Epstein-Barr Virus-Based Nasopharyngeal Carcinoma (NPC) Risk Prediction Scores Are Elevated in NPC Multiplex Family Members in Taiwan
Abstract Nasopharyngeal carcinoma (NPC) is caused by Epstein-Barr virus (EBV) and is more likely to occur in susceptible families. Whether genetic susceptibility operates through altered EBV control is incompletely understood. We used a NPC risk prediction model based on 14 EBV markers to compare ri...
Saved in:
| Published in | The Journal of infectious diseases Vol. 223; no. 3; pp. 441 - 444 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
US
Oxford University Press
13.02.2021
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-1899 1537-6613 1537-6613 |
| DOI | 10.1093/infdis/jiaa385 |
Cover
| Abstract | Abstract
Nasopharyngeal carcinoma (NPC) is caused by Epstein-Barr virus (EBV) and is more likely to occur in susceptible families. Whether genetic susceptibility operates through altered EBV control is incompletely understood. We used a NPC risk prediction model based on 14 EBV markers to compare risk score distribution in unaffected members from multiplex families with that in population-based controls. Despite the absence of NPC at the time of antibody measurement, we observed an upward shift in risk score among multiplex family members compared to the general population, consistent with the possibility that genetic factors affect NPC risk through alterations in EBV control. |
|---|---|
| AbstractList | Nasopharyngeal carcinoma (NPC) is caused by Epstein-Barr virus (EBV) and is more likely to occur in susceptible families. Whether genetic susceptibility operates through altered EBV control is incompletely understood. We used a NPC risk prediction model based on 14 EBV markers to compare risk score distribution in unaffected members from multiplex families with that in population-based controls. Despite the absence of NPC at the time of antibody measurement, we observed an upward shift in risk score among multiplex family members compared to the general population, consistent with the possibility that genetic factors affect NPC risk through alterations in EBV control. Abstract Nasopharyngeal carcinoma (NPC) is caused by Epstein-Barr virus (EBV) and is more likely to occur in susceptible families. Whether genetic susceptibility operates through altered EBV control is incompletely understood. We used a NPC risk prediction model based on 14 EBV markers to compare risk score distribution in unaffected members from multiplex families with that in population-based controls. Despite the absence of NPC at the time of antibody measurement, we observed an upward shift in risk score among multiplex family members compared to the general population, consistent with the possibility that genetic factors affect NPC risk through alterations in EBV control. Nasopharyngeal carcinoma (NPC) is caused by Epstein-Barr virus (EBV) and is more likely to occur in susceptible families. Whether genetic susceptibility operates through altered EBV control is incompletely understood. We used a NPC risk prediction model based on 14 EBV markers to compare risk score distribution in unaffected members from multiplex families with that in population-based controls. Despite the absence of NPC at the time of antibody measurement, we observed an upward shift in risk score among multiplex family members compared to the general population, consistent with the possibility that genetic factors affect NPC risk through alterations in EBV control.Nasopharyngeal carcinoma (NPC) is caused by