Cutaneous carcinosarcoma: a series of six cases and a review of the literature

Background Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial and mesenchymal components in cutaneous carcinosarcoma are variable, as an assortment of carcinomatous and sarcomatous patterns have been des...

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Published inJournal of cutaneous pathology Vol. 44; no. 1; pp. 34 - 44
Main Authors Clark, Joshua J., Bowen, Anneli R., Bowen, Glen M., Hyngstrom, John R., Hadley, Michael L., Duffy, Keith, Florell, Scott R., Wada, David A.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.01.2017
Wiley Subscription Services, Inc
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ISSN0303-6987
1600-0560
1600-0560
DOI10.1111/cup.12843

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Abstract Background Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial and mesenchymal components in cutaneous carcinosarcoma are variable, as an assortment of carcinomatous and sarcomatous patterns have been described in the literature. Methods Clinical information was obtained from patient charts and archival slides were retrieved and reviewed. Results We present a novel series of six distinct cases of cutaneous carcinosarcoma and review the literature. Our cases consisted of basal cell, pilomatrical, squamous cell, and trichoblastic variants. These cases occurred in elderly men on sun exposed skin with treatment and follow up was available for 4 of 6 cases. The four cases were treated with Mohs micrographic surgery with mean follow up of nine months. Conclusion We report six cases of cutaneous carcinosarcoma with distinctive clinical and histologic characterization not previously described in a single series.
AbstractList Background Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial and mesenchymal components in cutaneous carcinosarcoma are variable, as an assortment of carcinomatous and sarcomatous patterns have been described in the literature. Methods Clinical information was obtained from patient charts and archival slides were retrieved and reviewed. Results We present a novel series of six distinct cases of cutaneous carcinosarcoma and review the literature. Our cases consisted of basal cell, pilomatrical, squamous cell, and trichoblastic variants. These cases occurred in elderly men on sun exposed skin with treatment and follow up was available for 4 of 6 cases. The four cases were treated with Mohs micrographic surgery with mean follow up of nine months. Conclusion We report six cases of cutaneous carcinosarcoma with distinctive clinical and histologic characterization not previously described in a single series.
Background Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial and mesenchymal components in cutaneous carcinosarcoma are variable, as an assortment of carcinomatous and sarcomatous patterns have been described in the literature. Methods Clinical information was obtained from patient charts and archival slides were retrieved and reviewed. Results We present a novel series of six distinct cases of cutaneous carcinosarcoma and review the literature. Our cases consisted of basal cell, pilomatrical, squamous cell, and trichoblastic variants. These cases occurred in elderly men on sun exposed skin with treatment and follow up was available for 4 of 6 cases. The four cases were treated with Mohs micrographic surgery with mean follow up of nine months. Conclusion We report six cases of cutaneous carcinosarcoma with distinctive clinical and histologic characterization not previously described in a single series.
Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial and mesenchymal components in cutaneous carcinosarcoma are variable, as an assortment of carcinomatous and sarcomatous patterns have been described in the literature.BACKGROUNDCutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial and mesenchymal components in cutaneous carcinosarcoma are variable, as an assortment of carcinomatous and sarcomatous patterns have been described in the literature.Clinical information was obtained from patient charts and archival slides were retrieved and reviewed.METHODSClinical information was obtained from patient charts and archival slides were retrieved and reviewed.We present a novel series of six distinct cases of cutaneous carcinosarcoma and review the literature. Our cases consisted of basal cell, pilomatrical, squamous cell, and trichoblastic variants. These cases occurred in elderly men on sun exposed skin with treatment and follow up was available for 4 of 6 cases. The four cases were treated with Mohs micrographic surgery with mean follow up of nine months.RESULTSWe present a novel series of six distinct cases of cutaneous carcinosarcoma and review the literature. Our cases consisted of basal cell, pilomatrical, squamous cell, and trichoblastic variants. These cases occurred in elderly men on sun exposed skin with treatment and follow up was available for 4 of 6 cases. The four cases were treated with Mohs micrographic surgery with mean follow up of nine months.We report six cases of cutaneous carcinosarcoma with distinctive clinical and histologic characterization not previously described in a single series.CONCLUSIONWe report six cases of cutaneous carcinosarcoma with distinctive clinical and histologic characterization not previously described in a single series.
Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial and mesenchymal components in cutaneous carcinosarcoma are variable, as an assortment of carcinomatous and sarcomatous patterns have been described in the literature. Clinical information was obtained from patient charts and archival slides were retrieved and reviewed. We present a novel series of six distinct cases of cutaneous carcinosarcoma and review the literature. Our cases consisted of basal cell, pilomatrical, squamous cell, and trichoblastic variants. These cases occurred in elderly men on sun exposed skin with treatment and follow up was available for 4 of 6 cases. The four cases were treated with Mohs micrographic surgery with mean follow up of nine months. We report six cases of cutaneous carcinosarcoma with distinctive clinical and histologic characterization not previously described in a single series.
Author Clark, Joshua J.
Bowen, Anneli R.
Hyngstrom, John R.
Florell, Scott R.
Bowen, Glen M.
Wada, David A.
Hadley, Michael L.
Duffy, Keith
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Keywords histopathology
carcinosarcoma
dermatopathology
cutaneous neoplasm
cutaneous carcinosarcoma
Language English
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Snippet Background Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial...
Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial and...
Background Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial...
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StartPage 34
SubjectTerms Aged
Aged, 80 and over
Biomarkers, Tumor - analysis
carcinosarcoma
Carcinosarcoma - pathology
cutaneous carcinosarcoma
cutaneous neoplasm
dermatopathology
Female
Geriatrics
histopathology
Humans
Immunohistochemistry
Literature reviews
Male
Mesenchyme
Skin
Skin Neoplasms - pathology
Surgery
Title Cutaneous carcinosarcoma: a series of six cases and a review of the literature
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fcup.12843
https://www.ncbi.nlm.nih.gov/pubmed/27730657
https://www.proquest.com/docview/1920467715
https://www.proquest.com/docview/1835402139
https://www.proquest.com/docview/1859472960
Volume 44
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