Review of Precision Medicine and Diagnosis of Neonatal Illness

Background/Objectives: Precision medicine is a state-of-the-art medicine tactic that tailors information about people’s genes, environment, and lifestyle to aid the prevention, diagnosis, and treatment of various diseases to provide an overview of the currently available knowledge and applicability...

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Published inDiagnostics (Basel) Vol. 15; no. 4; p. 478
Main Authors ELMeneza, Safaa, Agaba, Naglaa, Fawaz, Rasha Abd El Samad, Abd Elgawad, Salwa Samir
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 16.02.2025
MDPI
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ISSN2075-4418
2075-4418
DOI10.3390/diagnostics15040478

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Abstract Background/Objectives: Precision medicine is a state-of-the-art medicine tactic that tailors information about people’s genes, environment, and lifestyle to aid the prevention, diagnosis, and treatment of various diseases to provide an overview of the currently available knowledge and applicability of precision medicine in the diagnosis of different cases admitted to the NICU, such as encephalopathies, respiratory distress syndrome of prematurity, hemodynamic instability, acute kidney injury, sepsis, and hyperbilirubinemia. Methods: The authors searched databases, such as PubMed and PubMed Central, for the terms neonatal “precision medicine”, “personalized medicine”, “genomics”, and “metabolomics”, all related to precision medicine in the diagnosis of neonatal illness. The related studies were collected. Results: The review highlights the diagnostic approach that serves to implement precision medicine in the NICU and provide precision diagnosis, monitoring, and treatment. Conclusions: In this review, we projected several diagnostic approaches that provide precision identification of health problems among sick neonates with complex illnesses in the NICU; some are noninvasive and available in ordinary healthcare settings, while others are invasive or not feasible or still in ongoing research as machine learning algorithms. Future studies are needed for the wide implementation of artificial intelligence tools in the diagnosis of neonatal illnesses.
AbstractList Background/Objectives: Precision medicine is a state-of-the-art medicine tactic that tailors information about people's genes, environment, and lifestyle to aid the prevention, diagnosis, and treatment of various diseases to provide an overview of the currently available knowledge and applicability of precision medicine in the diagnosis of different cases admitted to the NICU, such as encephalopathies, respiratory distress syndrome of prematurity, hemodynamic instability, acute kidney injury, sepsis, and hyperbilirubinemia. Methods: The authors searched databases, such as PubMed and PubMed Central, for the terms neonatal "precision medicine", "personalized medicine", "genomics", and "metabolomics", all related to precision medicine in the diagnosis of neonatal illness. The related studies were collected. Results: The review highlights the diagnostic approach that serves to implement precision medicine in the NICU and provide precision diagnosis, monitoring, and treatment. Conclusions: In this review, we projected several diagnostic approaches that provide precision identification of health problems among sick neonates with complex illnesses in the NICU; some are noninvasive and available in ordinary healthcare settings, while others are invasive or not feasible or still in ongoing research as machine learning algorithms. Future studies are needed for the wide implementation of artificial intelligence tools in the diagnosis of neonatal illnesses.Background/Objectives: Precision medicine is a state-of-the-art medicine tactic that tailors information about people's genes, environment, and lifestyle to aid the prevention, diagnosis, and treatment of various diseases to provide an overview of the currently available knowledge and applicability of precision medicine in the diagnosis of different cases admitted to the NICU, such as encephalopathies, respiratory distress syndrome of prematurity, hemodynamic instability, acute kidney injury, sepsis, and hyperbilirubinemia. Methods: The authors searched databases, such as PubMed and PubMed Central, for the terms neonatal "precision medicine", "personalized medicine", "genomics", and "metabolomics", all related to precision medicine in the diagnosis of neonatal illness. The related studies were collected. Results: The review highlights the diagnostic approach that serves to implement precision medicine in the NICU and provide precision diagnosis, monitoring, and treatment. Conclusions: In this review, we projected several diagnostic approaches that provide precision identification of health problems among sick neonates with complex illnesses in the NICU; some are noninvasive and available in ordinary healthcare settings, while others are invasive or not feasible or still in ongoing research as machine learning algorithms. Future studies are needed for the wide implementation of artificial intelligence tools in the diagnosis of neonatal illnesses.