Epstein-Barr virus (EBV) and is more likely to occur in susceptible families. Whether genetic susceptibility operates through altered EBV control is incompletely understood. We used a NPC risk prediction model based on 14 EBV markers to compare risk score distribution in unaffected members from multiplex families with that in population-based controls. Despite the absence of NPC at the time of antibody measurement, we observed an upward shift in risk score among multiplex family members compared to the general population, consistent with the possibility that genetic factors affect NPC risk through alterations in EBV control. |
| Author | Chien, Yin-Chu Yu, Kelly J Lee, Mei-Hsuan Hildesheim, Allan Wang, Cheng-Ping Liu, Zhiwei Chen, Chien-Jen Hsu, Wan-Lun Coghill, Anna E Chen, Tseng-Cheng Huang, Yu-Han |
| AuthorAffiliation | 1 Institute of Clinical Medicine, National Yang-Ming University , Taipei, Taiwan 2 Cancer Epidemiology Program, Division of Population Science, H. Lee Moffitt Cancer Center and Research Institute , Tampa, Florida, USA 5 Genomics Research Center, Academia Sinica , Taipei, Taiwan 6 Department of Otolaryngology, National Taiwan University Hospital and College of Medicine , Taipei, Taiwan 4 Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University , Taipei, Taiwan 3 Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute , Bethesda, Maryland, USA |
| AuthorAffiliation_xml | – name: 1 Institute of Clinical Medicine, National Yang-Ming University , Taipei, Taiwan – name: 6 Department of Otolaryngology, National Taiwan University Hospital and College of Medicine , Taipei, Taiwan – name: 2 Cancer Epidemiology Program, Division of Population Science, H. Lee Moffitt Cancer Center and Research Institute , Tampa, Florida, USA – name: 3 Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute , Bethesda, Maryland, USA – name: 4 Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University , Taipei, Taiwan – name: 5 Genomics Research Center, Academia Sinica , Taipei, Taiwan |
| Author_xml | – sequence: 1 givenname: Mei-Hsuan surname: Lee fullname: Lee, Mei-Hsuan email: meihlee@ntu.edu.tw organization: Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan – sequence: 2 givenname: Yu-Han surname: Huang fullname: Huang, Yu-Han organization: Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan – sequence: 3 givenname: Anna E surname: Coghill fullname: Coghill, Anna E organization: Cancer Epidemiology Program, Division of Population Science, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA – sequence: 4 givenname: Zhiwei orcidid: 0000-0002-0136-651X surname: Liu fullname: Liu, Zhiwei organization: Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA – sequence: 5 givenname: Kelly J surname: Yu fullname: Yu, Kelly J organization: Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA – sequence: 6 givenname: Wan-Lun surname: Hsu fullname: Hsu, Wan-Lun organization: Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan – sequence: 7 givenname: Yin-Chu surname: Chien fullname: Chien, Yin-Chu organization: Genomics Research Center, Academia Sinica, Taipei, Taiwan – sequence: 8 givenname: Cheng-Ping surname: Wang fullname: Wang, Cheng-Ping organization: Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan – sequence: 9 givenname: Tseng-Cheng surname: Chen fullname: Chen, Tseng-Cheng organization: Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan – sequence: 10 givenname: Chien-Jen surname: Chen fullname: Chen, Chien-Jen organization: Genomics Research Center, Academia