ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

Oncogenic Myc alters mitochondrial metabolism, making it dependent on exogenous glutamine (Gln) for cell survival. Accordingly, Gln deprivation selectively induces apoptosis in MYC-overexpressing cells via unknown mechanisms. Using MYCN-amplified neuroblastoma as a model, we identify PUMA, NOXA, and...

Full description

Saved in:

Bibliographic Details
Published in	Cancer cell Vol. 22; no. 5; pp. 631 - 644
Main Authors	Qing, Guoliang, Li, Bo, Vu, Annette, Skuli, Nicolas, Walton, Zandra E., Liu, Xueyuan, Mayes, Patrick A., Wise, David R., Thompson, Craig B., Maris, John M., Hogarty, Michael D., Simon, M. Celeste
Format	Journal Article
Language	English
Published	United States Elsevier Inc 13.11.2012
Subjects	Activating Transcription Factor 4 - genetics Activating Transcription Factor 4 - metabolism Activating Transcription Factor 4 - physiology Aminooxyacetic Acid - pharmacology Animals Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism bcl-2-Associated X Protein - metabolism Caspases - metabolism Cell Cycle Proteins - metabolism Cell Proliferation - drug effects Glutamine - metabolism Humans Mice Mice, Inbred BALB C Mice, Nude Neuroblastoma - metabolism Neuroblastoma - pathology Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Proto-Oncogene Proteins c-myc - physiology Repressor Proteins - metabolism Tumor Suppressor Protein p53 - physiology
Online Access	Get full text
ISSN	1535-6108 1878-3686 1878-3686
DOI	10.1016/j.ccr.2012.09.021

Cover

Abstract	Oncogenic Myc alters mitochondrial metabolism, making it dependent on exogenous glutamine (Gln) for cell survival. Accordingly, Gln deprivation selectively induces apoptosis in MYC-overexpressing cells via unknown mechanisms. Using MYCN-amplified neuroblastoma as a model, we identify PUMA, NOXA, and TRB3 as executors of Gln-starved cells. Gln depletion in MYC-transformed cells induces apoptosis through ATF4-dependent, but p53-independent, PUMA and NOXA induction. MYC-transformed cells depend on both glutamate-oxaloacetate transaminase and glutamate dehydrogenase to maintain Gln homeostasis and suppress apoptosis. Consequently, either ATF4 agonists or glutaminolysis inhibitors potently induce apoptosis in vitro and inhibit tumor growth in vivo. These results reveal mechanisms whereby Myc sensitizes cells to apoptosis, and validate ATF4 agonists and inhibitors of Gln metabolism as potential Myc-selective cancer therapeutics. ► MYCN-amplified neuroblastomas overexpress genes critical for glutamine metabolism ► PUMA, NOXA, and TRB3 are executers of Myc-mediated cell death upon glutamine deprivation ► MYCN transgenic mice treated with glutaminolysis inhibitors develop smaller tumors ► ATF4 agonists and glutaminolysis inhibitors are potential cancer therapeutics
AbstractList	Oncogenic Myc alters mitochondrial metabolism, making it dependent on exogenous glutamine (Gln) for cell survival. Accordingly, Gln deprivation selectively induces apoptosis in MYC-overexpressing cells via unknown mechanisms. Using MYCN-amplified neuroblastoma as a model, we identify PUMA, NOXA, and TRB3 as executors of Gln-starved cells. Gln depletion in MYC-transformed cells induces apoptosis through ATF4-dependent, but p53-independent, PUMA and NOXA induction. MYC-transformed cells depend on both glutamate-oxaloacetate transaminase and glutamate dehydrogenase to maintain Gln homeostasis and suppress apoptosis. Consequently, either ATF4 agonists or glutaminolysis inhibitors potently induce apoptosis in vitro and inhibit tumor growth in vivo. These results reveal mechanisms whereby Myc sensitizes cells to apoptosis, and validate ATF4 agonists and inhibitors of Gln metabolism as potential Myc-selective cancer therapeutics. Oncogenic Myc alters mitochondrial metabolism, making it dependent on exogenous glutamine (Gln) for cell survival. Accordingly, Gln deprivation selectively induces apoptosis in MYC-overexpressing cells via unknown mechanisms. Using MYCN-amplified neuroblastoma as a model, we identify PUMA, NOXA, and TRB3 as executors of Gln-starved cells. Gln depletion in MYC-transformed cells induces apoptosis through ATF4-dependent, but p53-independent, PUMA and NOXA induction. MYC-transformed cells depend on both glutamate-oxaloacetate transaminase and glutamate dehydrogenase to maintain Gln homeostasis and suppress apoptosis. Consequently, either ATF4 agonists or glutaminolysis inhibitors potently induce apoptosis in vitro and inhibit tumor growth in vivo. These results reveal mechanisms whereby Myc sensitizes cells to apoptosis, and validate ATF4 agonists and inhibitors of Gln metabolism as potential Myc-selective cancer therapeutics.Oncogenic Myc alters mitochondrial metabolism, making it dependent on exogenous glutamine (Gln) for cell survival. Accordingly, Gln deprivation selectively induces apoptosis in MYC-overexpressing cells via unknown mechanisms. Using MYCN-amplified neuroblastoma as a model, we identify PUMA, NOXA, and TRB3 as executors of Gln-starved cells. Gln depletion in MYC-transformed cells induces apoptosis through ATF4-dependent, but p53-independent, PUMA and NOXA induction. MYC-transformed cells depend on both glutamate-oxaloacetate transaminase and glutamate dehydrogenase to maintain Gln homeostasis and suppress apoptosis. Consequently, either ATF4 agonists or glutaminolysis inhibitors potently induce apoptosis in vitro and inhibit tumor growth in vivo. These results reveal mechanisms whereby Myc sensitizes cells to apoptosis, and validate ATF4 agonists and inhibitors of Gln metabolism as potential Myc-selective cancer therapeutics. Oncogenic Myc alters mitochondrial metabolism, making it dependent on exogenous glutamine (Gln) for cell survival. Accordingly, Gln deprivation selectively induces apoptosis in MYC -overexpressing cells via unknown mechanisms. Using MYCN -amplified neuroblastoma as a model, we identify PUMA , NOXA and TRB3 as executors of Gln-starved cells. Gln depletion in MYC -transformed cells induces apoptosis through ATF4-dependent, but p53-independent, PUMA and NOXA induction. MYC -transformed cells depend on both glutamate-oxaloacetate transaminase and glutamate dehydrogenase to maintain Gln homeostasis and suppress apoptosis. Consequently, either ATF4 agonists or glutaminolysis inhibitors potently induce apoptosis in vitro and inhibit tumor growth in vivo . These results reveal mechanisms whereby Myc sensitizes cells to apoptosis and validate ATF4 agonists and inhibitors of Gln metabolism as potential Myc-selective cancer therapeutics. Oncogenic Myc alters mitochondrial metabolism, making it dependent on exogenous glutamine (Gln) for cell survival. Accordingly, Gln deprivation selectively induces apoptosis in MYC-overexpressing cells via unknown mechanisms. Using MYCN-amplified neuroblastoma as a model, we identify PUMA, NOXA, and TRB3 as executors of Gln-starved cells. Gln depletion in MYC-transformed cells induces apoptosis through ATF4-dependent, but p53-independent, PUMA and NOXA induction. MYC-transformed cells depend on both glutamate-oxaloacetate transaminase and glutamate dehydrogenase to maintain Gln homeostasis and suppress apoptosis. Consequently, either ATF4 agonists or glutaminolysis inhibitors potently induce apoptosis in vitro and inhibit tumor growth in vivo. These results reveal mechanisms whereby Myc sensitizes cells to apoptosis, and validate ATF4 agonists and inhibitors of Gln metabolism as potential Myc-selective cancer therapeutics. ► MYCN-amplified neuroblastomas overexpress genes critical for glutamine metabolism ► PUMA, NOXA, and TRB3 are executers of Myc-mediated cell death upon glutamine deprivation ► MYCN transgenic mice treated with glutaminolysis inhibitors develop smaller tumors ► ATF4 agonists and glutaminolysis inhibitors are potential cancer therapeutics
