Genetic Predictors of Increase in Suicidal Ideation During Antidepressant Treatment in the GENDEP Project
The aim of this study was to investigate genetic predictors of an increase in suicidal ideation during treatment with a selective serotonin reuptake inhibitor or a tricyclic antidepressant. A total of 796 adult patients with major depressive disorder who were treated with a flexible dosage of escita...
Saved in:
| Published in | Neuropsychopharmacology (New York, N.Y.) Vol. 34; no. 12; pp. 2517 - 2528 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cham
Springer International Publishing
01.11.2009
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0893-133X 1740-634X 1740-634X |
| DOI | 10.1038/npp.2009.81 |
Cover
| Abstract | The aim of this study was to investigate genetic predictors of an increase in suicidal ideation during treatment with a selective serotonin reuptake inhibitor or a tricyclic antidepressant. A total of 796 adult patients with major depressive disorder who were treated with a flexible dosage of escitalopram or nortriptyline in Genome-based Therapeutic Drugs for Depression (GENDEP) were included in the sample and provided data on suicidal ideation. Nine candidate genes involved in neurotrophic, serotonergic, and noradrenergic pathways were selected based on previous association studies with suicidal ideation or behavior. Using a logistic regression model, 123 polymorphisms in these genes were compared between subjects with an increase in suicidal ideation and those without any increase in suicidal ideation. Polymorphisms in
BDNF
, the gene encoding the brain-derived neurotrophic factor, were significantly associated with an increase in suicidal ideation. The strongest association was observed for rs962369 in
BDNF
(
p
=0.0015). Moreover, a significant interaction was found between variants in
BDNF
and
NTRK2
, the gene encoding the BNDF receptor (
p
=0.0003). Among men taking nortriptyline, suicidality was also associated with rs11195419 SNP in the alpha
2A
-adrenergic receptor gene (
ADRA2A
) (
p
=0.007). The associations observed with polymorphisms in
BDNF
suggest the involvement of the neurotrophic system in vulnerability to suicidality. Epistasis between
BDNF
and
NTRK2
suggests that genetic variations in the two genes are involved in the same causal mechanisms leading to suicidality during antidepressant treatment. Among men, genetic variation in noradrenergic signaling may interact with norepinephrine reuptake-inhibiting antidepressants, thereby contributing to suicidality. |
|---|---|
| AbstractList | The aim of this study was to investigate genetic predictors of an increase in suicidal ideation during treatment with a selective serotonin reuptake inhibitor or a tricyclic antidepressant. A total of 796 adult patients with major depressive disorder who were treated with a flexible dosage of escitalopram or nortriptyline in Genome-based Therapeutic Drugs for Depression (GENDEP) were included in the sample and provided data on suicidal ideation. Nine candidate genes involved in neurotrophic, serotonergic, and noradrenergic pathways were selected based on previous association studies with suicidal ideation or behavior. Using a logistic regression model, 123 polymorphisms in these genes were compared between subjects with an increase in suicidal ideation and those without any increase in suicidal ideation. Polymorphisms in BDNF, the gene encoding the brain-derived neurotrophic factor, were significantly associated with an increase in suicidal ideation. The strongest association was observed for rs962369 in BDNF (p=0.0015). Moreover, a significant interaction was found between variants in BDNF and NTRK2, the gene encoding the BNDF receptor (p=0.0003). Among men taking nortriptyline, suicidality was also associated with rs11195419 SNP in the alpha(2A)-adrenergic receptor gene (ADRA2A) (p=0.007). The associations observed with polymorphisms in BDNF suggest the involvement of the neurotrophic system in vulnerability to suicidality. Epistasis between BDNF and NTRK2 suggests that genetic variations in the two genes are involved in the same causal mechanisms leading to suicidality during antidepressant treatment. Among men, genetic variation in noradrenergic signaling may interact with norepinephrine reuptake-inhibiting antidepressants, thereby contributing to suicidality.The aim of this study was to investigate genetic predictors of an increase in suicidal ideation during treatment with a selective serotonin reuptake inhibitor or a tricyclic antidepressant. A total of 796 adult patients with major depressive disorder who were treated with a flexible dosage of escitalopram or nortriptyline in Genome-based Therapeutic Drugs for Depression (GENDEP) were included in the sample and provided data on suicidal ideation. Nine candidate genes involved in neurotrophic, serotonergic, and noradrenergic pathways were selected based on previous association studies with suicidal ideation or behavior. Using a logistic regression model, 123 polymorphisms in these genes were compared between subjects with an increase in suicidal ideation and those