Sinica, Taipei, Taiwan – sequence: 11 givenname: Allan orcidid: 0000-0003-0257-2363 surname: Hildesheim fullname: Hildesheim, Allan organization: Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32614957$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkUlvFDEQhS0URBa4ckSWuCSHznjt5YIURhNASkIEgatV4_YkHtx2x-5OmB_A_8ajGbZIKCeXVN97rnq1j3Z88Aahl5QcU9LwifWL1qbJ0gLwWj5Be1TyqihLynfQHiGMFbRuml20n9KSECJ4WT1Du5yVVDSy2kM_Zn0ajPXFW4gRf7VxTLlMpsUXkEJ_A3Hlrw04PIWorQ8d4MOLy-kR_mTTN3wZTWv1YIPHn3WIJuGTaPDMmTsYsoX1OLP4fHSD7Z35jk-hs26Fz003NzGt-1dg78E_R08X4JJ5sX0P0JfT2dX0fXH28d2H6clZoYVkQ0E5qWXFZT2fa1oKXs0bKZngraY1Y6WkNXDOW9NIIJSXvKrruml1wxvQ1YIAP0CTje_oe1jdg3Oqj7bLSypK1DpQtQlUbQPNijcbRT_OO9Nq44cIf1QBrPq34-2Nug53qmpqJkSVDQ63BjHcjiYNqrNJG-fAmzAmxQQjVMj8VUZfP0CXYYw-B6KYFJWs8sXKTL36e6Lfo_y6aQbEBtAxpBTNQmk7wPpIeUDr_r_p8QPZo9EcbQRh7B9jfwKpK9a_ |
| CitedBy_id | crossref_primary_10_1038_s41598_021_02788_w crossref_primary_10_1158_1055_9965_EPI_20_1702 crossref_primary_10_1002_ijc_35037 crossref_primary_10_1093_ije_dyae098 crossref_primary_10_3390_cancers13194944 crossref_primary_10_1016_j_amjoto_2023_104206 crossref_primary_10_1007_s10552_022_01582_x |
| Cites_doi | 10.1001/jama.295.1.65 10.1099/jgv.0.001115 10.1002/ijc.24051 10.1093/aje/kws404 10.1002/ijc.24293 10.1002/ijc.20222 10.1093/annonc/mdz231 10.1093/aje/kws403 10.1158/1055-9965.EPI-06-0353 10.1093/jnci/94.23.1780 10.1158/1078-0432.CCR-17-1929 10.1038/s41598-019-46137-4 10.1016/j.semcancer.2012.01.007 10.1158/1078-0432.CCR-10-1681 10.1371/journal.pgen.1003147 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2020 The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. |
| Copyright_xml | – notice: The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2020 – notice: The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. |
| DBID | AAYXX CITATION NPM K9. NAPCQ 7X8 5PM ADTOC UNPAY |
| DOI | 10.1093/infdis/jiaa385 |
| DatabaseName | CrossRef PubMed ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall |
| DatabaseTitle | CrossRef PubMed ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic ProQuest Health & Medical Complete (Alumni) CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1537-6613 |
| EndPage | 444 |
| ExternalDocumentID | oai:pubmedcentral.nih.gov:7982447 PMC7982447 32614957 10_1093_infdis_jiaa385 10.1093/infdis/jiaa385 |
| Genre | Journal Article |
| GeographicLocations | Taiwan |
| GeographicLocations_xml | – name: Taiwan |
| GrantInformation_xml | – fundername: ; ; grantid: 107-2918-I-010-004 – fundername: ; ; |
| GroupedDBID | --- -DZ -~X ..I .2P .55 .GJ .I3 .XZ .ZR 08P 0R~ 123 1KJ 1TH 29K 2AX 2WC 36B 3O- 4.4 41~ 48X 53G 5GY 5RE 5VS 5WD 6.Y 70D 85S AABZA AACGO AACZT AAHBH AAHTB AAJKP AAJQQ AAMVS AANCE AAOGV AAPGJ AAPNW AAPQZ AAPXW AAQQT AARHZ AASNB AAUAY AAUQX AAVAP AAWDT AAWTL AAYOK ABBHK ABEUO ABIXL ABJNI ABKDP ABLJU ABNHQ ABNKS ABOCM ABPEJ ABPLY ABPPZ ABPTD ABQLI ABQNK ABSAR ABSMQ ABTLG ABWST ABXSQ ABXVV ABZBJ ACFRR ACGFO ACGFS ACGOD ACMRT ACPQN ACPRK ACUFI ACUTJ ACUTO ACYHN ACZBC ADACV ADBBV ADEYI ADGZP ADHKW ADHZD ADIPN ADJQC ADOCK ADQBN ADRIX ADRTK ADULT ADVEK ADYVW ADZXQ AEGPL AEGXH AEJOX AEKPW AEKSI AEMDU AENEX AENZO AEPUE AETBJ AEUPB AEWNT AEXZC AFFNX AFFZL AFHKK AFIYH AFOFC AFSHK AFXAL AFXEN AFYAG AGINJ AGKEF AGKRT AGMDO AGQXC AGSYK AGUTN AHMBA AHXPO AI. AIAGR AIJHB AJEEA ALMA_UNASSIGNED_HOLDINGS ALUQC APIBT APJGH APWMN AQDSO AQKUS AQVQM ATGXG AVNTJ AXUDD BAWUL BAYMD BCRHZ BEYMZ BHONS BR6 BTRTY BVRKM BZKNY C45 CDBKE CS3 CZ4 D-I DAKXR DCCCD DIK DILTD DOOOF DU5 D~K EBS ECGQY EE~ EIHJH EJD EMOBN ENERS ESX F5P F9B FECEO