Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone‐ and buprenorphine‐maintained subjects - Gelston, Eloise A.; Coller, Janet K.; Lopatko, Olga V.; James, Heather M.; Schmidt, Helmut; White, Jason M.; Somogyi, Andrew A. (British journal of clinical pharmacology, 2012)
Keywords: Adolescent; Adult; Analgesics, Opioid - pharmacology; Biological and medical sciences; buprenorphine; Buprenorphine - pharmacology; Codeine - pharmacokinetics; codeine metabolism; CYP2D6 inhibition; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Drug Metabolism; Female; Genotype; glucuronidation inhibition; Glucuronosyltransferase - antagonists & inhibitors; Humans; Male; Medical sciences; methadone; Methadone - pharmacology; Middle Aged; Pharmacology. Drug treatments; Statistics as Topic; Young Adult; Human; Drug; UDP-glucuronosyltransferase; CYP2D6 inhibition; Enzyme; Isozyme; Transferases; Cytochrome P450; glucuronidation inhibition; Glycosyltransferases; Immunoglobulin receptor; 2B4 receptor; Opiates; Glucuronic acid conjugation; Antitussive agent; Methadone; Narcotic analgesic; In vivo; Buprenorphine; codeine metabolism; Hexosyltransferases; Inhibitor; Pharmacokinetics