without any increase in suicidal ideation. Polymorphisms in BDNF, the gene encoding the brain-derived neurotrophic factor, were significantly associated with an increase in suicidal ideation. The strongest association was observed for rs962369 in BDNF (p=0.0015). Moreover, a significant interaction was found between variants in BDNF and NTRK2, the gene encoding the BNDF receptor (p=0.0003). Among men taking nortriptyline, suicidality was also associated with rs11195419 SNP in the alpha(2A)-adrenergic receptor gene (ADRA2A) (p=0.007). The associations observed with polymorphisms in BDNF suggest the involvement of the neurotrophic system in vulnerability to suicidality. Epistasis between BDNF and NTRK2 suggests that genetic variations in the two genes are involved in the same causal mechanisms leading to suicidality during antidepressant treatment. Among men, genetic variation in noradrenergic signaling may interact with norepinephrine reuptake-inhibiting antidepressants, thereby contributing to suicidality. The aim of this study was to investigate genetic predictors of an increase in suicidal ideation during treatment with a selective serotonin reuptake inhibitor or a tricyclic antidepressant. A total of 796 adult patients with major depressive disorder who were treated with a flexible dosage of escitalopram or nortriptyline in Genome-based Therapeutic Drugs for Depression (GENDEP) were included in the sample and provided data on suicidal ideation. Nine candidate genes involved in neurotrophic, serotonergic, and noradrenergic pathways were selected based on previous association studies with suicidal ideation or behavior. Using a logistic regression model, 123 polymorphisms in these genes were compared between subjects with an increase in suicidal ideation and those without any increase in suicidal ideation. Polymorphisms in BDNF, the gene encoding the brain-derived neurotrophic factor, were significantly associated with an increase in suicidal ideation. The strongest association was observed for rs962369 in BDNF (p=0.0015). Moreover, a significant interaction was found between variants in BDNF and NTRK2, the gene encoding the BNDF receptor (p=0.0003). Among men taking nortriptyline, suicidality was also associated with rs11195419 SNP in the alpha sub(2A)-adrenergic receptor gene (ADRA2A) (p=0.007). The associations observed with polymorphisms in BDNF suggest the involvement of the neurotrophic system in vulnerability to suicidality. Epistasis between BDNF and NTRK2 suggests that genetic variations in the two genes are involved in the same causal mechanisms leading to suicidality during antidepressant treatment. Among men, genetic variation in noradrenergic signaling may interact with norepinephrine reuptake-inhibiting antidepressants, thereby contributing to suicidality. The aim of this study was to investigate genetic predictors of an increase in suicidal ideation during treatment with a selective serotonin reuptake inhibitor or a tricyclic antidepressant. A total of 796 adult patients with major depressive disorder who were treated with a flexible dosage of escitalopram or nortriptyline in Genome-based Therapeutic Drugs for Depression (GENDEP) were included in the sample and provided data on suicidal ideation. Nine candidate genes involved in neurotrophic, serotonergic, and noradrenergic pathways were selected based on previous association studies with suicidal ideation or behavior. Using a logistic regression model, 123 polymorphisms in these genes were compared between subjects with an increase in suicidal ideation and those without any increase in suicidal ideation. Polymorphisms in BDNF , the gene encoding the brain-derived neurotrophic factor, were significantly associated with an increase in suicidal ideation. The strongest association was observed for rs962369 in BDNF ( p =0.0015). Moreover, a significant interaction was found between variants in BDNF and NTRK2 , the gene encoding the BNDF receptor ( p =0.0003). Among men taking nortriptyline, suicidality was also associated with rs11195419 SNP in the alpha 2A -adrenergic receptor gene ( ADRA2A ) ( p =0.007). The associations observed with polymorphisms in BDNF suggest the involvement of the neurotrophic system in vulnerability to suicidality. Epistasis between BDNF and NTRK2 suggests that genetic variations in the two genes are involved in the same causal mechanisms leading to suicidality during antidepressant treatment. Among men, genetic variation in noradrenergic signaling may interact with norepinephrine reuptake-inhibiting antidepressants, thereby contributing to suicidality. The aim of this study was to investigate genetic predictors of an increase in suicidal ideation during treatment with a selective serotonin reuptake inhibitor or a tricyclic antidepressant. A total of 796 adult patients with major depressive disorder who were treated with a flexible dosage of escitalopram or nortriptyline in Genome-based Therapeutic Drugs for Depression (GENDEP) were included in the sample and provided data on suicidal ideation. Nine candidate genes involved in neurotrophic, serotonergic, and