization: Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands – sequence: 5 givenname: Aloys C.M. surname: Kroes fullname: Kroes, Aloys C.M. organization: Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands – sequence: 6 givenname: Anne Marie surname: Oudesluys-Murphy fullname: Oudesluys-Murphy, Anne Marie organization: Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands – sequence: 7 givenname: Ann C.T.M. surname: Vossen fullname: Vossen, Ann C.T.M. organization: Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands |
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Cites_doi | 10.1002/jmv.10263 10.1002/rmv.544 10.3390/jcm11133582 10.1186/2051-5960-1-63 10.1159/000446690 10.1093/jpids/pix105 10.1136/archdischild-2022-324699 10.1016/j.ijporl.2020.110055 10.1007/s00431-010-1176-9 10.1097/01.mlg.0000154722.55044.fc 10.1542/peds.2018-3095 10.1016/j.jcv.2007.09.004 10.1097/INF.0000000000001763 10.1016/j.jcv.2018.03.006 10.1007/s00431-019-03558-7 10.3109/00016489.2015.1099733 10.1016/j.jcv.2012.10.008 10.1007/s00401-011-0895-y 10.1016/S1473-3099(17)30143-3 10.1056/NEJMoa1404599 10.1136/archdischild-2015-309154 10.1016/j.pediatrneurol.2020.05.006 10.1136/archdischild-2016-311859 10.1016/j.jcv.2005.09.015 10.1177/0009922813510204 10.1002/uog.12377 10.1016/j.jpeds.2018.02.028 10.1136/archdischild-2013-305276 10.1016/S0022-3476(03)00192-6 10.1016/j.jcv.2009.09.001 10.1097/01.mlg.0000149466.80703.55 10.1093/jpids/piu089 10.1002/lary.30027 10.3390/v13061078 10.1016/j.jcv.2012.06.001 10.1136/archdischild-2023-325790 10.1128/JCM.42.4.1498-1504.2004 10.1542/peds.2008-0770 10.1093/cid/ciy1128 |
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Keywords | RCT congenital infection targeted screening cCMV audiology CNS CONCERT 2.0 CMV BSID-III antiviral treatment DBS virology pediatrics NHS SNHL CONCERT dB |
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References | Luck, Wieringa, Blazquez-Gamero, Henneke, Schuster, Butler (bib12) 2017; 36 Amir, Wolf, Levy (bib18) 2010; 169 Faure-Bardon, Magny, Parodi, Couderc, Garcia, Maillotte (bib23) 2019; 69 Chung, Schornagel, Oudesluys-Murphy, de Vries, Soede, van Zwet (bib9) 2023; 108 del Rosal, Baquero-Artigao, Blazquez, Noguera-Julian, Moreno-Perez, Reyes (bib13) 2012; 55 Haller, Shoup, Park (bib11) 2020; 134 de Vries, Claas, Kroes, Vossen (bib8) 2009; 46 Hranilovich, Park, Knackstedt, Ostrander, Hedlund, Shi (bib37) 2020; 110 Kimberlin, Lin, Sanchez, Demmler, Dankner, Shelton (bib3) 2003; 143 Pass, Fowler, Boppana, Britt, Stagno (bib22) 2006; 35 Ari-Even Roth, Lubin, Kuint, Teperberg-Oikawa, Mendelson, Strauss (bib40) 2017; 102 Ogawa, Matsui, Baba, Yamada, Suzuki, Suzutani (bib29) 2016; 136 Dorfman, Amir, Attias, Bilavsky (bib15) 2020; 179 Sugiura, Yoshikawa, Nishiyama, Morishita, Sato, Beppu (bib28) 2004; 114 Chen, Holmes, Slifer, Ramachandran, Mackey, Hebson (bib32) 2016; 5 De Cuyper, Acke, Keymeulen, Dhooge (bib6) 2022; 132 Dollard, Grosse, Ross (bib1) 2007; 17 Pasternak, Ziv, Attias, Amir, Bilavsky (bib5) 2018; 199 Grosse, Ross, Dollard (bib2) 2008; 41 Sugiura, Yoshikawa, Nishiyama, Morishita, Sato, Hattori (bib27) 2003; 69 Kalpoe, Kroes, de Jong, Schinkel, de Brouwer, Beersma (bib7) 2004; 42 Amir, Attias, Pardo (bib14) 2014; 53 Rawlinson, Boppana, Fowler, Kimberlin, Lazzarotto, Alain (bib35) 2017; 17 Gabrielli, Bonasoni, Santini, Piccirilli, Chiereghin, Guerra (bib31) 2013; 1 Krstanovic, Britt, Jonjic, Brizic (bib33) 2021; 13 Foulon, Naessens, Foulon, Casteels, Gordts (bib21) 2008; 122 Teissier, Delezoide, Mas, Khung-Savatovsky, Bessieres, Nardelli (bib30) 2011; 122 Rawlinson, Palasanthiran, Hall, Al Yazidi, Cannon, Cottier (bib38) 2018; 102 