Quantification of myelinated endings and mechanoreceptors in human digital skin
We used immunohistochemistry and confocal microscopy applied to fingertip punch biopsy to study glabrous skin innervation in 14 healthy subjects. In addition to epidermal nerve fibers, we quantified mechanoreceptors and their myelinated afferents. Using digital images and dedicated software, we calc...
Saved in:
| Published in | Annals of neurology Vol. 54; no. 2; pp. 197 - 205 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.08.2003
Willey-Liss |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0364-5134 1531-8249 |
| DOI | 10.1002/ana.10615 |
Cover
| Abstract | We used immunohistochemistry and confocal microscopy applied to fingertip punch biopsy to study glabrous skin innervation in 14 healthy subjects. In addition to epidermal nerve fibers, we quantified mechanoreceptors and their myelinated afferents. Using digital images and dedicated software, we calculated caliber, internodal and nodal length, and G‐ratio of the last four internodes of the myelinated endings. In our skin samples, we found a mean density of 59.0 ± 29.3 myelinated endings per square millimeter with a mean diameter of 3.3 ± 0.5μm and an internodal length of 79.1 ± 13.8μm. These findings indicate that Aβ fibers undergo drastic changes in their course from the nerve trunk to the target organ, with repeated branching and consequent tapering and shortening of internodal length. Our work demonstrates that skin biopsy can give information on the status of large myelinated endings as well as unmyelinated sensory and autonomic nerves. Since distal endings are primarily involved in distal axonopathy, skin biopsy can be more suitable than sural nerve biopsy to detect early abnormalities. In addition to diagnostic applications, this technique allows clarification of the mode of termination of Aβ fibers and their relationship with mechanoreceptors, leading to relevant electrophysiological speculations. Ann Neurol 2003 |
|---|---|
| AbstractList | We used immunohistochemistry and confocal microscopy applied to fingertip punch biopsy to study glabrous skin innervation in 14 healthy subjects. In addition to epidermal nerve fibers, we quantified mechanoreceptors and their myelinated afferents. Using digital images and dedicated software, we calculated caliber, internodal and nodal length, and G-ratio of the last four internodes of the myelinated endings. In our skin samples, we found a mean density of 59.0 +/- 29.3 myelinated endings per square millimeter with a mean diameter of 3.3 +/- 0.5 microm and an internodal length of 79.1 +/- 13.8 microm. These findings indicate that Abeta fibers undergo drastic changes in their course from the nerve trunk to the target organ, with repeated branching and consequent tapering and shortening of internodal length. Our work demonstrates that skin biopsy can give information on the status of large myelinated endings as well as unmyelinated sensory and autonomic nerves. Since distal endings are primarily involved in distal axonopathy, skin biopsy can be more suitable than sural nerve biopsy to detect early abnormalities. In addition to diagnostic applications, this technique allows clarification of the mode of termination of Abeta fibers and their relationship with mechanoreceptors, leading to relevant electrophysiological speculations. We used immunohistochemistry and confocal microscopy applied to fingertip punch biopsy to study glabrous skin innervation in 14 healthy subjects. In addition to epidermal nerve fibers, we quantified mechanoreceptors and their myelinated afferents. Using digital images and dedicated software, we calculated caliber, internodal and nodal length, and G‐ratio of the last four internodes of the myelinated endings. In our skin samples, we found a mean density of 59.0 ± 29.3 myelinated endings per square millimeter with a mean diameter of 3.3 ± 0.5μm and an internodal length of 79.1 ± 13.8μm. These findings indicate that Aβ fibers undergo drastic changes in their course from the nerve trunk to the target organ, with repeated branching and consequent tapering and shortening of internodal length. Our work demonstrates that skin biopsy can give information on the status of large myelinated endings as well as unmyelinated sensory and autonomic nerves. Since distal endings are primarily involved in distal axonopathy, skin biopsy can be more suitable than sural nerve biopsy to detect early abnormalities. In addition to diagnostic applications, this technique allows clarification of the mode of termination of Aβ fibers and their relationship with mechanoreceptors, leading to relevant electrophysiological speculations. Ann Neurol 2003 We used immunohistochemistry and confocal microscopy applied to fingertip punch biopsy to study glabrous skin innervation in 14 healthy subjects. In addition to epidermal nerve fibers, we quantified mechanoreceptors and their myelinated afferents. Using digital images and dedicated software, we calculated caliber, internodal and nodal length, and G-ratio of the last four internodes of the myelinated endings. In our skin samples, we found a mean density of 59.0 +/- 29.3 myelinated endings per square millimeter with a mean diameter of 3.3 +/- 0.5 microm and an internodal length of 79.1 +/- 13.8 microm. These findings indicate that Abeta fibers undergo drastic changes in their course from the nerve trunk to the target organ, with repeated branching and consequent tapering and shortening of internodal length. Our work demonstrates that skin biopsy can give information on the status of large myelinated