Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow
The longevity of plasma cells is dependent on their ability to access and reside in so-called niches that are predominantly located in the bone marrow. Here, by employing a traceable method to label recently generated plasma cells, we showed that homeostatic plasma cells in the bone marrow and splee...
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| Published in | The Journal of experimental medicine Vol. 220; no. 2 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Rockefeller University Press
06.02.2023
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-1007 1540-9538 1540-9538 |
| DOI | 10.1084/jem.20221717 |
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| Abstract | The longevity of plasma cells is dependent on their ability to access and reside in so-called niches that are predominantly located in the bone marrow. Here, by employing a traceable method to label recently generated plasma cells, we showed that homeostatic plasma cells in the bone marrow and spleen were continuously replenished by newly generated B220hiMHC-IIhi populations that progressively differentiated into B220loMHC-IIlo long-lived plasma cell (LLPC) populations. We also found that, in the bone marrow, germinal center (GC)–independent and GC-dependent plasma cells decayed similarly upon NP-CGG engagement, and both entered the B220loMHC-IIlo LLPC pool. Compared with NP+B220hiMHC-IIhi plasma cells, NP+B220loMHC-IIlo cells were more immobilized in the bone marrow niches and showed better survival potential. Thus, our results suggest that the adhesion status of bone marrow plasma cells is dynamically altered during their differentiation and is associated with provision of survival signals. |
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| AbstractList | The longevity of plasma cells is dependent on their ability to access and reside in so-called niches that are predominantly located in the bone marrow. Here, by employing a traceable method to label recently generated plasma cells, we showed that homeostatic plasma cells in the bone marrow and spleen were continuously replenished by newly generated B220hiMHC-IIhi populations that progressively differentiated into B220loMHC-IIlo long-lived plasma cell (LLPC) populations. We also found that, in the bone marrow, germinal center (GC)–independent and GC-dependent plasma cells decayed similarly upon NP-CGG engagement, and both entered the B220loMHC-IIlo LLPC pool. Compared with NP+B220hiMHC-IIhi plasma cells, NP+B220loMHC-IIlo cells were more immobilized in the bone marrow niches and showed better survival potential. Thus, our results suggest that the adhesion status of bone marrow plasma cells is dynamically altered during their differentiation and is associated with provision of survival signals. Koike et al. employ a time-stamping method for plasma cells and measure the decay of the homeostatic plasma cells with distinct isotypes, or antigen-specific plasma cells that are generated in germinal center–independent or –dependent pathway. The longevity of plasma cells is dependent on their ability to access and reside in so-called niches that are predominantly located in the bone marrow. Here, by employing a traceable method to label recently generated plasma cells, we showed that homeostatic plasma cells in the bone marrow and spleen were continuously replenished by newly generated B220 hi MHC-II hi populations that progressively differentiated into B220 lo MHC-II lo long-lived plasma cell (LLPC) populations. We also found that, in the bone marrow, germinal center (GC)–independent and GC-dependent plasma cells decayed similarly upon NP-CGG engagement, and both entered the B220 lo MHC-II lo LLPC pool. Compared with NP + B220 hi MHC-II hi plasma cells, NP + B220 lo MHC-II lo cells were more immobilized in the bone marrow niches and showed better survival potential. Thus, our results suggest that the adhesion status of bone marrow plasma cells is dynamically altered during their differentiation and is associated with provision of survival signals. The longevity of plasma cells is dependent on their ability to access and reside in so-called niches that are predominantly located in the bone marrow. Here, by employing a traceable method to label recently generated plasma cells, we showed that homeostatic plasma cells in the bone marrow and spleen were continuously replenished by newly generated B220hiMHC-IIhi populations that progressively differentiated into B220loMHC-IIlo long-lived plasma cell (LLPC) populations. We also found that, in the bone marrow, germinal center (GC)-independent and GC-dependent plasma cells decayed similarly upon NP-CGG engagement, and both entered the B220loMHC-IIlo LLPC pool. Compared with NP+B220hiMHC-IIhi plasma cells, NP+B220loMHC-IIlo