Serum Levels of TGF-β1 and MCP-1 as Biomarkers for Progressive Coal Workers’ Pneumoconiosis in Retired Coal Workers: A Three-year Follow-up Study
Various cytokines activated by the inhalation of coal dust may mediate inflammation and lead to tissue damage. Objective of this study was to examine the relationships between coal workers’ pneumoconiosis (CWP) progression over a 3 yr period and the serum levels of cytokines in 85 retired coal worke...
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| Published in | Industrial Health Vol. 52; no. 2; pp. 129 - 136 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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National Institute of Occupational Safety and Health
2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0019-8366 1880-8026 |
| DOI | 10.2486/indhealth.2013-0112 |
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| Abstract | Various cytokines activated by the inhalation of coal dust may mediate inflammation and lead to tissue damage. Objective of this study was to examine the relationships between coal workers’ pneumoconiosis (CWP) progression over a 3 yr period and the serum levels of cytokines in 85 retired coal workers. To investigate the relevance of serum cytokines in CWP, serum levels of interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α), transforming growth factor–beta1 (TGF-β1), and monocyte chemotactic protein-1 (MCP-1) as progressive CWP biomarkers were studied in relation to the progression of pneumoconiosis over a 3 yr period in 85 patients with CWP. CWP progression was evaluated through paired comparisons of chest radiographs. Median levels of TGF-β1 and MCP-1 were significantly higher in subjects with progressive CWP than in those without CWP progression. The area under the ROC curve for TGF-β1 (0.693) and MCP-1 (0.653) indicated that these cytokines could serve as biomarkers for the progression of CWP. Serum TGF-β1 levels were related to the progression of CWP (β=0.247, p=0.016). The results suggest that high serum levels of TGF-β1 and MCP-1 are associated with the progression of CWP. |
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| AbstractList | Various cytokines activated by the inhalation of coal dust may mediate inflammation and lead to tissue damage. Objective of this study was to examine the relationships between coal workers’ pneumoconiosis (CWP) progression over a 3 yr period and the serum levels of cytokines in 85 retired coal workers. To investigate the relevance of serum cytokines in CWP, serum levels of interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α), transforming growth factor–beta1 (TGF-β1), and monocyte chemotactic protein-1 (MCP-1) as progressive CWP biomarkers were studied in relation to the progression of pneumoconiosis over a 3 yr period in 85 patients with CWP. CWP progression was evaluated through paired comparisons of chest radiographs. Median levels of TGF-β1 and MCP-1 were significantly higher in subjects with progressive CWP than in those without CWP progression. The area under the ROC curve for TGF-β1 (0.693) and MCP-1 (0.653) indicated that these cytokines could serve as biomarkers for the progression of CWP. Serum TGF-β1 levels were related to the progression of CWP (β=0.247, p=0.016). The results suggest that high serum levels of TGF-β1 and MCP-1 are associated with the progression of CWP. |
| Author | LEE, Jong Seong LEE, Kyung Myung HWANG, Ju-Hwan CHOI, Byung-Soon BAEK, Jin Ee SHIN, Jae Hoon KIM, Ji Hong |
| Author_xml | – sequence: 1 fullname: LEE, Kyung Myung organization: Forensic DNA Center, NFS, Republic of Korea – sequence: 1 fullname: CHOI, Byung-Soon organization: Occupational Lung Diseases Institute, Korea Workers’ Compensation and Welfare Service, Republic of Korea – sequence: 1 fullname: HWANG, Ju-Hwan organization: Occupational Lung Diseases Institute, Korea Workers’ Compensation and Welfare Service, Republic of Korea – sequence: 1 fullname: LEE, Jong Seong organization: Occupational Lung Diseases Institute, Korea Workers’ Compensation and Welfare Service, Republic of Korea – sequence: 1 fullname: KIM, Ji Hong organization: Ansan WCI Hospital, Korea Workers’ Compensation and Welfare Service, Republic of Korea – sequence: 1 fullname: BAEK, Jin Ee organization: Occupational Lung Diseases Institute, Korea Workers’ Compensation and Welfare Service, Republic of Korea – sequence: 1 fullname: SHIN, Jae Hoon organization: Occupational Lung Diseases Institute, Korea Workers’ Compensation and Welfare Service, Republic of Korea |