Lipitz, Yinon, Malinger, Yagel, Levit, Hoffman (bib20) 2013; 41 Foulon, De Brucker, Buyl, Lichtert, Verbruggen, Pierard (bib24) 2019; 144 bib17 Vancor, Shapiro, Loyal (bib41) 2019; 8 Bilavsky, Shahar-Nissan, Pardo, Attias, Amir (bib19) 2016; 101 de Vries, Vesseur, Rotteveel, Korver, Rusman, Wessels (bib25) 2013; 56 Alarcon, Martinez-Biarge, Cabanas, Quero, Garcia-Alix (bib34) 2016; 110 Kimberlin, Aban, Acosta (bib4) 2015; 372 Bauer, Parizi-Robinson, Roland, Yegappan (bib26) 2005; 115 Williams, Kadambari, Berrington, Luck, Atkinson, Walter (bib39) 2014; 99 Morioka, Kakei, Omori, Nozu, Fujioka, Takahashi (bib16) 2022; 11 Alarcon, de Vries, Parodi, Arnaez, Cabanas, Steggerda (bib36) 2024; 109 IBf (bib10) 1996 Chung (10.1016/j.jpeds.2024.113945_bib9) 2023; 108 Williams (10.1016/j.jpeds.2024.113945_bib39) 2014; 99 Teissier (10.1016/j.jpeds.2024.113945_bib30) 2011; 122 Ogawa (10.1016/j.jpeds.2024.113945_bib29) 2016; 136 Krstanovic (10.1016/j.jpeds.2024.113945_bib33) 2021; 13 Pass (10.1016/j.jpeds.2024.113945_bib22) 2006; 35 Gabrielli (10.1016/j.jpeds.2024.113945_bib31) 2013; 1 del Rosal (10.1016/j.jpeds.2024.113945_bib13) 2012; 55 Sugiura (10.1016/j.jpeds.2024.113945_bib28) 2004; 114 Rawlinson (10.1016/j.jpeds.2024.113945_bib38) 2018; 102 Bauer (10.1016/j.jpeds.2024.113945_bib26) 2005; 115 Luck (10.1016/j.jpeds.2024.113945_bib12) 2017; 36 Dorfman (10.1016/j.jpeds.2024.113945_bib15) 2020; 179 Foulon (10.1016/j.jpeds.2024.113945_bib24) 2019; 144 de Vries (10.1016/j.jpeds.2024.113945_bib25) 2013; 56 Vancor (10.1016/j.jpeds.2024.113945_bib41) 2019; 8 Sugiura (10.1016/j.jpeds.2024.113945_bib27) 2003; 69 Dollard (10.1016/j.jpeds.2024.113945_bib1) 2007; 17 Kalpoe (10.1016/j.jpeds.2024.113945_bib7) 2004; 42 De Cuyper (10.1016/j.jpeds.2024.113945_bib6) 2022; 132 Kimberlin (10.1016/j.jpeds.2024.113945_bib4) 2015; 372 Foulon (10.1016/j.jpeds.2024.113945_bib21) 2008; 122 Chen (10.1016/j.jpeds.2024.113945_bib32) 2016; 5 Grosse (10.1016/j.jpeds.2024.113945_bib2) 2008; 41 Amir (10.1016/j.jpeds.2024.113945_bib14) 2014; 53 Faure-Bardon (10.1016/j.jpeds.2024.113945_bib23) 2019; 69 Morioka (10.1016/j.jpeds.2024.113945_bib16) 2022; 11 Amir (10.1016/j.jpeds.2024.113945_bib18) 2010; 169 Kimberlin (10.1016/j.jpeds.2024.113945_bib3) 2003; 143 Alarcon (10.1016/j.jpeds.2024.113945_bib36) 2024; 109 Hranilovich (10.1016/j.jpeds.2024.113945_bib37) 2020; 110 Haller (10.1016/j.jpeds.2024.113945_bib11) 2020; 134 Bilavsky (10.1016/j.jpeds.2024.113945_bib19) 2016; 101 Ari-Even Roth (10.1016/j.jpeds.2024.113945_bib40) 2017; 102 IBf (10.1016/j.jpeds.2024.113945_bib10) Lipitz (10.1016/j.jpeds.2024.113945_bib20) 2013; 41 Alarcon (10.1016/j.jpeds.2024.113945_bib34) 2016; 110 de Vries (10.1016/j.jpeds.2024.113945_bib8) 2009; 46 Pasternak (10.1016/j.jpeds.2024.113945_bib5) 2018; 199 Rawlinson (10.1016/j.jpeds.2024.113945_bib35) 2017; 17 |
References_xml | – year: 1996 ident: bib10 article-title: BIAP recommendation 02/1: audiometric classification of hearing impairments – volume: 69 start-page: 72 year: 2003 end-page: 75 ident: bib27 article-title: Detection of human cytomegalovirus DNA in perilymph of patients with sensorineural hearing loss using real-time PCR publication-title: J Med Virol – volume: 13 start-page: 1078 year: 2021 ident: bib33 article-title: Cytomegalovirus infection and inflammation in developing brain publication-title: Viruses – ident: bib17 article-title: Valganciclovir therapy in infants and children with congenital CMV infection and hearing loss – volume: 42 start-page: 1498 year: 2004 end-page: 1504 ident: bib7 article-title: Validation of clinical application of cytomegalovirus plasma DNA load measurement and definition of treatment criteria by analysis of