FLUFQ FOEOM FOTVD FQBLK G8K GAUVT GJXCC GX1 H13 H5~ HAR HQ3 HTVGU HW0 HZ~ IH2 IOX IPSME J21 J5H JAAYA JBMMH JENOY JHFFW JKQEH JLS JLXEF JPM JSG JSODD JST KAQDR KBUDW KOP KQ8 KSI KSN L7B LSO LU7 M49 MBLQV MHKGH MJL ML0 MVM N4W N9A NEJ NGC NOMLY NOYVH NU- NVLIB O0~ O9- OAUYM OAWHX OCZFY ODMLO OJQWA OJZSN OK1 OPAEJ OVD OWPYF O~Y P0- P2P PAFKI PEELM PQQKQ Q1. Q5Y QBD RD5 ROX ROZ RUSNO RW1 RXO SA0 SJN TCURE TEORI TJX TMA TR2 VH1 W2D W8F WH7 X7H X7M Y6R YAYTL YKOAZ YXANX ZE2 ZGI ZKG ZXP ~91 AAYXX ABDFA ABEJV ABGNP ABPQP ABVGC ADNBA AEMQT AHGBF AHMMS AJBYB AJNCP ALXQX CITATION JXSIZ AGORE NPM K9. NAPCQ 7X8 5PM AAFWJ ABDPE ACHIC ACVCV ADMTO ADQXQ ADTOC AFFQV AFQQW AJDVS OBFPC UNPAY |
| ID | FETCH-LOGICAL-c452t-130857358bbc16437b955243dc18226518a333de95a0136378889dc939ac7f0a3 |
| ISSN | 0022-1899 1537-6613 |
| IngestDate | Wed Aug 20 00:10:14 EDT 2025 Tue Sep 30 16:58:34 EDT 2025 Sun Sep 28 03:16:49 EDT 2025 Mon Jun 30 10:32:32 EDT 2025 Mon Jul 21 05:57:40 EDT 2025 Wed Oct 01 02:15:47 EDT 2025 Thu Apr 24 22:57:52 EDT 2025 Wed Aug 28 03:20:21 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | host-virus interactions immune genetic susceptibility virus control multiplex antibody array |
| Language | English |
| License | This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c452t-130857358bbc16437b955243dc18226518a333de95a0136378889dc939ac7f0a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-0136-651X 0000-0003-0257-2363 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/7982447 |
| PMID | 32614957 |
| PQID | 2547579576 |
| PQPubID | 41591 |
| PageCount | 4 |
| ParticipantIDs | unpaywall_primary_10_1093_infdis_jiaa385 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7982447 proquest_miscellaneous_2420145853 proquest_journals_2547579576 pubmed_primary_32614957 crossref_citationtrail_10_1093_infdis_jiaa385 crossref_primary_10_1093_infdis_jiaa385 oup_primary_10_1093_infdis_jiaa385 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2021-Feb-13 |
| PublicationDateYYYYMMDD | 2021-02-13 |
| PublicationDate_xml | – month: 02 year: 2021 text: 2021-Feb-13 day: 13 |
| PublicationDecade | 2020 |
| PublicationPlace | US |
| PublicationPlace_xml | – name: US – name: United States – name: Oxford |
| PublicationTitle | The Journal of infectious diseases |
| PublicationTitleAlternate | J Infect Dis |
| PublicationYear | 2021 |
| Publisher | Oxford University Press |
| Publisher_xml | – name: Oxford University Press |
| References | Hildesheim (2021032204350864200_CIT0014) 2002; 94 Chen (2021032204350864200_CIT0013) 2006; 295 Ji (2021032204350864200_CIT0003) 2019; 30 Yu (2021032204350864200_CIT0011) 2011; 17 Yu (2021032204350864200_CIT0008) 2019; 9 Coghill (2021032204350864200_CIT0010) 2018; 99 Liu (2021032204350864200_CIT0002) 2013; 177 Yu (2021032204350864200_CIT0006) 2009; 124 Hildesheim (2021032204350864200_CIT0004) 2013; 177 Rubicz (2021032204350864200_CIT0015) 2013; 9 Hildesheim (2021032204350864200_CIT0007) 2012; 22 Chang (2021032204350864200_CIT0001) 2006; 15 Coghill (2021032204350864200_CIT0005) 2018; 24 Pickard (2021032204350864200_CIT0009) 2004; 111 Guo (2021032204350864200_CIT0012) 2009; 124 |
