Cutaneous carcinosarcoma: a series of six cases and a review of the literature
Background Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial and mesenchymal components in cutaneous carcinosarcoma are variable, as an assortment of carcinomatous and sarcomatous patterns have been des...
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Published in | Journal of cutaneous pathology Vol. 44; no. 1; pp. 34 - 44 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.01.2017
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
ISSN | 0303-6987 1600-0560 1600-0560 |
DOI | 10.1111/cup.12843 |
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Abstract | Background
Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial and mesenchymal components in cutaneous carcinosarcoma are variable, as an assortment of carcinomatous and sarcomatous patterns have been described in the literature.
Methods
Clinical information was obtained from patient charts and archival slides were retrieved and reviewed.
Results
We present a novel series of six distinct cases of cutaneous carcinosarcoma and review the literature. Our cases consisted of basal cell, pilomatrical, squamous cell, and trichoblastic variants. These cases occurred in elderly men on sun exposed skin with treatment and follow up was available for 4 of 6 cases. The four cases were treated with Mohs micrographic surgery with mean follow up of nine months.
Conclusion
We report six cases of cutaneous carcinosarcoma with distinctive clinical and histologic characterization not previously described in a single series. |
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AbstractList | Background
Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial and mesenchymal components in cutaneous carcinosarcoma are variable, as an assortment of carcinomatous and sarcomatous patterns have been described in the literature.
Methods
Clinical information was obtained from patient charts and archival slides were retrieved and reviewed.
Results
We present a novel series of six distinct cases of cutaneous carcinosarcoma and review the literature. Our cases consisted of basal cell, pilomatrical, squamous cell, and trichoblastic variants. These cases occurred in elderly men on sun exposed skin with treatment and follow up was available for 4 of 6 cases. The four cases were treated with Mohs micrographic surgery with mean follow up of nine months.
Conclusion
We report six cases of cutaneous carcinosarcoma with distinctive clinical and histologic characterization not previously described in a single series. Background Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial and mesenchymal components in cutaneous carcinosarcoma are variable, as an assortment of carcinomatous and sarcomatous patterns have been described in the literature. Methods Clinical information was obtained from patient charts and archival slides were retrieved and reviewed. Results We present a novel series of six distinct cases of cutaneous carcinosarcoma and review the literature. Our cases consisted of basal cell, pilomatrical, squamous cell, and trichoblastic variants. These cases occurred in elderly men on sun exposed skin with treatment and follow up was available for 4 of 6 cases. The four cases were treated with Mohs micrographic surgery with mean follow up of nine months. Conclusion We report six cases of cutaneous carcinosarcoma with distinctive clinical and histologic characterization not previously described in a single series. Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial and mesenchymal components in cutaneous carcinosarcoma are variable, as an assortment of carcinomatous and sarcomatous patterns have been described in the literature.BACKGROUNDCutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial and mesenchymal components in cutaneous carcinosarcoma are variable, as an assortment of carcinomatous and sarcomatous patterns have been described in the literature.Clinical information was obtained from patient charts and archival slides were retrieved and reviewed.METHODSClinical information was obtained from patient charts and archival slides were retrieved and reviewed.We present a novel series of six distinct cases of cutaneous carcinosarcoma and review the literature. Our cases consisted of basal cell, pilomatrical, squamous cell, and trichoblastic variants. These cases occurred in elderly men on sun exposed skin with treatment and follow up was available for 4 of 6 cases. The four cases were treated with Mohs micrographic surgery with mean follow up of nine months.RESULTSWe present a novel series of six distinct cases of cutaneous carcinosarcoma and review the literature. Our cases consisted of basal cell, pilomatrical, squamous cell, and trichoblastic variants. These cases occurred in elderly men on sun exposed skin with treatment and follow up was available for 4 of 6 cases. The four cases were treated with Mohs micrographic surgery with mean follow up of nine months.We report six cases of cutaneous carcinosarcoma with distinctive clinical and histologic characterization not previously described in a single series.CONCLUSIONWe report six cases of cutaneous carcinosarcoma with distinctive clinical and histologic characterization not previously described in a single series. Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial and mesenchymal components in cutaneous carcinosarcoma are variable, as an assortment of carcinomatous and sarcomatous patterns have been described in the literature. Clinical information was obtained from patient charts and archival slides were retrieved and reviewed. We present a novel series of six distinct cases of cutaneous carcinosarcoma and review the literature. Our cases consisted of basal cell, pilomatrical, squamous cell, and trichoblastic variants. These cases occurred in elderly men on sun exposed skin with treatment and follow up was available for 4 of 6 cases. The four cases were treated with Mohs micrographic surgery with mean follow up of nine months. We report six cases of cutaneous carcinosarcoma with distinctive clinical and histologic characterization not previously described in a single series. |
Author | Clark, Joshua J. Bowen, Anneli R. Hyngstrom, John R. Florell, Scott R. Bowen, Glen M. Wada, David A. Hadley, Michael L. Duffy, Keith |
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Keywords | histopathology carcinosarcoma dermatopathology cutaneous neoplasm cutaneous carcinosarcoma |
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Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial... Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial and... Background Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial... |
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SubjectTerms | Aged Aged, 80 and over Biomarkers, Tumor - analysis carcinosarcoma Carcinosarcoma - pathology cutaneous carcinosarcoma cutaneous neoplasm dermatopathology Female Geriatrics histopathology Humans Immunohistochemistry Literature reviews Male Mesenchyme Skin Skin Neoplasms - pathology Surgery |
Title | Cutaneous carcinosarcoma: a series of six cases and a review of the literature |
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