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| Cites_doi | 10.1183/09031936.00011810 10.1165/ajrcmb/7.4.365 10.1016/S0003-4878(98)00069-6 10.1186/1471-2466-9-11 10.1183/09031936.97.10030557 10.1080/13550280290100996 10.1016/S0378-4274(99)00101-0 10.1201/9781003066927-10 10.2174/1381612033392341 10.1164/ajrccm.150.4.7921435 10.1152/ajplung.00167.2003 10.5491/SHAW.2010.1.1.69 10.1165/ajrcmb/5.2.155 10.1136/oem.52.7.441 10.1164/ajrccm.154.4.8887610 10.1080/15287390500196537 10.1016/0167-5699(90)90035-8 10.1093/toxsci/kfh110 10.1002/cyto.b.20169 10.4049/jimmunol.153.10.4733 10.1183/09031936.01.18s320127 10.1165/ajrcmb/5.5.431 10.1159/000013550 10.1002/jcp.1041400226 10.1097/00043764-197107000-00021 10.1309/6VJ4DWGYDU0XYJ8Q 10.5051/jpis.2010.40.3.119 10.1165/ajrcmb/2.4.321 |
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In: Silica, some silicates, coal dust and para-aramid fibrils. Vol. 68. IARC Press, Geneva. 3) Gulumian M, Borm PJA, Vallyathan V, Castranova V, Donaldson K, Nelson G, Murray J (2006) Mechanistically identified suitable biomarkers of exposure, effect, and susceptibility for silicosis and coal-worker’s pneumoconiosis: a comprehensive review. J Toxicol Environ Health B Crit Rev 9, 357–95. 23) Gosset P, Lassalle P, Vanhée D, Wallaert B, Aerts C, Voisin C, Tonnel AB (1991) Production of tumor necrosis factor-α and interleukin-6 by human alveolar macrophages exposed in vitro to coal mine dust. Am J Respir Cell Mol Biol 5, 431–6. 9) Kelly M, Kolb M, Bonniaud P, Gauldie J (2003) Re-evaluation of fibrogenic cytokines in lung fibrosis. Curr Pharm Des 9, 39–49. 32) Langford D, Masliah E (2002) Role of trophic factors on neuroimmunity in neurodegenerative infectious diseases. J Neurovirol 8, 625–38. 29) Zhang K, Gharaee-Kermani M, Jones ML, Warren JS, Phan SH (1994) Lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis. J Immunol 153, 4733–41. 22 23 24 25 26 27 28 29 30 31 10 32 11 33 12 13 14 15 16 17 18 19 1 2 3 4 5 6 7 8 9 20 21 |
| References_xml | – reference: 13) Morris JF, Koski A, Johnson LC (1971) Spirometric standards for healthy nonsmoking adults. Am Rev Respir Dis 103, 57–67. – reference: 5) Elias JA, Zitnik RJ (1992) Cytokine-cytokine interactions in the context of cytokine networking. Am J Respir Cell Mol Biol 7, 365–7. – reference: 31) Kythreotis P, Kokkini A, Avgeropoulou S, Hadjioannou A, Anastasakou E, Rasidakis A, Bakakos P (2009) Plasma leptin and insulin-like growth factor I levels during acute exacerbations of chronic obstructive pulmonary disease. BMC Pulm Med 9, 11. – reference: 24) Jagirdar J, Begin R, Dufresne A, Goswami S, Lee TC, Rom WN (1996) Transforming growth factor-beta (TGF-beta) in silicosis. Am J Respir Crit Care Med 154, 1076–81. – reference: 9) Kelly M, Kolb M, Bonniaud P, Gauldie J (2003) Re-evaluation of fibrogenic cytokines in lung fibrosis. Curr Pharm Des 9, 39–49. – reference: 10) Vanhee D, Gosset P, Wallaert B, Voisin C, Tonnel AB (1994) Mechanisms of fibrosis in coal workers’ pneumoconiosis. Increased production of platelet-derived growth factor, insulin-like growth factor type I, and transforming growth factor beta and relationship to disease severity. Am J Respir Crit Care Med 150, 1049–55. – reference: 21) Grotendorst GR, Smale G, Pencev D (1989) Production of transforming growth factor beta by human peripheral blood monocytes and neutrophils. J Cell Physiol 140, 396–402. – reference: 17) Manco M, Marcellini M, Giannone G, Nobili V (2007) Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver disease. Am J Clin Pathol 127, 954–60. – reference: 29) Zhang K, Gharaee-Kermani M, Jones ML, Warren JS, Phan SH (1994) Lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis. J Immunol 153, 4733–41. – reference: 3) Gulumian M, Borm PJA, Vallyathan V, Castranova V, Donaldson K, Nelson G, Murray J (2006) Mechanistically identified suitable biomarkers of exposure, effect, and susceptibility for silicosis and coal-worker’s pneumoconiosis: a comprehensive review. J Toxicol Environ Health B Crit Rev 9, 357–95. – reference: 11) Boitelle A, Gosset P, Copin MC, Vanhee D, Marquette CH, Wallaert B, Gosselin B, Tonnel AB (1997) MCP-1 secretion in lung from nonsmoking patients with coal worker’s pneumoconiosis. Eur Respir J 10, 557–62. – reference: 14) International Labour Office (ILO) (2002) Guidelines for the use of the ILO international classification of radiographs of pneumoconiosis. Revised Edition 2000. (Occupational Safety and Health Series, No. 22.) International Labor Organization, Geneva. – reference: 