correlation to antigen detection publication-title: J Clin Microbiol – volume: 122 start-page: e1123 year: 2008 end-page: e1127 ident: bib21 article-title: Hearing loss in children with congenital cytomegalovirus infection in relation to the maternal trimester in which the maternal primary infection occurred publication-title: Pediatrics – volume: 1 start-page: 63 year: 2013 ident: bib31 article-title: Human fetal inner ear involvement in congenital cytomegalovirus infection publication-title: Acta Neuropathol Commun – volume: 8 start-page: 55 year: 2019 end-page: 59 ident: bib41 article-title: Results of a targeted screening program for congenital cytomegalovirus infection in infants who fail newborn hearing screening publication-title: J Pediatric Infect Dis Soc – volume: 102 start-page: F519 year: 2017 end-page: F524 ident: bib40 article-title: Contribution of targeted saliva screening for congenital CMV-related hearing loss in newborns who fail hearing screening publication-title: Arch Dis Child Fetal Neonatal Ed – volume: 110 start-page: 277 year: 2016 end-page: 285 ident: bib34 article-title: A prognostic neonatal neuroimaging scale for symptomatic congenital cytomegalovirus infection publication-title: Neonatology – volume: 372 start-page: 2463 year: 2015 ident: bib4 article-title: Valganciclovir for congenital cytomegalovirus publication-title: N Engl J Med – volume: 53 start-page: 444 year: 2014 end-page: 448 ident: bib14 article-title: Treatment of late-onset hearing loss in infants with congenital cytomegalovirus infection publication-title: Clin Pediatr (Phila) – volume: 5 start-page: 14 year: 2016 end-page: 20 ident: bib32 article-title: Longitudinal Kinetics of cytomegalovirus-specific T-cell immunity and viral replication in infants with congenital cytomegalovirus infection publication-title: J Pediatric Infect Dis Soc – volume: 35 start-page: 216 year: 2006 end-page: 220 ident: bib22 article-title: Congenital cytomegalovirus infection following first trimester maternal infection: symptoms at birth and outcome publication-title: J Clin Virol – volume: 132 start-page: 2241 year: 2022 end-page: 2250 ident: bib6 article-title: The effect of (Val)ganciclovir on hearing in congenital cytomegalovirus: a systematic review publication-title: Laryngoscope – volume: 144 year: 2019 ident: bib24 article-title: Hearing loss with congenital cytomegalovirus infection publication-title: Pediatrics – volume: 108 start-page: 302 year: 2023 end-page: 308 ident: bib9 article-title: Targeted screening for congenital cytomegalovirus infection: clinical, audiological and neuroimaging findings publication-title: Arch Dis Child Fetal Neonatal Ed – volume: 41 start-page: 57 year: 2008 end-page: 62 ident: bib2 article-title: Congenital cytomegalovirus (CMV) infection as a cause of permanent bilateral hearing loss: a quantitative assessment publication-title: J Clin Virol – volume: 110 start-page: 55 year: 2020 end-page: 58 ident: bib37 article-title: Brain magnetic resonance imaging in congenital cytomegalovirus with failed newborn hearing screen publication-title: Pediatr Neurol – volume: 179 start-page: 807 year: 2020 end-page: 812 ident: bib15 article-title: Treatment of congenital cytomegalovirus beyond the neonatal period: an observational study publication-title: Eur J Pediatr – volume: 169 start-page: 1061 year: 2010 end-page: 1067 ident: bib18 article-title: Treatment of symptomatic congenital cytomegalovirus infection with intravenous ganciclovir followed by long-term oral valganciclovir publication-title: Eur J Pediatr – volume: 56 start-page: 113 year: 2013 end-page: 117 ident: bib25 article-title: Cytomegalovirus DNA detection