Author	Simon, M. Celeste Walton, Zandra E. Li, Bo Liu, Xueyuan Mayes, Patrick A. Wise, David R. Skuli, Nicolas Hogarty, Michael D. Maris, John M. Thompson, Craig B. Qing, Guoliang Vu, Annette
AuthorAffiliation	1 Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA 2 Howard Hughes Medical Institute, 421 Curie Blvd., Philadelphia, PA 19104, USA 4 Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
AuthorAffiliation_xml	– name: 2 Howard Hughes Medical Institute, 421 Curie Blvd., Philadelphia, PA 19104, USA – name: 4 Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA – name: 1 Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
Author_xml	– sequence: 1 givenname: Guoliang surname: Qing fullname: Qing, Guoliang organization: Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 2 givenname: Bo surname: Li fullname: Li, Bo organization: Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 3 givenname: Annette surname: Vu fullname: Vu, Annette organization: Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 4 givenname: Nicolas surname: Skuli fullname: Skuli, Nicolas organization: Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 5 givenname: Zandra E. surname: Walton fullname: Walton, Zandra E. organization: Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 6 givenname: Xueyuan surname: Liu fullname: Liu, Xueyuan organization: Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 7 givenname: Patrick A. surname: Mayes fullname: Mayes, Patrick A. organization: Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 8 givenname: David R. surname: Wise fullname: Wise, David R. organization: Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 9 givenname: Craig B. surname: Thompson fullname: Thompson, Craig B. organization: Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 10 givenname: John M. surname: Maris fullname: Maris, John M. organization: Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 11 givenname: Michael D. surname: Hogarty fullname: Hogarty, Michael D. organization: Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 12 givenname: M. Celeste surname: Simon fullname: Simon, M. Celeste email: celeste2@mail.med.upenn.edu organization: Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/23153536$$D View this record in MEDLINE/PubMed
BookMark	eNp9UU1v1DAUtFAR_YAfwAXlyCXBz47tREhI1ZYWpJZK0Asny3FeWq-SeLGdlfj39XZbBBx6sf383szYM8fkYPYzEvIWaAUU5Id1ZW2oGAVW0baiDF6QI2hUU3LZyIN8FlyUEmhzSI5jXNOMAdW-IoeM71pcHpHr05vzuviOt8toEsbi6ueqvMLe5aIvvuESfDeamPxkihWOY3GGJt0Vy8bPxcW4JDO5GfPlJritSc7Pr8nLwYwR3zzuJ-TH-eeb1Zfy8vri6-r0srS1gFRKg1C3DWVCUkmZqoWSgC2zQ82MHIxE1dB2YJ3tuaCd4Fb1A4WuVoIzyU_Ipz3rZukm7C3OKZhR51dMJvzW3jj9b2d2d_rWbzUXQKWkmeD9I0HwvxaMSU8u2vxBM6NfogZQ0DR5gTz67m-tPyJPHuYBtR-wwccYcNDWpQczsrQbNVC9S0uvdU5L79LStNU5rYyE_5BP5M9hPu4xmN3dOgw6WoezzZkFtEn33j2DvgcH7KvS
CitedBy_id	crossref_primary_10_1186_s12943_014_0285_x crossref_primary_10_1002_path_4518 crossref_primary_10_1016_j_bbrc_2019_10_200 crossref_primary_10_1134_S000629791910002X crossref_primary_10_1016_j_bbagrm_2014_07_004 crossref_primary_10_1016_j_aaf_2023_05_005 crossref_primary_10_4252_wjsc_v13_i7_737 crossref_primary_10_1016_j_molmet_2023_101771 crossref_primary_10_1038_s41467_019_09179_w crossref_primary_10_3389_fonc_2020_625332 crossref_primary_10_1146_annurev_cancerbio_030617_050329 crossref_primary_10_1126_sciadv_adf0005 crossref_primary_10_1038_s44318_024_00338_4 crossref_primary_10_1002_jcp_25349 crossref_primary_10_1016_j_taap_2016_07_015 crossref_primary_10_1128_mBio_01179_17 crossref_primary_10_1002_advs_202103887 crossref_primary_10_1038_s41392_023_01589_z crossref_primary_10_1016_j_devcel_2024_07_015 crossref_primary_10_1016_j_ccell_2017_12_003 crossref_primary_10_3390_ijms24010621 crossref_primary_10_5713_ab_21_0174 crossref_primary_10_1016_j_cmet_2024_06_014 crossref_primary_10_1186_s40170_016_0156_6 crossref_primary_10_1111_mmi_13168 crossref_primary_10_1016_j_bbcan_2023_188962 crossref_primary_10_1084_jem_20200662 crossref_primary_10_1016_j_ccell_2014_11_024 crossref_primary_10_1128_MCB_00479_16 crossref_primary_10_1074_jbc_M114_616359 crossref_primary_10_1038_s41467_020_18987_4 crossref_primary_10_1158_0008_5472_CAN_15_1939 crossref_primary_10_1016_j_ajpath_2013_07_035 crossref_primary_10_18632_oncotarget_20691 crossref_primary_10_1002_cam4_70082 crossref_primary_10_1158_1535_7163_MCT_19_0385 crossref_primary_10_1038_s41419_017_0164_7 crossref_primary_10_1038_onc_2015_360 crossref_primary_10_1007_s12035_024_04680_w crossref_primary_10_1186_s13046_019_1414_6 crossref_primary_10_1016_j_bbagrm_2014_11_002 crossref_primary_10_1097_PPO_0000000000000099 crossref_primary_10_1016_j_bbcan_2018_07_002 crossref_primary_10_1038_s41401_020_00599_9 crossref_primary_10_1002_stem_2333 crossref_primary_10_1158_1078_0432_CCR_15_2254 crossref_primary_10_3892_ijo_2023_5581 crossref_primary_10_1002_path_4429 crossref_primary_10_1016_j_molmed_2013_12_003 crossref_primary_10_1038_s41467_025_57225_7 crossref_primary_10_1038_s41467_020_15136_9 crossref_primary_10_1093_neuonc_noae152 crossref_primary_10_1172_JCI87800 crossref_primary_10_3390_metabo13080910 crossref_primary_10_3390_ijms20225658 crossref_primary_10_3390_pharmaceutics14071453 crossref_primary_10_1016_j_molcel_2016_09_016 crossref_primary_10_1016_j_celrep_2024_114711 crossref_primary_10_1016_j_trecan_2021_05_002 crossref_primary_10_1083_jcb_201907022 crossref_primary_10_1002_iub_2773 crossref_primary_10_3109_07853890_2013_874664 crossref_primary_10_1126_science_1250256 crossref_primary_10_1038_s41419_018_0295_5 crossref_primary_10_3389_fcell_2020_603837 crossref_primary_10_1016_j_tem_2023_05_004 crossref_primary_10_1038_s43018_022_00355_4 crossref_primary_10_3390_cancers15082228 crossref_primary_10_4155_fmc_13_130 crossref_primary_10_3389_fcvm_2021_667446 crossref_primary_10_1016_j_biochi_2021_03_009 crossref_primary_10_1016_j_molcel_2022_03_016 crossref_primary_10_1172_JCI69600 crossref_primary_10_1007_s12311_022_01431_2 crossref_primary_10_1371_journal_pone_0129802 crossref_primary_10_1016_j_canlet_2024_217263 crossref_primary_10_1096_fj_202302547RR crossref_primary_10_1016_j_molcel_2014_09_025 crossref_primary_10_3390_cancers14174113 crossref_primary_10_1038_ncomms11971 crossref_primary_10_1038_nrclinonc_2016_108 crossref_primary_10_3390_ijms23158761 crossref_primary_10_1007_s10549_018_05111_w crossref_primary_10_1016_j_cmet_2017_09_001 crossref_primary_10_3390_cancers11050675 crossref_primary_10_1016_j_jbc_2023_105375 crossref_primary_10_1016_j_tem_2021_03_003 crossref_primary_10_1038_ncb2738 crossref_primary_10_1038_nrd3976 crossref_primary_10_1038_s41467_018_08033_9 crossref_primary_10_1172_jci_insight_153836 