Stevens-Johnson syndrome and toxic epidermal necrolysis: a report of six cases

• Published in: Turkish journal of pediatrics Vol. 61; no. 4; pp. 538 - 543
• Main Authors: Kara, Ahu, Devrim, İlker, Çağlar, İlknur, Bayram, Nuri, Kundak, Selcen, Apa, Hurşit, Altan, Emir Volkan
• Format: Journal Article
• Language: English
• Published: Turkey Hacettepe University Faculty of Medicine 2019; Hacettepe University Institute of Child Health
• Subjects: Adolescent; Antibiotics; Child; Child, Preschool; Cornea; drug reaction; Drugs; Female; Humans; Immunoglobulins; Immunoglobulins, Intravenous - therapeutic use; Immunologic Factors - therapeutic use; Male; Mortality; mycoplasma; Nosocomial infections; Patients; Pediatrics; Polymerase chain reaction; Skin; Skin diseases; Stevens-Johnson syndrome; Stevens-Johnson Syndrome - complications; Stevens-Johnson Syndrome - diagnosis; Stevens-Johnson Syndrome - drug therapy; drug reaction; Stevens-Johnson syndrome; mycoplasma
• ISSN: 0041-4301; 2791-6421
• DOI: 10.24953/turkjped.2019.04.010

Stevens-Johnson syndrome and toxic epidermal necrolysis are severe cutaneous adverse reactions commonly caused by exposure to drugs and can end up with significant morbidity and mortality. We reported our experience with six patients who were diagnosed with Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis with a different clinical presentation. In patients, drugs and Mycoplasma pneumoniae infection were implicated as a trigger. Intravenous Immunoglobulin treatment was given to all patients, and intensive treatment was applied for skin and mucosal lesions. The median period of stay in hospital was 13.5 days. The most common long-term complication was ocular involvement. Among six patients, corneal epithelial defects occurred in one patient. Consequently, ophthalmological evaluation should be performed both at the time of diagnosis and before hospital discharge.