Background/Objectives: Precision medicine is a state-of-the-art medicine tactic that tailors information about people’s genes, environment, and lifestyle to aid the prevention, diagnosis, and treatment of various diseases to provide an overview of the currently available knowledge and applicability of precision medicine in the diagnosis of different cases admitted to the NICU, such as encephalopathies, respiratory distress syndrome of prematurity, hemodynamic instability, acute kidney injury, sepsis, and hyperbilirubinemia. Methods: The authors searched databases, such as PubMed and PubMed Central, for the terms neonatal “precision medicine”, “personalized medicine”, “genomics”, and “metabolomics”, all related to precision medicine in the diagnosis of neonatal illness. The related studies were collected. Results: The review highlights the diagnostic approach that serves to implement precision medicine in the NICU and provide precision diagnosis, monitoring, and treatment. Conclusions: In this review, we projected several diagnostic approaches that provide precision identification of health problems among sick neonates with complex illnesses in the NICU; some are noninvasive and available in ordinary healthcare settings, while others are invasive or not feasible or still in ongoing research as machine learning algorithms. Future studies are needed for the wide implementation of artificial intelligence tools in the diagnosis of neonatal illnesses.
: Precision medicine is a state-of-the-art medicine tactic that tailors information about people's genes, environment, and lifestyle to aid the prevention, diagnosis, and treatment of various diseases to provide an overview of the currently available knowledge and applicability of precision medicine in the diagnosis of different cases admitted to the NICU, such as encephalopathies, respiratory distress syndrome of prematurity, hemodynamic instability, acute kidney injury, sepsis, and hyperbilirubinemia. : The authors searched databases, such as PubMed and PubMed Central, for the terms neonatal "precision medicine", "personalized medicine", "genomics", and "metabolomics", all related to precision medicine in the diagnosis of neonatal illness. The related studies were collected. : The review highlights the diagnostic approach that serves to implement precision medicine in the NICU and provide precision diagnosis, monitoring, and treatment. : In this review, we projected several diagnostic approaches that provide precision identification of health problems among sick neonates with complex illnesses in the NICU; some are noninvasive and available in ordinary healthcare settings, while others are invasive or not feasible or still in ongoing research as machine learning algorithms. Future studies are needed for the wide implementation of artificial intelligence tools in the diagnosis of neonatal illnesses.
Author ELMeneza, Safaa
Agaba, Naglaa
Abd Elgawad, Salwa Samir
Fawaz, Rasha Abd El Samad
AuthorAffiliation Pediatrics Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo 11651, Egypt; naglaafathi778@gmail.com (N.A.); rasha85@azhar.edu.eg (R.A.E.S.F.); salwa.samir@azhar.edu.eg (S.S.A.E.)
AuthorAffiliation_xml – name: Pediatrics Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo 11651, Egypt; naglaafathi778@gmail.com (N.A.); rasha85@azhar.edu.eg (R.A.E.S.F.); salwa.samir@azhar.edu.eg (S.S.A.E.)
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  givenname: Salwa Samir
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Keywords neonatal hemodynamics
BPD
hyperbilirubinemia
pharmacokinetics
NICU
precision medicine
neonatal sepsis
neonatal brain injury
neonatal RDS
AKI
Language English
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Snippet Background/Objectives: Precision medicine is a state-of-the-art medicine tactic that tailors information about people’s genes, environment, and lifestyle to...
: Precision medicine is a state-of-the-art medicine tactic that tailors information about people's genes, environment, and lifestyle to aid the prevention,...
Background/Objectives: Precision medicine is a state-of-the-art medicine tactic that tailors information about people's genes, environment, and lifestyle to...
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SubjectTerms Artificial intelligence
Brain damage
Brain research
Cerebral palsy
Disease prevention
Genomes
Genomics
Hemodynamics
hyperbilirubinemia
Hypoxia
Ischemia
Kidneys
Medical prognosis
neonatal brain injury
neonatal hemodynamics
neonatal RDS
neonatal sepsis
Newborn babies
Precision medicine
Respiratory distress syndrome
Review
Sepsis
Trauma
Traumatic brain injury
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Title Review of Precision Medicine and Diagnosis of Neonatal Illness
URI https://www.ncbi.nlm.nih.gov/pubmed/40002629
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