Preparation and evaluation of β-TCP/polylactide microspheres as osteogenesis materials
In the osteological field, the study of repairing and recovering processes for bone tissues has been one of the major clinical research subjects. To promote the bone healing, bioactive composite materials have been employed for the filling and supporting of defects, voids or diseased parts. In this...
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| Published in | Journal of applied polymer science Vol. 108; no. 5; pp. 3210 - 3217 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
05.06.2008
Wiley |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-8995 1097-4628 |
| DOI | 10.1002/app.27309 |
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| Abstract | In the osteological field, the study of repairing and recovering processes for bone tissues has been one of the major clinical research subjects. To promote the bone healing, bioactive composite materials have been employed for the filling and supporting of defects, voids or diseased parts. In this study, a series of microsphere composites made from polylactide (PLA), a biodegradable polymer, and β-calcium phosphate (β-TCP), an osteogenesis material, were prepared and estimated their potential applications in participation to the growth of new bone tissues on bone defects. By employing the water/oil/water (w/o/w) emulsion technique to fabricate a series of bioactive and biodegradable microspheres materials, we have found that one type of the microspheres: with diameter at 177 ± 33 μm, and enclosure of β-TCP at 18% (wt/wt), exhibiting smooth surface by the optical microscopy and scanning electron microscopy (SEM) observations, and showing slow yet steady calcium ion release and PLA degradation by in vitro test, showed excellent repairing and recovery of the chondrocyte and osteocyte tissues on drilled defects on the condyle of New Zealand rabbits within 1 month of application. |
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| AbstractList | In the osteological field, the study of repairing and recovering processes for bone tissues has been one of the major clinical research subjects. To promote the bone healing, bioactive composite materials have been employed for the filling and supporting of defects, voids or diseased parts. In this study, a series of microsphere composites made from polylactide (PLA), a biodegradable polymer, and β‐calcium phosphate (β‐TCP), an osteogenesis material, were prepared and estimated their potential applications in participation to the growth of new bone tissues on bone defects. By employing the water/oil/water (w/o/w) emulsion technique to fabricate a series of bioactive and biodegradable microspheres materials, we have found that one type of the microspheres: with diameter at 177 ± 33 μm, and enclosure of β‐TCP at 18% (wt/wt), exhibiting smooth surface by the optical microscopy and scanning electron microscopy (SEM) observations, and showing slow yet steady calcium ion release and PLA degradation by
in vitro
test, showed excellent repairing and recovery of the chondrocyte and osteocyte tissues on drilled defects on the condyle of New Zealand rabbits within 1 month of application. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008 In the osteological field, the study of repairing and recovering processes for bone tissues has been one of the major clinical research subjects. To promote the bone healing, bioactive composite materials have been employed for the filling and supporting of defects, voids or diseased parts. In this study, a series of microsphere composites made from polylactide (PLA), a biodegradable polymer, and -calcium phosphate (-TCP), an osteogenesis material, were prepared and estimated their potential applications in participation to the growth of new bone tissues on bone defects. By employing the water/oil/water (w/o/w) emulsion technique to fabricate a series of bioactive and biodegradable microspheres materials, we have found that one type of the microspheres: with diameter at 177 +/- 33 m, and enclosure of -TCP at 18% (wt/wt), exhibiting smooth surface by the optical microscopy and scanning electron microscopy (SEM) observations, and showing slow yet steady calcium ion release and PLA degradation by in vitro test, showed excellent repairing and recovery of the chondrocyte and osteocyte tissues on drilled defects on the condyle of New Zealand rabbits within 1 month of application. In the osteological field, the study of repairing and recovering processes for bone tissues has been one of the major clinical research subjects. To promote the bone healing, bioactive composite materials have been employed for the filling and supporting of defects, voids or diseased parts. In this study, a series of microsphere composites made from polylactide (PLA), a biodegradable polymer, and β-calcium phosphate (β-TCP), an osteogenesis material, were prepared and estimated their potential applications in participation to the growth of new bone tissues on bone defects. By employing the water/oil/water (w/o/w) emulsion technique to fabricate a series of bioactive and biodegradable microspheres materials, we have found that one type of the microspheres: with diameter at 177 ± 33 μm, and enclosure of β-TCP at 18% (wt/wt), exhibiting smooth surface by the optical microscopy and scanning electron microscopy (SEM) observations, and showing slow yet steady calcium ion release and PLA degradation by in vitro test, showed excellent repairing and recovery of the chondrocyte and osteocyte tissues on drilled defects on the condyle of New Zealand rabbits within 1 month of application. In the osteological field, the study of repairing and recovering processes for bone tissues has been one of the major clinical research subjects. To promote the bone healing, bioactive composite materials have been employed for the filling and supporting of defects, voids or diseased parts. In this study, a series of microsphere composites made from polylactide (PLA), a biodegradable polymer, and β-calcium phosphate (β-TCP), an osteogenesis material, were prepared and estimated their potential applications in participation to the growth of new bone tissues on bone defects. By employing the water/oil/water (w/o/w) emulsion technique to fabricate a series of bioactive and biodegradable microspheres materials, we have found that one type of the microspheres: with diameter at 177 ± 33 µm, and enclosure of β-TCP at 18% (wt/wt), exhibiting smooth surface by the optical microscopy and scanning electron microscopy (SEM) observations, and showing slow yet steady calcium ion release and PLA degradation by in vitro test, showed excellent repairing and recovery of the chondrocyte and osteocyte tissues on drilled defects on the condyle of New Zealand rabbits within 1 month of application. In the osteological field, the study of repairing and recovering processes for bone tissues has been one of the major clinical research subjects. To promote the bone healing, bioactive composite materials have been employed for the filling and supporting of defects, voids or diseased parts. In this study, a series of microsphere composites made from polylactide (PLA), a biodegradable polymer, and β‐calcium phosphate (β‐TCP), an osteogenesis material, were prepared and estimated their potential applications in participation to the growth of new bone tissues on bone defects. By employing the water/oil/water (w/o/w) emulsion technique to fabricate a series of bioactive and biodegradable microspheres materials, we have found that one type of the microspheres: with diameter at 177 ± 33 μm, and enclosure of β‐TCP at 18% (wt/wt), exhibiting smooth surface by the optical microscopy and scanning electron microscopy (SEM) observations, and showing slow yet steady calcium ion release and PLA degradation by in vitro test, showed excellent repairing and recovery of the chondrocyte and osteocyte tissues on drilled defects on the condyle of New Zealand rabbits within 1 month of application. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008 |
| Author | Niu, Gregory Cheng-Chie Chang, Shwu Jen Kuo, Shyh Ming Tsai, Pei Hua Lin, Li Chun Keng, Hao Kai |
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| Keywords | Cell proliferation Biological properties Microsphere Biodegradability Emulsification Tissue engineering microspheres Experimental study Composite particles Lactone polymer β-calcium phosphate Calcium Phosphates osteogenesis material Lactic acid polymer Morphology Aliphatic polymer Water oil water emulsion Osteoblast Manufacturing polylactide w/o/w emulsion Osteogenesis |
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| SubjectTerms | Applied sciences Biological and medical sciences Composites Exact sciences and technology Forms of application and semi-finished materials Medical sciences microspheres osteogenesis material polylactide Polymer industry, paints, wood Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology of polymers Technology. Biomaterials. Equipments w/o/w emulsion β-calcium phosphate |
| Title | Preparation and evaluation of β-TCP/polylactide microspheres as osteogenesis materials |
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