MEK Is a Therapeutic and Chemopreventative Target in Squamous Cell Carcinoma
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| Published in | Journal of investigative dermatology Vol. 136; no. 9; pp. 1920 - 1924 |
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| Main Authors | , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.09.2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-202X 1523-1747 1523-1747 |
| DOI | 10.1016/j.jid.2016.05.110 |
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| Author | Truong, Kimberly A. Bansal, Varun Tsai, Kenneth Y. Nicholas, Courtney South, Andrew P. Lee, Woojin Flores, Elsa R. Saporito, Rachael C. Leigh, Irene M. Mino, Barbara Napoli, Marco Adelmann, Charles H. Gandee, Leah Du, Lili Coarfa, Cristian Liang, Roger J. Proby, Charlotte M. |
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| AuthorAffiliation | 3 Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 6 Jacqui Wood Cancer Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland 5 Centre Molecular Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland 7 Department of Molecular Biology, Baylor College of Medicine, Houston, TX 77030 4 Department of Dermatology, Jefferson University, Philadelphia, PA 19107 1 Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 2 Department of Molecular & Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 |
| AuthorAffiliation_xml | – name: 6 Jacqui Wood Cancer Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland – name: 7 Department of Molecular Biology, Baylor College of Medicine, Houston, TX 77030 – name: 3 Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 – name: 2 Department of Molecular & Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 – name: 5 Centre Molecular Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland – name: 1 Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 – name: 4 Department of Dermatology, Jefferson University, Philadelphia, PA 19107 |
| Author_xml | – sequence: 1 givenname: Charles H. surname: Adelmann fullname: Adelmann, Charles H. organization: Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA – sequence: 2 givenname: Kimberly A. surname: Truong fullname: Truong, Kimberly A. organization: Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA – sequence: 3 givenname: Roger J. surname: Liang fullname: Liang, Roger J. organization: Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA – sequence: 4 givenname: Varun surname: Bansal fullname: Bansal, Varun organization: Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA – sequence: 5 givenname: Leah surname: Gandee fullname: Gandee, Leah organization: Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA – sequence: 6 givenname: Rachael C. surname: Saporito fullname: Saporito, Rachael C. organization: Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA – sequence: 7 givenname: Woojin surname: Lee fullname: Lee, Woojin organization: Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA – sequence: 8 givenname: Lili surname: Du fullname: Du, Lili organization: Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA – sequence: 9 givenname: Courtney surname: Nicholas fullname: Nicholas, Courtney organization: Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA – sequence: 10 givenname: Marco surname: Napoli fullname: Napoli, Marco organization: Department of Molecular & Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA – sequence: 11 givenname: Barbara surname: Mino fullname: Mino, Barbara organization: Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA – sequence: 12 givenname: Andrew P. surname: South fullname: South, Andrew P. organization: Department of Dermatology, Jefferson University, Philadelphia, Pennsylvania, USA – sequence: 13 givenname: Charlotte M. surname: Proby fullname: Proby, Charlotte M. organization: Centre Molecular Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland – sequence: 14 givenname: Irene M. surname: Leigh fullname: Leigh, Irene M. organization: Jacqui Wood Cancer Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland – sequence: 15 givenname: Cristian surname: Coarfa fullname: Coarfa, Cristian organization: Department of Molecular Biology, Baylor College of Medicine, Houston, Texas, USA – sequence: 16 givenname: Elsa R. surname: Flores fullname: Flores, Elsa R. organization: Department of Molecular & Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA – sequence: 17 givenname: Kenneth Y. surname: Tsai fullname: Tsai, Kenneth Y. email: kytsai@mdanderson.org organization: Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA |
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| Cites_doi | 10.1038/nature01283 10.1200/JCO.2011.36.7680 10.1016/j.ejca.2015.06.110 10.1111/pcmr.12132 10.1016/j.jaad.2012.11.037 10.1038/jid.2014.154 10.1158/1078-0432.CCR-14-1768 10.7554/eLife.00969 10.1056/NEJMoa1210093 10.1056/NEJMoa1105358 10.1073/pnas.1114669108 10.1158/1940-6207.CAPR-11-0427 10.1158/1078-0432.CCR-14-1773 10.1038/onc.2011.180 10.1038/nrm3823 |
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| SubjectTerms | Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis - drug effects Azetidines - pharmacology Azetidines - therapeutic use Carcinoma, Squamous Cell - drug therapy Cell Line, Tumor Cellular Senescence - drug effects Humans Mitogen-Activated Protein Kinases - antagonists & inhibitors Molecular Targeted Therapy - methods Piperidines - pharmacology Piperidines - therapeutic use Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Pyridones - pharmacology Pyridones - therapeutic use Pyrimidinones - pharmacology Pyrimidinones - therapeutic use Skin Neoplasms - drug therapy Xenograft Model Antitumor Assays |
| Title | MEK Is a Therapeutic and Chemopreventative Target in Squamous Cell Carcinoma |
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