Simultaneous quantification of emtricitabine and tenofovir nucleotides in peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry - Jansen, Robert S.; Rosing, Hilde; Kromdijk, Wiete; ter Heine, Rob; Schellens, Jan HM; Beijnen, Jos H. (Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010)
Keywords: Adenine - analogs & derivatives; Adenine - blood; Adenine Nucleotides - blood; Analysis; Analytical, structural and metabolic biochemistry; Anions - chemistry; Biological and medical sciences; Chromatography, Ion Exchange - methods; Deoxycytidine - analogs & derivatives; Deoxycytidine - blood; Drug Stability; Emtricitabine; Fundamental and applied biological sciences. Psychology; General pharmacology; Humans; LC-MS; Leukocytes, Mononuclear - chemistry; Linear Models; Medical sciences; Nucleotides; Nucleotides - blood; Organophosphonates - blood; Pharmacology. Drug treatments; Phosphorylation; Pyrimidine Nucleotides - blood; Reproducibility of Results; Tandem Mass Spectrometry - methods; Tenofovir; Weak anion-exchange; Emtricitabine; Tenofovir; Nucleotides; Weak anion-exchange; LC–MS; Antiretroviral agent; RNA-directed DNA polymerase; Chemical analysis; HPLC chromatography; Nucleotide analog; Phosphorus Organic compounds; Ion exchange chromatography; Anion exchange; Mononuclear cell; Reverse transcriptase inhibitor; Nucleoside analog; Antiviral; Quantitative analysis; Purine nucleotide; Acyclic nucleotide; Enzyme; Transferases; Enzyme inhibitor; Organic phosphonate; Nucleotidyltransferases; Blood cell; LC-MS; Simultaneous measurement; Anion exchanger; Mass spectrometry