Daily magnesium supplements improve glucose handling in elderly subjects
We demonstrated similar plasma concentrations and urinary losses but lower erythrocyte magnesium concentrations (2.18 ± 0.04 vs 1.86 ± 0.03 mmol/L, P < 0.01) in twelve aged (77.8 ± 2.1 y) vs 25 young (36.1 ± 0.4 y), nonobese subjects. Subsequently, aged subjects were enrolled in a double-blind, r...
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| Published in | The American journal of clinical nutrition Vol. 55; no. 6; pp. 1161 - 1167 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Bethesda, MD
Elsevier Inc
01.06.1992
American Society for Clinical Nutrition |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0002-9165 1938-3207 |
| DOI | 10.1093/ajcn/55.6.1161 |
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| Abstract | We demonstrated similar plasma concentrations and urinary losses but lower erythrocyte magnesium concentrations (2.18 ± 0.04 vs 1.86 ± 0.03 mmol/L, P < 0.01) in twelve aged (77.8 ± 2.1 y) vs 25 young (36.1 ± 0.4 y), nonobese subjects. Subsequently, aged subjects were enrolled in a double-blind, randomized, crossover study in which placebo (for 4 wk) and chronic magnesium administration (CMA) (4.5 g/d for 4 wk) were provided. At the end of each treatment period an intravenous glucose tolerance test (0.33 g/kg body wt) and a euglycemic glucose clamp with simultaneous [D-3H]glucose infusion and indirect calorimetry were performed. CMA vs placebo significantly increased erythrocyte magnesium concentration and improved insulin response and action. Net increase in erythrocyte magnesium significantly and positively correlated with the decrease in erythrocyte membrane microviscosity and with the net increase in both insulin secretion and action. In aged patients, correction of a low erythrocyte magnesium concentration may allow an improvement of glucose handling. |
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| AbstractList | We demonstrated similar plasma concentrations and urinary losses but lower erythrocyte magnesium concentrations (2.18 +/- 0.04 vs 1.86 +/- 0.03 mmol/L, P less than 0.01) in twelve aged (77.8 +/- 2.1 y) vs 25 young (36.1 +/- 0.4 y), nonobese subjects. Subsequently, aged subjects were enrolled in a double-blind, randomized, crossover study in which placebo (for 4 wk) and chronic magnesium administration (CMA) (4.5 g/d for 4 wk) were provided. At the end of each treatment period an intravenous glucose tolerance test (0.33 g/kg body wt) and a euglycemic glucose clamp with simultaneous [D-3H]glucose infusion and indirect calorimetry were performed. CMA vs placebo significantly increased erythrocyte magnesium concentration and improved insulin response and action. Net increase in erythrocyte magnesium significantly and positively correlated with the decrease in erythrocyte membrane microviscosity and with the net increase in both insulin secretion and action. In aged patients, correction of a low erythrocyte magnesium concentration may allow an improvement of glucose handling. We demonstrated similar plasma concentrations and urinary losses but lower erythrocyte magnesium concentrations (2.18 ± 0.04 vs 1.86 ± 0.03 mmol/L, P < 0.01) in twelve aged (77.8 ± 2.1 y) vs 25 young (36.1 ± 0.4 y), nonobese subjects. Subsequently, aged subjects were enrolled in a double-blind, randomized, crossover study in which placebo (for 4 wk) and chronic magnesium administration (CMA) (4.5 g/d for 4 wk) were provided. At the end of each treatment period an intravenous glucose tolerance test (0.33 g/kg body wt) and a euglycemic glucose clamp with simultaneous [D-3H]glucose infusion and indirect calorimetry were performed. CMA vs placebo significantly increased erythrocyte magnesium concentration and improved insulin response and action. Net increase in erythrocyte magnesium significantly and positively correlated with the decrease in erythrocyte membrane microviscosity and with the net increase in both insulin secretion and action. In aged patients, correction of a low erythrocyte magnesium concentration may allow an improvement of glucose handling. We demonstrated similar plasma concentrations and urinary losses but lower erythrocyte