noradrenergic pathways were selected based on previous association studies with suicidal ideation or behavior. Using a logistic regression model, 123 polymorphisms in these genes were compared between subjects with an increase in suicidal ideation and those without any increase in suicidal ideation. Polymorphisms in BDNF, the gene encoding the brain-derived neurotrophic factor, were significantly associated with an increase in suicidal ideation. The strongest association was observed for rs962369 in BDNF (p=0.0015). Moreover, a significant interaction was found between variants in BDNF and NTRK2, the gene encoding the BNDF receptor (p=0.0003). Among men taking nortriptyline, suicidality was also associated with rs11195419 SNP in the alpha(2A)-adrenergic receptor gene (ADRA2A) (p=0.007). The associations observed with polymorphisms in BDNF suggest the involvement of the neurotrophic system in vulnerability to suicidality. Epistasis between BDNF and NTRK2 suggests that genetic variations in the two genes are involved in the same causal mechanisms leading to suicidality during antidepressant treatment. Among men, genetic variation in noradrenergic signaling may interact with norepinephrine reuptake-inhibiting antidepressants, thereby contributing to suicidality. |
| Author | Farmer, Anne E Petrovic, Ana Craig, Ian Jorgensen, Lisbeth Kapelski, Pawel Mors, Ole Huezo-Diaz, Patricia Placentino, Anna Maier, Wolfgang Rietschel, Marcella Kalember, Petra Zobel, Astrid Gupta, Bhanu Bonvicini, Cristian Lewis, Cathryn M Uher, Rudolf Gray, Joanna McGuffin, Peter Hauser, Joanna Marusic, Andrej Perroud, Nader Smith, Rebecca Henigsberg, Neven Schulze, Thomas G Aitchison, Katherine J Souery, Daniel |
| Author_xml | – sequence: 1 givenname: Nader surname: Perroud fullname: Perroud, Nader email: nader.perroud@iop.kcl.ac.uk, nader.perroud@hcuge.ch organization: MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King's College Lodon – sequence: 2 givenname: Katherine J surname: Aitchison fullname: Aitchison, Katherine J organization: MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King's College Lodon – sequence: 3 givenname: Rudolf surname: Uher fullname: Uher, Rudolf organization: MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King's College Lodon – sequence: 4 givenname: Rebecca surname: Smith fullname: Smith, Rebecca organization: MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King's College Lodon – sequence: 5 givenname: Patricia surname: Huezo-Diaz fullname: Huezo-Diaz, Patricia organization: MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King's College Lodon – sequence: 6 givenname: Andrej surname: Marusic fullname: Marusic, Andrej organization: Institute of Public Health, Trubarjeva 2 – sequence: 7 givenname: Wolfgang surname: Maier fullname: Maier, Wolfgang organization: Department of Psychiatry, University of Bonn, Sigmund-Freud-Str 25 – sequence: 8 givenname: Ole surname: Mors fullname: Mors, Ole organization: Centre for Psychiatric Research, Aarhus University Hospital, Skovagervej 2 – sequence: 9 givenname: Anna surname: Placentino fullname: Placentino, Anna organization: Biological Psychiatry Unit and Dual Diagnosis ward IRCCS, Centro San Giovanni di Dio, FBF – sequence: 10 givenname: Neven surname: Henigsberg fullname: Henigsberg, Neven organization: Department of Neuropharmacology and Behavioural Pharmacology, Croatian Institute for Brain Research, Medical School, University of Zagreb, Salata 12 – sequence: 11 givenname: Marcella surname: Rietschel fullname: Rietschel, Marcella organization: Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health – sequence: 12 givenname: Joanna surname: Hauser fullname: Hauser, Joanna organization: Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences – sequence: 13 givenname: Daniel surname: Souery fullname: Souery, Daniel organization: Department of Psychiatry, Laboratoire de Psychologie Médicale, Université Libre de Bruxelles and Psy Pluriel—Centre Européen de Psychologie Médicale – sequence: 14 givenname: Pawel surname: Kapelski fullname: Kapelski, Pawel organization: Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences – sequence: 15 givenname: Cristian surname: Bonvicini fullname: Bonvicini, Cristian organization: Biological Psychiatry Unit and Dual Diagnosis ward IRCCS, Centro San Giovanni di Dio, FBF – sequence: 16 givenname: Astrid surname: Zobel fullname: Zobel, Astrid organization: Department of Psychiatry, University of Bonn, Sigmund-Freud-Str 25 – sequence: 17 givenname: Lisbeth surname: Jorgensen fullname: Jorgensen, Lisbeth organization: Mood Disorders Research Unit, Aarhus University Hospital, Risskov – sequence: 18 givenname: Ana surname: Petrovic fullname: Petrovic, Ana organization: Institute of Public Health, Trubarjeva 2 – sequence: 19 givenname: Petra surname: Kalember fullname: Kalember, Petra organization: Department of Neuropharmacology and Behavioural Pharmacology, Croatian Institute for Brain Research, Medical School, University of Zagreb, Salata 12 – sequence: 20 givenname: Thomas G surname: Schulze fullname: Schulze, Thomas G