endings as well as unmyelinated sensory and autonomic nerves. Since distal endings are primarily involved in distal axonopathy, skin biopsy can be more suitable than sural nerve biopsy to detect early abnormalities. In addition to diagnostic applications, this technique allows clarification of the mode of termination of Abeta fibers and their relationship with mechanoreceptors, leading to relevant electrophysiological speculations.We used immunohistochemistry and confocal microscopy applied to fingertip punch biopsy to study glabrous skin innervation in 14 healthy subjects. In addition to epidermal nerve fibers, we quantified mechanoreceptors and their myelinated afferents. Using digital images and dedicated software, we calculated caliber, internodal and nodal length, and G-ratio of the last four internodes of the myelinated endings. In our skin samples, we found a mean density of 59.0 +/- 29.3 myelinated endings per square millimeter with a mean diameter of 3.3 +/- 0.5 microm and an internodal length of 79.1 +/- 13.8 microm. These findings indicate that Abeta fibers undergo drastic changes in their course from the nerve trunk to the target organ, with repeated branching and consequent tapering and shortening of internodal length. Our work demonstrates that skin biopsy can give information on the status of large myelinated endings as well as unmyelinated sensory and autonomic nerves. Since distal endings are primarily involved in distal axonopathy, skin biopsy can be more suitable than sural nerve biopsy to detect early abnormalities. In addition to diagnostic applications, this technique allows clarification of the mode of termination of Abeta fibers and their relationship with mechanoreceptors, leading to relevant electrophysiological speculations. |
| Author | Kennedy, William Robert Stancanelli, Annamaria Crisci, Claudio Wendelschafer-Crabb, Gwen Provitera, Vincenzo Santoro, Lucio Nolano, Maria |
| Author_xml | – sequence: 1 givenname: Maria surname: Nolano fullname: Nolano, Maria email: mnolano@fsm.it organization: Salvatore Maugeri Foundation, IRCCS, Center of Telese Terme, Italy – sequence: 2 givenname: Vincenzo surname: Provitera fullname: Provitera, Vincenzo organization: Salvatore Maugeri Foundation, IRCCS, Center of Telese Terme, Italy – sequence: 3 givenname: Claudio surname: Crisci fullname: Crisci, Claudio organization: Salvatore Maugeri Foundation, IRCCS, Center of Telese Terme, Italy – sequence: 4 givenname: Annamaria surname: Stancanelli fullname: Stancanelli, Annamaria organization: Salvatore Maugeri Foundation, IRCCS, Center of Telese Terme, Italy – sequence: 5 givenname: Gwen surname: Wendelschafer-Crabb fullname: Wendelschafer-Crabb, Gwen organization: Department of Neurology University of Minnesota, Minneapolis, MN – sequence: 6 givenname: William Robert surname: Kennedy fullname: Kennedy, William Robert organization: Department of Neurology University of Minnesota, Minneapolis, MN – sequence: 7 givenname: Lucio surname: Santoro fullname: Santoro, Lucio organization: Department of Neurological Sciences, University of Naples, Federico II, Naples, Italy |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15025312$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/12891672$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kV1rFDEYhYNU7LZ64R-Q3Ch4MTafk5nLZdGt0A8FRe_Cu5k3bexMZpvMoPvvne1uWyh6lRCe50DOOSIHsY9IyGvOPnDGxAlEmC4l18_IjGvJi0qo-oDMmCxVoblUh-Qo51-Msbrk7AU55KKqeWnEjFx-HSEOwQcHQ-gj7T3tNtiGCAM2FGMT4lWmEBvaobuG2Cd0uB76lGmI9HrsINImXIUBWppvQnxJnntoM77an8fk-6eP3xanxdnl8vNiflY4pbUugFdSQY1cKTBsZSSWBpipavSlVh6948JXTSNXXIlSKlkpzfkKpweFpgZ5TN7tctepvx0xD7YL2WHbQsR-zNZILaQS9QS-2YPjqsPGrlPoIG3sfQUT8HYPQHbQ-gTRhfzIaSamSrfcyY5zqc85obdu-vW2tCFBaC1ndjuGncawd2NMxvsnxkPoP9h9-u_Q4ub_oJ1fzO-NYmeEPOCfBwPSjS2NNNr-uFhazU-_LJbnPy2TfwECyqab |
| CODEN | ANNED3 |
| CitedBy_id | crossref_primary_10_1038_ncpneuro0630 crossref_primary_10_1212_WNL_0b013e318219fadd crossref_primary_10_1007_s11517_013_1079_9 crossref_primary_10_1111_joa_12001 crossref_primary_10_1111_j_1464_5491_2009_02823_x crossref_primary_10_1136_jnnp_2014_308855 crossref_primary_10_1016_j_medengphy_2006_07_005 crossref_primary_10_1007_s00592_022_01903_1 crossref_primary_10_1590_1678_7757_2016_0462 crossref_primary_10_1002_acn3_126 crossref_primary_10_1093_brain_awp113 crossref_primary_10_15547_tjs_2019_s_02_006 crossref_primary_10_1002_jbio_202000321 crossref_primary_10_1109_JMEMS_2005_844843 crossref_primary_10_1093_jnen_nlz015 crossref_primary_10_1002_ar_24856 crossref_primary_10_1002_ar_21464 crossref_primary_10_1109_TOH_2024_3385294 crossref_primary_10_1016_j_praneu_2012_10_001 crossref_primary_10_1097_SAP_0b013e3181640873 crossref_primary_10_1093_brain_awaa163 crossref_primary_10_1111_j_1474_7766_2005_t01_1_00293_x crossref_primary_10_1097_NEN_0000000000000249 crossref_primary_10_12659_MSM_882124 crossref_primary_10_1093_oncolo_oyac106 crossref_primary_10_1002_mus_20872 crossref_primary_10_1016_j_tria_2023_100234 crossref_primary_10_1177_15347346211054598 crossref_primary_10_1212_01_wnl_0000282762_34274_94 crossref_primary_10_1093_brain_awad426 crossref_primary_10_1212_WNL_0000000000001773 crossref_primary_10_1002_cne_21051 crossref_primary_10_1007_s00415_012_6432_7 crossref_primary_10_1109_TBME_2022_3177006 crossref_primary_10_1038_s41598_020_80132_4 crossref_primary_10_1002_ana_25662 crossref_primary_10_1002_cne_24302 crossref_primary_10_5115_acb_20_105 crossref_primary_10_5535_arm_2011_35_4_541 crossref_primary_10_1038_s41598_018_23688_6 crossref_primary_10_1523_JNEUROSCI_1716_20_2021 crossref_primary_10_1007_s00401_016_1645_y crossref_primary_10_1002_mus_21036 