Study on toxicity effects of environmental pollutants based on metabolomics: A review

In the past few decades, the toxic effects of environmental pollutants on non-target organisms have received more and more attention. As a new omics technology, metabolomics can clarify the metabolic homeostasis of the organism at the overall level by studying the changes in the relative contents of...

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Published inChemosphere (Oxford) Vol. 286; no. Pt 2; p. 131815
Main Authors Liu, Li, Wu, Qinchao, Miao, Xinyi, Fan, Tianle, Meng, Zhiyuan, Chen, Xiaojun, Zhu, Wentao
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.01.2022
Subjects
biphenyl
Environmental pollutants
homeostasis
metabolites
Metabolomics
microplastics
Muti-omics
polychlorinated biphenyls
Toxicity
toxicity testing
Metabolomics
Environmental pollutants
Toxicity
Muti-omics
Online AccessGet full text
ISSN0045-6535
1879-1298
1879-1298
DOI10.1016/j.chemosphere.2021.131815

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Abstract In the past few decades, the toxic effects of environmental pollutants on non-target organisms have received more and more attention. As a new omics technology, metabolomics can clarify the metabolic homeostasis of the organism at the overall level by studying the changes in the relative contents of endogenous metabolites in the organism. Recently, a large number of studies have used metabolomics technology to study the toxic effects of environmental pollutants on organisms. In this review, we reviewed the analysis processes and data processes of metabolomics and its application in the study of the toxic effects of environmental pollutants including heavy metals, pesticides, polychlorinated biphenyls, polycyclic aromatic hydrocarbons, polybrominated diphenyl ethers and microplastics. In addition, we emphasized that the combination of metabolomics and other omics technologies will help to explore the toxic mechanism of environmental pollutants and provide new research ideas for the toxicological evaluation of environmental pollutants. [Display omitted] •Metabolomics was widely used in the study of the toxic effects of environmental pollutants.•Metabolomics could comprehensively evaluate the toxic effects of environmental pollutants.•Multi-omics could help to explore the toxic mechanisms of environmental pollutants.
AbstractList In the past few decades, the toxic effects of environmental pollutants on non-target organisms have received more and more attention. As a new omics technology, metabolomics can clarify the metabolic homeostasis of the organism at the overall level by studying the changes in the relative contents of endogenous metabolites in the organism. Recently, a large number of studies have used metabolomics technology to study the toxic effects of environmental pollutants on organisms. In this review, we reviewed the analysis processes and data processes of metabolomics and its application in the study of the toxic effects of environmental pollutants including heavy metals, pesticides, polychlorinated biphenyls, polycyclic aromatic hydrocarbons, polybrominated diphenyl ethers and microplastics. In addition, we emphasized that the combination of metabolomics and other omics technologies will help to explore the toxic mechanism of environmental pollutants and provide new research ideas for the toxicological evaluation of environmental pollutants.
In the past few decades, the toxic effects of environmental pollutants on non-target organisms have received more and more attention. As a new omics technology, metabolomics can clarify the metabolic homeostasis of the organism at the overall level by studying the changes in the relative contents of endogenous metabolites in the organism. Recently, a large number of studies have used metabolomics technology to study the toxic effects of environmental pollutants on organisms. In this review, we reviewed the analysis processes and data processes of metabolomics and its application in the study of the toxic effects of environmental pollutants including heavy metals, pesticides, polychlorinated biphenyls, polycyclic aromatic hydrocarbons, polybrominated diphenyl ethers and microplastics. In addition, we emphasized that the combination of metabolomics and other omics technologies will help to explore the toxic mechanism of environmental pollutants and provide new research ideas for the toxicological evaluation of environmental pollutants. [Display omitted] •Metabolomics was widely used in the study of the toxic effects of environmental pollutants.•Metabolomics could comprehensively evaluate the toxic effects of environmental pollutants.•Multi-omics could help to explore the toxic mechanisms of environmental pollutants.
In the past few decades, the toxic effects of environmental pollutants on non-target organisms have received more and more attention. As a new omics technology, metabolomics can clarify the metabolic homeostasis of the organism at the overall level by studying the changes in the relative contents of endogenous metabolites in the organism. Recently, a large number of studies have used metabolomics technology to study the toxic effects of environmental pollutants on organisms. In this review, we reviewed the analysis processes and data processes of metabolomics and its application in the study of the toxic effects of environmental pollutants including heavy metals, pesticides, polychlorinated biphenyls, polycyclic aromatic hydrocarbons, polybrominated diphenyl ethers and microplastics. In addition, we emphasized that the combination of metabolomics and other omics technologies will help to explore the toxic mechanism of environmental pollutants and provide new research ideas for the toxicological evaluation of environmental pollutants.In the past few decades, the toxic effects of environmental pollutants on non-target organisms have received more and more attention. As a new omics technology, metabolomics can clarify the metabolic homeostasis of the organism at the overall level by studying the changes in the relative contents of endogenous metabolites in the organism. Recently, a large number of studies have used metabolomics technology to study the toxic effects of environmental pollutants on organisms. In this review, we reviewed the analysis processes and data processes of metabolomics and its application in the study of the toxic effects of environmental pollutants including heavy metals, pesticides, polychlorinated biphenyls, polycyclic aromatic hydrocarbons, polybrominated diphenyl ethers and microplastics. In addition, we emphasized that the combination of metabolomics and other omics technologies will help to explore the toxic mechanism of environmental pollutants and provide new research ideas for the toxicological evaluation of environmental pollutants.
ArticleNumber 131815
Author Chen, Xiaojun
Liu, Li
Wu, Qinchao
Zhu, Wentao
Meng, Zhiyuan
Fan, Tianle
Miao, Xinyi
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  fullname: Miao, Xinyi
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  organization: School of Horticulture and Plant Protection, Yangzhou University, Yangzhou, Jiangsu, 225009, China
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  givenname: Zhiyuan
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  givenname: Wentao
  surname: Zhu
  fullname: Zhu, Wentao
  organization: Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing, 100193, China
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SubjectTerms biphenyl
Environmental pollutants
homeostasis
metabolites
Metabolomics
microplastics
Muti-omics
polychlorinated biphenyls
Toxicity
toxicity testing
Title Study on toxicity effects of environmental pollutants based on metabolomics: A review
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