organization: Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health – sequence: 21 givenname: Bhanu surname: Gupta fullname: Gupta, Bhanu organization: MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King's College Lodon – sequence: 22 givenname: Joanna surname: Gray fullname: Gray, Joanna organization: MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King's College Lodon – sequence: 23 givenname: Cathryn M surname: Lewis fullname: Lewis, Cathryn M organization: MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King's College Lodon, Department of Medical and Molecular Genetics, King's College London – sequence: 24 givenname: Anne E surname: Farmer fullname: Farmer, Anne E organization: MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King's College Lodon – sequence: 25 givenname: Peter surname: McGuffin fullname: McGuffin, Peter organization: MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King's College Lodon – sequence: 26 givenname: Ian surname: Craig fullname: Craig, Ian organization: MRC Social Genetic and Developmental Psychiatry Center, Institute of Psychiatry, King's College Lodon |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22057954$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19641488$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kUFv1DAQhS1URLeFE3dkIdEeaBY7dmL7WLXLslIFlShSb5HjjMGrrBNs59B_X293oVJFOXkO33vjN-8IHfjBA0JvKZlTwuQnP47zkhA1l_QFmlHBSVEzfnuAZkQqVlDGbg_RUYxrQmglavkKHVJVc8qlnCG3BA_JGXwdoHMmDSHiweKVNwF0BOw8_j454zrd41UHOrnB48spOP8Tn_vkOhgDxKh9wjdZkTaQpyxKvwAvF18vF9fZeViDSa_RS6v7CG_27zH68Xlxc_GluPq2XF2cXxWGVyQVltUm_61kXEtiOyNbQTmntTUVb9tSEyu0VayzmnFhWlvnvKQTqtZG2bbi7Bid7nzHMPyeIKZm46KBvtcehik2gjGpKOEikyf_JUtKRS0Iy-D7J-B6mILPKZqyrKhSktEMvdtDU7uBrhmD2-hw1_y5dQY-7AEdje5t0N64-JcrS1IJ9RDg444zYYgxgH20Is228SY33mwbb-R2LX1CG5ceakpBu_4ZzdlOE8dtkRAe8_wLvwdDa7wt |
| CODEN | NEROEW |
| CitedBy_id | crossref_primary_10_1016_j_jad_2016_07_029 crossref_primary_10_7759_cureus_38627 crossref_primary_10_2217_pgs_2016_0165 crossref_primary_10_1016_j_psc_2011_02_003 crossref_primary_10_1017_S1461145710000829 crossref_primary_10_1038_s41598_019_39622_3 crossref_primary_10_1111_appy_12148 crossref_primary_10_1002_phar_1978 crossref_primary_10_1002_gps_4498 crossref_primary_10_3109_15622975_2016_1142608 crossref_primary_10_1038_mp_2015_27 crossref_primary_10_3390_ph16101497 crossref_primary_10_1586_ern_10_186 crossref_primary_10_1016_j_euroneuro_2012_08_009 crossref_primary_10_1007_s12325_017_0555_2 crossref_primary_10_1038_ncomms15497 crossref_primary_10_1176_appi_ajp_2010_10081227 crossref_primary_10_1177_0269881111414452 crossref_primary_10_1016_j_neubiorev_2020_12_033 crossref_primary_10_1038_npp_2011_257 crossref_primary_10_1017_S1092852913000278 crossref_primary_10_1016_j_jad_2011_11_013 crossref_primary_10_1038_tp_2016_261 crossref_primary_10_1093_ijnp_pyw059 crossref_primary_10_1038_tp_2016_101 crossref_primary_10_2217_pgs_12_1 crossref_primary_10_2217_pme_13_93 crossref_primary_10_1016_j_jpsychires_2019_03_007 crossref_primary_10_3109_07420528_2014_899244 crossref_primary_10_1038_tpj_2010_70 crossref_primary_10_1111_acer_13414 crossref_primary_10_1002_brb3_706 crossref_primary_10_1371_journal_pone_0064947 crossref_primary_10_4306_pi_2010_7_4_236 crossref_primary_10_1038_npp_2012_49 crossref_primary_10_1038_tp_2015_15 crossref_primary_10_1016_j_biopsych_2010_07_023 crossref_primary_10_2165_11589420_000000000_00000 crossref_primary_10_3109_01612840_2010_541588 crossref_primary_10_1016_j_pharmthera_2023_108390 crossref_primary_10_17116_jnevro201511531113_121 crossref_primary_10_3389_fpsyt_2022_880496 crossref_primary_10_3390_jpm13030501 crossref_primary_10_7202_1014947ar crossref_primary_10_1038_srep42676 crossref_primary_10_1016_j_yebeh_2017_03_030 crossref_primary_10_1159_000487321 crossref_primary_10_1038_s41398_020_01003_0 crossref_primary_10_1007_s00018_012_1237_5 crossref_primary_10_1017_S1461145711001313 crossref_primary_10_1016_j_bbr_2021_113350 crossref_primary_10_1002_ajmg_b_32913 crossref_primary_10_1016_j_jad_2009_09_001 crossref_primary_10_1016_j_neubiorev_2013_07_011 crossref_primary_10_1016_j_psc_2016_04_001 crossref_primary_10_1016_j_pharmthera_2012_08_015 crossref_primary_10_1176_appi_ajp_2009_09070932 crossref_primary_10_1007_s13353_012_0113_1 crossref_primary_10_1016_j_pnpbp_2012_04_014 crossref_primary_10_1016_j_pnpbp_2024_111154 crossref_primary_10_1017_neu_2022_22 crossref_primary_10_1177_0269881110376693 crossref_primary_10_2217_pgs_13_58 crossref_primary_10_3390_biomedicines10040896 crossref_primary_10_3390_biomedicines11082243 crossref_primary_10_2217_pgs_10_189 crossref_primary_10_1002_pds_1850 crossref_primary_10_1016_j_pnpbp_2010_10_014 crossref_primary_10_2217_pgs_10_64 |