crossref_primary_10_1152_jn_00313_2020 crossref_primary_10_1016_j_clinph_2022_01_002 crossref_primary_10_2337_db13_0352 crossref_primary_10_1002_mus_27019 crossref_primary_10_1111_j_1468_1331_2005_01260_x crossref_primary_10_1002_ana_20527 crossref_primary_10_1007_s10072_007_0833_x crossref_primary_10_1111_nan_12692 crossref_primary_10_1016_j_anndiagpath_2006_09_001 crossref_primary_10_1002_ana_20364 crossref_primary_10_1111_j_1529_8027_2012_00415_x crossref_primary_10_1093_brain_awn102 crossref_primary_10_1093_brain_awh483 crossref_primary_10_1097_j_pain_0000000000002054 crossref_primary_10_1111_nan_12332 crossref_primary_10_1016_j_xcrp_2024_101943 crossref_primary_10_1097_nen_0b013e31815c8989 crossref_primary_10_1093_brain_awp274 crossref_primary_10_1523_JNEUROSCI_3684_09_2009 crossref_primary_10_1523_JNEUROSCI_1447_10_2010 crossref_primary_10_1111_j_1468_1331_2004_00791_x crossref_primary_10_1177_1753193414554752 crossref_primary_10_1002_cne_23943 crossref_primary_10_1016_S1474_4422_07_70172_2 crossref_primary_10_1002_mus_20771 crossref_primary_10_1111_j_1365_2559_2008_03096_x crossref_primary_10_1371_journal_pcbi_1008303 crossref_primary_10_1016_j_wear_2015_02_030 crossref_primary_10_1113_JP283174 crossref_primary_10_1212_WNL_0000000000013175 crossref_primary_10_1007_s11517_010_0725_8 crossref_primary_10_1155_2014_105950 crossref_primary_10_1007_s11892_012_0280_9 crossref_primary_10_1093_brain_awu288 crossref_primary_10_1212_WNL_0000000000001993 crossref_primary_10_1002_mus_20098 crossref_primary_10_3233_JPD_223421 crossref_primary_10_1093_brain_awq005 crossref_primary_10_1093_brain_awq004 crossref_primary_10_1016_j_ajpath_2011_07_047 crossref_primary_10_3390_brainsci10120989 crossref_primary_10_1007_s00415_018_8897_5 crossref_primary_10_1016_j_ajpath_2014_02_009 crossref_primary_10_1016_j_jbmt_2020_06_009 crossref_primary_10_1038_ncpneuro0044 crossref_primary_10_1111_jns5_12023 crossref_primary_10_1038_nrneurol_2017_31 crossref_primary_10_1371_journal_pone_0084650 crossref_primary_10_1016_j_jaad_2015_04_060 crossref_primary_10_1016_j_bjps_2004_12_017 crossref_primary_10_1002_jemt_20651 crossref_primary_10_1002_mus_23510 crossref_primary_10_1111_j_1469_7580_2009_01078_x crossref_primary_10_1145_3386569_3392398 crossref_primary_10_1212_WNL_0000000000001188 crossref_primary_10_1111_j_1529_8027_2012_00414_x crossref_primary_10_1111_j_1526_4610_2010_01754_x crossref_primary_10_3389_fnhum_2022_862344 crossref_primary_10_1186_1756_0500_5_298 crossref_primary_10_1016_j_mehy_2012_07_019 crossref_primary_10_1016_j_jns_2017_05_025 crossref_primary_10_1016_j_clbc_2017_04_011 crossref_primary_10_1097_WNP_0b013e3181942cd2 crossref_primary_10_1007_s00221_021_06193_7 crossref_primary_10_1073_pnas_1704856114 crossref_primary_10_1007_s11910_012_0323_2 crossref_primary_10_1016_j_scr_2021_102535 crossref_primary_10_1002_mus_22050 crossref_primary_10_1186_s13104_016_2085_4 crossref_primary_10_7554_eLife_31200 crossref_primary_10_1212_WNL_0000000000004274 crossref_primary_10_1038_s41598_021_04483_2 crossref_primary_10_1111_j_1085_9489_2005_10305_x crossref_primary_10_1111_jns_12467 crossref_primary_10_1145_1060581_1060586 crossref_primary_10_1136_jnnp_2021_327742 crossref_primary_10_7554_eLife_81476 crossref_primary_10_1002_mus_21506 crossref_primary_10_1586_14737175_8_12_1807 crossref_primary_10_1016_j_jbiomech_2006_03_004 crossref_primary_10_1016_S0035_3787_07_78418_7 crossref_primary_10_1111_ner_12163 crossref_primary_10_1212_WNL_0b013e3182759608 crossref_primary_10_1136_ard_2005_038935 crossref_primary_10_1002_ar_a_20119 crossref_primary_10_1152_jn_00564_2017 crossref_primary_10_3389_fnana_2015_00105 crossref_primary_10_1016_j_jneumeth_2011_06_022 crossref_primary_10_1212_WNL_0b013e318225ab51 |
| Cites_doi | 10.1007/BF00690642 10.1212/WNL.16.1.1 10.1177/002215540004800215 10.1024/0300-9831.70.3.126 10.1002/ana.1283 10.1001/archneur.1981.00510100067011 10.1212/WNL.48.3.708 10.1007/s100720170007 10.1007/s004030050432 10.1113/jphysiol.1894.sp000528 10.1212/WNL.47.4.1042 10.1523/JNEUROSCI.21-18-07236.2001 10.1007/BF00329435 10.1016/B978-0-12-470348-3.50013-6 10.1002/cne.900910105 10.1212/WNL.52.6.1249 10.1212/WNL.45.10.1848 10.1002/aja.1000990206 10.1212/WNL.58.1.115 10.1212/WNL.16.1.10 10.1002/cne.901130202 10.1016/0006-8993(85)90909-6 10.1016/0168-5597(93)90112-3 10.1002/mus.880170303 10.1212/WNL.53.8.1641 10.1016/0022-510X(93)90223-L 10.1002/ana.410440111 10.1093/brain/115.6.1925 10.1212/WNL.13.2.91 10.1093/alcalc/36.5.393 |
| ContentType | Journal Article |
| Copyright | Copyright © 2003 American Neurological Association 2004 INIST-CNRS |
| Copyright_xml | – notice: Copyright © 2003 American Neurological Association – notice: 2004 INIST-CNRS |
| DBID | BSCLL AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1002/ana.10615 |
| DatabaseName | Istex CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1531-8249 |
| EndPage | 205 |
| ExternalDocumentID | 12891672 15025312 10_1002_ana_10615 ANA10615 ark_67375_WNG_51HPCGMX_0 |
| Genre | article Clinical Trial Journal Article |