magnesium concentrations (2.18 +/- 0.04 vs 1.86 +/- 0.03 mmol/L, P less than 0.01) in twelve aged (77.8 +/- 2.1 y) vs 25 young (36.1 +/- 0.4 y), nonobese subjects. Subsequently, aged subjects were enrolled in a double-blind, randomized, crossover study in which placebo (for 4 wk) and chronic magnesium administration (CMA) (4.5 g/d for 4 wk) were provided. At the end of each treatment period an intravenous glucose tolerance test (0.33 g/kg body wt) and a euglycemic glucose clamp with simultaneous [D-3H]glucose infusion and indirect calorimetry were performed. CMA vs placebo significantly increased erythrocyte magnesium concentration and improved insulin response and action. Net increase in erythrocyte magnesium significantly and positively correlated with the decrease in erythrocyte membrane microviscosity and with the net increase in both insulin secretion and action. In aged patients, correction of a low erythrocyte magnesium concentration may allow an improvement of glucose handling.We demonstrated similar plasma concentrations and urinary losses but lower erythrocyte magnesium concentrations (2.18 +/- 0.04 vs 1.86 +/- 0.03 mmol/L, P less than 0.01) in twelve aged (77.8 +/- 2.1 y) vs 25 young (36.1 +/- 0.4 y), nonobese subjects. Subsequently, aged subjects were enrolled in a double-blind, randomized, crossover study in which placebo (for 4 wk) and chronic magnesium administration (CMA) (4.5 g/d for 4 wk) were provided. At the end of each treatment period an intravenous glucose tolerance test (0.33 g/kg body wt) and a euglycemic glucose clamp with simultaneous [D-3H]glucose infusion and indirect calorimetry were performed. CMA vs placebo significantly increased erythrocyte magnesium concentration and improved insulin response and action. Net increase in erythrocyte magnesium significantly and positively correlated with the decrease in erythrocyte membrane microviscosity and with the net increase in both insulin secretion and action. In aged patients, correction of a low erythrocyte magnesium concentration may allow an improvement of glucose handling. We demonstrated similar plasma concentrations and urinary losses but lower erythrocyte magnesium concentrations (2.18 +/- 0.04 vs 1.86 +/- 0.03 mmol/L, P < 0.01) in twelve aged (77.8 +/- 2.1 y) vs 25 young (36.1 +/- 0.4 y), nonobese subjects. Subsequently, aged subjects were enrolled in a double-blind, randomized, crossover study in which placebo (for 4 wk) and chronic magnesium administration (CMA) (4.5 g/d for 4 wk) were provided. At the end of each treatment period an intravenous glucose tolerance test (0.33 g/kg body wt) and a euglycemic glucose clamp with simultaneous [D-3H]glucose infusion and indirect calorimetry were performed. CMA vs placebo significantly increased erythrocyte magnesium concentration and improved insulin response and action. Net increase in erythrocyte magnesium significantly and positively correlated with the decrease in erythrocyte membrane microviscosity and with the net increase in both insulin secretion and action. In aged patients, correction of a low erythrocyte magnesium concentration may allow an improvement of glucose handling. We demonstrated similar plasma concentrations and urinary losses but lower erythrocyte magnesium concentrations (2.18 +/- 0.04 vs 1.86 +/- 0.03 mmol/L, P 0.01) in twelve aged (77.8 +/- 2.1 y) vs 25 young (36.1 +/- 0.4 y), nonobese subjects. Subsequently, aged subjects were enrolled in a double-blind, randomized, crossover study in which placebo (for 4 wk) and chronic magnesium administration (CMA) (4.5 g/d for 4 wk) were provided. At the end of each treatment period an intravenous glucose tolerance test (0.33 g/kg body wt) and a euglycemic glucose clamp with simultaneous [D-3H]glucose infusion and indirect calorimetry were performed. CMA vs placebo significantly increased erythrocyte magnesium concentration and improved insulin response and action. Net increase in erythrocyte magnesium significantly and positively correlated with the decrease in erythrocyte membrane microviscosity and with the net increase in both insulin secretion and action. In aged patients, correction of a low erythrocyte magnesium concentration may allow an improvement of glucose handling |