crossref_primary_10_1007_s11523_022_00870_5 crossref_primary_10_3390_cancers14071802 crossref_primary_10_3390_ijms160922830 crossref_primary_10_1101_gad_297374_117 crossref_primary_10_3389_fceld_2024_1507960 crossref_primary_10_1530_ERC_15_0192 crossref_primary_10_1017_erm_2019_4 crossref_primary_10_1038_ncomms5900 crossref_primary_10_1152_ajpcell_00292_2014 crossref_primary_10_1093_abbs_gmw064 crossref_primary_10_15252_emmm_202216951 crossref_primary_10_1038_s41388_018_0180_9 crossref_primary_10_1016_j_canlet_2023_216064 crossref_primary_10_1111_imr_12533 crossref_primary_10_1038_nchembio_1712 crossref_primary_10_3389_fimmu_2018_00040 crossref_primary_10_1038_s41388_020_1235_2 crossref_primary_10_18632_oncotarget_7448 crossref_primary_10_1021_jacs_4c11809 crossref_primary_10_18632_oncotarget_5821 crossref_primary_10_1038_onc_2015_447 crossref_primary_10_1038_s41419_021_03790_w crossref_primary_10_1007_s00204_024_03681_x crossref_primary_10_1016_j_ejphar_2021_174723 crossref_primary_10_1182_bloodadvances_2020001639 crossref_primary_10_3390_cancers11060804 crossref_primary_10_1016_j_bbcan_2014_08_006 crossref_primary_10_1038_bjc_2014_461 crossref_primary_10_1148_radiol_2017162610 crossref_primary_10_1073_pnas_2009620118 crossref_primary_10_1152_ajpcell_00061_2013 crossref_primary_10_1158_1078_0432_CCR_14_1200 crossref_primary_10_1016_j_semcancer_2015_04_002 crossref_primary_10_1016_j_jare_2024_04_016 crossref_primary_10_1038_s41419_017_0060_1 crossref_primary_10_1126_scitranslmed_aar5012 crossref_primary_10_1038_s41419_022_05346_y crossref_primary_10_1016_j_neo_2021_01_004 crossref_primary_10_3390_ijms241713260 crossref_primary_10_1186_s13578_017_0165_3 crossref_primary_10_1016_j_medj_2021_01_002 crossref_primary_10_1016_j_bcp_2022_114943 crossref_primary_10_1371_journal_pone_0116998 crossref_primary_10_1038_s41467_020_15051_z crossref_primary_10_1074_jbc_M114_619833 crossref_primary_10_18632_oncotarget_21458 crossref_primary_10_1016_j_neuro_2016_10_018 crossref_primary_10_3390_metabo13040560 crossref_primary_10_3390_cancers12051097 crossref_primary_10_3390_cancers10010003 crossref_primary_10_3390_ijms24010012 crossref_primary_10_1126_sciadv_abq0117 crossref_primary_10_5352_JLS_2013_23_6_832 crossref_primary_10_3390_cancers16203513 crossref_primary_10_1158_2159_8290_CD_16_0615 crossref_primary_10_1038_s41467_024_46572_6 crossref_primary_10_1038_s41467_020_14682_6 crossref_primary_10_1111_cpr_12536 crossref_primary_10_46308_kmj_2020_00059 crossref_primary_10_1371_journal_pbio_2002810 crossref_primary_10_1016_j_molcel_2014_08_018 crossref_primary_10_1172_JCI179570 crossref_primary_10_1038_s41392_018_0008_7 crossref_primary_10_3389_fcvm_2022_838657 crossref_primary_10_1002_hep_27577 crossref_primary_10_1016_j_celrep_2017_12_002 crossref_primary_10_1038_s41375_023_02107_4 crossref_primary_10_3389_fendo_2018_00129 crossref_primary_10_1158_1078_0432_CCR_18_1040 crossref_primary_10_1186_2049_3002_1_7 crossref_primary_10_1002_jcb_28740 crossref_primary_10_1038_s41420_022_01156_5 crossref_primary_10_1242_dev_200331 crossref_primary_10_1002_2211_5463_13569 crossref_primary_10_1002_jmv_25872 crossref_primary_10_2139_ssrn_3195357 crossref_primary_10_3390_cancers17010155 crossref_primary_10_18632_oncotarget_14035 crossref_primary_10_3390_genes8040113 crossref_primary_10_1007_s13277_015_4671_9 crossref_primary_10_15252_emmm_201911845 crossref_primary_10_1093_carcin_bgv003 crossref_primary_10_1002_mc_23696 crossref_primary_10_1242_jcs_164103 crossref_primary_10_1158_0008_5472_CAN_20_1641 crossref_primary_10_1002_1878_0261_12172 crossref_primary_10_4155_fdd_2022_0011 crossref_primary_10_1038_s41598_022_04987_5 crossref_primary_10_3390_cancers12051119 crossref_primary_10_3892_ol_2017_7024 crossref_primary_10_1038_s41388_019_0912_5 crossref_primary_10_1038_s41598_018_25802_0 crossref_primary_10_1016_j_ejmech_2018_11_066 crossref_primary_10_15252_emmm_201910769 crossref_primary_10_3389_fonc_2020_624079 crossref_primary_10_3390_ijms22147761 crossref_primary_10_1002_mc_23349 crossref_primary_10_1042_BST20211252 crossref_primary_10_18632_oncotarget_16202 crossref_primary_10_1016_j_tranon_2015_01_002 crossref_primary_10_1016_j_cmet_2016_03_016 crossref_primary_10_1158_1535_7163_MCT_17_1148 crossref_primary_10_3390_diseases9040078 crossref_primary_10_36660_abc_20200672 crossref_primary_10_1038_s41598_020_64040_1 crossref_primary_10_18632_oncotarget_9666 crossref_primary_10_3390_cells9092081 crossref_primary_10_3390_cancers14184421 crossref_primary_10_1016_j_bbagrm_2014_05_016 crossref_primary_10_1016_j_jbc_2025_108252 crossref_primary_10_3390_pr12040687 crossref_primary_10_12998_wjcc_v11_i27_6318 crossref_primary_10_1038_cddis_2015_183 crossref_primary_10_4161_auto_29456 crossref_primary_10_18632_oncotarget_15828 crossref_primary_10_1039_D0BM01153C crossref_primary_10_1111_febs_13369 crossref_primary_10_1155_2022_3403009 crossref_primary_10_1016_j_canlet_2023_216396 crossref_primary_10_1038_s41420_022_00963_0 crossref_primary_10_15252_embj_201796662 crossref_primary_10_1016_j_celrep_2022_111516 crossref_primary_10_3390_molecules24173110 crossref_primary_10_1007_s13277_016_5343_0 crossref_primary_10_1016_j_molcel_2019_09_002 crossref_primary_10_15252_embj_201796438 crossref_primary_10_1093_annonc_mdt551 crossref_primary_10_18632_oncotarget_4544 crossref_primary_10_1016_j_cell_2013_04_023 crossref_primary_10_1016_j_jconrel_2023_04_001 crossref_primary_10_4062_biomolther_2017_178 crossref_primary_10_18632_oncotarget_16904 crossref_primary_10_3390_cancers15153898 crossref_primary_10_1016_j_bcp_2024_116038 crossref_primary_10_1111_febs_13598 crossref_primary_10_1016_j_drudis_2019_11_014 crossref_primary_10_1016_j_chembiol_2014_08_007 crossref_primary_10_3389_fphar_2021_768861 crossref_primary_10_1038_nrc_2016_71 crossref_primary_10_1101_cshperspect_a035477 crossref_primary_10_1016_j_cca_2024_119836 crossref_primary_10_1038_s41419_019_1504_6 crossref_primary_10_1007_s11427_020_1703_2 crossref_primary_10_1038_s41392_020_00235_2 crossref_primary_10_1158_1078_0432_CCR_12_3629 crossref_primary_10_2478_enr_2024_0010 crossref_primary_10_3389_fendo_2023_1144747 crossref_primary_10_1016_j_semcancer_2017_01_008 crossref_primary_10_2478_enr_2023_0005 crossref_primary_10_1093_pnasnexus_pgac232 crossref_primary_10_1016_j_tranon_2022_101534 crossref_primary_10_1038_s41419_023_06278_x crossref_primary_10_1186_s12935_022_02524_y crossref_primary_10_1016_j_bbrc_2017_01_045 crossref_primary_10_1186_s12964_022_00909_0 crossref_primary_10_1038_onc_2015_381 crossref_primary_10_3390_cells9102308 crossref_primary_10_1007_s10565_021_09608_x crossref_primary_10_1111_febs_15480 crossref_primary_10_1126_sciadv_adh9547 crossref_primary_10_1021_acs_chemrev_7b00775 crossref_primary_10_1186_s13046_020_01791_9 crossref_primary_10_1002_pros_24654 crossref_primary_10_1158_0008_5472_CAN_20_2153 crossref_primary_10_1152_ajpgi_00135_2017 crossref_primary_10_18632_oncotarget_5774 crossref_primary_10_15252_embj_201696151 crossref_primary_10_1038_s41419_021_03574_2 crossref_primary_10_1016_j_tem_2017_07_003 crossref_primary_10_1186_s12885_018_4599_8 crossref_primary_10_1002_jbmr_4532 crossref_primary_10_1186_s40170_016_0154_8 crossref_primary_10_3389_fonc_2020_00791 crossref_primary_10_1126_scitranslmed_aac6008 