| GroupedDBID | --- .3N .55 .GA .GJ .Y3 05W 0R~ 10A 1CY 1L6 1OB 1OC 1ZS 23M 2QL 31~ 33P 3O- 3SF 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5VS 66C 6J9 6P2 6PF 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAEJM AAESR AAEVG AAHQN AAIPD AAMMB AAMNL AANHP AANLZ AAONW AAQQT AASGY AAWTL AAXRX AAYCA AAZKR ABCQN ABCUV ABEML ABIJN ABIVO ABJNI ABLJU ABOCM ABPVW ABQWH ABXGK ACAHQ ACBMB ACBWZ ACCZN ACGFO ACGFS ACGOF ACMXC ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZMN AEFGJ AEGXH AEIGN AEIMD AENEX AEUYR AEYWJ AFAZI AFBPY AFFNX AFFPM AFGKR AFRAH AFWVQ AFZJQ AGHNM AGQPQ AGXDD AGYGG AHBTC AHMBA AI. AIACR AIAGR AIDQK AIDYY AIQQE AITYG AIURR AJJEV ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR1 DR2 DRFUL DRMAN DRSTM EBS EJD EMOBN F00 F01 F04 F5P F8P FEDTE FUBAC FYBCS G-S G.N GNP GODZA GOZPB GRPMH H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ IX1 J0M J5H JPC KBYEO KD1 KQQ L7B LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LXL LXN LXY LYRES M6M MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N4W N9A NF~ NNB O66 O9- OHT OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.- Q.N Q11 QB0 QRW R.K RIWAO RJQFR ROL RX1 SAMSI SJN SUPJJ TEORI UB1 V2E V8K V9Y VH1 W8V W99 WBKPD WH7 WHWMO WIB WIH WIJ WIK WJL WOHZO WQJ WVDHM WXI WXSBR X7M XG1 XJT XPP XSW XV2 YOC YQJ ZGI ZRF ZRR ZXP ZZTAW ~IA ~WT ~X8 AAHHS AAYXX ACCFJ ADZOD AEEZP AEQDE AIWBW AJBDE CITATION IQODW ACRZS AEUQT AFPWT CGR CUY CVF ECM EIF NPM RWD RWI WRC WUP 7X8 |
| ID | FETCH-LOGICAL-c4555-a1834a9e144a70b73e67a0789ef654fefc12f8dd3b142634384511bed3b4e79a3 |
| IEDL.DBID | DR2 |
| ISSN | 0364-5134 |
| IngestDate | Fri Sep 05 04:11:07 EDT 2025 Wed Feb 19 01:34:09 EST 2025 Mon Jul 21 09:13:52 EDT 2025 Thu Apr 24 23:06:35 EDT 2025 Tue Jul 01 03:06:18 EDT 2025 Sun Sep 21 06:19:58 EDT 2025 Sun Sep 21 06:19:55 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | Human Immunohistochemistry Nervous system diseases Biopsy Mechanoreceptor Myelinated nerve fiber Neuropathy |
| Language | English |
| License | http://onlinelibrary.wiley.com/termsAndConditions#vor CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4555-a1834a9e144a70b73e67a0789ef654fefc12f8dd3b142634384511bed3b4e79a3 |
| Notes | ark:/67375/WNG-51HPCGMX-0 ArticleID:ANA10615 istex:D242949DCC66967E96796AA172D7959DE0706521 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| PMID | 12891672 |
| PQID | 73523429 |
| PQPubID | 23479 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_73523429 pubmed_primary_12891672 pascalfrancis_primary_15025312 crossref_citationtrail_10_1002_ana_10615 crossref_primary_10_1002_ana_10615 wiley_primary_10_1002_ana_10615_ANA10615 istex_primary_ark_67375_WNG_51HPCGMX_0 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | August 2003 |
| PublicationDateYYYYMMDD | 2003-08-01 |
| PublicationDate_xml | – month: 08 year: 2003 text: August 2003 |
| PublicationDecade | 2000 |
| PublicationPlace | Hoboken |
| PublicationPlace_xml | – name: Hoboken – name: United States |
| PublicationTitle | Annals of neurology |
| PublicationTitleAlternate | Ann Neurol |
| PublicationYear | 2003 |
| Publisher | Wiley Subscription Services, Inc., A Wiley Company Willey-Liss |
| Publisher_xml | – name: Wiley Subscription Services, Inc., A Wiley Company – name: Willey-Liss |
| References | Nolano M, Provitera V, Lullo F, et al. Meissner corpuscles and myelinated nerve fibers in human digital skin: a correlation with electrophysiological findings. J Peripher Nerv Syst 2001; 6: 165. Castano P, Rumio C, Morini L, et al. Three-dimensional reconstruction of the Meissner's corpuscles of man after silver impregnation and immunofluorescence with PGP 9.5 antibodies using confocal scanning laser microscopy. J Anat 1995; 186: 261-270. Vittadini G, Buonocore M, Colli G, et al. Alcoholic polyneuropathy: a clinical and epidemiological study. Alcohol Alcohol 2001; 36: 393-400. Winkelmann RK. Cutaneous sensory nerves. Semin Dermatol 1988; 7: 236-268. Caruso G, Massini R, Crisci C, et al. The relationship between electrophysiological findings, upper limb growth and histological features of median and ulnar nerves in man. Brain 1992; 115: 1925-1945. Marolda M, Filla A, Giordano-Lanza G, et al. Diagnostic significance of pacinian corpuscle degeneration in Friedreich's ataxia. Acta Neurol 1980; 5: 373-381. Paré M, Elde R, Mazurkiewicz JE, et al. The Meissner corpuscle revised: a multiafferented mechanoreceptor with nociceptor immunochemical properties. J Neurosci 2001; 21: 7236-7246. Holland NR, Crawford TO, Hauer P, et al. Small-fiber sensory neuropathies: clinical course and neuropathology of idiopathic cases. Ann Neurol 1998; 44: 47-59. Kennedy WR, Wendelschafer-Crabb G. The innervation of human epidermis. J Neurol Sci 1993; 115: 184-190. Polydefkis M, Yiannoutsos CT, Cohen BA, et al. Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy. Neurology 2002; 58: 115-119. Caruso G, Nilsson J, Crisci C, et al. Sensory nerve findings by tactile stimulation of median and ulnar nerves in healthy subjects of different ages. Electroenceph Clin Neurophysiol 1993; 89: 392-398. Nolano M, Provitera V, Lullo F, et al. Tactile stimulation and mechanoreceptors in sensory neuropathies. Neurol Sci 2001; 22: S31-S36. Behse F. Morphometric studies on the human sural nerve. Acta Neurol Scand Suppl 1990; 82: 1-38. Cauna N. Nerve supply and nerve endings in Meissner corpuscles. Am J Anat 1956; 99: 315. McCarthy BG, Hsieh ST, Stocks MA, et al. Cutaneous innervation in sensory neuropathies: evaluation by skin biopsy. Neurology 1995; 45: 1848-1855. Kennedy WR, Wendelschafer-Crabb G, Johnson T. Quantitation of epidermal nerves in diabetic neuropathy. Neurology 1996; 47: 1042-1048. Dickens NW, Winkelmann RK, Mulder DW. Cholinesterase demonstration of dermal nerve endings in patients with impaired sensation. Neurology 1962; 13: 91-100. Periquet MI, Novak V, Collins MP, et al. Painful sensory neuropathy: prospective evaluation using skin biopsy. Neurology 1999; 53: 1641-1647. Nolano M, Provitera V, Crisci C, et al. Small fibers involvement in Friedreich's ataxia. Ann Neurol 2001; 50: 17-25. Guinard D, Usson Y, Guillermet C, et al. PS-100 and NF 70-200 double immunolabeling