| Cites_doi | 10.1038/sj.hdy.6800717 10.1002/ajmg.c.30043 10.1016/S0165-6147(00)01758-2 10.1086/519795 10.1001/archpsyc.60.8.804 10.1017/S0033291707001730 10.1016/j.mehy.2005.05.010 10.1086/383251 10.1001/archpsyc.64.6.689 10.1002/ajmg.c.30042 10.1046/j.1471-4159.1994.63010256.x 10.1111/j.1399-5618.2008.00603.x 10.1016/j.brainres.2004.06.085 10.1038/tpj.2009.12 10.1176/appi.ajp.2007.06122018 10.1023/A:1021055617738 10.1016/j.molbrainres.2004.12.020 10.1016/j.neures.2005.06.008 10.1016/S0028-3908(03)00198-9 10.1038/nn1659 10.1002/ajmg.b.20015 10.1016/S0092-8674(03)00035-7 10.1038/nrn1220 10.1002/gepi.20379 10.1038/mp.2008.61 10.1038/sj.mp.4001778 10.1002/ajmg.b.30849 10.1016/S0028-3908(03)00077-7 10.1371/journal.pgen.0020143 10.1126/science.1120972 10.1093/genetics/155.2.945 10.1111/j.1601-183X.2007.00354.x 10.1001/archpsyc.60.3.273 10.1016/S0140-6736(09)60046-5 10.1097/00041444-200010010-00007 10.1007/s00213-002-1364-z 10.1007/PL00000701 10.1016/j.pnpbp.2006.06.024 10.1016/j.psychres.2003.12.002 10.1159/000142361 10.1038/sj.npp.1300459 10.1046/j.1471-4159.1999.0720282.x 10.1192/bjp.bp.108.062521 10.1192/bjp.bp.108.057554 10.1073/pnas.96.26.15239 10.1038/sj.mp.4001822 10.1016/j.pnpbp.2008.02.003 10.1038/sj.mp.4001890 10.1016/S0193-953X(05)70140-4 10.1023/A:1006986824213 10.1038/ng1669 10.1027//0227-5910.22.2.61 10.1016/S0006-3223(03)00073-8 |
| ContentType | Journal Article |
| Copyright | American College of Neuropsychopharmacology 2009 2009 INIST-CNRS Copyright Nature Publishing Group Nov 2009 |
| Copyright_xml | – notice: American College of Neuropsychopharmacology 2009 – notice: 2009 INIST-CNRS – notice: Copyright Nature Publishing Group Nov 2009 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 3V. 7TK 7X7 7XB 88E 88G 8AO 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2M M7P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ Q9U 8FD FR3 P64 RC3 7X8 |
| DOI | 10.1038/npp.2009.81 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Neurosciences Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Psychology Database (Alumni) ProQuest Pharma Collection ProQuest SciTech Collection ProQuest Natural Science Journals Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Database ProQuest Central Natural Science Collection ProQuest One ProQuest Central Health Research Premium Collection (UHCL Subscription) Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection (UHCL Subscription) ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni) Medical Database ProQuest Psychology Database (NC LIVE) Biological Science Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Psychology ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) Genetics Abstracts Engineering Research Database Technology Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic Genetics Abstracts ProQuest One Psychology MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1740-634X |
| EndPage | 2528 |
| ExternalDocumentID | 1879508391 19641488 22057954 10_1038_npp_2009_81 |
| Genre | Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | Denmark United Kingdom--UK Germany Aarhus Denmark |
| GeographicLocations_xml | – name: Denmark – name: Aarhus Denmark – name: Germany – name: United Kingdom--UK |
| GrantInformation_xml | – fundername: Medical Research Council grantid: G0701003 – fundername: Department of Health |
| GroupedDBID | --- --K -DZ -Q- 0R~ 1B1 29N 2WC 36B 39C 3V. 4.4 406 53G 5RE 5VS 70F 7X7 88E 8AO 8FI 8FJ 8R4 8R5 AACDK AAEDT AALRI AANZL AAQFI AAQXK AASML AATNV AAXUO AAYZH AAZLF ABAKF ABIVO ABJNI ABLJU ABMAC ABUWG ABWVN ABZZP ACAOD ACGFO ACGFS ACIUM ACKTT ACMJI ACPRK ACRPL ACRQY ACZOJ ADBBV ADFRT ADHDB ADMUD ADNMO AEFQL AEJRE AEMSY AENEX AESKC AEVLU AEXYK AFBBN AFKRA AFRAH AFSHS AGAYW AGHAI AGQEE AHMBA AHSBF AIGIU AILAN AJRNO ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMYLF AOIJS ASPBG AVWKF AZFZN AZQEC BAWUL BBNVY BENPR BHPHI BPHCQ BVXVI CAG CCPQU COF CS3 DIK DNIVK DPUIP DWQXO E3Z EBLON EBS EE. EIOEI EJD EMB EMOBN F5P FDB FDQFY FEDTE FERAY FGOYB FIGPU FIZPM FSGXE FYUFA GNUQQ GX1 HCIFZ HMCUK HVGLF HYE HZ~ IHE IWAJR JSO JZLTJ KQ8 LGEZI LOTEE M1P M2M M41 M7P MK0 NADUK NAO NQ- NQJWS NXXTH O9- OK1 P2P P6G PQQKQ PROAC PSQYO PSYQQ Q2X R2- RIG RNS RNT RNTTT ROL RPM RPZ SEW SNX SNYQT SOHCF SOJ SRMVM SSZ SV3 SWTZT TAOOD TBHMF TDRGL TR2 UKHRP W2D ZGI ZKB AAYXX ABBRH ABDBE ABFSG ACMFV ACSTC AEZWR AFDZB AFHIU AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT IQODW ABRTQ ACVFH ADCNI AEUPX AFPUW AGQPQ CGR CUY CVF ECM EIF NPM PJZUB PPXIY PQGLB 7TK 7XB 8FE 8FH 8FK K9. LK8 PKEHL PQEST PQUKI PRINS Q9U 8FD FR3 P64 PUEGO RC3 7X8 |
| ID | FETCH-LOGICAL-c450t-f36c414234a80fdc8b714416fc54bb2a0f7af93dfa347cbf67400d796ac9fb543 |
| IEDL.DBID | 7X7 |
| ISSN | 0893-133X 1740-634X |
| IngestDate | Fri Sep 05 08:47:39 EDT 2025 Sun Sep 28 02:05:42 EDT 2025 Sat Aug 23 13:19:56 EDT 2025 Mon Jul 21 06:03:57 EDT 2025 Mon Mar 31 10:57:24 EDT 2025 Tue Jul 01 01:05:17 EDT 2025 Thu Apr 24 23:06:53 EDT 2025 Fri Feb 21 02:38:35 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Keywords | norepinephrine suicidal ideation antidepressive agents serotonin BDNF ADRA2A Serotonin Psychotropic Catecholamine Treatment Neurotransmitter Antidepressant agent Genetics Norepinephrine Brain derived neurotrophic factor Predictive factor Suicide ideation |
| Language | English |
| License | http://www.springer.com/tdm CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c450t-f36c414234a80fdc8b714416fc54bb2a0f7af93dfa347cbf67400d796ac9fb543 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 |
| OpenAccessLink | https://www.nature.com/articles/npp200981.pdf |
