Protein Corona in Response to Flow: Effect on Protein Concentration and Structure
Nanoparticles used in cellular applications encounter free serum proteins that adsorb onto the surface of the nanoparticle, forming a protein corona. This protein layer controls the interaction of nanoparticles with cells. For nanomedicine applications, it is important to consider how intravenous in...
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| Published in | Biophysical journal Vol. 115; no. 2; pp. 209 - 216 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
17.07.2018
The Biophysical Society |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0006-3495 1542-0086 1542-0086 |
| DOI | 10.1016/j.bpj.2018.02.036 |
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| Abstract | Nanoparticles used in cellular applications encounter free serum proteins that adsorb onto the surface of the nanoparticle, forming a protein corona. This protein layer controls the interaction of nanoparticles with cells. For nanomedicine applications, it is important to consider how intravenous injection and the subsequent shear flow will affect the protein corona. Our goal was to determine if shear flow changed the composition of the protein corona and if these changes affected cellular binding. Colorimetric assays of protein concentration and gel electrophoresis demonstrate that polystyrene nanoparticles subjected to flow have a greater concentration of serum proteins adsorbed on the surface, especially plasminogen. Plasminogen, in the absence of nanoparticles, undergoes changes in structure in response to flow, characterized by fluorescence and circular dichroism spectroscopy. The protein-nanoparticle complexes formed from fetal bovine serum after flow had decreased cellular binding, as measured with flow cytometry. In addition to the relevance for nanomedicine, these results also highlight the technical challenges of protein corona studies. The composition of the protein corona was highly dependent on the initial mixing step: rocking, vortexing, or flow. Overall, these results reaffirm the importance of the protein corona in nanoparticle-cell interactions and point toward the challenges of predicting corona composition based on nanoparticle properties. |
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| AbstractList | Nanoparticles used in cellular applications encounter free serum proteins that adsorb onto the surface of the nanoparticle, forming a protein corona. This protein layer controls the interaction of nanoparticles with cells. For nanomedicine applications, it is important to consider how intravenous injection and the subsequent shear flow will affect the protein corona. Our goal was to determine if shear flow changed the composition of the protein corona and if these changes affected cellular binding. Colorimetric assays of protein concentration and gel electrophoresis demonstrate that polystyrene nanoparticles subjected to flow have a greater concentration of serum proteins adsorbed on the surface, especially plasminogen. Plasminogen, in the absence of nanoparticles, undergoes changes in structure in response to flow, characterized by fluorescence and circular dichroism spectroscopy. The protein-nanoparticle complexes formed from fetal bovine serum after flow had decreased cellular binding, as measured with flow cytometry. In addition to the relevance for nanomedicine, these results also highlight the technical challenges of protein corona studies. The composition of the protein corona was highly dependent on the initial mixing step: rocking, vortexing, or flow. Overall, these results reaffirm the importance of the protein corona in nanoparticle-cell interactions and point toward the challenges of predicting corona composition based on nanoparticle properties. Nanoparticles used in cellular applications encounter free serum proteins that adsorb onto the surface of the nanoparticle, forming a protein corona. This protein layer controls the interaction of nanoparticles with cells. For nanomedicine applications, it is important to consider how intravenous injection and the subsequent shear flow will affect the protein corona. Our goal was to determine if shear flow changed the composition of the protein corona and if these changes affected cellular binding. Colorimetric assays of protein concentration and gel electrophoresis demonstrate that polystyrene nanoparticles subjected to flow have a greater concentration of serum proteins adsorbed on the surface, especially plasminogen. Plasminogen, in the absence of nanoparticles, undergoes changes in structure in response to flow, characterized by fluorescence and circular dichroism spectroscopy. The protein-nanoparticle complexes formed from fetal bovine serum after flow had decreased cellular binding, as measured with flow cytometry. In addition to the relevance for nanomedicine, these results also highlight the technical challenges of protein corona studies. The composition of the protein corona was highly dependent on the initial mixing step: rocking, vortexing, or flow. Overall, these results reaffirm the importance of the protein corona in nanoparticle-cell interactions and point toward the challenges of predicting corona composition based on nanoparticle properties.Nanoparticles used in cellular applications encounter free serum proteins that adsorb onto the surface of the nanoparticle, forming a protein corona. This protein layer controls the interaction of nanoparticles with cells. For nanomedicine applications, it is important to consider how intravenous injection and the subsequent shear flow will affect the protein corona. Our goal was to determine if shear flow changed the composition of the protein corona and if these changes affected cellular binding. Colorimetric assays of protein concentration and gel electrophoresis demonstrate that polystyrene nanoparticles subjected to flow have a greater concentration of serum proteins adsorbed on the surface, especially plasminogen. Plasminogen, in the absence of nanoparticles, undergoes changes in structure in response to flow, characterized by fluorescence and circular dichroism spectroscopy. The protein-nanoparticle complexes formed from fetal bovine serum after flow had decreased cellular binding, as measured with flow cytometry. In addition to the relevance for nanomedicine, these results also highlight the technical challenges of protein corona studies. The composition of the protein corona was highly dependent on the initial mixing step: rocking, vortexing, or flow. Overall, these results reaffirm the importance of the protein corona in nanoparticle-cell interactions and point toward the challenges of predicting corona composition based on nanoparticle properties. |
| Author | Jayaram, Dhanya T. Pustulka, Samantha M. Mannino, Robert G. Payne, Christine K. Lam, Wilbur A. |
| AuthorAffiliation | 2 School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 1 School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 4 Division of Pediatric Hematology/Oncology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 5 Children’s Healthcare of Atlanta, Aflac Cancer & Blood Disorders Center, Atlanta, Georgia 3 The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 6 Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia |
| AuthorAffiliation_xml | – name: 3 The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia – name: 1 School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia – name: 6 Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia – name: 5 Children’s Healthcare of Atlanta, Aflac Cancer & Blood Disorders Center, Atlanta, Georgia – name: 4 Division of Pediatric Hematology/Oncology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia – name: 2 School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia |
| Author_xml | – sequence: 1 givenname: Dhanya T. surname: Jayaram fullname: Jayaram, Dhanya T. organization: School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia – sequence: 2 givenname: Samantha M. surname: Pustulka fullname: Pustulka, Samantha M. organization: School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia – sequence: 3 givenname: Robert G. surname: Mannino fullname: Mannino, Robert G. organization: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia – sequence: 4 givenname: Wilbur A. surname: Lam fullname: Lam, Wilbur A. organization: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia – sequence: 5 givenname: Christine K. surname: Payne fullname: Payne, Christine K. email: christine.payne@duke.edu organization: School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia |
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| SubjectTerms | Adsorption Animals Cattle HeLa Cells Humans Hydrodynamics Nanoparticles - chemistry Plasminogen - chemistry Plasminogen - metabolism Polystyrenes - chemistry Protein Corona - chemistry |
| Title | Protein Corona in Response to Flow: Effect on Protein Concentration and Structure |
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