| References_xml | – volume: 295 start-page: 65 year: 2006 ident: 2021032204350864200_CIT0013 article-title: Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level publication-title: JAMA doi: 10.1001/jama.295.1.65 – volume: 99 start-page: 1268 year: 2018 ident: 2021032204350864200_CIT0010 article-title: Elevated antibodies against Epstein-Barr virus among individuals predicted to carry nasopharyngeal carcinoma susceptibility variants publication-title: J Gen Virol doi: 10.1099/jgv.0.001115 – volume: 124 start-page: 1622 year: 2009 ident: 2021032204350864200_CIT0006 article-title: Cancer patterns in nasopharyngeal carcinoma multiplex families in Taiwan publication-title: Int J Cancer doi: 10.1002/ijc.24051 – volume: 177 start-page: 242 year: 2013 ident: 2021032204350864200_CIT0002 article-title: Two Epstein-Barr virus-related serologic antibody tests in nasopharyngeal carcinoma screening: results from the initial phase of a cluster randomized controlled trial in Southern China publication-title: Am J Epidemiol doi: 10.1093/aje/kws404 – volume: 124 start-page: 2942 year: 2009 ident: 2021032204350864200_CIT0012 article-title: Evaluation of nonviral risk factors for nasopharyngeal carcinoma in a high-risk population of Southern China publication-title: Int J Cancer doi: 10.1002/ijc.24293 – volume: 111 start-page: 117 year: 2004 ident: 2021032204350864200_CIT0009 article-title: Epstein-Barr virus seroreactivity among unaffected individuals within high-risk nasopharyngeal carcinoma families in Taiwan publication-title: Int J Cancer doi: 10.1002/ijc.20222 – volume: 30 start-page: 1630 year: 2019 ident: 2021032204350864200_CIT0003 article-title: Incidence and mortality of nasopharyngeal carcinoma: interim analysis of a cluster randomized controlled screening trial (PRO-NPC-001) in southern China publication-title: Ann Oncol doi: 10.1093/annonc/mdz231 – volume: 177 start-page: 251 year: 2013 ident: 2021032204350864200_CIT0004 article-title: Invited commentary: Epstein-Barr virus-based screening for the early detection of nasopharyngeal carcinoma: a new frontier publication-title: Am J Epidemiol doi: 10.1093/aje/kws403 – volume: 15 start-page: 1765 year: 2006 ident: 2021032204350864200_CIT0001 article-title: The enigmatic epidemiology of nasopharyngeal carcinoma publication-title: Cancer Epidemiol Biomarkers Prev doi: 10.1158/1055-9965.EPI-06-0353 – volume: 94 start-page: 1780 year: 2002 ident: 2021032204350864200_CIT0014 article-title: Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan publication-title: J Natl Cancer Inst doi: 10.1093/jnci/94.23.1780 – volume: 24 start-page: 1305 year: 2018 ident: 2021032204350864200_CIT0005 article-title: Identification of a novel, EBV-based antibody risk stratification signature for early detection of nasopharyngeal carcinoma in Taiwan publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-17-1929 – volume: 9 start-page: 9916 year: 2019 ident: 2021032204350864200_CIT0008 article-title: Whole-exome sequencing of nasopharyngeal carcinoma families reveals novel variants potentially involved in nasopharyngeal carcinoma publication-title: Sci Rep doi: 10.1038/s41598-019-46137-4 – volume: 22 start-page: 107 year: 2012 ident: 2021032204350864200_CIT0007 article-title: Genetic predisposition factors and nasopharyngeal carcinoma risk: a review of epidemiological association studies, 2000–2011: Rosetta stone for NPC: genetics, viral infection, and other environmental factors publication-title: Semin Cancer Biol doi: 10.1016/j.semcancer.2012.01.007 – volume: 17 start-page: 1906 year: 2011 ident: 2021032204350864200_CIT0011 article-title: Prognostic utility of anti-EBV antibody testing for defining NPC risk among individuals from high-risk NPC families publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-10-1681 – volume: 9 start-page: e1003147 year: 2013 ident: 2021032204350864200_CIT0015 article-title: A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1) publication-title: PLoS Genet doi: 10.1371/journal.pgen.1003147 |