for human digital skin Meissner corpuscles 3d imaging. J Histochem Cytochem 2000; 48: 295-302. Wang L, Hilliges M, Jernberg T, et al. Protein gene product 9.5-immunoreactive nerve fibers and cell in human skin. Cell Tissue Res 1990; 261: 25-33. Sherrington CS. On the anatomical constitution of nerves of skeletal muscles; with remarks on recurrent fibers in the ventral spinal root. J Physiol (Lond) 1894; 17: 211-258. Caruso G, Nolano M, Lullo F, et al. Median nerve sensory responses evoked by tactile stimulation of the finger proximal and distal phalanx in normal subjects. Muscle Nerve 1994; 17: 269-275. Holland NR, Stocks MA, Hauer P, et al. Intraepidermal nerve fiber density in patients with painful sensory neuropathy. Neurology 1997; 48: 708-711. Ochoa J, Mair WPG. The normal sural nerve in man. I. Ultrastructure and numbers of fibres and cells. Acta Neuropathol (Berlin) 1969; 13: 197-216. Halata Z, Munger BL. The terminal myelin segments of afferent axons to cutaneous mechanoreceptors. Brain Res 1985; 347: 177-182. Barnouin J, Perez Cristia R, Chassagne M, et al. Vitamin and nutritional status in Cuban smokers and nonsmokers in the context of an emerging epidemic neuropathy. Int J Vitam Nutr Res 2000; 70: 126-138. Johansson O, Fantini F, Hu H. Neuronal structural proteins, transmitters, transmitter enzymes and neuropeptides in human Meissner's corpuscles: a reappraisal using immunohistochemistry. Arch Dermatol Res 1999; 291: 419-424. Sunderland S, Lavarack JO, Ray LJ. The caliber of nerve fibers in human cutaneous nerves. J Comp Neurol 1949; 91: 87-101. Ronge H. Alterveränderungen der Meissnerschen körperchen in der fingerhaut. Z Mikrosk Anat Forsch 1943: 54: 167. Bolton CF, Winkelmann RK, Dyck PJ. A quantitative study of Meissner's corpuscles in man. Neurology 1966; 16: 1-9. Scott LJ, Griffin JW, Luciano C, et al. Quantitative analysis of epidermal innervation in Fabry disease. Neurology 1999; 52: 1249-1254. Faden A, Mendoza E, Flynn F. Subclinical neuropathy associated with chronic obstructive pulmonary disease: possible pathophysiologic role of smoking. Arch Neurol 1981; 38: 639-642. Dyck PJ, Winkelmann RK, Bolton CF. Quantitation of Meissner corpuscles in hereditary neurologic disorders. Neurology 1966; 16: 10-17. Cauna N. The mode of termination of the sensory nerves and its significance. J Comp Neurol 1959; 113: 169-209. 2002; 58 2001; 50 1993; 89 1966; 16 1943; 54 2000; 48 1997; 48 1956; 99 1999; 291 2000; 70 1969; 13 1985; 347 1993 1962; 13 2001; 22 1959; 113 1998; 44 1949; 91 1990; 82 1990; 261 2001; 21 1894; 17 1988; 2 2001; 6 1995; 45 1988; 7 1992; 115 1980; 5 1981; 38 1999; 53 1999; 52 1994; 17 1996; 47 1995; 186 1993; 115 2001; 36 Ronge H (e_1_2_6_23_2) 1943; 54 Marolda M (e_1_2_6_16_2) 1980; 5 Winkelmann RK (e_1_2_6_26_2) 1988; 7 Behse F (e_1_2_6_31_2) 1990; 82 e_1_2_6_30_2 Nolano M (e_1_2_6_21_2) 2001; 6 e_1_2_6_18_2 e_1_2_6_19_2 e_1_2_6_12_2 e_1_2_6_35_2 e_1_2_6_13_2 e_1_2_6_34_2 e_1_2_6_10_2 e_1_2_6_33_2 e_1_2_6_11_2 e_1_2_6_32_2 e_1_2_6_17_2 e_1_2_6_38_2 e_1_2_6_14_2 e_1_2_6_37_2 e_1_2_6_36_2 e_1_2_6_20_2 Castano P (e_1_2_6_27_2) 1995; 186 Thomas PK (e_1_2_6_15_2) 1993 e_1_2_6_8_2 e_1_2_6_7_2 e_1_2_6_9_2 e_1_2_6_29_2 e_1_2_6_4_2 e_1_2_6_3_2 e_1_2_6_6_2 e_1_2_6_5_2 e_1_2_6_24_2 e_1_2_6_2_2 e_1_2_6_22_2 e_1_2_6_28_2 e_1_2_6_25_2 |
| References_xml | – reference: Kennedy WR, Wendelschafer-Crabb G. The innervation of human epidermis. J Neurol Sci 1993; 115: 184-190. – reference: Halata Z, Munger BL. The terminal myelin segments of afferent axons to cutaneous mechanoreceptors. Brain Res 1985; 347: 177-182. – reference: Holland NR, Stocks MA, Hauer P, et al. Intraepidermal nerve fiber density in patients with painful sensory neuropathy. Neurology 1997; 48: 708-711. – reference: Scott LJ, Griffin JW, Luciano C, et al. Quantitative analysis of epidermal innervation in Fabry disease. Neurology 1999; 52: 1249-1254. – reference: Behse F. Morphometric studies on the human sural nerve. Acta Neurol Scand Suppl 1990; 82: 1-38. – reference: Bolton CF, Winkelmann RK, Dyck PJ. A quantitative study of Meissner's corpuscles in man. Neurology 1966; 16: 1-9. – reference: Paré M, Elde R, Mazurkiewicz JE, et al. The Meissner corpuscle revised: a multiafferented mechanoreceptor with nociceptor immunochemical properties. J Neurosci 2001; 21: 7236-7246. – reference: Winkelmann RK. Cutaneous sensory nerves. Semin Dermatol 1988; 7: 236-268. – reference: Vittadini G, Buonocore M, Colli G, et al. Alcoholic polyneuropathy: a clinical and epidemiological study. Alcohol Alcohol 2001; 36: 393-400. – reference: Polydefkis M, Yiannoutsos CT, Cohen BA, et al. Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy. Neurology 2002; 58: 115-119. – reference: Marolda M, Filla A, Giordano-Lanza G, et al. Diagnostic significance of pacinian corpuscle degeneration in Friedreich's ataxia. Acta Neurol 1980; 5: 373-381. – reference: Cauna N. Nerve supply and nerve endings in Meissner corpuscles. Am J Anat 1956; 99: 315. – reference: Caruso G, Nolano M, Lullo F, et al. Median nerve sensory responses evoked by tactile stimulation of the finger proximal and distal phalanx in normal subjects. Muscle Nerve 1994; 17: 269-275. – reference: Ronge H. Alterveränderungen der Meissnerschen körperchen in der fingerhaut. Z Mikrosk Anat Forsch 1943: 54: 167. – reference: Holland NR, Crawford TO, Hauer P, et al. Small-fiber sensory neuropathies: clinical course and neuropathology of idiopathic cases. Ann Neurol 1998; 44: 47-59. – reference: Dyck PJ, Winkelmann RK, Bolton CF. Quantitation of Meissner corpuscles in hereditary neurologic disorders. Neurology 