Structural biology: Variability without change

Sequence variability in microbial surface proteins can be extensive in order to promote immune escape, but the changes must not interfere with the function of the protein. Structural analysis of a streptococcal protein now clarifies how an extremely variable region retains its ability to specificall...

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Published inNature microbiology Vol. 1; no. 11; p. 16218
Main Authors Lindahl, Gunnar, Persson, Jenny J.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 26.10.2016
Nature Publishing Group
Subjects
631/326/41/2531
631/326/41/2534
631/326/41/2536
631/535/1266
Amino acid sequence
Basic Medicine
Biomedical and Life Sciences
Computational Biology
Infectious Diseases
Life Sciences
Medical and Health Sciences
Medical Microbiology
Medicin och hälsovetenskap
Medicinska och farmaceutiska grundvetenskaper
Microbiology
Microbiology in the Medical Area
Mikrobiologi inom det medicinska området
Molecular Biology
news-and-views
Parasitology
Protein Conformation
Variable region
Virology
Online AccessGet full text
ISSN2058-5276
1740-1534
2058-5276
DOI10.1038/nmicrobiol.2016.218

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Abstract Sequence variability in microbial surface proteins can be extensive in order to promote immune escape, but the changes must not interfere with the function of the protein. Structural analysis of a streptococcal protein now clarifies how an extremely variable region retains its ability to specifically bind its human target.
AbstractList Sequence variability in microbial surface proteins can be extensive in order to promote immune escape, but the changes must not interfere with the function of the protein. Structural analysis of a streptococcal protein now clarifies how an extremely variable region retains its ability to specifically bind its human target.
ArticleNumber 16218
Author Lindahl, Gunnar
Persson, Jenny J.
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10.1084/jem.48.6.751
10.1038/nature09967
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10.1038/362603a0
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10.1073/pnas.78.8.4689
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631/326/41/2534
631/326/41/2536
631/535/1266
Amino acid sequence
Basic Medicine
Biomedical and Life Sciences
Computational Biology
Infectious Diseases
Life Sciences
Medical and Health Sciences
Medical Microbiology
Medicin och hälsovetenskap
Medicinska och farmaceutiska grundvetenskaper
Microbiology
Microbiology in the Medical Area
Mikrobiologi inom det medicinska området
Molecular Biology
news-and-views
Parasitology
Protein Conformation
Variable region
Virology
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