crossref_primary_10_1007_s11307_019_01330_9 crossref_primary_10_1016_j_biopha_2016_10_015 crossref_primary_10_1016_j_celrep_2019_02_037 crossref_primary_10_1007_s00726_016_2254_8 crossref_primary_10_18632_oncotarget_16365 crossref_primary_10_1016_j_mito_2014_08_007 crossref_primary_10_3892_mmr_2016_5533 crossref_primary_10_18632_oncotarget_6879 crossref_primary_10_1186_s12964_023_01449_x crossref_primary_10_1016_j_ccell_2016_01_002 crossref_primary_10_1371_journal_pone_0185092 crossref_primary_10_1002_advs_202401748 crossref_primary_10_1038_s43018_023_00649_1 crossref_primary_10_1101_gad_287235_116 crossref_primary_10_3390_ijms19072093 crossref_primary_10_3390_cancers15194803 crossref_primary_10_18632_oncotarget_3132 crossref_primary_10_1038_s12276_020_00504_8 crossref_primary_10_1158_0008_5472_CAN_19_0008 crossref_primary_10_3390_ijms21217941 crossref_primary_10_1186_s10020_025_01064_1 crossref_primary_10_1007_s00277_024_05829_2 crossref_primary_10_1038_oncsis_2017_59 crossref_primary_10_1186_s40169_016_0106_5 crossref_primary_10_1016_j_toxlet_2014_05_012 crossref_primary_10_1155_2018_6716547 crossref_primary_10_1002_bies_201400085 crossref_primary_10_1002_1878_0261_13319 crossref_primary_10_18632_oncotarget_6519 crossref_primary_10_1158_2326_6066_CIR_20_0418
Cites_doi	10.1016/j.cmet.2011.12.009 10.1016/j.ccr.2009.01.027 10.1016/j.ccr.2006.03.005 10.1073/pnas.0810199105 10.1056/NEJMra0804577 10.1126/science.1059108 10.1016/j.biocel.2007.01.020 10.1038/nature07823 10.1083/jcb.200703099 10.1016/j.cell.2012.03.003 10.1084/jem.20071460 10.1038/nature07260 10.1038/nature10642 10.1074/jbc.M109.078584 10.1073/pnas.1117773108 10.1016/j.cell.2008.11.044 10.1016/j.tem.2009.05.008 10.1038/nature10602 10.1038/onc.2009.45 10.1038/ncb1584 10.1016/0163-7258(90)90094-I 10.1016/j.cmet.2007.10.002 10.1038/nature03043 10.1126/science.1160809 10.1016/j.cell.2006.05.036 10.1523/JNEUROSCI.1598-10.2010 10.1016/S1535-6108(02)00127-7 10.1038/sj.onc.1210769 10.1038/emboj.2010.81 10.1021/bi7018783 10.1200/JCO.2005.03.9271 10.1038/nature09609 10.1038/sj.bjc.6603672 10.1128/MCB.21.22.7653-7662.2001 10.1016/j.ccr.2010.08.009 10.1038/nature07261 10.1158/0008-5472.CAN-10-0740 10.1016/j.bbagen.2009.07.018 10.1038/sj.emboj.7600596 10.1016/j.canlet.2008.04.014 10.1016/j.ccr.2009.01.021 10.1038/75007 10.1038/ng.374
ContentType	Journal Article
Copyright	2012 Elsevier Inc. Copyright © 2012 Elsevier Inc. All rights reserved. 2012 Elsevier Inc. All rights reserved. 2012
Copyright_xml	– notice: 2012 Elsevier Inc. – notice: Copyright © 2012 Elsevier Inc. All rights reserved. – notice: 2012 Elsevier Inc. All rights reserved. 2012
DBID	6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM
DOI	10.1016/j.ccr.2012.09.021
DatabaseName	ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1878-3686
EndPage	644
ExternalDocumentID	PMC3510660 23153536 10_1016_j_ccr_2012_09_021 S1535610812003996
Genre	Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NCI NIH HHS grantid: P01 CA097323 – fundername: NCI NIH HHS grantid: P01 CA104838 – fundername: NCI NIH HHS grantid: F32 CA137988 – fundername: NCI NIH HHS grantid: CA097323 – fundername: NCI NIH HHS grantid: CA104838 – fundername: Howard Hughes Medical Institute – fundername: NCI NIH HHS grantid: P30 CA016520 – fundername: NCI NIH HHS grantid: CA97323 – fundername: NCI NIH HHS grantid: 1F32CA137988 – fundername: NCI NIH HHS grantid: CA105463 – fundername: National Cancer Institute : NCI grantid: P01 CA104838 \|\| CA
GroupedDBID	--- --K 0R~ 1~5 29B 2WC 4.4 457 4G. 53G 5GY 5VS 62- 6I. 6J9 7-5 AACTN AAEDT AAEDW AAFTH AAIAV AAIKJ AAKRW AAKUH AALRI AAQFI AAUCE AAVLU AAXJY AAXUO ABJNI ABMAC ABMWF ABVKL ACGFO ACGFS ADBBV ADEZE ADJPV AEFWE AENEX AEXQZ AFTJW AGHFR AGKMS AITUG ALKID ALMA_UNASSIGNED_HOLDINGS AMRAJ ASPBG AVWKF AZFZN BAWUL CS3 DIK DU5 E3Z EBS EJD F5P FCP FDB FEDTE FIRID HVGLF HZ~ IH2 IHE IXB J1W JIG M3Z M41 NCXOZ O-L O9- OK1 P2P RCE RIG ROL RPZ SES SSZ TR2 UDS WQ6 ZA5 AAFWJ AAMRU AAYWO AAYXX ABDGV ACVFH ADCNI ADVLN AEUPX AFPUW AGCQF AIGII AKAPO AKBMS AKRWK AKYEP APXCP CITATION OZT UHS CGR CUY CVF ECM EIF NPM 7X8 EFKBS 5PM
ID	FETCH-LOGICAL-c451t-6ae149802560602745761e92cf42a6fa6e7809f2bcd350b53c7df01b4753263
IEDL.DBID	IXB
ISSN	1535-6108 1878-3686
IngestDate	Thu Aug 21 13:56:56 EDT 2025 Sat Sep 27 18:00:12 EDT 2025 Thu Apr 03 06:53:56 EDT 2025 Tue Jul 01 01:26:16 EDT 2025 Thu Apr 24 23:09:33 EDT 2025 Fri Feb 23 02:27:45 EST 2024
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	5
Language	English
License	http://www.elsevier.com/open-access/userlicense/1.0 Copyright © 2012 Elsevier Inc. All rights reserved.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c451t-6ae149802560602745761e92cf42a6fa6e7809f2bcd350b53c7df01b4753263
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Present address: Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA These authors contributed equally to this work. Present address: the Provincial Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation, Tongji Medical College, Huazhong University Science & Technology, 13 Hangkong Rd, Wuhan, Hubei Province 430030, China
OpenAccessLink	https://www.sciencedirect.com/science/article/pii/S1535610812003996
PMID	23153536
PQID	1171881711
PQPubID	23479
PageCount	14
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_3510660 proquest_miscellaneous_1171881711 pubmed_primary_23153536 crossref_citationtrail_10_1016_j_ccr_2012_09_021 crossref_primary_10_1016_j_ccr_2012_09_021 elsevier_sciencedirect_doi_10_1016_j_ccr_2012_09_021
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	2012-11-13
PublicationDateYYYYMMDD	2012-11-13
PublicationDate_xml	– month: 11 year: 2012 text: 2012-11-13 day: 13
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	Cancer cell
PublicationTitleAlternate	Cancer Cell
PublicationYear	2012
Publisher	Elsevier Inc
Publisher_xml	– name: Elsevier Inc
References	Ohoka, Yoshii, Hattori, Onozaki, Hayashi (bib26) 2005; 24 Gao, Tchernyshyov, Chang, Lee, Kita, Ochi, Zeller, De Marzo, Van Eyk, Mendell, Dang (bib13) 2009; 458 Nicklin, Bergman, Zhang, Triantafellow, Wang, Nyfeler, Yang, Hild, Kung, Wilson (bib25) 2009; 136 Corazzari, Lovat, Armstrong, Fimia, Hill, Birch-Machin, Redfern, Piacentini (bib7) 2007; 96 Sawada, Sun, Hayes, Leskov, Boothman, Matsuyama (bib30) 2007; 9 Kilberg, Shan, Su (bib15) 2009; 20 Butkinaree, Park, Hart (bib4) 2010; 1800 Yu, Zhang (bib42) 2008; 27 Khan, Mukhtar (bib14) 2008; 269 Metallo, Gameiro, Bell, Mattaini, Yang, Hiller, Jewell, Johnson, Irvine, Guarente (bib22) 2012; 481 Carracedo, Lorente, Egia, Blázquez, García, Giroux, Malicet, Villuendas, Gironella, González-Feria (bib6) 2006; 9 Li, Allen, Smith (bib19) 2007; 46 Bensaad, Tsuruta, Selak, Vidal, Nakano, Bartrons, Gottlieb, Vousden (bib3) 2006; 126 DeBerardinis, Lum, Hatzivassiliou, Thompson (bib9) 2008; 7 Letai, Bassik, Walensky, Sorcinelli, Weiler, Korsmeyer (bib18) 2002; 2 Shachaf, Kopelman, Arvanitis, Karlsson, Beer, Mandl, Bachmann, Borowsky, Ruebner, Cardiff (bib31) 2004; 431 Wise, DeBerardinis, Mancuso, Sayed, Zhang, Pfeiffer, Nissim, Daikhin, Yudkoff, McMahon, Thompson (bib39) 2008; 105 Capasso, Devoto, Hou, Asgharzadeh, Glessner, Attiyeh, Mosse, Kim, Diskin, Cole (bib5) 2009; 41 Ameri, Harris (bib2) 2008; 40 