The PARK2 gene is involved in the maintenance of pancreatic β-cell functions related to insulin production and secretion - Jin, Hyun-Seok; Kim, Jeonghyun; Lee, Soo-Jin; Kim, Kyunga; Go, Min Jin; Lee, Jong-Young; Lee, Hye-Ja; Song, Jihyun; Jeon, Byeong Tak; Roh, Gu Seob; Kim, Sung-Jun; Kim, Bo-Young; et al. (Molecular and cellular endocrinology, 2014)
Keywords: adenosine triphosphate; Adenosine Triphosphate - metabolism; Adult; Aged; Animals; ATP; blood glucose; Cohort Studies; diabetes; fasting; gene expression; Gene Expression Profiling; gene expression regulation; Gene Knockdown Techniques; Genes; Genetic association; Glucose; Humans; Insulin; Insulin - biosynthesis; Insulin - metabolism; Insulin Secretion; Insulin-Secreting Cells - metabolism; islets of Langerhans; Maintenance; Male; Males; membrane potential; Middle Aged; Mitochondria; Mitochondria - metabolism; mitochondrial membrane; Nucleotides; Pancreatic β-cell; PARK2; Polymorphism, Single Nucleotide - genetics; Quantitative Trait, Heritable; Rats; Secretions; single nucleotide polymorphism; Type 2 diabetes; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Type 2 diabetes; Mitochondria; Pancreatic β-cell; Genetic association; PARK2; Insulin secretion