Synthesis of 1-and 3-(1-Substituted 4-Piperidinyl)-1, 2, 3, 4-tetrahydro-2-oxoquinazolines as Potential Antihypertensive Agents - TAKAI, HARUKI; SHUTO, KATSUICHI; TERANISHI, MASAYUKI; KUBO, KAZUHIRO; KASUYA, YUTAKA; KARASHIMA, NAOKO; OBASE, HIROYUKI; NAKAMIZO, NOBUHIRO; SHIGENOBU, KOKI; HASHIKAMI, MAKIKO (Chem. Pharm. Bull, 1985)
Keywords: alpha adrenergic blocking; Animals; antihypertensive activity; Antihypertensive Agents - chemical synthesis; Blood Pressure - drug effects; Heart Rate - drug effects; Male; piperidine; Piperidines - chemical synthesis; Piperidines - pharmacology; quinazoline; Quinazolines - chemical synthesis; Quinazolines - pharmacology; Rats; Rats, Inbred SHR; Rats, Inbred Strains; reductive cleavage; Structure-Activity Relationship