| Author | Pizza, G Tesauro, P Paolisso, G Gambardella, A Varricchio, M D'Onofrio, F Sgambato, S |
| Author_xml | – sequence: 1 givenname: G surname: Paolisso fullname: Paolisso, G organization: From the Department of Geriatric Medicine and Metabolic Diseases and the Cattedra di Diagnostica Radioisotopic, 1st Medical School, University of Naples, Naples, Italy – sequence: 2 givenname: S surname: Sgambato fullname: Sgambato, S organization: From the Department of Geriatric Medicine and Metabolic Diseases and the Cattedra di Diagnostica Radioisotopic, 1st Medical School, University of Naples, Naples, Italy – sequence: 3 givenname: A surname: Gambardella fullname: Gambardella, A organization: From the Department of Geriatric Medicine and Metabolic Diseases and the Cattedra di Diagnostica Radioisotopic, 1st Medical School, University of Naples, Naples, Italy – sequence: 4 givenname: G surname: Pizza fullname: Pizza, G organization: From the Department of Geriatric Medicine and Metabolic Diseases and the Cattedra di Diagnostica Radioisotopic, 1st Medical School, University of Naples, Naples, Italy – sequence: 5 givenname: P surname: Tesauro fullname: Tesauro, P organization: From the Department of Geriatric Medicine and Metabolic Diseases and the Cattedra di Diagnostica Radioisotopic, 1st Medical School, University of Naples, Naples, Italy – sequence: 6 givenname: M surname: Varricchio fullname: Varricchio, M organization: From the Department of Geriatric Medicine and Metabolic Diseases and the Cattedra di Diagnostica Radioisotopic, 1st Medical School, University of Naples, Naples, Italy – sequence: 7 givenname: F surname: D'Onofrio fullname: D'Onofrio, F organization: From the Department of Geriatric Medicine and Metabolic Diseases and the Cattedra di Diagnostica Radioisotopic, 1st Medical School, University of Naples, Naples, Italy |
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| Copyright | 1992 American Society for Nutrition. 1992 INIST-CNRS |
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| Keywords | glucose homeostasis plasma lactate Magnesium hepatic glucose output glucose disappearance rate membrane microviscosity Human Oligoelement Carbohydrate Glucose Metabolism Elderly |
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| References | Lostroh, Krahl (bib24) 1973; 291 Paolisso, Sgambato, Pizza, Passariello, Varricchio, D’Onofrio (bib9) 1989; 12 Groop, Bonadonna, Del, et (bib15) 1989; 84 Paolisso, Salvatore, Sgambato, et (bib13) 1990; 123 Jackson (bib3) 1990; 13 Rowe, Minaker, Pallotta, Flier (bib2) 1983; 71 Henquin, Nenquin, Awouters, Cogneau (bib21) 1986; 155 Legrand, Okitolonda, Pottier, Lederer, Henquin (bib22) 1987; 36 Steele (bib14) 1959; 82 Paolisso, Scheen, D’Onofrio, Lefebvre (bib6) 1990; 33 Paolisso, Sacchettino, Sgambato, Gentile, Varricchio, D’Onofrio (bib10) 1988; 1 Kury, Duportail, Brauner, Laustriat (bib12) 1985; 845 Thomas, Bunker, Sodha, Clayton (bib20) 1989; 62 Curry, Joy, Holley, Bennet (bib23) 1977; 101 Moles, Mullen (bib5) 1982; 285 Paolisso, Passariello, Sgambato, et (bib17) 1987; 73 Ferrannini (bib11) 1988; 37 Lostroh, Krahl (bib25) 1974; 12 Fink, Kolterman, Griffin, Olefsky (bib1) 1983; 71 Paolisso, Pizza, De, et (bib18) 1990; 16 Tonyai, Motto, Rayssiguer, Heaton (bib26) 1985; 4 Paolisso, Passariello, Pizza, et (bib8) 1989; 121 Sonui, Robin (bib27) 1978; 96 Resnick (bib19) 1989; 87 Durlach, Rayssiguer (bib4) 1983; 2 Paolisso, Sgambato, Giugliano, et (bib16) 1988; 31 Paolisso, Sgambato, Passariello, et (bib7) 1986; 29 Moles (10.1093/ajcn/55.6.1161_bib5) 1982; 285 Ferrannini (10.1093/ajcn/55.6.1161_bib11) 1988; 37 Paolisso (10.1093/ajcn/55.6.1161_bib9) 1989; 12 Sonui (10.1093/ajcn/55.6.1161_bib27) 1978; 96 Paolisso (10.1093/ajcn/55.6.1161_bib6) 1990; 33 Thomas (10.1093/ajcn/55.6.1161_bib20) 1989; 62 Rowe (10.1093/ajcn/55.6.1161_bib2) 1983; 71 Paolisso (10.1093/ajcn/55.6.1161_bib16) 1988; 31 Henquin (10.1093/ajcn/55.6.1161_bib21) 1986; 155 Paolisso (10.1093/ajcn/55.6.1161_bib7) 1986; 29 Curry (10.1093/ajcn/55.6.1161_bib23) 1977; 101 Jackson (10.1093/ajcn/55.6.1161_bib3) 1990; 13 Legrand (10.1093/ajcn/55.6.1161_bib22) 1987; 36 Paolisso (10.1093/ajcn/55.6.1161_bib17) 1987; 73 Lostroh (10.1093/ajcn/55.6.1161_bib24) 1973; 291 Paolisso (10.1093/ajcn/55.6.1161_bib8) 1989; 121 Paolisso (10.1093/ajcn/55.6.1161_bib13) 1990; 123 Resnick (10.1093/ajcn/55.6.1161_bib19) 1989; 87 Durlach (10.1093/ajcn/55.6.1161_bib4) 1983; 2 Lostroh (10.1093/ajcn/55.6.1161_bib25) 1974; 12 Fink (10.1093/ajcn/55.6.1161_bib1) 1983; 71 Tonyai (10.1093/ajcn/55.6.1161_bib26) 1985; 4 Steele (10.1093/ajcn/55.6.1161_bib14) 1959; 82 Paolisso (10.1093/ajcn/55.6.1161_bib18) 1990; 16 Paolisso (10.1093/ajcn/55.6.1161_bib10) 1988; 1 Groop (10.1093/ajcn/55.6.1161_bib15) 1989; 84 Kury (10.1093/ajcn/55.6.1161_bib12) 1985; 845 8318108 - Am J Clin Nutr. 1993 Apr;57(4):594-6 |
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Am J Med – volume: 1 start-page: 215 year: 1988 ident: 10.1093/ajcn/55.6.1161_bib10 article-title: Impaired insulin-mediated erythrocyte magnesium accumulation in the elderly publication-title: Diabetes Nutr Metab – volume: 155 start-page: 653 year: 1986 ident: 10.1093/ajcn/55.6.1161_bib21 article-title: Magnesium uptake by pancreatic islet cell is modulated by stimulators and inhibitors of the В-cell function publication-title: Eur J Biochem doi: 10.1111/j.1432-1033.1986.tb09536.x – volume: 4 start-page: 399A year: 1985 ident: 10.1093/ajcn/55.6.1161_bib26 article-title: Erythrocyte membrane in magnesium deficiency publication-title: Am J Nutr – volume: 71 start-page: 1523 year: 1983 ident: 10.1093/ajcn/55.6.1161_bib1 article-title: The mechanisms of insulin resistance in aging publication-title: J Clin Invest doi: 10.1172/JCI110908 – volume: 121 start-page: 16 year: 1989 ident: 10.1093/ajcn/55.6.1161_bib8 article-title: Dietary magnesium supplements improve В-cell response to glucose and arginine in elderly non-insulin dependent diabetic patients publication-title: Acta Endocrinol – volume: 2 start-page: 192 year: 1983 ident: 10.1093/ajcn/55.6.1161_bib4 article-title: Magnesium and glucides. 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| Snippet | We demonstrated similar plasma concentrations and urinary losses but lower erythrocyte magnesium concentrations (2.18 ± 0.04 vs 1.86 ± 0.03 mmol/L, P < 0.01)... We demonstrated similar plasma concentrations and urinary losses but lower erythrocyte magnesium concentrations (2.18 +/- 0.04 vs 1.86 +/- 0.03 mmol/L, P 0.01)... We demonstrated similar plasma concentrations and urinary losses but lower erythrocyte magnesium concentrations (2.18 +/- 0.04 vs 1.86 +/- 0.03 mmol/L, P less... We demonstrated similar plasma concentrations and urinary losses but lower erythrocyte magnesium concentrations (2.18 +/- 0.04 vs 1.86 +/- 0.03 mmol/L, P <... |
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| SubjectTerms | ACIDE LACTIQUE ACIDO LACTICO administration & dosage Adult Aged Aged, 80 and over analysis Biological and medical sciences blood blood glucose Blood Glucose - analysis Blood Glucose - metabolism blood plasma Blood Viscosity Body Mass Index c-peptide C-Peptide - blood carbohydrate metabolism Carbohydrates cell membranes chemistry dietary mineral supplements Double-Blind Method elderly ERITROCITOS ERYTHROCYTE erythrocytes Erythrocytes - chemistry Erythrocytes - physiology Female Fundamental and applied biological sciences. Psychology GLICEMIA GLUCAGON Glucagon - blood glucose disappearance rate glucose homeostasis GLYCEMIE hepatic glucose output Homeostasis Humans Insulin Insulin - blood Insulin Resistance Insulin Resistance - physiology INSULINA INSULINE Lactates Lactates - blood lactic acid MAGNESIO MAGNESIUM Magnesium - administration & dosage Magnesium - blood Magnesium - urine Male MEMBRANAS CELULARES MEMBRANE CELLULAIRE membrane microviscosity metabolism METABOLISME DES GLUCIDES METABOLISMO DE CARBOHIDRATOS Metabolisms and neurohumoral controls MINERALES MINERAUX PEPTIDE PEPTIDOS PERSONNE AGEE physiology plasma lactate PLASMA SANGUIN PLASMA SANGUINEO Pyruvates Pyruvates - blood TERCERA EDAD urine Vertebrates: anatomy and physiology, studies on body, several organs or systems VISCOSIDAD VISCOSITE viscosity |
| Title | Daily magnesium supplements improve glucose handling in elderly subjects |
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