| PMID | 19641488 |
| PQID | 225199831 |
| PQPubID | 33935 |
| PageCount | 12 |
| ParticipantIDs | proquest_miscellaneous_733891047 proquest_miscellaneous_21176703 proquest_journals_225199831 pubmed_primary_19641488 pascalfrancis_primary_22057954 crossref_primary_10_1038_npp_2009_81 crossref_citationtrail_10_1038_npp_2009_81 springer_journals_10_1038_npp_2009_81 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2009-11-01 |
| PublicationDateYYYYMMDD | 2009-11-01 |
| PublicationDate_xml | – month: 11 year: 2009 text: 2009-11-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Cham |
| PublicationPlace_xml | – name: Cham – name: Basingstoke – name: England – name: New York |
| PublicationSubtitle | At the intersection of brain, behavior, and therapeutics |
| PublicationTitle | Neuropsychopharmacology (New York, N.Y.) |
| PublicationTitleAbbrev | Neuropsychopharmacol |
| PublicationTitleAlternate | Neuropsychopharmacology |
| PublicationYear | 2009 |
| Publisher | Springer International Publishing Nature Publishing Group |
| Publisher_xml | – name: Springer International Publishing – name: Nature Publishing Group |
| References | S Purcell (BFnpp200981_CR42) 2007; 81 MF Seldin (BFnpp200981_CR47) 2006; 2 A Cipriani (BFnpp200981_CR7) 2009; 373 P McGuffin (BFnpp200981_CR31) 2001; 22 BG Dias (BFnpp200981_CR13) 2003; 45 F Karege (BFnpp200981_CR24) 2005; 136 N Perroud (BFnpp200981_CR37) 2008; 7 F Bellivier (BFnpp200981_CR2) 2004; 124B P Courtet (BFnpp200981_CR10) 2005; 133C JA Garcia-Sevilla (BFnpp200981_CR21) 1999; 72 M Sarchiapone (BFnpp200981_CR46) 2008; 57 WE Lyons (BFnpp200981_CR29) 1999; 96 A Sequeira (BFnpp200981_CR48) 2004; 125 KM Small (BFnpp200981_CR49) 2001; 22 R Uher (BFnpp200981_CR54) 2009; 194 DA Brent (BFnpp200981_CR5) 2005; 133C PI de Bakker (BFnpp200981_CR12) 2005; 37 O Berton (BFnpp200981_CR4) 2006; 311 P Huezo-Diaz (BFnpp200981_CR23) 2008; 195 NM Tsankova (BFnpp200981_CR51) 2006; 9 L Pezawas (BFnpp200981_CR39) 2008; 13 JK Pritchard (BFnpp200981_CR41) 2000; 155 S Rabe-Hesketh (BFnpp200981_CR43) 2005 BFnpp200981_CR38 JM Pizarro (BFnpp200981_CR40) 2004; 1025 S Finkbeiner (BFnpp200981_CR18) 2000; 57 S Murakami (BFnpp200981_CR32) 2005; 53 MA Oquendo (BFnpp200981_CR35) 2000; 23 M Fukutake (BFnpp200981_CR20) 2008; 32 F Zarrilli (BFnpp200981_CR57) 2008; 150B T Okada (BFnpp200981_CR34) 2006; 11 Y Dwivedi (BFnpp200981_CR15) 2003; 60 G Laje (BFnpp200981_CR26) 2007; 164 CA Altar (BFnpp200981_CR1) 2003; 54 DE Comings (BFnpp200981_CR8) 2000; 10 C Sanchez (BFnpp200981_CR45) 1999; 19 I Vincze (BFnpp200981_CR56) 2008; 10 Y Dwivedi (BFnpp200981_CR14) 2003; 60 T Dadd (BFnpp200981_CR11) 2008; 33 MF Egan (BFnpp200981_CR16) 2003; 112 DR Nyholt (BFnpp200981_CR33) 2004; 74 AL Coppell (BFnpp200981_CR9) 2003; 44 R Cheng (BFnpp200981_CR6) 2006; 11 RH Perlis (BFnpp200981_CR36) 2007; 64 YK Kim (BFnpp200981_CR25) 2007; 31 B Freeman (BFnpp200981_CR19) 2003; 33 AM Gonzalez (BFnpp200981_CR22) 1994; 63 J Li (BFnpp200981_CR28) 2005; 95 BFnpp200981_CR55 BFnpp200981_CR53 SJ Tsai (BFnpp200981_CR50) 2005; 65 PV Escriba (BFnpp200981_CR17) 2004; 29 Y Benjamini (BFnpp200981_CR3) 1995; 57 D Li (BFnpp200981_CR27) 2007; 12 JJ Mann (BFnpp200981_CR30) 2003; 4 C Sanchez (BFnpp200981_CR44) 2003; 167 R Uher (BFnpp200981_CR52) 2008; 38 |
| References_xml | – ident: BFnpp200981_CR55 – volume: 95 start-page: 221 year: 2005 ident: BFnpp200981_CR28 publication-title: Heredity doi: 10.1038/sj.hdy.6800717 – volume: 133C start-page: 25 year: 2005 ident: BFnpp200981_CR10 publication-title: Am J Med Genet C Semin Med Genet doi: 10.1002/ajmg.c.30043 – volume: 57 start-page: 289 year: 1995 ident: BFnpp200981_CR3 publication-title: J R Stat Soc, Series B – volume: 22 start-page: 471 year: 2001 ident: BFnpp200981_CR49 publication-title: Trends Pharmacol Sci doi: 10.1016/S0165-6147(00)01758-2 – volume: 81 start-page: 559 year: 2007 ident: BFnpp200981_CR42 publication-title: Am J Hum Genet doi: 10.1086/519795 – volume: 60 start-page: 804 year: 2003 ident: BFnpp200981_CR15 publication-title: Arch gen psychiatry doi: 10.1001/archpsyc.60.8.804 – volume: 38 start-page: 289 year: 2008 ident: BFnpp200981_CR52 publication-title: Psychol Med doi: 10.1017/S0033291707001730 – volume: 65 start-page: 942 year: 2005 ident: BFnpp200981_CR50 publication-title: Med hypotheses doi: 10.1016/j.mehy.2005.05.010 – volume: 74 start-page: 765 year: 2004 ident: BFnpp200981_CR33 publication-title: Am J Hum Genet doi: 10.1086/383251 – volume: 64 start-page: 689 year: 2007 ident: BFnpp200981_CR36 publication-title: Arch gen psychiatry doi: 10.1001/archpsyc.64.6.689 – volume: 133C start-page: 13 year: 2005 ident: BFnpp200981_CR5 publication-title: Am J Med Genet C Semin Med Genet doi: 10.1002/ajmg.c.30042 – volume: 63 start-page: 256 year: 1994 ident: BFnpp200981_CR22 publication-title: J neurochem doi: 10.1046/j.1471-4159.1994.63010256.x – volume: 10 start-page: 580 year: 2008 ident: BFnpp200981_CR56 publication-title: Bipolar Disord doi: 10.1111/j.1399-5618.2008.00603.x – volume: 1025 start-page: 10 year: 2004 ident: BFnpp200981_CR40 publication-title: Brain research doi: 10.1016/j.brainres.2004.06.085 – ident: BFnpp200981_CR53 doi: 10.1038/tpj.2009.12 – volume: 164 start-page: 1530 year: 2007 ident: BFnpp200981_CR26 publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.2007.06122018 – volume: 33 start-page: 67 year: 2003 ident: BFnpp200981_CR19 publication-title: Behav genet doi: 10.1023/A:1021055617738 – volume: 136 start-page: 29 year: 2005 ident: BFnpp200981_CR24 publication-title: Brain Res Mol Brain Res doi: 10.1016/j.molbrainres.2004.12.020 – volume: 53 start-page: 129 year: 2005 ident: BFnpp200981_CR32 publication-title: Neurosci res doi: 10.1016/j.neures.2005.06.008 – volume: 45 start-page: 553 year: 2003 ident: BFnpp200981_CR13 publication-title: Neuropharmacology doi: 10.1016/S0028-3908(03)00198-9 – volume: 9 start-page: 519 year: 2006 ident: BFnpp200981_CR51 publication-title: Nat neurosci doi: 10.1038/nn1659 – volume: 124B start-page: 87 year: 2004 ident: BFnpp200981_CR2 publication-title: Am J Med Genet B Neuropsychiatr Genet doi: 10.1002/ajmg.b.20015 – volume: 112 start-page: 257 year: 2003 ident: BFnpp200981_CR16 publication-title: Cell doi: 10.1016/S0092-8674(03)00035-7 – volume: 4 start-page: 819 year: 2003 ident: BFnpp200981_CR30 publication-title: Nat Rev Neurosci doi: 10.1038/nrn1220 – volume: 33 start-page: 290 year: 2008 ident: BFnpp200981_CR11 publication-title: Genet Epidemiol doi: 10.1002/gepi.20379 – volume: 13 start-page: 654 year: 2008 ident: BFnpp200981_CR39 publication-title: Mol psychiatry doi: 10.1038/mp.2008.61 – volume: 11 start-page: 252 year: 2006 ident: BFnpp200981_CR6 publication-title: Mol psychiatry doi: 10.1038/sj.mp.4001778 – volume: 150B start-page: 599 year: 2008 ident: BFnpp200981_CR57 publication-title: Am J Med Genet B Neuropsychiatr Genet doi: 10.1002/ajmg.b.30849 – volume: 44 start-page: 903 year: 2003 ident: BFnpp200981_CR9 publication-title: Neuropharmacology doi: 10.1016/S0028-3908(03)00077-7 – volume: 2 start-page: e143 year: 2006 ident: BFnpp200981_CR47 publication-title: PLoS Genet doi: 10.1371/journal.pgen.0020143 – volume-title: Multilevel and longitudinal modeling using Stata year: 2005 ident: BFnpp200981_CR43 – volume: 311 start-page: 864 year: 2006 ident: BFnpp200981_CR4 publication-title: Science (New York, NY) doi: 10.1126/science.1120972 – volume: 155 start-page: 945 year: 2000 ident: BFnpp200981_CR41 publication-title: Genetics doi: 10.1093/genetics/155.2.945 – ident: BFnpp200981_CR38 – volume: 7 start-page: 314 year: 2008 ident: BFnpp200981_CR37 publication-title: Genes brain behav doi: 10.1111/j.1601-183X.2007.00354.x – volume: 60 start-page: 273 year: 2003 ident: BFnpp200981_CR14 publication-title: Arch gen psychiatry doi: 10.1001/archpsyc.60.3.273 – volume: 373 start-page: 746 year: 2009 ident: BFnpp200981_CR7 publication-title: Lancet doi: 10.1016/S0140-6736(09)60046-5 – volume: 10 start-page: 39 year: 2000 ident: BFnpp200981_CR8 publication-title: Psychiatric genet doi: 10.1097/00041444-200010010-00007 – volume: 167 start-page: 353 year: 2003 ident: BFnpp200981_CR44 publication-title: Psychopharmacology (Berlin) doi: 10.1007/s00213-002-1364-z – volume: 57 start-page: 394 year: 2000 ident: BFnpp200981_CR18 publication-title: Cell Mol Life Sci doi: 10.1007/PL00000701 – volume: 31 start-page: 78 year: 2007 ident: BFnpp200981_CR25 publication-title: Prog Neuropsychopharmacol Biol Psychiatry doi: 10.1016/j.pnpbp.2006.06.024 – volume: 125 start-page: 87 year: 2004 ident: BFnpp200981_CR48 publication-title: Psychiatry Res doi: 10.1016/j.psychres.2003.12.002 – volume: 57 start-page: 139 year: 2008 ident: BFnpp200981_CR46 publication-title: Neuropsychobiology doi: 10.1159/000142361 – volume: 29 start-page: 1512 year: 2004 ident: BFnpp200981_CR17 publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1300459 – volume: 72 start-page: 282 year: 1999 ident: BFnpp200981_CR21 publication-title: J neurochem doi: 10.1046/j.1471-4159.1999.0720282.x – volume: 195 start-page: 30 year: 2008 ident: BFnpp200981_CR23 publication-title: Br J Psychiatry doi: 10.1192/bjp.bp.108.062521 – volume: 194 start-page: 252 year: 2009 ident: BFnpp200981_CR54 publication-title: Br J Psychiatry doi: 10.1192/bjp.bp.108.057554 – volume: 96 start-page: 15239 year: 1999 ident: BFnpp200981_CR29 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.96.26.15239 – volume: 11 start-page: 695 year: 2006 ident: BFnpp200981_CR34 publication-title: Mol psychiatry doi: 10.1038/sj.mp.4001822 – volume: 32 start-page: 1428 year: 2008 ident: BFnpp200981_CR20 publication-title: Prog Neuropsychopharmacol Biol Psychiatry doi: 10.1016/j.pnpbp.2008.02.003 – volume: 12 start-page: 47 year: 2007 ident: BFnpp200981_CR27 publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4001890 – volume: 23 start-page: 11 year: 2000 ident: BFnpp200981_CR35 publication-title: Psychiatr clin North Am doi: 10.1016/S0193-953X(05)70140-4 – volume: 19 start-page: 467 year: 1999 ident: BFnpp200981_CR45 publication-title: Cell Mol Neurobiol doi: 10.1023/A:1006986824213 – volume: 37 start-page: 1217 year: 2005 ident: BFnpp200981_CR12 publication-title: Nat genet doi: 10.1038/ng1669 – volume: 22 start-page: 61 year: 2001 ident: BFnpp200981_CR31 publication-title: Crisis doi: 10.1027//0227-5910.22.2.61 – volume: 54 start-page: 703 year: 2003 ident: BFnpp200981_CR1 publication-title: Biol psychiatry doi: 10.1016/S0006-3223(03)00073-8 |
