Skin Microbiome in Atopic Dermatitis

Atopic dermatitis is a common inflammatory skin disease with a complex pathogenesis that includes imbalanced immune system signalling, impaired skin barrier and enhanced Staphylococcus aureus skin colonization. The skin bacterial communities are characterized by increasing abundance of S. aureus, le...

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Published inActa dermato-venereologica Vol. 100; no. 12; p. adv00164
Main Authors Edslev, S, Agner, T, Andersen, P
Format Journal Article
LanguageEnglish
Published Sweden Society for Publication of Acta Dermato-Venereologica 09.06.2020
Medical Journals Sweden
Subjects
Animals
atopic dermatitis
Dermatitis, Atopic - immunology
Dermatitis, Atopic - metabolism
Dermatitis, Atopic - microbiology
Dermatitis, Atopic - pathology
Disease Progression
Dysbiosis
filaggrin
Host-Pathogen Interactions
Humans
Intermediate Filament Proteins - metabolism
Microbiota
Review
Severity of Illness Index
Skin - immunology
Skin - metabolism
Skin - microbiology
Skin - pathology
skin microbiome
staphylococcus aureus
Staphylococcus aureus - growth & development
Staphylococcus aureus - immunology
Staphylococcus aureus - pathogenicity
Virulence
skin microbiome
atopic dermatitis
filaggrin
Staphylococcus aureus
Online AccessGet full text
ISSN1651-2057
0001-5555
1651-2057
DOI10.2340/00015555-3514

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Abstract Atopic dermatitis is a common inflammatory skin disease with a complex pathogenesis that includes imbalanced immune system signalling, impaired skin barrier and enhanced Staphylococcus aureus skin colonization. The skin bacterial communities are characterized by increasing abundance of S. aureus, leading to reduced diversity compared with the bacterial communities on healthy skin, and increasing disease severity. In contrast, fungal communities are richer and more diverse on the skin of patients with atopic dermatitis, although distribution of the most common species is similar in patients and controls. Filaggrin deficiency in atopic dermatitis skin might be related to the enhanced skin colonization by S. aureus. In addition, S. aureus expressing variant virulence factors have been shown to elicit atopic dermatitis-like phenotypes in mice, indicating that specific S. aureus strains can induce flare-ups. This review aims to provide an overview of the recent literature on the skin microbiome in atopic dermatitis.
AbstractList Atopic dermatitis is a common inflammatory skin disease with a complex pathogenesis that includes imbalanced immune system signalling, impaired skin barrier and enhanced Staphylococcus aureus skin colonization. The skin bacterial communities are characterized by increasing abundance of S. aureus, leading to reduced diversity compared with the bacterial communities on healthy skin, and increasing disease severity. In contrast, fungal communities are richer and more diverse on the skin of patients with atopic dermatitis, although distribution of the most common species is similar in patients and controls. Filaggrin deficiency in atopic dermatitis skin might be related to the enhanced skin colonization by S. aureus. In addition, S. aureus expressing variant virulence factors have been shown to elicit atopic dermatitis-like phenotypes in mice, indicating that specific S. aureus strains can induce flare-ups. This review aims to provide an overview of the recent literature on the skin microbiome in atopic dermatitis.Atopic dermatitis is a common inflammatory skin disease with a complex pathogenesis that includes imbalanced immune system signalling, impaired skin barrier and enhanced Staphylococcus aureus skin colonization. The skin bacterial communities are characterized by increasing abundance of S. aureus, leading to reduced diversity compared with the bacterial communities on healthy skin, and increasing disease severity. In contrast, fungal communities are richer and more diverse on the skin of patients with atopic dermatitis, although distribution of the most common species is similar in patients and controls. Filaggrin deficiency in atopic dermatitis skin might be related to the enhanced skin colonization by S. aureus. In addition, S. aureus expressing variant virulence factors have been shown to elicit atopic dermatitis-like phenotypes in mice, indicating that specific S. aureus strains can induce flare-ups. This review aims to provide an overview of the recent literature on the skin microbiome in atopic dermatitis.
Atopic dermatitis is a common inflammatory skin disease with a complex pathogenesis that includes imbalanced immune system signalling, impaired skin barrier and enhanced Staphylococcus aureus skin colonization. The skin bacterial communities are characterized by increasing abundance of S. aureus, leading to reduced diversity compared with the bacterial communities on healthy skin, and increasing disease severity. In contrast, fungal communities are richer and more diverse on the skin of patients with atopic dermatitis, although distribution of the most common species is similar in patients and controls. Filaggrin deficiency in atopic dermatitis skin might be related to the enhanced skin colonization by S. aureus. In addition, S. aureus expressing variant virulence factors have been shown to elicit atopic dermatitis-like phenotypes in mice, indicating that specific S. aureus strains can induce flare-ups. This review aims to provide an overview of the recent literature on the skin microbiome in atopic dermatitis.
Atopic dermatitis is a common inflammatory skin disease with a complex pathogenesis that includes imbalanced immune system signalling, impaired skin barrier and enhanced Staphylococcus aureus skin colonization. The skin bacterial communities are characterized by increasing abundance of S. aureus , leading to reduced diversity compared with the bacterial communities on healthy skin, and increasing disease severity. In contrast, fungal communities are richer and more diverse on the skin of patients with atopic dermatitis, although distribution of the most common species is similar in patients and controls. Filaggrin deficiency in atopic dermatitis skin might be related to the enhanced skin colonization by S. aureus . In addition, S. aureus expressing variant virulence factors have been shown to elicit atopic dermatitis-like phenotypes in mice, indicating that specific S. aureus strains can induce flare-ups. This review aims to provide an overview of the recent literature on the skin microbiome in atopic dermatitis.
Author Agner, T
Edslev, S
Andersen, P
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Keywords skin microbiome
atopic dermatitis
filaggrin
Staphylococcus aureus
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Snippet Atopic dermatitis is a common inflammatory skin disease with a complex pathogenesis that includes imbalanced immune system signalling, impaired skin barrier...
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SubjectTerms Animals
atopic dermatitis
Dermatitis, Atopic - immunology
Dermatitis, Atopic - metabolism
Dermatitis, Atopic - microbiology
Dermatitis, Atopic - pathology
Disease Progression
Dysbiosis
filaggrin
Host-Pathogen Interactions
Humans
Intermediate Filament Proteins - metabolism
Microbiota
Review
Severity of Illness Index
Skin - immunology
Skin - metabolism
Skin - microbiology
Skin - pathology
skin microbiome
staphylococcus aureus
Staphylococcus aureus - growth & development
Staphylococcus aureus - immunology
Staphylococcus aureus - pathogenicity
Virulence
Title Skin Microbiome in Atopic Dermatitis
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