Endothelial adhesion molecule expression is unaltered in the peripheral nerve from patients with AIDS and distal sensory polyneuropathy
Some evidence suggests that endothelial dysfunction, including altered expression of cell adhesion molecules contributes to pathophysiology of nervous system disorders in the course of HIV infection. In this immunohistochemical study we investigated and compared the expression of E-selectin, interce...
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| Published in | Journal of neuroimmunology Vol. 178; no. 1; pp. 111 - 116 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.09.2006
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0165-5728 1872-8421 |
| DOI | 10.1016/j.jneuroim.2006.06.013 |
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| Abstract | Some evidence suggests that endothelial dysfunction, including altered expression of cell adhesion molecules contributes to pathophysiology of nervous system disorders in the course of HIV infection. In this immunohistochemical study we investigated and compared the expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), platelet endothelial cell adhesion molecule-1 (PECAM-1) in peripheral nerve blood vessels from patients with distal sensory polyneuropathy (DSP) and control patients with other axonal neuropathies. Similar quantitative pattern of immunoreactivity was found in patients with DSP and controls. E-selectin and PECAM-1 immunostained vessels tended to increase in number only in patients with major CD4 cell depletion. The vascular endothelium of the peripheral nerve in HIV-infected subjects with DSP shows no changes facilitating the migration of infected or activated monocytes/macrophages into the nerve. These phenomena probably do not play a critical role in the development of axonal damage in DSP. |
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| AbstractList | Some evidence suggests that endothelial dysfunction, including altered expression of cell adhesion molecules contributes to pathophysiology of nervous system disorders in the course of HIV infection. In this immunohistochemical study we investigated and compared the expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), platelet endothelial cell adhesion molecule-1 (PECAM-1) in peripheral nerve blood vessels from patients with distal sensory polyneuropathy (DSP) and control patients with other axonal neuropathies. Similar quantitative pattern of immunoreactivity was found in patients with DSP and controls. E-selectin and PECAM-1 immunostained vessels tended to increase in number only in patients with major CD4 cell depletion. The vascular endothelium of the peripheral nerve in HIV-infected subjects with DSP shows no changes facilitating the migration of infected or activated monocytes/macrophages into the nerve. These phenomena probably do not play a critical role in the development of axonal damage in DSP. Some evidence suggests that endothelial dysfunction, including altered expression of cell adhesion molecules contributes to pathophysiology of nervous system disorders in the course of HIV infection. In this immunohistochemical study we investigated and compared the expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), platelet endothelial cell adhesion molecule-1 (PECAM-1) in peripheral nerve blood vessels from patients with distal sensory polyneuropathy (DSP) and control patients with other axonal neuropathies. Similar quantitative pattern of immunoreactivity was found in patients with DSP and controls. E-selectin and PECAM-1 immunostained vessels tended to increase in number only in patients with major CD4 cell depletion. The vascular endothelium of the peripheral nerve in HIV-infected subjects with DSP shows no changes facilitating the migration of infected or activated monocytes/macrophages into the nerve. These phenomena probably do not play a critical role in the development of axonal damage in DSP.Some evidence suggests that endothelial dysfunction, including altered expression of cell adhesion molecules contributes to pathophysiology of nervous system disorders in the course of HIV infection. In this immunohistochemical study we investigated and compared the expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), platelet endothelial cell adhesion molecule-1 (PECAM-1) in peripheral nerve blood vessels from patients with distal sensory polyneuropathy (DSP) and control patients with other axonal neuropathies. Similar quantitative pattern of immunoreactivity was found in patients with DSP and controls. E-selectin and PECAM-1 immunostained vessels tended to increase in number only in patients with major CD4 cell depletion. The vascular endothelium of the peripheral nerve in HIV-infected subjects with DSP shows no changes facilitating the migration of infected or activated monocytes/macrophages into the nerve. These phenomena probably do not play a critical role in the development of axonal damage in DSP. |
| Author | Ferrari, Sergio Rizzuto, Nicolò Cavallaro, Tiziana Rossi, Francesca Fenzi, Flavio Rava, Marta |
| Author_xml | – sequence: 1 givenname: Flavio surname: Fenzi fullname: Fenzi, Flavio email: flavio.fenzi@univr.it organization: Department of Neurological and Visual Sciences, Section of Neurology, University of Verona, Verona, Italy – sequence: 2 givenname: Francesca surname: Rossi fullname: Rossi, Francesca organization: Department of Neurological and Visual Sciences, Section of Neurology, University of Verona, Verona, Italy – sequence: 3 givenname: Marta surname: Rava fullname: Rava, Marta organization: Department of Medicine and Public Health, Unit of Epidemiology and Medical Statistics, University of Verona, Verona, Italy – sequence: 4 givenname: Tiziana surname: Cavallaro fullname: Cavallaro, Tiziana organization: Department of Neurological and Visual Sciences, Section of Neurology, University of Verona, Verona, Italy – sequence: 5 givenname: Sergio surname: Ferrari fullname: Ferrari, Sergio organization: Department of Neurological and Visual Sciences, Section of Neurology, University of Verona, Verona, Italy – sequence: 6 givenname: Nicolò surname: Rizzuto fullname: Rizzuto, Nicolò organization: Department of Neurological and Visual Sciences, Section of Neurology, University of Verona, Verona, Italy |
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| Cites_doi | 10.1128/JVI.76.13.6689-6700.2002 10.1002/ana.410230510 10.1002/mus.10484 10.1001/archneur.1988.00520330023005 10.3109/10623320009072210 10.1001/archneur.58.10.1561 10.1016/j.virol.2005.01.027 10.1097/00002030-199304000-00024 10.1038/labinvest.3780418 10.1055/s-0038-1656027 10.1007/s004010100391 10.1007/s00401-003-0704-3 10.1177/120347549800200407 10.1001/archneur.61.4.546 10.1212/WNL.58.12.1764 10.1016/S0002-9440(10)65400-4 10.1016/S1473-3099(04)00971-5 10.1001/archneur.1993.00540020045016 10.1016/S0923-2494(97)82482-0 10.1007/BF00296507 10.1016/S1474-4422(05)70165-4 10.1016/S0163-4453(94)91151-7 |
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| Keywords | Immunohistochemistry Blood vessels Endothelial adhesion molecules Distal sensory polyneuropathy HIV infection Sural nerve |
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| SubjectTerms | Acquired Immunodeficiency Syndrome - complications Adult Blood vessels Cell Adhesion Molecules - biosynthesis Distal sensory polyneuropathy Endothelial adhesion molecules Endothelial Cells - metabolism Female HIV infection Human immunodeficiency virus Humans Immunohistochemistry Male Middle Aged Peripheral Nervous System Diseases - etiology Peripheral Nervous System Diseases - metabolism Sural nerve Sural Nerve - blood supply Sural Nerve - metabolism Sural Nerve - pathology |
| Title | Endothelial adhesion molecule expression is unaltered in the peripheral nerve from patients with AIDS and distal sensory polyneuropathy |
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