Wise, Ward, Shay, Cross, Gruber, Sachdeva, Platt, DeMatteo, Simon, Thompson (bib40) 2011; 108 Qing, Skuli, Mayes, Pawel, Martinez, Maris, Simon (bib29) 2010; 70 Wei, Zong, Cheng, Lindsten, Panoutsakopoulou, Ross, Roth, MacGregor, Thompson, Korsmeyer (bib38) 2001; 292 Eischen, Roussel, Korsmeyer, Cleveland (bib11) 2001; 21 Maris (bib21) 2010; 362 Villablanca, Krailo, Ames, Reid, Reaman, Reynolds (bib35) 2006; 24 Lange, Chavez, Pinto, Coppola, Sun, Townes, Geschwind, Ratan (bib16) 2008; 205 Porro, Haber, Diolaiti, Iraci, Henderson, Gherardi, Valli, Munoz, Xue, Flemming (bib28) 2010; 285 Le, Lane, Hamaker, Bose, Gouw, Barbi, Tsukamoto, Rojas, Slusher, Zhang (bib17) 2012; 15 Ebos, Lee, Cruz-Munoz, Bjarnason, Christensen, Kerbel (bib10) 2009; 15 Teitz, Wei, Valentine, Vanin, Grenet, Valentine, Behm, Look, Lahti, Kidd (bib33) 2000; 6 Wang, Erickson, Fuji, Ramachandran, Gao, Dinavahi, Wilson, Ambrosio, Dias, Dang, Cerione (bib36) 2010; 18 Vander Heiden, Cantley, Thompson (bib34) 2009; 324 Ahluwalia, Grem, Hao, Cooney (bib1) 1990; 46 Galehdar, Swan, Fuerth, Callaghan, Park, Cregan (bib12) 2010; 30 Dang (bib8) 2012; 149 Pàez-Ribes, Allen, Hudock, Takeda, Okuyama, Viñals, Inoue, Bergers, Hanahan, Casanovas (bib27) 2009; 15 Wang, Diskin, Zhang, Attiyeh, Winter, Hou, Schnepp, Diamond, Bosse, Mayes (bib37) 2011; 469 Liu, Mazanek, Dam, Wang, Zhao, Guo, Jagannathan, Cnaan, Maris, Hogarty (bib20) 2008; 27 Ye, Kumanova, Hart, Sloane, Zhang, De Panis, Bobrovnikova-Marjon, Diehl, Ron, Koumenis (bib41) 2010; 29 Mossé, Laudenslager, Longo, Cole, Wood, Attiyeh, Laquaglia, Sennett, Lynch, Perri (bib23) 2008; 455 Soucek, Whitfield, Martins, Finch, Murphy, Sodir, Karnezis, Swigart, Nasi, Evan (bib32) 2008; 455 Yuneva, Zamboni, Oefner, Sachidanandam, Lazebnik (bib43) 2007; 178 Mullen, Wheaton, Jin, Chen, Sullivan, Cheng, Yang, Linehan, Chandel, DeBerardinis (bib24) 2012; 481 Sawada (10.1016/j.ccr.2012.09.021_bib30) 2007; 9 Wise (10.1016/j.ccr.2012.09.021_bib40) 2011; 108 Wang (10.1016/j.ccr.2012.09.021_bib36) 2010; 18 Ebos (10.1016/j.ccr.2012.09.021_bib10) 2009; 15 Mullen (10.1016/j.ccr.2012.09.021_bib24) 2012; 481 Wang (10.1016/j.ccr.2012.09.021_bib37) 2011; 469 Vander Heiden (10.1016/j.ccr.2012.09.021_bib34) 2009; 324 Letai (10.1016/j.ccr.2012.09.021_bib18) 2002; 2 Yuneva (10.1016/j.ccr.2012.09.021_bib43) 2007; 178 DeBerardinis (10.1016/j.ccr.2012.09.021_bib9) 2008; 7 Dang (10.1016/j.ccr.2012.09.021_bib8) 2012; 149 Yu (10.1016/j.ccr.2012.09.021_bib42) 2008; 27 Nicklin (10.1016/j.ccr.2012.09.021_bib25) 2009; 136 Ye (10.1016/j.ccr.2012.09.021_bib41) 2010; 29 Shachaf (10.1016/j.ccr.2012.09.021_bib31) 2004; 431 Wise (10.1016/j.ccr.2012.09.021_bib39) 2008; 105 Ahluwalia (10.1016/j.ccr.2012.09.021_bib1) 1990; 46 Carracedo (10.1016/j.ccr.2012.09.021_bib6) 2006; 9 Gao (10.1016/j.ccr.2012.09.021_bib13) 2009; 458 Li (10.1016/j.ccr.2012.09.021_bib19) 2007; 46 Mossé (10.1016/j.ccr.2012.09.021_bib23) 2008; 455 Bensaad (10.1016/j.ccr.2012.09.021_bib3) 2006; 126 Khan (10.1016/j.ccr.2012.09.021_bib14) 2008; 269 Le (10.1016/j.ccr.2012.09.021_bib17) 2012; 15 Galehdar (10.1016/j.ccr.2012.09.021_bib12) 2010; 30 Pàez-Ribes (10.1016/j.ccr.2012.09.021_bib27) 2009; 15 Wei (10.1016/j.ccr.2012.09.021_bib38) 2001; 292 Metallo (10.1016/j.ccr.2012.09.021_bib22) 2012; 481 Ameri (10.1016/j.ccr.2012.09.021_bib2) 2008; 40 Kilberg (10.1016/j.ccr.2012.09.021_bib15) 2009; 20 Qing (10.1016/j.ccr.2012.09.021_bib29) 2010; 70 Maris (10.1016/j.ccr.2012.09.021_bib21) 2010; 362 Porro (10.1016/j.ccr.2012.09.021_bib28) 2010; 285 Teitz (10.1016/j.ccr.2012.09.021_bib33) 2000; 6 Ohoka (10.1016/j.ccr.2012.09.021_bib26) 2005; 24 Soucek (10.1016/j.ccr.2012.09.021_bib32) 2008; 455 Corazzari (10.1016/j.ccr.2012.09.021_bib7) 2007; 96 Butkinaree (10.1016/j.ccr.2012.09.021_bib4) 2010; 1800 Capasso (10.1016/j.ccr.2012.09.021_bib5) 2009; 41 Eischen (10.1016/j.ccr.2012.09.021_bib11) 2001; 21 Villablanca (10.1016/j.ccr.2012.09.021_bib35) 2006; 24 Lange (10.1016/j.ccr.2012.09.021_bib16) 2008; 205 Liu (10.1016/j.ccr.2012.09.021_bib20) 2008; 27 11326099 - Science. 2001 Apr 27;292(5517):727-30 15475948 - Nature. 2004 Oct 28;431(7012):1112-7 18044977 - Biochemistry. 2007 Dec 25;46(51):15089-102 20233711 - J Biol Chem. 2010 Jun 18;285(25):19532-43 19249681 - Cancer Cell. 2009 Mar 3;15(3):232-9 20558371 - N Engl J Med. 2010 Jun 10;362(23):2202-11 16616335 - Cancer Cell. 2006 Apr;9(4):301-12 18501505 - Cancer Lett. 2008 Oct 8;269(2):269-80 17466566 - Int J Biochem Cell Biol. 2008;40(1):14-21 19412175 - Nat Genet. 2009 Jun;41(6):718-23 17606868 - J Cell Biol. 2007 Jul 2;178(1):93-105 19641508 - Oncogene. 2008 Dec;27 Suppl 1:S71-83 22225880 - Cell Metab. 2012 Jan 4;15(1):110-21 17724465 - Oncogene. 2008 Feb 28;27(10):1478-88 18724359 - Nature. 2008 Oct 16;455(7215):930-5 21124317 - Nature. 2011 Jan 13;469(7329):216-20 12652308 - Nat Cell Biol. 2003 Apr;5(4):320-9 22101431 - Nature. 2012 Jan 19;481(7381):385-8 22106302 - Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19611-6 18177721 - Cell Metab. 2008 Jan;7(1):11-20 22101433 - Nature. 2012 Jan 19;481(7381):380-4 11604501 - Mol Cell Biol. 2001 Nov;21(22):7653-62 19219026 - Nature. 2009 Apr 9;458(7239):762-5 19203585 - Cell. 2009 Feb 6;136(3):521-34 18716624 - Nature. 2008 Oct 2;455(7213):679-83 10802708 - Nat Med. 2000 May;6(5):529-35 21159964 - J Neurosci. 2010 Dec 15;30(50):16938-48 19460998 - Science. 2009 May 22;324(5930):1029-33 12242151 - Cancer Cell. 2002 Sep;2(3):183-92 19033189 - Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18782-7 20473272 - EMBO J. 2010 Jun 16;29(12):2082-96 2108451 - Pharmacol Ther. 1990;46(2):243-71 15775988 - EMBO J. 2005 Mar 23;24(6):1243-55 22464321 - Cell. 2012 Mar 30;149(1):22-35 16839880 - Cell. 2006 Jul 14;126(1):107-20 17353921 - Br J Cancer. 2007 Apr 10;96(7):1062-71 18458112 - J Exp Med. 2008 May 12;205(5):1227-42 19800252 - Trends Endocrinol Metab. 2009 Nov;20(9):436-43 16849757 - J Clin Oncol. 2006 Jul 20;24(21):3423-30 19249680 - Cancer Cell. 2009 Mar 3;15(3):220-31 20961996 - Cancer Res. 2010 Dec 15;70(24):10351-61 19647786 - Biochim Biophys Acta. 2010 Feb;1800(2):96-106 20832749 - Cancer Cell. 2010 Sep 14;18(3):207-19
References_xml	– volume: 18 start-page: 207 year: 2010 end-page: 219 ident: bib36 article-title: Targeting mitochondrial glutaminase activity inhibits oncogenic transformation publication-title: Cancer Cell – volume: 20 start-page: 436 year: 2009 end-page: 443 ident: bib15 article-title: ATF4-dependent transcription mediates signaling of amino acid limitation publication-title: Trends Endocrinol. Metab. – volume: 7 start-page: 11 year: 2008 end-page: 20 ident: bib9 article-title: The biology of cancer: metabolic reprogramming fuels cell growth and proliferation publication-title: Cell Metab. – volume: 362 start-page: 2202 year: 2010 end-page: 2211 ident: bib21 article-title: Recent advances in neuroblastoma publication-title: N. Engl. J. Med. – volume: 21 start-page: 7653 year: 2001 end-page: 7662 ident: bib11 article-title: Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis publication-title: Mol. Cell. Biol. – volume: 46 start-page: 15089 year: 2007 end-page: 15102 ident: bib19 article-title: High throughput screening reveals several new classes of glutamate dehydrogenase inhibitors publication-title: Biochemistry – volume: 15 start-page: 220 year: 2009 end-page: 231 ident: bib27 article-title: Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis publication-title: Cancer Cell – volume: 6 start-page: 529 year: 2000 end-page: 535 ident: bib33 article-title: Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN publication-title: Nat. Med. – volume: 24 start-page: 3423 year: 2006 end-page: 3430 ident: bib35 article-title: Phase I trial of oral fenretinide in children with high-risk solid tumors: a report from the Children’s Oncology Group (CCG 09709) publication-title: J. Clin. Oncol. – volume: 178 start-page: 93 year: 2007 end-page: 105 ident: bib43 article-title: Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells publication-title: J. Cell Biol. – volume: 455 start-page: 679 year: 2008 end-page: 683 ident: bib32 article-title: Modelling Myc inhibition as a cancer therapy publication-title: Nature – volume: 29 start-page: 2082 year: 2010 end-page: 2096 ident: bib41 article-title: The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation publication-title: EMBO J. – volume: 481 start-page: 385 year: 2012 end-page: 388 ident: bib24 article-title: Reductive carboxylation supports growth in tumour cells with defective mitochondria publication-title: Nature – volume: 9 start-page: 480 year: 2007 ident: bib30 article-title: Retraction publication-title: Nat. Cell Biol. – volume: 324 start-page: 1029 year: 2009 end-page: 1033 ident: bib34 article-title: Understanding the Warburg effect: the metabolic requirements of cell proliferation publication-title: Science – volume: 292 start-page: 727 year: 2001 end-page: 730 ident: bib38 article-title: Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death publication-title: Science – volume: 1800 start-page: 96 year: 2010 end-page: 106 ident: bib4 article-title: O-linked beta-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress publication-title: Biochim. Biophys. Acta – volume: 469 start-page: 216 year: 2011 end-page: 220 ident: bib37 article-title: Integrative genomics identifies LMO1 as a neuroblastoma oncogene publication-title: Nature – volume: 2 start-page: 183 year: 2002 end-page: 192 ident: bib18 article-title: Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics publication-title: Cancer Cell – volume: 24 start-page: 1243 year: 2005 end-page: 1255 ident: bib26 article-title: TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death publication-title: EMBO J. – volume: 15 start-page: 232 year: 2009 end-page: 239 ident: bib10 article-title: Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis publication-title: Cancer Cell – volume: 458 start-page: 762 year: 2009 end-page: 765 ident: bib13 article-title: c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism publication-title: Nature – volume: 431 start-page: 1112 year: 2004 end-page: 1117 ident: bib31 article-title: MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer publication-title: Nature – volume: 46 start-page: 243 year: 1990 end-page: 271 ident: bib1 article-title: Metabolism and action of amino acid analog anti-cancer agents publication-title: Pharmacol. Ther. – volume: 108 start-page: 19611 year: 2011 end-page: 19616 ident: bib40 article-title: Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability publication-title: Proc. Natl. Acad. Sci. USA – volume: 27 start-page: 1478 year: 2008 end-page: 1488 ident: bib20 article-title: Deregulated Wnt/beta-catenin program in high-risk neuroblastomas without MYCN amplification publication-title: Oncogene – volume: 149 start-page: 22 year: 2012 end-page: 35 ident: bib8 article-title: MYC on the path to cancer publication-title: Cell – volume: 41 start-page: 718 year: 2009 end-page: 723 ident: bib5 article-title: Common variations in BARD1 influence susceptibility to high-risk neuroblastoma publication-title: Nat. Genet. – volume: 481 start-page: 380 year: 2012 end-page: 384 ident: bib22 article-title: Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia publication-title: Nature – volume: 70 start-page: 10351 year: 2010 end-page: 10361 ident: bib29 article-title: Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha publication-title: Cancer Res. – volume: 9 start-page: 301 year: 2006 end-page: 312 ident: bib6 article-title: The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells publication-title: Cancer Cell – volume: 269 start-page: 269 year: 2008 end-page: 280 ident: bib14 article-title: Multitargeted therapy of cancer by green tea polyphenols publication-title: Cancer Lett. – volume: 15 start-page: 110 year: 2012 end-page: 121 ident: bib17 article-title: Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells publication-title: Cell Metab. – volume: 30 start-page: 16938 year: 2010 end-page: 16948 ident: bib12 article-title: Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA publication-title: J. Neurosci. – volume: 105 start-page: 18782 year: 2008 end-page: 18787 ident: bib39 article-title: Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction publication-title: Proc. Natl. Acad. Sci. USA – volume: 40 start-page: 14 year: 2008 end-page: 21 ident: bib2 article-title: Activating transcription factor 4 publication-title: Int. J. Biochem. Cell Biol. – volume: 285 start-page: 19532 year: 2010 end-page: 19543 ident: bib28 article-title: Direct and coordinate regulation of ATP-binding cassette transporter genes by Myc factors generates specific transcription signatures that significantly affect the chemoresistance phenotype of cancer cells publication-title: J. Biol. Chem. – volume: 96 start-page: 1062 year: 2007 end-page: 1071 ident: bib7 article-title: Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: the role of stress proteins ERdj5 and ERp57 publication-title: Br. J. Cancer – volume: 455 start-page: 930 year: 2008 end-page: 935 ident: bib23 article-title: Identification of ALK as a major familial neuroblastoma predisposition gene publication-title: Nature – volume: 205 start-page: 1227 year: 2008 end-page: 1242 ident: bib16 article-title: ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo publication-title: J. Exp. Med. – volume: 27 start-page: S71 year: 2008 end-page: S83 ident: bib42 article-title: PUMA, a potent killer with or without p53 publication-title: Oncogene – volume: 126 start-page: 107 year: 2006 end-page: 120 ident: bib3 article-title: TIGAR, a p53-inducible regulator of glycolysis and apoptosis publication-title: Cell – volume: 136 start-page: 521 year: 2009 end-page: 534 ident: bib25 article-title: Bidirectional transport of amino acids regulates mTOR and autophagy publication-title: Cell – volume: 15 start-page: 110 year: 2012 ident: 10.1016/j.ccr.2012.09.021_bib17 article-title: Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells publication-title: Cell Metab. doi: 10.1016/j.cmet.2011.12.009 – volume: 15 start-page: 220 year: 2009 ident: 10.1016/j.ccr.2012.09.021_bib27 article-title: Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis publication-title: Cancer Cell doi: 10.1016/j.ccr.2009.01.027 – volume: 9 start-page: 301 year: 2006 ident: 10.1016/j.ccr.2012.09.021_bib6 article-title: The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells publication-title: Cancer Cell doi: 