Structural biology: Variability without change

Sequence variability in microbial surface proteins can be extensive in order to promote immune escape, but the changes must not interfere with the function of the protein. Structural analysis of a streptococcal protein now clarifies how an extremely variable region retains its ability to specificall...

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Bibliographic Details
Published in	Nature microbiology Vol. 1; no. 11; p. 16218
Main Authors	Lindahl, Gunnar, Persson, Jenny J.
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 26.10.2016 Nature Publishing Group
Subjects	631/326/41/2531 631/326/41/2534 631/326/41/2536 631/535/1266 Amino acid sequence Basic Medicine Biomedical and Life Sciences Computational Biology Infectious Diseases Life Sciences Medical and Health Sciences Medical Microbiology Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Microbiology Microbiology in the Medical Area Mikrobiologi inom det medicinska området Molecular Biology news-and-views Parasitology Protein Conformation Variable region Virology
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ISSN	2058-5276 1740-1534 2058-5276
DOI	10.1038/nmicrobiol.2016.218

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Summary:	Sequence variability in microbial surface proteins can be extensive in order to promote immune escape, but the changes must not interfere with the function of the protein. Structural analysis of a streptococcal protein now clarifies how an extremely variable region retains its ability to specifically bind its human target.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Commentary-3 content type line 23
ISSN:	2058-5276 1740-1534 2058-5276
DOI:	10.1038/nmicrobiol.2016.218