1966; 16: 10-17. – reference: Nolano M, Provitera V, Lullo F, et al. Tactile stimulation and mechanoreceptors in sensory neuropathies. Neurol Sci 2001; 22: S31-S36. – reference: Castano P, Rumio C, Morini L, et al. Three-dimensional reconstruction of the Meissner's corpuscles of man after silver impregnation and immunofluorescence with PGP 9.5 antibodies using confocal scanning laser microscopy. J Anat 1995; 186: 261-270. – reference: Wang L, Hilliges M, Jernberg T, et al. Protein gene product 9.5-immunoreactive nerve fibers and cell in human skin. Cell Tissue Res 1990; 261: 25-33. – reference: Faden A, Mendoza E, Flynn F. Subclinical neuropathy associated with chronic obstructive pulmonary disease: possible pathophysiologic role of smoking. Arch Neurol 1981; 38: 639-642. – reference: McCarthy BG, Hsieh ST, Stocks MA, et al. Cutaneous innervation in sensory neuropathies: evaluation by skin biopsy. Neurology 1995; 45: 1848-1855. – reference: Nolano M, Provitera V, Lullo F, et al. Meissner corpuscles and myelinated nerve fibers in human digital skin: a correlation with electrophysiological findings. J Peripher Nerv Syst 2001; 6: 165. – reference: Barnouin J, Perez Cristia R, Chassagne M, et al. Vitamin and nutritional status in Cuban smokers and nonsmokers in the context of an emerging epidemic neuropathy. Int J Vitam Nutr Res 2000; 70: 126-138. – reference: Sunderland S, Lavarack JO, Ray LJ. The caliber of nerve fibers in human cutaneous nerves. J Comp Neurol 1949; 91: 87-101. – reference: Ochoa J, Mair WPG. The normal sural nerve in man. I. Ultrastructure and numbers of fibres and cells. Acta Neuropathol (Berlin) 1969; 13: 197-216. – reference: Nolano M, Provitera V, Crisci C, et al. Small fibers involvement in Friedreich's ataxia. Ann Neurol 2001; 50: 17-25. – reference: Caruso G, Nilsson J, Crisci C, et al. Sensory nerve findings by tactile stimulation of median and ulnar nerves in healthy subjects of different ages. Electroenceph Clin Neurophysiol 1993; 89: 392-398. – reference: Dickens NW, Winkelmann RK, Mulder DW. Cholinesterase demonstration of dermal nerve endings in patients with impaired sensation. Neurology 1962; 13: 91-100. – reference: Johansson O, Fantini F, Hu H. Neuronal structural proteins, transmitters, transmitter enzymes and neuropeptides in human Meissner's corpuscles: a reappraisal using immunohistochemistry. Arch Dermatol Res 1999; 291: 419-424. – reference: Cauna N. The mode of termination of the sensory nerves and its significance. J Comp Neurol 1959; 113: 169-209. – reference: Kennedy WR, Wendelschafer-Crabb G, Johnson T. Quantitation of epidermal nerves in diabetic neuropathy. Neurology 1996; 47: 1042-1048. – reference: Guinard D, Usson Y, Guillermet C, et al. PS-100 and NF 70-200 double immunolabeling for human digital skin Meissner corpuscles 3d imaging. J Histochem Cytochem 2000; 48: 295-302. – reference: Periquet MI, Novak V, Collins MP, et al. Painful sensory neuropathy: prospective evaluation using skin biopsy. Neurology 1999; 53: 1641-1647. – reference: Caruso G, Massini R, Crisci C, et al. The relationship between electrophysiological findings, upper limb growth and histological features of median and ulnar nerves in man. Brain 1992; 115: 1925-1945. – reference: Sherrington CS. On the anatomical constitution of nerves of skeletal muscles; with remarks on recurrent fibers in the ventral spinal root. J Physiol (Lond) 1894; 17: 211-258. – volume: 91 start-page: 87 year: 1949 end-page: 101 article-title: The caliber of nerve fibers in human cutaneous nerves publication-title: J Comp Neurol – volume: 7 start-page: 236 year: 1988 end-page: 268 article-title: Cutaneous sensory nerves publication-title: Semin Dermatol – volume: 54 start-page: 167 year: 1943 article-title: Alterveränderungen der Meissnerschen körperchen in der fingerhaut publication-title: Z Mikrosk Anat Forsch – volume: 17 start-page: 269 year: 1994 end-page: 275 article-title: Median nerve sensory responses evoked by tactile stimulation of the finger proximal and distal phalanx in normal subjects publication-title: Muscle Nerve – volume: 347 start-page: 177 year: 1985 end-page: 182 article-title: The terminal myelin segments of afferent axons to cutaneous mechanoreceptors publication-title: Brain Res – volume: 58 start-page: 115 year: 2002 end-page: 119 article-title: Reduced intraepidermal nerve fiber density in HIV‐associated sensory neuropathy publication-title: Neurology – volume: 48 start-page: 295 year: 2000 end-page: 302 article-title: PS‐100 and NF 70‐200 double immunolabeling for human digital skin Meissner corpuscles 3d imaging publication-title: J Histochem Cytochem – volume: 89 start-page: 392 year: 1993 end-page: 398 article-title: Sensory nerve findings by tactile stimulation of median and ulnar nerves in healthy subjects of different ages publication-title: Electroenceph Clin Neurophysiol – volume: 261 start-page: 25 year: 1990 end-page: 33 article-title: Protein gene product 9.5‐immunoreactive nerve fibers and cell in human skin publication-title: Cell Tissue Res – volume: 21 start-page: 7236 year: 2001 end-page: 7246 article-title: The Meissner corpuscle revised: a multiafferented mechanoreceptor with nociceptor immunochemical properties publication-title: J Neurosci – volume: 47 start-page: 1042 year: 1996 end-page: 1048 article-title: Quantitation of epidermal nerves in diabetic neuropathy publication-title: Neurology – volume: 82 start-page: 1 issue: Suppl year: 1990 end-page: 38 article-title: Morphometric studies on the human sural nerve publication-title: Acta Neurol Scand – volume: 50 start-page: 17 year: 