A Data-Driven Approach for Leveraging Inline and Offline Data to Determine the Causes of Monoclonal Antibody Productivity Reduction in the Commercial-Scale Cell Culture Process - Zhang, Sheng; Chen, Hang; Wan, Yuxiang; Wang, Haibin; Qu, Haibin (Pharmaceutics, 2024)
Keywords: Algorithms; Amino acids; Biological products; Case studies; Cell culture; Cell growth; contrastive principal component analysis; Data analysis; Data processing; data-driven; Digital twins; exploratory data analysis; functional data analysis; Machine learning; Manufacturing; Process controls; Productivity; Protein expression; root cause analysis; Variables; contrastive principal component analysis; functional data analysis; exploratory data analysis; cell culture; data-driven; root cause analysis