| SSID | ssj0004367 |
| Score | 2.399143 |
| Snippet | Abstract
Nasopharyngeal carcinoma (NPC) is caused by Epstein-Barr virus (EBV) and is more likely to occur in susceptible families. Whether genetic... Nasopharyngeal carcinoma (NPC) is caused by Epstein-Barr virus (EBV) and is more likely to occur in susceptible families. Whether genetic susceptibility... |
| SourceID | unpaywall pubmedcentral proquest pubmed crossref oup |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 441 |
| SubjectTerms | Epstein-Barr virus Families & family life Genetic factors Head & neck cancer Health risks Major and Brief Reports Nasopharyngeal carcinoma Prediction models Throat cancer |
| Title | Epstein-Barr Virus-Based Nasopharyngeal Carcinoma (NPC) Risk Prediction Scores Are Elevated in NPC Multiplex Family Members in Taiwan |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/32614957 https://www.proquest.com/docview/2547579576 https://www.proquest.com/docview/2420145853 https://pubmed.ncbi.nlm.nih.gov/PMC7982447 https://www.ncbi.nlm.nih.gov/pmc/articles/7982447 |
| UnpaywallVersion | submittedVersion |
| Volume | 223 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1537-6613 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0004367 issn: 1537-6613 databaseCode: KQ8 dateStart: 19970401 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1537-6613 dateEnd: 20241001 omitProxy: true ssIdentifier: ssj0004367 issn: 1537-6613 databaseCode: DIK dateStart: 19970101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1537-6613 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0004367 issn: 1537-6613 databaseCode: GX1 dateStart: 0 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbKEJcXBONWGMggJIaqbCTO9XFUHdVEpwl1qDxFTuKwTCWrkoZS3vlf_DTOiZ0bG9rgJYqc40bp-XJ8Yh9_HyGvuM6iyA0DjTPBNVPEseaaWONumzHk67FhlVqHk0N7fGwezKxZr_erVbVULIOd8MeF-0r-x6vQBn7FXbL_4Nn6R6EBzsG_cAQPw_FKPh4tchSr1N7xLBt8SrIih9McUshDjuoEPFunX5A4eIiCQenZV15q7xwNcSrgI9aUH2W4TiODBvJZ5oO9TAxGc_GNYyaapAOwHkxU0eH3SiZjIlBGpKyknfJkpQB22gDvoM1HIau9irxaDKqzeFUENBGJNs6LBqbjQk1ify60cdPcIt9G2udmD8WHpCjXWE6SlUja0xiGjpXPchdqa1uB7kq1pB1RRWMHUKPMVLg2DNbCJWsFX1NSaKlx3JS8kueGCEmfBU0RkjjsnyacM6ka1GXj_mOUrGsX5ao98-Uv-Kr_NXLdcGwbNTTez5oiI5PZTsVXjw9X04ayXdl_V_XvpEWdrZatL57zhbu3inTB1ys-n7eyouldckf5me5JbN4jPZFukhtS4HS9SW5OVOnGffKzDVbaAivtgpXWYKXbAL43FIFKG6BSCVS4paAVUGmSUrClNVCpBCpVQMXrEqgPyPH-aDoca0oDRAtNy1gCRFCCgVluEIQ6LjIHngXhg0UhfBgbtqW7nDEWCc_iyD6I6giuF4Ue83joxG85e0g20rNUPCY0ZAYPDDeyuGOYtjC8KNYdZprCtbyQu1GfaJUL_FAR5KNOy9y_2OV98rq2X0hqmL9avgSPXmq0VTncVzEm9w3LdCzHsxy7T17Ul2EEwGU9ngp4eX1IsrE2APLuPnkk8VHfCj7OcArE6ROng5zaANnlu1fS5KRkmXc8F1J_6LldY-ySJ3hy5T_kKbndxIAtsrHMCvEMkvtl8Lx8f34DT87_rw |
| linkProvider | Geneva Foundation for Medical Education and Research |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Epstein-Barr+Virus-Based+Nasopharyngeal+Carcinoma+%28NPC%29+Risk+Prediction+Scores+Are+Elevated+in+NPC+Multiplex+Family+Members+in+Taiwan&rft.jtitle=The+Journal+of+infectious+diseases&rft.au=Lee%2C+Mei-Hsuan&rft.au=Huang%2C+Yu-Han&rft.au=Coghill%2C+Anna+E&rft.au=Liu%2C+Zhiwei&rft.date=2021-02-13&rft.issn=0022-1899&rft.eissn=1537-6613&rft.volume=223&rft.issue=3&rft.spage=441&rft.epage=444&rft_id=info:doi/10.1093%2Finfdis%2Fjiaa385&rft.externalDBID=n%2Fa&rft.externalDocID=10_1093_infdis_jiaa385 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-1899&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-1899&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-1899&client=summon |