2001 end-page: 25 article-title: Small fibers involvement in Friedreich's ataxia publication-title: Ann Neurol – volume: 113 start-page: 169 year: 1959 end-page: 209 article-title: The mode of termination of the sensory nerves and its significance publication-title: J Comp Neurol – volume: 70 start-page: 126 year: 2000 end-page: 138 article-title: Vitamin and nutritional status in Cuban smokers and nonsmokers in the context of an emerging epidemic neuropathy publication-title: Int J Vitam Nutr Res – volume: 36 start-page: 393 year: 2001 end-page: 400 article-title: Alcoholic polyneuropathy: a clinical and epidemiological study publication-title: Alcohol Alcohol – volume: 13 start-page: 197 year: 1969 end-page: 216 article-title: The normal sural nerve in man. I. Ultrastructure and numbers of fibres and cells publication-title: Acta Neuropathol (Berlin) – volume: 38 start-page: 639 year: 1981 end-page: 642 article-title: Subclinical neuropathy associated with chronic obstructive pulmonary disease: possible pathophysiologic role of smoking publication-title: Arch Neurol – volume: 186 start-page: 261 year: 1995 end-page: 270 article-title: Three‐dimensional reconstruction of the Meissner's corpuscles of man after silver impregnation and immunofluorescence with PGP 9.5 antibodies using confocal scanning laser microscopy publication-title: J Anat – volume: 2 start-page: 209 year: 1988 end-page: 228 – volume: 44 start-page: 47 year: 1998 end-page: 59 article-title: Small‐fiber sensory neuropathies: clinical course and neuropathology of idiopathic cases publication-title: Ann Neurol – start-page: 28 year: 1993 end-page: 91 – volume: 22 start-page: S31 year: 2001 end-page: S36 article-title: Tactile stimulation and mechanoreceptors in sensory neuropathies publication-title: Neurol Sci – volume: 53 start-page: 1641 year: 1999 end-page: 1647 article-title: Painful sensory neuropathy: prospective evaluation using skin biopsy publication-title: Neurology – volume: 52 start-page: 1249 year: 1999 end-page: 1254 article-title: Quantitative analysis of epidermal innervation in Fabry disease publication-title: Neurology – volume: 99 start-page: 315 year: 1956 article-title: Nerve supply and nerve endings in Meissner corpuscles publication-title: Am J Anat – volume: 16 start-page: 10 year: 1966 end-page: 17 article-title: Quantitation of Meissner corpuscles in hereditary neurologic disorders publication-title: Neurology – volume: 17 start-page: 211 year: 1894 end-page: 258 article-title: On the anatomical constitution of nerves of skeletal muscles; with remarks on recurrent fibers in the ventral spinal root publication-title: J Physiol (Lond) – volume: 45 start-page: 1848 year: 1995 end-page: 1855 article-title: Cutaneous innervation in sensory neuropathies: evaluation by skin biopsy publication-title: Neurology – volume: 48 start-page: 708 year: 1997 end-page: 711 article-title: Intraepidermal nerve fiber density in patients with painful sensory neuropathy publication-title: Neurology – volume: 16 start-page: 1 year: 1966 end-page: 9 article-title: A quantitative study of Meissner's corpuscles in man publication-title: Neurology – volume: 13 start-page: 91 year: 1962 end-page: 100 article-title: Cholinesterase demonstration of dermal nerve endings in patients with impaired sensation publication-title: Neurology – volume: 6 start-page: 165 year: 2001 article-title: Meissner corpuscles and myelinated nerve fibers in human digital skin: a correlation with electrophysiological findings publication-title: J Peripher Nerv Syst – volume: 291 start-page: 419 year: 1999 end-page: 424 article-title: Neuronal structural proteins, transmitters, transmitter enzymes and neuropeptides in human Meissner's corpuscles: a reappraisal using immunohistochemistry publication-title: Arch Dermatol Res – volume: 115 start-page: 1925 year: 1992 end-page: 1945 article-title: The relationship between electrophysiological findings, upper limb growth and histological features of median and ulnar nerves in man publication-title: Brain – volume: 5 start-page: 373 year: 1980 end-page: 381 article-title: Diagnostic significance of pacinian corpuscle degeneration in Friedreich's ataxia publication-title: Acta Neurol – volume: 115 start-page: 184 year: 1993 end-page: 190 article-title: The innervation of human epidermis publication-title: J Neurol Sci – volume: 6 start-page: 165 year: 2001 ident: e_1_2_6_21_2 article-title: Meissner corpuscles and myelinated nerve fibers in human digital skin: a correlation with electrophysiological findings publication-title: J Peripher Nerv Syst – ident: e_1_2_6_34_2 doi: 10.1007/BF00690642 – ident: e_1_2_6_18_2 doi: 10.1212/WNL.16.1.1 – ident: e_1_2_6_28_2 doi: 10.1177/002215540004800215 – ident: e_1_2_6_12_2 doi: 10.1024/0300-9831.70.3.126 – ident: e_1_2_6_14_2 doi: 10.1002/ana.1283 – ident: e_1_2_6_11_2 doi: 10.1001/archneur.1981.00510100067011 – ident: e_1_2_6_8_2 doi: 10.1212/WNL.48.3.708 – ident: e_1_2_6_22_2 doi: 10.1007/s100720170007 – ident: e_1_2_6_29_2 doi: 10.1007/s004030050432 – ident: e_1_2_6_32_2 doi: 10.1113/jphysiol.1894.sp000528 – ident: e_1_2_6_3_2 doi: 10.1212/WNL.47.4.1042 – ident: e_1_2_6_30_2 doi: 10.1523/JNEUROSCI.21-18-07236.2001 – ident: e_1_2_6_4_2 doi: 10.1007/BF00329435 – ident: e_1_2_6_20_2 doi: 10.1016/B978-0-12-470348-3.50013-6 – ident: e_1_2_6_33_2 doi: 10.1002/cne.900910105 – volume: 54 start-page: 167 year: 1943 ident: e_1_2_6_23_2 article-title: Alterveränderungen der Meissnerschen körperchen in der fingerhaut publication-title: Z Mikrosk Anat Forsch – volume: 7 start-page: 236 year: 1988 ident: e_1_2_6_26_2 