Model-integrated process development demonstrated on the optimization of a robotic cation exchange step - Osberghaus, A.; Drechsel, K.; Hansen, S.; Hepbildikler, S.K.; Nath, S.; Haindl, M.; von Lieres, E.; Hubbuch, J. (Chemical engineering science, 2012)
Keywords: agarose; Applied sciences; case studies; cation exchange; Chemical engineering; Chromatography; cytochrome c; Cytochromes; Downstream processing; Elution; Exact sciences and technology; experimental design; Flexibility; Ion exchange; lysozyme; Mathematical modeling; Mathematical models; mechanistic models; Optimization; prediction; Ribonuclease A; ribonucleases; Scale-up; Separation; Simulation; Mathematical modeling; Simulation; Optimization; Chromatography; Downstream processing; Scale-up; Cation exchange; Elution; Scale effect; Prediction; Retention; Flexibility; Modeling; Design; Extrapolation; Experimental design; Morphology; Miniaturized; pH; Robustness; Ion exchange