10.1016/j.ccr.2006.03.005 – volume: 105 start-page: 18782 year: 2008 ident: 10.1016/j.ccr.2012.09.021_bib39 article-title: Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0810199105 – volume: 362 start-page: 2202 year: 2010 ident: 10.1016/j.ccr.2012.09.021_bib21 article-title: Recent advances in neuroblastoma publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra0804577 – volume: 292 start-page: 727 year: 2001 ident: 10.1016/j.ccr.2012.09.021_bib38 article-title: Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death publication-title: Science doi: 10.1126/science.1059108 – volume: 40 start-page: 14 year: 2008 ident: 10.1016/j.ccr.2012.09.021_bib2 article-title: Activating transcription factor 4 publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/j.biocel.2007.01.020 – volume: 458 start-page: 762 year: 2009 ident: 10.1016/j.ccr.2012.09.021_bib13 article-title: c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism publication-title: Nature doi: 10.1038/nature07823 – volume: 178 start-page: 93 year: 2007 ident: 10.1016/j.ccr.2012.09.021_bib43 article-title: Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells publication-title: J. Cell Biol. doi: 10.1083/jcb.200703099 – volume: 149 start-page: 22 year: 2012 ident: 10.1016/j.ccr.2012.09.021_bib8 article-title: MYC on the path to cancer publication-title: Cell doi: 10.1016/j.cell.2012.03.003 – volume: 205 start-page: 1227 year: 2008 ident: 10.1016/j.ccr.2012.09.021_bib16 article-title: ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo publication-title: J. Exp. Med. doi: 10.1084/jem.20071460 – volume: 455 start-page: 679 year: 2008 ident: 10.1016/j.ccr.2012.09.021_bib32 article-title: Modelling Myc inhibition as a cancer therapy publication-title: Nature doi: 10.1038/nature07260 – volume: 481 start-page: 385 year: 2012 ident: 10.1016/j.ccr.2012.09.021_bib24 article-title: Reductive carboxylation supports growth in tumour cells with defective mitochondria publication-title: Nature doi: 10.1038/nature10642 – volume: 285 start-page: 19532 year: 2010 ident: 10.1016/j.ccr.2012.09.021_bib28 article-title: Direct and coordinate regulation of ATP-binding cassette transporter genes by Myc factors generates specific transcription signatures that significantly affect the chemoresistance phenotype of cancer cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.078584 – volume: 108 start-page: 19611 year: 2011 ident: 10.1016/j.ccr.2012.09.021_bib40 article-title: Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1117773108 – volume: 136 start-page: 521 year: 2009 ident: 10.1016/j.ccr.2012.09.021_bib25 article-title: Bidirectional transport of amino acids regulates mTOR and autophagy publication-title: Cell doi: 10.1016/j.cell.2008.11.044 – volume: 20 start-page: 436 year: 2009 ident: 10.1016/j.ccr.2012.09.021_bib15 article-title: ATF4-dependent transcription mediates signaling of amino acid limitation publication-title: Trends Endocrinol. Metab. doi: 10.1016/j.tem.2009.05.008 – volume: 481 start-page: 380 year: 2012 ident: 10.1016/j.ccr.2012.09.021_bib22 article-title: Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia publication-title: Nature doi: 10.1038/nature10602 – volume: 27 start-page: S71 issue: Suppl 1 year: 2008 ident: 10.1016/j.ccr.2012.09.021_bib42 article-title: PUMA, a potent killer with or without p53 publication-title: Oncogene doi: 10.1038/onc.2009.45 – volume: 9 start-page: 480 year: 2007 ident: 10.1016/j.ccr.2012.09.021_bib30 article-title: Retraction publication-title: Nat. Cell Biol. doi: 10.1038/ncb1584 – volume: 46 start-page: 243 year: 1990 ident: 10.1016/j.ccr.2012.09.021_bib1 article-title: Metabolism and action of amino acid analog anti-cancer agents publication-title: Pharmacol. Ther. doi: 10.1016/0163-7258(90)90094-I – volume: 7 start-page: 11 year: 2008 ident: 10.1016/j.ccr.2012.09.021_bib9 article-title: The biology of cancer: metabolic reprogramming fuels cell growth and proliferation publication-title: Cell Metab. doi: 10.1016/j.cmet.2007.10.002 – volume: 431 start-page: 1112 year: 2004 ident: 10.1016/j.ccr.2012.09.021_bib31 article-title: MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer publication-title: Nature doi: 10.1038/nature03043 – volume: 324 start-page: 1029 year: 2009 ident: 10.1016/j.ccr.2012.09.021_bib34 article-title: Understanding the Warburg effect: the metabolic requirements of cell proliferation publication-title: Science doi: 10.1126/science.1160809 – volume: 126 start-page: 107 year: 2006 ident: 10.1016/j.ccr.2012.09.021_bib3 article-title: TIGAR, a p53-inducible regulator of glycolysis and apoptosis publication-title: Cell doi: 10.1016/j.cell.2006.05.036 – volume: 30 start-page: 16938 year: 2010 ident: 10.1016/j.ccr.2012.09.021_bib12 article-title: Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1598-10.2010 – volume: 2 start-page: 183 year: 2002 ident: 10.1016/j.ccr.2012.09.021_bib18 article-title: Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics publication-title: Cancer Cell doi: 10.1016/S1535-6108(02)00127-7 – volume: 27 start-page: 1478 year: 2008 ident: 10.1016/j.ccr.2012.09.021_bib20 article-title: Deregulated Wnt/beta-catenin program in high-risk neuroblastomas without MYCN amplification publication-title: Oncogene doi: 10.1038/sj.onc.1210769 – volume: 29 start-page: 2082 year: 2010 ident: 10.1016/j.ccr.2012.09.021_bib41 article-title: The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation publication-title: EMBO J. doi: 10.1038/emboj.2010.81 – volume: 46 start-page: 15089 year: 2007 ident: 10.1016/j.ccr.2012.09.021_bib19 article-title: High throughput screening reveals several new classes of glutamate dehydrogenase inhibitors publication-title: Biochemistry doi: 10.1021/bi7018783 – volume: 24 start-page: 3423 year: 2006 ident: 10.1016/j.ccr.2012.09.021_bib35 article-title: Phase I trial of oral fenretinide in children with high-risk solid tumors: a report from the Children’s Oncology Group (CCG 09709) publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2005.03.9271 – volume: 469 start-page: 216 year: 2011 ident: 10.1016/j.ccr.2012.09.021_bib37 article-title: Integrative genomics identifies LMO1 as a neuroblastoma oncogene publication-title: Nature doi: 10.1038/nature09609 – volume: 96 start-page: 1062 year: 2007 ident: 10.1016/j.ccr.2012.09.021_bib7 article-title: Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: the role of stress proteins ERdj5 and ERp57 publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6603672 – volume: 21 start-page: 7653 year: 2001 ident: 10.1016/j.ccr.2012.09.021_bib11 article-title: Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.21.22.7653-7662.2001 – volume: 18 start-page: 207 year: 2010 ident: 10.1016/j.ccr.2012.09.021_bib36 article-title: Targeting mitochondrial glutaminase activity inhibits oncogenic transformation publication-title: Cancer Cell doi: 10.1016/j.ccr.2010.08.009 – volume: 455 start-page: 930 year: 2008 ident: 10.1016/j.ccr.2012.09.021_bib23 article-title: Identification of ALK as a major familial neuroblastoma predisposition gene publication-title: Nature doi: 10.1038/nature07261 – volume: 70 start-page: 10351 year: 2010 ident: 10.1016/j.ccr.2012.09.021_bib29 article-title: Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-10-0740 – volume: 1800 start-page: 96 year: 2010 ident: 10.1016/j.ccr.2012.09.021_bib4 article-title: O-linked beta-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbagen.2009.07.018 – volume: 24 start-page: 1243 year: 2005 ident: 10.1016/j.ccr.2012.09.021_bib26 article-title: TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death publication-title: EMBO J. doi: 10.1038/sj.emboj.7600596 – volume: 269 start-page: 269 year: 2008 ident: 10.1016/j.ccr.2012.09.021_bib14 article-title: Multitargeted therapy of cancer by green tea polyphenols publication-title: Cancer Lett. doi: 10.1016/j.canlet.2008.04.014 – volume: 15 start-page: 232 year: 2009 ident: 10.1016/j.ccr.2012.09.021_bib10 article-title: Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis publication-title: Cancer Cell doi: 10.1016/j.ccr.2009.01.021 – volume: 6 start-page: 529 year: 2000 ident: 10.1016/j.ccr.2012.09.021_bib33 article-title: Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN publication-title: Nat. Med. doi: 10.1038/75007 – volume: 41 start-page: 718 year: 2009 ident: 10.1016/j.ccr.2012.09.021_bib5 article-title: Common variations in BARD1 influence susceptibility to high-risk neuroblastoma publication-title: Nat. Genet. doi: 10.1038/ng.374 – reference: 10802708 - Nat Med. 2000 May;6(5):529-35 – reference: 22225880 - Cell Metab. 2012 Jan 4;15(1):110-21 – reference: 22464321 - Cell. 2012 Mar 30;149(1):22-35 – reference: 21159964 - J Neurosci. 2010 Dec 15;30(50):16938-48 – reference: 18724359 - Nature. 2008 Oct 16;455(7215):930-5 – reference: 19412175 - Nat Genet. 2009 Jun;41(6):718-23 – reference: 22101433 - Nature. 2012 Jan 19;481(7381):380-4 – reference: 15775988 - EMBO J. 2005 Mar 23;24(6):1243-55 – reference: 20473272 - EMBO J. 2010 Jun 16;29(12):2082-96 – reference: 17606868 - J Cell Biol. 2007 Jul 2;178(1):93-105 – reference: 16616335 - Cancer Cell. 2006 Apr;9(4):301-12 – reference: 22106302 - Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19611-6 – reference: 19249681 - Cancer Cell. 2009 Mar 3;15(3):232-9 – reference: 19219026 - Nature. 2009 Apr 9;458(7239):762-5 – reference: 12242151 - Cancer Cell. 2002 Sep;2(3):183-92 – reference: 19647786 - Biochim Biophys Acta. 2010 Feb;1800(2):96-106 – reference: 20558371 - N Engl J Med. 2010 Jun 10;362(23):2202-11 – reference: 19249680 - Cancer Cell. 2009 Mar 3;15(3):220-31 – reference: 2108451 - Pharmacol Ther. 1990;46(2):243-71 – reference: 18458112 - J Exp Med. 2008 May 12;205(5):1227-42 – reference: 17466566 - Int J Biochem Cell Biol. 2008;40(1):14-21 – reference: 17353921 - Br J Cancer. 2007 Apr 10;96(7):1062-71 – reference: 18716624 - Nature. 2008 Oct 2;455(7213):679-83 – reference: 19641508 - Oncogene. 2008 Dec;27 Suppl 1:S71-83 – reference: 17724465 - Oncogene. 2008 Feb 28;27(10):1478-88 – reference: 19033189 - Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18782-7 – reference: 20233711 - J Biol Chem. 2010 Jun 18;285(25):19532-43 – reference: 19203585 - Cell. 2009 Feb 6;136(3):521-34 – reference: 19800252 - Trends Endocrinol Metab. 2009 Nov;20(9):436-43 – reference: 22101431 - Nature. 2012 Jan 19;481(7381):385-8 – reference: 20832749 - Cancer Cell. 2010 Sep 14;18(3):207-19 – reference: 18177721 - Cell Metab. 2008 Jan;7(1):11-20 – reference: 18501505 - Cancer Lett. 2008 Oct 8;269(2):269-80 – reference: 16839880 - Cell. 2006 Jul 14;126(1):107-20 – reference: 21124317 - Nature. 2011 Jan 13;469(7329):216-20 – reference: 20961996 - Cancer Res. 2010 Dec 15;70(24):10351-61 – reference: 12652308 - Nat Cell Biol. 2003 Apr;5(4):320-9 – reference: 11326099 - Science. 2001 Apr 27;292(5517):727-30 – reference: 15475948 - Nature. 2004 Oct 28;431(7012):1112-7 – reference: 16849757 - J Clin Oncol. 2006 Jul 20;24(21):3423-30 – reference: 19460998 - Science. 2009 May 22;324(5930):1029-33 – reference: 11604501 - Mol Cell Biol. 2001 Nov;21(22):7653-62 – reference: 18044977 - Biochemistry. 2007 Dec 25;46(51):15089-102
SSID	ssj0016179
Score	2.552505
Snippet	Oncogenic Myc alters mitochondrial metabolism, making it dependent on exogenous glutamine (Gln) for cell survival. Accordingly, Gln deprivation selectively...
SourceID	pubmedcentral proquest pubmed crossref elsevier
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	631
SubjectTerms	Activating Transcription Factor 4 - genetics Activating Transcription Factor 4 - metabolism Activating Transcription Factor 4 - physiology Aminooxyacetic Acid - pharmacology Animals Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism bcl-2-Associated X Protein - metabolism Caspases - metabolism Cell Cycle Proteins - metabolism Cell Proliferation - drug effects Glutamine - metabolism Humans Mice Mice, Inbred BALB C Mice, Nude Neuroblastoma - metabolism Neuroblastoma - pathology Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Proto-Oncogene Proteins c-myc - physiology Repressor Proteins - metabolism Tumor Suppressor Protein p53 - physiology
Title	ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation
URI	https://dx.doi.org/10.1016/j.ccr.2012.09.021 https://www.ncbi.nlm.nih.gov/pubmed/23153536 https://www.proquest.com/docview/1171881711 https://pubmed.ncbi.nlm.nih.gov/PMC3510660
Volume	22
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9swDBaKHoZehnbrI31BBXYa4MWWJVk6ttnSdkNWYGmB7CRYioSmSJwgTf5_ST-CZUVz6MWAbcoQSIqkTPEjIV9UErTwLI9k7lnEA_ORskJFToUA3oUrXWZ0e7_lzQP_ORCDLdJpamHwWGVt-yubXlrr-km75mZ7Nhq1-7BW0fmDh8ICU42w21hVikV8g6tVJgE8tK4wU0WE1E1mszzj5RxCguLvQP0tZslbvul17Pn_Ecp_fFJ3l3ysg0l6Wc13j2z54hP50KvT5Z_J3eV9l9M_Vbt5_0x7fztRr-zN4Ye0hOWwEDwvppOcdvx4TL9jPEiXs2lBr0Ej8wl8BR7O5nULtH3S7_6479xEdQeFyHGRLFAAsANSZVwjcQMKu4vEa-YCZ7kMufSZinVg1g1TEVuRumwY4sRy2MQwmR6Q7WJa-CNChZBe-zSIzA95lia5xYSf5Tx2VlrBWiRuOGdcDS6OPS7GpjlF9mSA2QaZbWJtgNkt8nU1ZFYha2wi5o04zJp6GLD8m4ZdNKIzsGwwF5IXfrp8RozzRCm4AM1hJcrVLCDkBW1JZYtka0JeESAk9_qbYvRYQnOnYOKkjI_fN90TsoN3WOqYpKdkezFf-jOIeRb2HKL921_npWq_ALbg_g4
linkProvider	Elsevier
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELfGkIAXtMGAwtiMxBNSqOPYjv04CqUby5BYkcqTFbu2KOrSamv_f-7yUdEh9sBLHpxzZN2d78658-8IeavTaGTgZaLKwBMReUi0kzrxOkbwLkKbOqNbXKjRd3E2kZMdMujuwmBZZWv7G5teW-t2pN9ys7-czfqXsFfR-YOHwgumRt0j9yEaYKjap5MPm1QCuGjTgKbKBMm71GZd5OU9YoLi_0DznvH0X87p7-Dzdg3lH05puEcet9EkPWkWvE92QvWEPCjafPlT8vVkPBT0W9NvPtzQ4scgKermHGFKa1wOB9HzanFV0kGYz-lHDAjpermo6GdQyfIKvgKDy-u2B9oBuRx-Gg9GSdtCIfFCpiuUAByBdB3YKDyBwvEiDYb7KHipYqlCrpmJ3PlpJpmTmc-nkaVOwCmGq-wZ2a0WVXhBqJQqmJBFmYepyLO0dJjxc0Iw75STvEdYxznrW3RxbHIxt10Z2S8LzLbIbMuMBWb3yLvNlGUDrXEXsejEYbf0w4Lpv2vam050FvYNJkPKKizWNwhynmoND6B53ohyswqIeUFbMtUj-ZaQNwSIyb39ppr9rLG5M7BxSrGX_7fcY_JwNC7O7fnpxZdX5BG-wXuPaXZIdlfX6_AaAqCVO6oV_DeN8QBH
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=ATF4+Regulates+MYC-mediated+Neuroblastoma+Cell+Death+upon+Glutamine+Deprivation&rft.jtitle=Cancer+cell&rft.au=Qing%2C+Guoliang&rft.au=Li%2C+Bo&rft.au=Vu%2C+Annette&rft.au=Skuli%2C+Nicolas&rft.date=2012-11-13&rft.issn=1535-6108&rft.eissn=1878-3686&rft.volume=22&rft.issue=5&rft.spage=631&rft.epage=644&rft_id=info:doi/10.1016%2Fj.ccr.2012.09.021&rft_id=info%3Apmid%2F23153536&rft.externalDocID=PMC3510660
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1535-6108&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1535-6108&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1535-6108&client=summon