article-title: Cutaneous sensory nerves publication-title: Semin Dermatol – ident: e_1_2_6_10_2 doi: 10.1212/WNL.52.6.1249 – ident: e_1_2_6_5_2 doi: 10.1212/WNL.45.10.1848 – ident: e_1_2_6_24_2 doi: 10.1002/aja.1000990206 – ident: e_1_2_6_9_2 doi: 10.1212/WNL.58.1.115 – ident: e_1_2_6_17_2 doi: 10.1212/WNL.16.1.10 – start-page: 28 volume-title: Peripheral neuropathy year: 1993 ident: e_1_2_6_15_2 – volume: 5 start-page: 373 year: 1980 ident: e_1_2_6_16_2 article-title: Diagnostic significance of pacinian corpuscle degeneration in Friedreich's ataxia publication-title: Acta Neurol – ident: e_1_2_6_25_2 doi: 10.1002/cne.901130202 – ident: e_1_2_6_36_2 doi: 10.1016/0006-8993(85)90909-6 – ident: e_1_2_6_37_2 doi: 10.1016/0168-5597(93)90112-3 – ident: e_1_2_6_38_2 doi: 10.1002/mus.880170303 – ident: e_1_2_6_7_2 doi: 10.1212/WNL.53.8.1641 – ident: e_1_2_6_2_2 doi: 10.1016/0022-510X(93)90223-L – ident: e_1_2_6_6_2 doi: 10.1002/ana.410440111 – ident: e_1_2_6_35_2 doi: 10.1093/brain/115.6.1925 – volume: 186 start-page: 261 year: 1995 ident: e_1_2_6_27_2 article-title: Three‐dimensional reconstruction of the Meissner's corpuscles of man after silver impregnation and immunofluorescence with PGP 9.5 antibodies using confocal scanning laser microscopy publication-title: J Anat – ident: e_1_2_6_19_2 doi: 10.1212/WNL.13.2.91 – ident: e_1_2_6_13_2 doi: 10.1093/alcalc/36.5.393 – volume: 82 start-page: 1 year: 1990 ident: e_1_2_6_31_2 article-title: Morphometric studies on the human sural nerve publication-title: Acta Neurol Scand |
| SSID | ssj0009610 |
| Score | 2.1629455 |
| Snippet | We used immunohistochemistry and confocal microscopy applied to fingertip punch biopsy to study glabrous skin innervation in 14 healthy subjects. In addition... |
| SourceID | proquest pubmed pascalfrancis crossref wiley istex |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 197 |
| SubjectTerms | Adult Amyloid beta-Peptides - metabolism Autonomic Nervous System - cytology Autonomic Nervous System - physiology Biological and medical sciences Cell Count Female Fingers - innervation Humans Immunohistochemistry Male Mechanoreceptors - physiology Medical sciences Microscopy, Confocal Middle Aged Myelin Basic Protein - metabolism Myelin Sheath - physiology Nerve Endings - physiology Nerve Fibers - physiology Nervous system involvement in other diseases. Miscellaneous Neurology Reference Values Skin - innervation |
| Title | Quantification of myelinated endings and mechanoreceptors in human digital skin |
| URI | https://api.istex.fr/ark:/67375/WNG-51HPCGMX-0/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fana.10615 https://www.ncbi.nlm.nih.gov/pubmed/12891672 https://www.proquest.com/docview/73523429 |
| Volume | 54 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9swFD6UDsZedr94l06MMfriNLIkO2ZPoVsbBskurCwPAyFZ0ghZnVInsO3X7xw5TsjoYOzNGEnY5y7pnO8AvEQPLaxxVYqW0KdSeJHafsVT4zw6-Mpz56k4eTzJR2fy3VRN9-B1VwvT4kNsDtxIM6K9JgU3tjnagoaa2vRoP0MF5lzkhJv_5tMWOqrMIxIBXbOligvZoQr1s6PNzB1fdI3I-oNyI02D5AltX4urAs_dODY6opNb8LX7hTb_ZN5bLW2v-vUHuuN__uNtuLkOUNmwlag7sOfru3B9vL6CvwfvP65Mm2AUecoWgZ3_pKJ2DFod87FIpmGmduzcU1XxAk2qv6CePmxWs9gSkLnZN-pVwpr5rL4PZydvPx-P0nVXhrSSSqnUoBGQpvS4EzNF3xbC54Uh0HofciWDDxXPwsA5QcdLuZBiQBBo1uML6YvSiAewXy9q_whY6YLFLVrBTRakdBYXFg75JsPAlqIKCRx2_NHVGrKcOmd81y3YcqaRQDoSKIEXm6EXLU7HVYNeRSZvRpjLOSW2FUp_mZxqxUcfjk_HU91P4GBHCrZLKowRBc8SeN6JhUZ9pEsWU_vFqtEFRrQCnXwCD1tp2c7FvS3PC5x7GHn-9-_Uw8kwPjz-96FP4EbMM4y5iU9hf3m58s8wXlrag6gYvwF18Q9i |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED-NTQJeGN-EwWYhhPaSrontpJH2Uk1sBdbyoU30BVl2bKOqLJ3WVgL--t05TauiISHeosi2kjvb97Pv7ncAr9FCc6NtGeNO6GLBHY9Nu0xibR0a-NIl1lFycn-Q9c7F-6EcbsBhkwtT80MsL9xoZYT9mhY4XUgfrFhDdaVbdKCRt2Ar-OcIEn1ZkUcVWeAiIEdbLBMuGl6hdnqw7LpmjbZIsD8pOlJPUUC-rmxxE_RcR7LBFB1vw7fmJ-oIlHFrPjOt8vcf_I7_-5f34d4Co7JuPakewIarHsLt_sIL_wg-fp7rOsYoqJVNPLv4RXntiFstcyFPZsp0ZdmFo8TiCe6q7pLK-rBRxUJVQGZH36lcCZuOR9VjOD9-e3bUixeFGeJSSCljjfuA0IXDw5jO2ybnLss18dY7n0nhnS-T1Hes5XTDlHHBO8SCZhy-EC4vNH8Cm9Wkcs-AFdYbPKXliU69ENbgwNyi4oTvmIKXPoL9RkGqXLCWU_GMH6rmW04VCkgFAUXwatn0sqbquKnRm6DlZQt9NabYtlyqr4MTJZPep6OT_lC1I9hdmwarISXCRJ6kEew180LhkiQ_i67cZD5VOYJajnY-gqf1dFn1xeNtkuXYdz8o_e_fqbqDbnh4_u9N9-BO76x_qk7fDT7swN0QdhhCFV_A5uxq7l4ifJqZ3bBKrgFmhxOA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3ra9swED-6Fsq-7P3wHq0YY_SL09iS7Jh9Ct3S7JGsGyvLh4GQrNMIWZ3QJLDtr99JjhMyOhj7ZsxJ2DrdS7r7HcBzstDcaFvGpAkxFhx5bNplEmuLZOBLTCz64uTBMOufi7cjOdqBl00tTI0PsT5w85IR9LUX8Jl1xxvQUF3plo9n5DXYExmZSe8RfdpgRxVZgCLw92yxTLhoYIXa6fF66JYx2vPr-sMnR-o5rY-rG1tc5XluO7LBEvVuwtfmH-oElElruTCt8tcf8I7_-ZO34MbKQ2Xdekvdhh2s7sD-YHUHfxc-fFzqOsMoMJVNHbv46avayWu1DEOVzJzpyrIL9GXFU9KpOPNNfdi4YqEnILPjb75ZCZtPxtU9OO-9_nzSj1dtGeJSSCljTVpA6AIpFNN52-Qcs1x71Hp0mRQOXZmkrmMt9-dLGRe84zHQDNILgXmh-X3YraYVPgRWWGcoRssTnTohrKGJuSW-CdcxBS9dBEcNf1S5wiz3rTO-qxptOVW0QCosUATP1qSzGqjjKqIXgclrCn058ZltuVRfhqdKJv2zk9PBSLUjONjaBZspJTmJPEkjOGy2hSKB9LcsusLpcq5ycmk5WfkIHtS7ZTOWgtsky2nsUeD5379TdYfd8PDo30kPYf_sVU-9fzN89xiuh5zDkKf4BHYXl0t8Sr7TwhwEGfkNH1QSLw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Quantification+of+myelinated+endings+and+mechanoreceptors+in+human+digital+skin&rft.jtitle=Annals+of+neurology&rft.au=Nolano%2C+Maria&rft.au=Provitera%2C+Vincenzo&rft.au=Crisci%2C+Claudio&rft.au=Stancanelli%2C+Annamaria&rft.date=2003-08-01&rft.issn=0364-5134&rft.volume=54&rft.issue=2&rft.spage=197&rft_id=info:doi/10.1002%2Fana.10615&rft_id=info%3Apmid%2F12891672&rft.externalDocID=12891672 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0364-5134&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0364-5134&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0364-5134&client=summon |