Highly potent and selective cannabinoid receptor 2 agonists: Initial hit optimization of an adamantyl hit series identified from high-through-put screening - Nettekoven, Matthias; Fingerle, Jürgen; Grether, Uwe; Grüner, Sabine; Kimbara, Atsushi; Püllmann, Bernd; Rogers-Evans, Mark; Röver, Stephan; Schuler, Franz; Schulz-Gasch, Tanja; Ullmer, Christoph (Bioorganic & medicinal chemistry letters, 2013)
Keywords: Adamantane; Adamantane - analogs & derivatives; Adamantane - pharmacology; agonists; Cannabinoid receptor; Cannabinoid Receptor Agonists - chemistry; Cannabinoid Receptor Agonists - pharmacology; cannabinoids; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Drug Evaluation, Preclinical - methods; High-Throughput Screening Assays - methods; Hit optimization; Humans; Life Sciences & Biomedicine; Models, Molecular; Pharmacology & Pharmacy; Physical Sciences; physicochemical properties; Receptor, Cannabinoid, CB2 - agonists; Science & Technology; screening; Structure-Activity Relationship; β-Arrestin; β-Arrestin; Adamantane; Cannabinoid receptor; Hit optimization; TARGET; DRUG DISCOVERY; ENDOCANNABINOID SYSTEM; CB2 RECEPTORS; DISEASES; LIGANDS; ABSORPTION; beta-Arrestin; MODULATION; PERMEATION; INDEXES