in dried blood spots and perilymphatic fluids from pediatric and adult cochlear implant recipients with prelingual deafness publication-title: J Clin Virol – volume: 199 start-page: 166 year: 2018 end-page: 170 ident: bib5 article-title: Valganciclovir is beneficial in children with congenital cytomegalovirus and isolated hearing loss publication-title: J Pediatr – volume: 101 start-page: 433 year: 2016 end-page: 438 ident: bib19 article-title: Hearing outcome of infants with congenital cytomegalovirus and hearing impairment publication-title: Arch Dis Child – volume: 115 start-page: 223 year: 2005 end-page: 225 ident: bib26 article-title: Cytomegalovirus in the perilymphatic fluid publication-title: Laryngoscope – volume: 134 year: 2020 ident: bib11 article-title: Should hearing targeted screening for congenital cytomegalovirus infection be implemented? publication-title: Int J Pediatr Otorhi – volume: 136 start-page: 132 year: 2016 end-page: 135 ident: bib29 article-title: Presence of cytomegalovirus in the perilymphatic fluid of patients with profound sensorineural hearing loss caused by congenital cytomegalovirus infection publication-title: Acta Otolaryngol – volume: 55 start-page: 72 year: 2012 end-page: 74 ident: bib13 article-title: Treatment of symptomatic congenital cytomegalovirus infection beyond the neonatal period publication-title: J Clin Virol – volume: 46 start-page: S37 year: 2009 end-page: S42 ident: bib8 article-title: Evaluation of DNA extraction methods for dried blood spots in the diagnosis of congenital cytomegalovirus infection publication-title: J Clin Virol – volume: 143 start-page: 16 year: 2003 end-page: 25 ident: bib3 article-title: Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial publication-title: J Pediatr – volume: 36 start-page: 1205 year: 2017 end-page: 1213 ident: bib12 article-title: Congenital cytomegalovirus: a European expert consensus statement on diagnosis and management publication-title: Pediatr Infect Dis J – volume: 122 start-page: 763 year: 2011 end-page: 774 ident: bib30 article-title: Inner ear lesions in congenital cytomegalovirus infection of human fetuses publication-title: Acta Neuropathol – volume: 99 start-page: F230 year: 2014 end-page: F236 ident: bib39 article-title: Feasibility and acceptability of targeted screening for congenital CMV-related hearing loss publication-title: Arch Dis Child Fetal Neonatal Ed – volume: 69 start-page: 1526 year: 2019 end-page: 1532 ident: bib23 article-title: Sequelae of congenital cytomegalovirus following maternal primary infections are limited to those acquired in the first trimester of pregnancy publication-title: Clin Infect Dis – volume: 102 start-page: 110 year: 2018 end-page: 115 ident: bib38 article-title: Neonates with congenital cytomegalovirus and hearing loss identified via the universal newborn hearing screening program publication-title: J Clin Virol – volume: 109 start-page: 151 year: 2024 end-page: 158 ident: bib36 article-title: Neuroimaging in infants with congenital cytomegalovirus infection and its correlation with outcome: emphasis on white matter abnormalities publication-title: Arch Dis Child Fetal Neonatal Ed – volume: 41 start-page: 508 year: 2013 end-page: 514 ident: bib20 article-title: Risk of cytomegalovirus-associated sequelae in relation to time of infection and findings on prenatal imaging publication-title: Ultrasound Obstet Gynecol – volume: 114 start-page: 2235 year: 2004 end-page: 2238 ident: bib28 article-title: Detection of herpesvirus DNAs in perilymph obtained from patients with sensorineural hearing loss by real-time polymerase chain reaction publication-title: Laryngoscope – volume: 