| SSID | ssj0015768 |
| Score | 2.3074872 |
| Snippet | The aim of this study was to investigate genetic predictors of an increase in suicidal ideation during treatment with a selective serotonin reuptake inhibitor... |
| SourceID | proquest pubmed pascalfrancis crossref springer |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 2517 |
| SubjectTerms | Adult Adult and adolescent clinical studies Antidepressants Antidepressive Agents - adverse effects Antidepressive Agents - therapeutic use Behavioral Sciences Biological and medical sciences Biological Psychology Brain research Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Citalopram - adverse effects Citalopram - therapeutic use Depressive Disorder, Major - drug therapy Depressive Disorder, Major - genetics Female Follow-Up Studies Genes Genetic Predisposition to Disease Haplotypes Humans Linkage Disequilibrium Logistic Models Male Medical sciences Medicine Medicine & Public Health Mental depression Neuropharmacology Neurosciences Nortriptyline - adverse effects Nortriptyline - therapeutic use original-article Pharmacology. Drug treatments Pharmacotherapy Polymorphism, Genetic Polymorphism, Single Nucleotide Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Receptor, trkB - genetics Receptors, Adrenergic, alpha-2 - genetics Serotonin Sex Factors Sociodemographics Suicidal behavior Suicide Suicides & suicide attempts |
| Title | Genetic Predictors of Increase in Suicidal Ideation During Antidepressant Treatment in the GENDEP Project |
| URI | https://link.springer.com/article/10.1038/npp.2009.81 https://www.ncbi.nlm.nih.gov/pubmed/19641488 https://www.proquest.com/docview/225199831 https://www.proquest.com/docview/21176703 https://www.proquest.com/docview/733891047 |
| Volume | 34 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwED_BJiEkhEYHI4wVP4w9oEVLaid2nlC3dmygVRV0Ut-ixImlSpCWtX3of8-d46SaKDxWObtOzh-_8338AE7JNZbnRvu8KJQvdCxwzXG0UpRUWtCBZ9kb7kbxzb34Oo2mLjZn6cIqmz3RbtTFXNMd-UWPUiwTxcPPi98-kUaRc9UxaDyF_RCBCDE3yGlrb4UEpS2ITLiPptjUpecFXF1UC1erUoWPDqQXi2yJ38bUpBa7UOdfHlN7EF0fwEuHIFm_VvkreFJWHTjsV2g9_9qwM2ZjOu1leQee3TnXeQfOxnWR6s05m2xzrpbntkVbvnpzCDOqRI2P2PiBGhMbD5sbhhsJxa-XbFaxH2vstMBB3BY15GQDm-3I-tVq5mJrUWNs0kSxUyNEmuzLcDQYjrFne_3zGu6vh5OrG98RMvhaRMHKNzzWIkQAJjIVmEKrXJI9FhsdiTzvZYGRmUl4YTIupM4NKjoICpnEmU5MHgn-BvaqeVW-BRYWCsFkZOKIC1Fic9OLOXaSk6tWlaUHnxqtpNpVKyfSjJ-p9ZpzlaIKiUMzSVXowWkrvKiLdOwW6z5SbytLycYyiYQHx42-U7eUl2k78Tz40D7FNUiOlawq52sUCUMZ49bpAfuHhOTkDw6E9OConkfbgSYxflOlPPjYTKztn-94i3f_HeQxPLf-Lpst-R72Vg_r8gRh0yrv2sXRhf3L4Wj8HX8Nbr_9ATQsGIA |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED-NIQESQtABC4PND9se0KIlsZM4DwhVtKNla1WJTupbljixVImlZW2F-kfxP3LnfFQThbc95-w4uTv7zr_7ADgmaCxNtbJ5lklbqECgznH0UmQolaADz3RvGAyD3rX4NvEnO_C7zoWhsMp6TzQbdTZTdEd-7lGKZSS5-3n-06amUQSu1h00Sqm4zNe_0GNbfOp3kL0nnnfRHX_p2VVTAVsJ31namgdKuGhEiEQ6OlMyDcmnCLTyRZp6iaPDREc80wkXoUo1LtZxsjAKEhXp1Bcc530EjwUhjKg-4aTx71wy3Y3RGnEbXb9JlQ7ocHlezKvamNK9dwA-nycL5IUum2hss3L_QmjNwXfxEl5UFitrlyL2CnbyogV77QK99ds1O2UmhtRczrfgyaCC6ltwOiqLYq_P2HiT47U4MyOactnrPZhS5Wt8xEZ3NJi6_7CZZrhxUbx8zqYF-77CSTNcRD8rTVzWMdmVrF0sp1UsL0oIG9dR8zQILVv2tTvsdEc4s7lueg3XD8KrN7BbzIp8H5ibSWSYrwOfC5HjcO0FHCdJCRqWeW7Bx5orsaqqo1OTjh-xQem5jJGF1LMziqVrwXFDPC-LgmwnO7zH3oaWkpvDyBcWHNT8jqutYxE3gm7BUfMUdZ6AnKTIZyskcd0wwK3aAvYPipAT_uyI0IK3pRxtFhoF-E-ltOCkFqzNy7d8xbv_LvIInvbGg6v4qj-8PIBnBmszmZrvYXd5t8o_oMm2TA-NojC4eWjN_AOA71NK |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED-NTZqQEIKOjzDY_LDtAS1qUjuJ8zChQltWxqoKNqlvIXFiaRKkZW2F-ifyX3HnOKkmCm97ztlxcr7znX_3AXBE0FiWaeXyPJeuUKFAmePopchIKkEHnunecDkKz6_Fp0kw2YLfdS4MhVXWOtEo6nyq6I683aEUy1hyv61tVMS4N3g3--lSAykCWutuGqntspCfmWpjNsfjolj9Qm9ufjbsIeuPO51B_-rDuWsbDrhKBN7C1TxUwkcDQ6TS07mSWUT-RqhVILKsk3o6SnXMc51yEalM44d4Xh7FYapinQWC47wPYCfCQx_9wJ33_dH4SwNpkGFvTNqYu-gYTmyyoMdlu5zZypnSv3M8Ppqlc-SUrlpsbLKB_8JvzbE4eAKPrT3LutUGfApbRdmCvW6JvvyPFTthJsLUXN23YPfSAvktOBlXJbNXp-xqnQE2PzUjmmLaqz24obrY-IiNb2kw9QZiU81QrVE0fcFuSvZ1iZPmuIhhXhnArGdyL1mX-FNF-uL-YVd1TD0NQruXfeyPev0xzmwuo57B9b1w6zlsl9OyeAnMzyWatoEOAy5EgcN1J-Q4SUbAsSwKB97WXEmUrZ1OLTy-JwbD5zJBFlJHzziRvgNHDfGsKhmymezgDnsbWkp9juJAOLBf8zuximWeNGLgwGHzFDUCwTxpWUyXSOL7UYiK3AH2D4qIEzrticiBF9U-Wi80DvGfSunAcb2x1i_f8BWv_rvIQ9hFKU0-D0cX-_DQAHEmjfM1bC9ul8UbtOcW2YGVFAbf7ls4_wD5CF4l |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetic+Predictors+of+Increase+in+Suicidal+Ideation+During+Antidepressant+Treatment+in+the+GENDEP+Project&rft.jtitle=Neuropsychopharmacology+%28New+York%2C+N.Y.%29&rft.au=PERROUD%2C+Nader&rft.au=AITCHISON%2C+Katherine+J&rft.au=RIETSCHEL%2C+Marcella&rft.au=HAUSER%2C+Joanna&rft.date=2009-11-01&rft.pub=Nature+Publishing+Group&rft.issn=0893-133X&rft.volume=34&rft.issue=12&rft.spage=2517&rft.epage=2528&rft_id=info:doi/10.1038%2Fnpp.2009.81&rft.externalDBID=n%2Fa&rft.externalDocID=22057954 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0893-133X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0893-133X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0893-133X&client=summon |