18) Strieter RM, Standiford TJ, Rolfe MW, Kunkel SL (1993) Cytokines of lung: Interleukin-8, Kelly J (Ed.), 281–305, Marcel Dekker, New York. – reference: 19) Strieter RM, Chensue SW, Basha MA, Standiford TJ, Lynch JP, Baggiolini M, Kunkel SL (1990) Human alveolar macrophage gene expression of interleukin-8 by tumor necrosis factor-alpha, lipopolysaccharide, and interleukin-1 beta. Am J Respir Cell Mol Biol 2, 321–6. – reference: 32) Langford D, Masliah E (2002) Role of trophic factors on neuroimmunity in neurodegenerative infectious diseases. J Neurovirol 8, 625–38. – reference: 33) Rostaing L, Peres C, Tkaczuk J, Charlet JP, Bories P, Durand D, Ohayon E, de Préval C, Abbal M (2000) Ex vivo flow cytometry determination of intracytoplasmic expression of IL-2, IL-6, IFN-gamma, and TNF-alpha in monocytes and T lymphocytes, in chronic hemodialysis patients. Am J Nephrol 20, 18–26. – reference: 1) Schins RPF, Borm PJA (1999) Mechanisms and mediators in coal dust induced toxicity: a review. Ann Occup Hyg 43, 7–33. – reference: 6) Lee JS, Shin JH, Lee JO, Lee KM, Kim JH, Choi BS (2010) Serum Levels of Interleukin-8 and Tumor Necrosis Factor-alpha in Coal Workers’ Pneumoconiosis: one-year Follow-up Study. Saf Health Work 1, 69–79. – reference: 27) Rollins BJ, Yoshimura T, Leonard EJ, Pober JS (1990) Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE. Am J Pathol 136, 1229–33. – reference: 20) Zhang W, Chen H (2002) [The study on the interleukin-8 (IL-8)]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 19, 697–702 (in Chinese with English abstract). – reference: 8) Kim KA, Lim Y, Kim JH, Kim EK, Chang HS, Park YM, Ahn BY (1999) Potential biomarker of coal workers’ pneumoconiosis. Toxicol Lett 108, 297–302. – reference: 26) Leonard EJ, Yoshimura T (1990) Human monocyte chemoattractant protein-1 (MCP-1). Immunol Today 11, 97–101. – reference: 23) Gosset P, Lassalle P, Vanhée D, Wallaert B, Aerts C, Voisin C, Tonnel AB (1991) Production of tumor necrosis factor-α and interleukin-6 by human alveolar macrophages exposed in vitro to coal mine dust. Am J Respir Cell Mol Biol 5, 431–6. – reference: 16) Laso FJ, Vaquero JM, Almeida J, Marcos M, Orfao A (2007) Production of inflammatory cytokines by peripheral blood monocytes in chronic alcoholism: relationship with ethanol intake and liver disease. Cytometry B Clin Cytom 72, 408–15. – reference: 30) Kim SJ (2010) Leptin potentiates Prevotella intermedia lipopolysaccharide-induced production of TNF-alpha in monocyte-derived macrophages. J Periodont Implant Sci 40, 119–24. – reference: 28) Inoshima I, Kuwano K, Hamada N, Hagimoto N, Yoshimi M, Maeyama T, Takeshita A, Kitamoto S, Egashira K, Hara N (2004) Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol 286, L1038–44. – reference: 25) Tarantal AF, Chen H, Shi TT, Lu CH, Fang AB, Buckley S, Kolb M, Gauldie J, Warburton D, Shi W (2010) Overexpression of transforming growth factor-beta1 in fetal monkey lung results in prenatal pulmonary fibrosis. Eur Respir J 36, 907–14. – reference: 7) Schins RPF, Borm PJA (1995) Epidemiological evaluation of release of monocyte TNF-α as an exposure and effect marker in pneumoconiosis: a five year follow up study of coal workers. Occup Environ Med 52, 441–50. – reference: 22) Borm PJA, Schins RPF (2001) Genotype and phenotype in susceptibility to coal workers’ pneumoconiosis. the use of cytokines in perspective. Eur Respir J Suppl 32, 127s–33s. – reference: 2) IARC (1997) IARC Monograph on the evaluation of the carcinogenic risk of chemicals to humans. In: Silica, some silicates, coal dust and para-aramid fibrils. Vol. 68. IARC Press, Geneva. – reference: 12) Brusasco V, Crapo R, Viegi G (2005) Series “ATS/ERS Task Force: standardisation of lung function testing”. Eur Respir J 26, 318–38. – reference: 4) Porter DW, Hubbs AF, Mercer R, Robinson VA, Ramsey D, McLaurin J, Khan A, Battelli L, Brumbaugh K, Teass A, Castranova V (2004) Progression of lung inflammation and damage in rats after cessation of silica inhalation. Toxicol Sci 79, 370–80. – reference: 15) Khalil N, O’Connor RN, Unruh HW, Warren PW, Flanders KC, Kemp A, Bereznay OH, Greenberg AH (1991) Increased production and immunohistochemical localization of transforming growth factor-beta in idiopathic pulmonary fibrosis. 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| Title | Serum Levels of TGF-β1 and MCP-1 as Biomarkers for Progressive Coal Workers’ Pneumoconiosis in Retired Coal Workers: A Three-year Follow-up Study |
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