17 start-page: e177 year: 2017 end-page: e188 ident: bib35 article-title: Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy publication-title: Lancet Infect Dis – volume: 17 start-page: 355 year: 2007 end-page: 363 ident: bib1 article-title: New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection publication-title: Rev Med Virol – volume: 11 start-page: 3582 year: 2022 ident: bib16 article-title: Oral valganciclovir therapy in infants aged </=2 Months with congenital cytomegalovirus disease: a multicenter, single-arm, open-label clinical trial in Japan publication-title: J Clin Med – volume: 69 start-page: 72 year: 2003 ident: 10.1016/j.jpeds.2024.113945_bib27 article-title: Detection of human cytomegalovirus DNA in perilymph of patients with sensorineural hearing loss using real-time PCR publication-title: J Med Virol doi: 10.1002/jmv.10263 – volume: 17 start-page: 355 year: 2007 ident: 10.1016/j.jpeds.2024.113945_bib1 article-title: New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection publication-title: Rev Med Virol doi: 10.1002/rmv.544 – volume: 11 start-page: 3582 year: 2022 ident: 10.1016/j.jpeds.2024.113945_bib16 article-title: Oral valganciclovir therapy in infants aged </=2 Months with congenital cytomegalovirus disease: a multicenter, single-arm, open-label clinical trial in Japan publication-title: J Clin Med doi: 10.3390/jcm11133582 – volume: 1 start-page: 63 year: 2013 ident: 10.1016/j.jpeds.2024.113945_bib31 article-title: Human fetal inner ear involvement in congenital cytomegalovirus infection publication-title: Acta Neuropathol Commun doi: 10.1186/2051-5960-1-63 – volume: 110 start-page: 277 year: 2016 ident: 10.1016/j.jpeds.2024.113945_bib34 article-title: A prognostic neonatal neuroimaging scale for symptomatic congenital cytomegalovirus infection publication-title: Neonatology doi: 10.1159/000446690 – volume: 8 start-page: 55 year: 2019 ident: 10.1016/j.jpeds.2024.113945_bib41 article-title: Results of a targeted screening program for congenital cytomegalovirus infection in infants who fail newborn hearing screening publication-title: J Pediatric Infect Dis Soc doi: 10.1093/jpids/pix105 – volume: 108 start-page: 302 year: 2023 ident: 10.1016/j.jpeds.2024.113945_bib9 article-title: Targeted screening for congenital cytomegalovirus infection: clinical, audiological and neuroimaging findings publication-title: Arch Dis Child Fetal Neonatal Ed doi: 10.1136/archdischild-2022-324699 – volume: 134 year: 2020 ident: 10.1016/j.jpeds.2024.113945_bib11 article-title: Should hearing targeted screening for congenital cytomegalovirus infection be implemented? publication-title: Int J Pediatr Otorhi doi: 10.1016/j.ijporl.2020.110055 – volume: 169 start-page: 1061 year: 2010 ident: 10.1016/j.jpeds.2024.113945_bib18 article-title: Treatment of symptomatic congenital cytomegalovirus infection with intravenous ganciclovir followed by long-term oral valganciclovir publication-title: Eur J Pediatr doi: 10.1007/s00431-010-1176-9 – volume: 115 start-page: 223 year: 2005 ident: 10.1016/j.jpeds.2024.113945_bib26 article-title: Cytomegalovirus in the perilymphatic fluid publication-title: Laryngoscope doi: 10.1097/01.mlg.0000154722.55044.fc – volume: 144 year: 2019 ident: 10.1016/j.jpeds.2024.113945_bib24 article-title: Hearing loss with congenital cytomegalovirus infection publication-title: Pediatrics doi: 10.1542/peds.2018-3095 – volume: 41 start-page: 57 year: 2008 ident: 10.1016/j.jpeds.2024.113945_bib2 article-title: Congenital cytomegalovirus (CMV) infection as a cause of permanent bilateral hearing loss: a quantitative assessment publication-title: J Clin Virol doi: 10.1016/j.jcv.2007.09.004 – volume: 36 start-page: 1205 year: 2017 ident: 10.1016/j.jpeds.2024.113945_bib12 article-title: Congenital cytomegalovirus: a European expert consensus statement on diagnosis and management publication-title: Pediatr Infect Dis J doi: 10.1097/INF.0000000000001763 – volume: 102 start-page: 110 year: 2018 ident: 10.1016/j.jpeds.2024.113945_bib38 article-title: Neonates with congenital cytomegalovirus and hearing loss identified via the universal newborn hearing screening program publication-title: J Clin Virol doi: 10.1016/j.jcv.2018.03.006 – volume: 179 start-page: 807 year: 2020 ident: 10.1016/j.jpeds.2024.113945_bib15 article-title: Treatment of congenital cytomegalovirus beyond the neonatal period: an observational study publication-title: Eur J Pediatr doi: 10.1007/s00431-019-03558-7 – volume: 136 start-page: 132 year: 2016 ident: 10.1016/j.jpeds.2024.113945_bib29 article-title: Presence of cytomegalovirus in the perilymphatic fluid of patients with profound sensorineural hearing loss caused by congenital cytomegalovirus infection publication-title: Acta Otolaryngol doi: 10.3109/00016489.2015.1099733 – volume: 56 start-page: 113 year: 2013 ident: 10.1016/j.jpeds.2024.113945_bib25 article-title: Cytomegalovirus DNA detection in dried blood spots and perilymphatic fluids from pediatric and adult cochlear implant recipients with prelingual deafness publication-title: J Clin Virol doi: 10.1016/j.jcv.2012.10.008 – volume: 122 start-page: 763 year: 2011 ident: 10.1016/j.jpeds.2024.113945_bib30 article-title: Inner ear lesions in congenital cytomegalovirus infection of human fetuses publication-title: Acta Neuropathol doi: 10.1007/s00401-011-0895-y – volume: 17 start-page: e177 year: 2017 ident: 10.1016/j.jpeds.2024.113945_bib35 article-title: Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(17)30143-3 – volume: 372 start-page: 2463 year: 2015 ident: 10.1016/j.jpeds.2024.113945_bib4 article-title: Valganciclovir for congenital cytomegalovirus publication-title: N Engl J Med doi: 10.1056/NEJMoa1404599 – volume: 101 start-page: 433 year: 2016 ident: 10.1016/j.jpeds.2024.113945_bib19 article-title: Hearing outcome of infants with congenital cytomegalovirus and hearing impairment publication-title: Arch Dis Child doi: 10.1136/archdischild-2015-309154 – volume: 110 start-page: 55 year: 2020 ident: 10.1016/j.jpeds.2024.113945_bib37 article-title: Brain magnetic resonance imaging in congenital cytomegalovirus with failed newborn hearing screen publication-title: Pediatr Neurol doi: 10.1016/j.pediatrneurol.2020.05.006 – volume: 102 start-page: F519 year: 2017 ident: 10.1016/j.jpeds.2024.113945_bib40 article-title: Contribution of targeted saliva screening for congenital CMV-related hearing loss in newborns who fail hearing screening publication-title: Arch Dis Child Fetal Neonatal Ed doi: 10.1136/archdischild-2016-311859 – volume: 35 start-page: 216 year: 2006 ident: 10.1016/j.jpeds.2024.113945_bib22 article-title: Congenital cytomegalovirus infection following first trimester maternal infection: symptoms at birth and outcome publication-title: J Clin Virol doi: 10.1016/j.jcv.2005.09.015 – volume: 53 start-page: 444 year: 2014 ident: 10.1016/j.jpeds.2024.113945_bib14 article-title: Treatment of late-onset hearing loss in infants with congenital cytomegalovirus infection publication-title: Clin Pediatr (Phila) doi: 10.1177/0009922813510204 – volume: 41 start-page: 508 year: 2013 ident: 10.1016/j.jpeds.2024.113945_bib20 article-title: Risk of cytomegalovirus-associated sequelae in relation to time of infection and findings on prenatal imaging publication-title: Ultrasound Obstet Gynecol doi: 10.1002/uog.12377 – volume: 199 start-page: 