cells were more immobilized in the bone marrow niches and showed better survival potential. Thus, our results suggest that the adhesion status of bone marrow plasma cells is dynamically altered during their differentiation and is associated with provision of survival signals.The longevity of plasma cells is dependent on their ability to access and reside in so-called niches that are predominantly located in the bone marrow. Here, by employing a traceable method to label recently generated plasma cells, we showed that homeostatic plasma cells in the bone marrow and spleen were continuously replenished by newly generated B220hiMHC-IIhi populations that progressively differentiated into B220loMHC-IIlo long-lived plasma cell (LLPC) populations. We also found that, in the bone marrow, germinal center (GC)-independent and GC-dependent plasma cells decayed similarly upon NP-CGG engagement, and both entered the B220loMHC-IIlo LLPC pool. Compared with NP+B220hiMHC-IIhi plasma cells, NP+B220loMHC-IIlo cells were more immobilized in the bone marrow niches and showed better survival potential. Thus, our results suggest that the adhesion status of bone marrow plasma cells is dynamically altered during their differentiation and is associated with provision of survival signals. |
| Author | Kikuta, Junichi Fujii, Kentaro Koike, Takuya Ishii, Masaru Funakoshi, Kenji Butler, Noah S. Ise, Wataru Kometani, Kohei Yari, Shinya Kurosaki, Tomohiro |
| AuthorAffiliation | 8 Division of Microbiology and Immunology, Center for Infectious Disease Education and Research, Osaka University, Osaka, Japan 2 Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan 5 Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan 7 Laboratory of Bioimaging and Drug Discovery, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan 4 Department of Microbiology and Immunology, The University of Iowa, Iowa City, IA, USA 6 Laboratory of Immunology and Cell Biology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan 3 Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan 1 Regulation of Host Defense Team, Division of Microbiology and Immunology, Center for Infectious Disease Education and Research, Osaka University, Osaka, Japan |
| AuthorAffiliation_xml | – name: 4 Department of Microbiology and Immunology, The University of Iowa, Iowa City, IA, USA – name: 8 Division of Microbiology and Immunology, Center for Infectious Disease Education and Research, Osaka University, Osaka, Japan – name: 3 Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan – name: 7 Laboratory of Bioimaging and Drug Discovery, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan – name: 2 Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan – name: 1 Regulation of Host Defense Team, Division of Microbiology and Immunology, Center for Infectious Disease Education and Research, Osaka University, Osaka, Japan – name: 6 Laboratory of Immunology and Cell Biology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan – name: 5 Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan |
| Author_xml | – sequence: 1 givenname: Takuya orcidid: 0000-0002-4193-6679 surname: Koike fullname: Koike, Takuya – sequence: 2 givenname: Kentaro orcidid: 0000-0002-3692-493X surname: Fujii fullname: Fujii, Kentaro – sequence: 3 givenname: Kohei orcidid: 0000-0003-4281-4371 surname: Kometani fullname: Kometani, Kohei – sequence: 4 givenname: Noah S. orcidid: 0000-0002-1429-0796 surname: Butler fullname: Butler, Noah S. – sequence: 5 givenname: Kenji orcidid: 0000-0002-1757-6925 surname: Funakoshi fullname: Funakoshi, Kenji – sequence: 6 givenname: Shinya orcidid: 0000-0001-7915-5926 surname: Yari fullname: Yari, Shinya – sequence: 7 givenname: Junichi orcidid: 0000-0002-1549-5961 surname: Kikuta fullname: Kikuta, Junichi – sequence: 8 givenname: Masaru orcidid: 0000-0002-4215-007X surname: Ishii fullname: Ishii, Masaru – sequence: 9 givenname: Tomohiro orcidid: 0000-0002-6352-304X surname: Kurosaki fullname: Kurosaki, Tomohiro – sequence: 10 givenname: Wataru orcidid: 0000-0003-0457-3386 surname: Ise fullname: Ise, Wataru |
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| Snippet | The longevity of plasma cells is dependent on their ability to access and reside in so-called niches that are predominantly located in the bone marrow. Here,... Koike et al. employ a time-stamping method for plasma cells and measure the decay of the homeostatic plasma cells with distinct isotypes, or antigen-specific... |
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| SubjectTerms | Bone Marrow Bone Marrow Cells Brief Definitive Report Cell Differentiation Cell Survival Germinal Center Plasma Cells - metabolism |
| Title | Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow |
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