Critical Roles of N6-Methyladenosine (m6A) in Cancer and Virus Infection

Studies have shown that epigenetic abnormalities are involved in various diseases, including cancer. In particular, in order to realize precision medicine, the integrated analysis of genetics and epigenetics is considered to be important; detailed epigenetic analysis in the medical field has been be...

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Published inBiomolecules (Basel, Switzerland) Vol. 10; no. 7; p. 1071
Main Authors Asada, Ken, Bolatkan, Amina, Takasawa, Ken, Komatsu, Masaaki, Kaneko, Syuzo, Hamamoto, Ryuji
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 17.07.2020
MDPI
Subjects
Cancer
Coronaviruses
COVID-19
Disease transmission
DNA methylation
Epigenetics
Gene expression
Infections
methylation
MicroRNAs
N6-methyladenosine
Precision medicine
Proteins
Proteomics
Review
RNA modification
RNA virus
Severe acute respiratory syndrome coronavirus 2
Online AccessGet full text
ISSN2218-273X
2218-273X
DOI10.3390/biom10071071

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Abstract Studies have shown that epigenetic abnormalities are involved in various diseases, including cancer. In particular, in order to realize precision medicine, the integrated analysis of genetics and epigenetics is considered to be important; detailed epigenetic analysis in the medical field has been becoming increasingly important. In the epigenetics analysis, DNA methylation and histone modification analyses have been actively studied for a long time, and many important findings were accumulated. On the other hand, recently, attention has also been focused on RNA modification in the field of epigenetics; now it is known that RNA modification is associated with various biological functions, such as regulation of gene expression. Among RNA modifications, functional analysis of N6-methyladenosine (m6A), the most abundant RNA modification found from humans to plants is actively progressing, and it has also been known that m6A abnormality is involved in cancer and other diseases. Importantly, recent studies have shown that m6A is related to viral infections. Considering the current world situation under threat of viral infections, it is important to deepen knowledge of RNA modification from the viewpoint of viral diseases. Hence, in this review, we have summarized the recent findings regarding the roles of RNA modifications in biological functions, cancer biology, and virus infection, particularly focusing on m6A in mRNA.
AbstractList Studies have shown that epigenetic abnormalities are involved in various diseases, including cancer. In particular, in order to realize precision medicine, the integrated analysis of genetics and epigenetics is considered to be important; detailed epigenetic analysis in the medical field has been becoming increasingly important. In the epigenetics analysis, DNA methylation and histone modification analyses have been actively studied for a long time, and many important findings were accumulated. On the other hand, recently, attention has also been focused on RNA modification in the field of epigenetics; now it is known that RNA modification is associated with various biological functions, such as regulation of gene expression. Among RNA modifications, functional analysis of N6-methyladenosine (m6A), the most abundant RNA modification found from humans to plants is actively progressing, and it has also been known that m6A abnormality is involved in cancer and other diseases. Importantly, recent studies have shown that m6A is related to viral infections. Considering the current world situation under threat of viral infections, it is important to deepen knowledge of RNA modification from the viewpoint of viral diseases. Hence, in this review, we have summarized the recent findings regarding the roles of RNA modifications in biological functions, cancer biology, and virus infection, particularly focusing on m6A in mRNA.
Studies have shown that epigenetic abnormalities are involved in various diseases, including cancer. In particular, in order to realize precision medicine, the integrated analysis of genetics and epigenetics is considered to be important; detailed epigenetic analysis in the medical field has been becoming increasingly important. In the epigenetics analysis, DNA methylation and histone modification analyses have been actively studied for a long time, and many important findings were accumulated. On the other hand, recently, attention has also been focused on RNA modification in the field of epigenetics; now it is known that RNA modification is associated with various biological functions, such as regulation of gene expression. Among RNA modifications, functional analysis of N6-methyladenosine (m6A), the most abundant RNA modification found from humans to plants is actively progressing, and it has also been known that m6A abnormality is involved in cancer and other diseases. Importantly, recent studies have shown that m6A is related to viral infections. Considering the current world situation under threat of viral infections, it is important to deepen knowledge of RNA modification from the viewpoint of viral diseases. Hence, in this review, we have summarized the recent findings regarding the roles of RNA modifications in biological functions, cancer biology, and virus infection, particularly focusing on m6A in mRNA.Studies have shown that epigenetic abnormalities are involved in various diseases, including cancer. In particular, in order to realize precision medicine, the integrated analysis of genetics and epigenetics is considered to be important; detailed epigenetic analysis in the medical field has been becoming increasingly important. In the epigenetics analysis, DNA methylation and histone modification analyses have been actively studied for a long time, and many important findings were accumulated. On the other hand, recently, attention has also been focused on RNA modification in the field of epigenetics; now it is known that RNA modification is associated with various biological functions, such as regulation of gene expression. Among RNA modifications, functional analysis of N6-methyladenosine (m6A), the most abundant RNA modification found from humans to plants is actively progressing, and it has also been known that m6A abnormality is involved in cancer and other diseases. Importantly, recent studies have shown that m6A is related to viral infections. Considering the current world situation under threat of viral infections, it is important to deepen knowledge of RNA modification from the viewpoint of viral diseases. Hence, in this review, we have summarized the recent findings regarding the roles of RNA modifications in biological functions, cancer biology, and virus infection, particularly focusing on m6A in mRNA.
Author Hamamoto, Ryuji
Asada, Ken
Takasawa, Ken
Kaneko, Syuzo
Komatsu, Masaaki
Bolatkan, Amina
AuthorAffiliation 1 Cancer Translational Research Team, RIKEN Center for Advanced Intelligence Project, 1-4-1 Nihonbashi, Chuo-ku, Tokyo 103-0027, Japan; abolatka@ncc.go.jp (A.B.); ktakazaw@ncc.go.jp (K.T.); maskomat@ncc.go.jp (M.K.)
2 Division of Molecular Modification and Cancer Biology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan; sykaneko@ncc.go.jp
AuthorAffiliation_xml – name: 2 Division of Molecular Modification and Cancer Biology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan; sykaneko@ncc.go.jp
– name: 1 Cancer Translational Research Team, RIKEN Center for Advanced Intelligence Project, 1-4-1 Nihonbashi, Chuo-ku, Tokyo 103-0027, Japan; abolatka@ncc.go.jp (A.B.); ktakazaw@ncc.go.jp (K.T.); maskomat@ncc.go.jp (M.K.)
Author_xml – sequence: 1
  givenname: Ken
  orcidid: 0000-0003-0548-4449
  surname: Asada
  fullname: Asada, Ken
– sequence: 2
  givenname: Amina
  surname: Bolatkan
  fullname: Bolatkan, Amina
– sequence: 3
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  orcidid: 0000-0001-8699-0858
  surname: Takasawa
  fullname: Takasawa, Ken
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  givenname: Masaaki
  orcidid: 0000-0003-0421-8085
  surname: Komatsu
  fullname: Komatsu, Masaaki
– sequence: 5
  givenname: Syuzo
  surname: Kaneko
  fullname: Kaneko, Syuzo
– sequence: 6
  givenname: Ryuji
  surname: Hamamoto
  fullname: Hamamoto, Ryuji
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Snippet Studies have shown that epigenetic abnormalities are involved in various diseases, including cancer. In particular, in order to realize precision medicine, the...
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SubjectTerms Cancer
Coronaviruses
COVID-19
Disease transmission
DNA methylation
Epigenetics
Gene expression
Infections
methylation
MicroRNAs
N6-methyladenosine
Precision medicine
Proteins
Proteomics
Review
RNA modification
RNA virus
Severe acute respiratory syndrome coronavirus 2
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