The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures

• Published in: Epilepsia (Copenhagen) Vol. 62; no. 3; pp. 615 - 628
• Main Authors: Pressler, Ronit M., Cilio, Maria Roberta, Mizrahi, Eli M., Moshé, Solomon L., Nunes, Magda L., Plouin, Perrine, Vanhatalo, Sampsa, Yozawitz, Elissa, de Vries, Linda S., Puthenveettil Vinayan, Kollencheri, Triki, Chahnez C., Wilmshurst, Jo M., Yamamoto, Hitoshi, Zuberi, Sameer M.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2021
• Subjects: Advisory Committees; Autonomic nervous system; Children; Classification; Convulsions & seizures; Diagnosis, Differential; EEG; Electroencephalography; Epilepsy; Epilepsy - classification; Epilepsy - diagnosis; Epilepsy, Benign Neonatal - classification; Epilepsy, Benign Neonatal - diagnosis; Humans; Infant, Newborn; neonatal seizures; Neonates; Seizures; Seizures - classification; Seizures - diagnosis; semiology; Task forces; epilepsy; semiology; classification; neonatal seizures; EEG
• ISSN: 0013-9580; 1528-1167; 1528-1167
• DOI: 10.1111/epi.16815

Seizures are the most common neurological emergency in the neonatal period and in contrast to those in infancy and childhood, are often provoked seizures with an acute cause and may be electrographic‐only. Hence, neonatal seizures may not fit easily into classification schemes for seizures and epilepsies primarily developed for older children and adults. A Neonatal Seizures Task Force was established by the International League Against Epilepsy (ILAE) to develop a modification of the 2017 ILAE Classification of Seizures and Epilepsies, relevant to neonates. The neonatal classification framework emphasizes the role of electroencephalography (EEG) in the diagnosis of seizures in the neonate and includes a classification of seizure types relevant to this age group. The seizure type is determined by the predominant clinical feature. Many neonatal seizures are electrographic‐only with no evident clinical features; therefore, these are included in the proposed classification. Clinical events without an EEG correlate are not included. Because seizures in the neonatal period have been shown to have a focal onset, a division into focal and generalized is unnecessary. Seizures can have a motor (automatisms, clonic, epileptic spasms, myoclonic, tonic), non‐motor (autonomic, behavior arrest), or sequential presentation. The classification allows the user to choose the level of detail when classifying seizures in this age group.