166 year: 2018 ident: 10.1016/j.jpeds.2024.113945_bib5 article-title: Valganciclovir is beneficial in children with congenital cytomegalovirus and isolated hearing loss publication-title: J Pediatr doi: 10.1016/j.jpeds.2018.02.028 – volume: 99 start-page: F230 year: 2014 ident: 10.1016/j.jpeds.2024.113945_bib39 article-title: Feasibility and acceptability of targeted screening for congenital CMV-related hearing loss publication-title: Arch Dis Child Fetal Neonatal Ed doi: 10.1136/archdischild-2013-305276 – volume: 143 start-page: 16 year: 2003 ident: 10.1016/j.jpeds.2024.113945_bib3 article-title: Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial publication-title: J Pediatr doi: 10.1016/S0022-3476(03)00192-6 – volume: 46 start-page: S37 year: 2009 ident: 10.1016/j.jpeds.2024.113945_bib8 article-title: Evaluation of DNA extraction methods for dried blood spots in the diagnosis of congenital cytomegalovirus infection publication-title: J Clin Virol doi: 10.1016/j.jcv.2009.09.001 – volume: 114 start-page: 2235 year: 2004 ident: 10.1016/j.jpeds.2024.113945_bib28 article-title: Detection of herpesvirus DNAs in perilymph obtained from patients with sensorineural hearing loss by real-time polymerase chain reaction publication-title: Laryngoscope doi: 10.1097/01.mlg.0000149466.80703.55 – volume: 5 start-page: 14 year: 2016 ident: 10.1016/j.jpeds.2024.113945_bib32 article-title: Longitudinal Kinetics of cytomegalovirus-specific T-cell immunity and viral replication in infants with congenital cytomegalovirus infection publication-title: J Pediatric Infect Dis Soc doi: 10.1093/jpids/piu089 – volume: 132 start-page: 2241 year: 2022 ident: 10.1016/j.jpeds.2024.113945_bib6 article-title: The effect of (Val)ganciclovir on hearing in congenital cytomegalovirus: a systematic review publication-title: Laryngoscope doi: 10.1002/lary.30027 – volume: 13 start-page: 1078 year: 2021 ident: 10.1016/j.jpeds.2024.113945_bib33 article-title: Cytomegalovirus infection and inflammation in developing brain publication-title: Viruses doi: 10.3390/v13061078 – volume: 55 start-page: 72 year: 2012 ident: 10.1016/j.jpeds.2024.113945_bib13 article-title: Treatment of symptomatic congenital cytomegalovirus infection beyond the neonatal period publication-title: J Clin Virol doi: 10.1016/j.jcv.2012.06.001 – ident: 10.1016/j.jpeds.2024.113945_bib10 – volume: 109 start-page: 151 year: 2024 ident: 10.1016/j.jpeds.2024.113945_bib36 article-title: Neuroimaging in infants with congenital cytomegalovirus infection and its correlation with outcome: emphasis on white matter abnormalities publication-title: Arch Dis Child Fetal Neonatal Ed doi: 10.1136/archdischild-2023-325790 – volume: 42 start-page: 1498 year: 2004 ident: 10.1016/j.jpeds.2024.113945_bib7 article-title: Validation of clinical application of cytomegalovirus plasma DNA load measurement and definition of treatment criteria by analysis of correlation to antigen detection publication-title: J Clin Microbiol doi: 10.1128/JCM.42.4.1498-1504.2004 – volume: 122 start-page: e1123 year: 2008 ident: 10.1016/j.jpeds.2024.113945_bib21 article-title: Hearing loss in children with congenital cytomegalovirus infection in relation to the maternal trimester in which the maternal primary infection occurred publication-title: Pediatrics doi: 10.1542/peds.2008-0770 – volume: 69 start-page: 1526 year: 2019 ident: 10.1016/j.jpeds.2024.113945_bib23 article-title: Sequelae of congenital cytomegalovirus following maternal primary infections are limited to those acquired in the first trimester of pregnancy publication-title: Clin Infect Dis doi: 10.1093/cid/ciy1128 |
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