Single Injection of High Volume of Autologous Pure PRP Provides a Significant Improvement in Knee Osteoarthritis: A Prospective Routine Care Study
Background: Evidence is growing regarding the ability of platelet-rich plasma (PRP) injections to enhance functional capacity and alleviate pain in knee osteoarthritis (OA). However, heterogeneity in common practice regarding PRP preparation and biological content makes the initiation of this activi...
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| Published in | International journal of molecular sciences Vol. 20; no. 6; p. 1327 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
MDPI AG
15.03.2019
MDPI |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1422-0067 1661-6596 1422-0067 |
| DOI | 10.3390/ijms20061327 |
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| Abstract | Background: Evidence is growing regarding the ability of platelet-rich plasma (PRP) injections to enhance functional capacity and alleviate pain in knee osteoarthritis (OA). However, heterogeneity in common practice regarding PRP preparation and biological content makes the initiation of this activity in a hospital complex. The aim of this study was to document the efficacy of a single PRP injection to treat knee OA and validate a routine care procedure. Methods: Fifty-seven patients with symptomatic knee OA received a single injection of large volume of very pure PRP. They were assessed at baseline and after one, three and six months, by measuring Knee Injury and Osteoarthritis Score (KOOS), Observed Pain after a 50-foot walk test and Visual Analog Scale (VAS) assessments. Magnetic Resonance Imaging (MRI) analysis was performed at baseline and six months after the procedure. The objective was to recover 50% of responders three months after the procedure using OMERACT-OARSI criteria. Results: A single administration of high volume pure PRP provided significant clinical benefit for 84.2% of the responders, three months after the procedure. The KOOS total score significantly increased from 43.5 ± 14.3 to 66.4 ± 21.7 six months after the procedure (p < 0.001). Pain also significantly decreased from 37.5 ± 25.1 to 12.9 ± 20.9 (p < 0.001). No difference was observed on MRI parameters. Conclusion: A single injection of large volume of very pure PRP is associated with significant functional improvement and pain relief, allowing initiation of daily PRP injection within our hospital. |
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| AbstractList | Evidence is growing regarding the ability of platelet-rich plasma (PRP) injections to enhance functional capacity and alleviate pain in knee osteoarthritis (OA). However, heterogeneity in common practice regarding PRP preparation and biological content makes the initiation of this activity in a hospital complex. The aim of this study was to document the efficacy of a single PRP injection to treat knee OA and validate a routine care procedure.
Fifty-seven patients with symptomatic knee OA received a single injection of large volume of very pure PRP. They were assessed at baseline and after one, three and six months, by measuring Knee Injury and Osteoarthritis Score (KOOS), Observed Pain after a 50-foot walk test and Visual Analog Scale (VAS) assessments. Magnetic Resonance Imaging (MRI) analysis was performed at baseline and six months after the procedure. The objective was to recover 50% of responders three months after the procedure using OMERACT-OARSI criteria.
A single administration of high volume pure PRP provided significant clinical benefit for 84.2% of the responders, three months after the procedure. The KOOS total score significantly increased from 43.5 ± 14.3 to 66.4 ± 21.7 six months after the procedure (
< 0.001). Pain also significantly decreased from 37.5 ± 25.1 to 12.9 ± 20.9 (
< 0.001). No difference was observed on MRI parameters.
A single injection of large volume of very pure PRP is associated with significant functional improvement and pain relief, allowing initiation of daily PRP injection within our hospital. Background: Evidence is growing regarding the ability of platelet-rich plasma (PRP) injections to enhance functional capacity and alleviate pain in knee osteoarthritis (OA). However, heterogeneity in common practice regarding PRP preparation and biological content makes the initiation of this activity in a hospital complex. The aim of this study was to document the efficacy of a single PRP injection to treat knee OA and validate a routine care procedure. Methods: Fifty-seven patients with symptomatic knee OA received a single injection of large volume of very pure PRP. They were assessed at baseline and after one, three and six months, by measuring Knee Injury and Osteoarthritis Score (KOOS), Observed Pain after a 50-foot walk test and Visual Analog Scale (VAS) assessments. Magnetic Resonance Imaging (MRI) analysis was performed at baseline and six months after the procedure. The objective was to recover 50% of responders three months after the procedure using OMERACT-OARSI criteria. Results: A single administration of high volume pure PRP provided significant clinical benefit for 84.2% of the responders, three months after the procedure. The KOOS total score significantly increased from 43.5 ± 14.3 to 66.4 ± 21.7 six months after the procedure (p < 0.001). Pain also significantly decreased from 37.5 ± 25.1 to 12.9 ± 20.9 (p < 0.001). No difference was observed on MRI parameters. Conclusion: A single injection of large volume of very pure PRP is associated with significant functional improvement and pain relief, allowing initiation of daily PRP injection within our hospital. Among them, platelet-rich plasma (PRP) is defined as an autologous plasma suspension of platelets, characterized by a platelet concentration higher than in physiological blood [9] and able to release growth factors (GFs) involved in reparative and regenerative processes. PRP has been the subject of increased clinical interest in the orthopaedic field and a recent meta analysis indicates that, compared with HA and saline, an intra-articular PRP injection may have more benefits in pain relief and functional improvement in patients with symptomatic knee OA at one year post-injection [10], providing orthopaedic surgeons and rheumatologists a new validated non-invasive option to improve knee OA related symptoms [11]. Substantial differences in the content of platelets concentrates produced by the various automated and manual protocols have been described [12,13] and their consequences on clinical results in PRP therapy is currently being investigated [14,15]. [...]the initiation of PRP injection activity within a hospital necessitates the selection of dedicated material and the establishment of a precise patient care procedure which should take into account recent recommendations from the AAOS regarding minimum reporting standards for clinical studies evaluating PRP [16]. [...]the medical device used in this study was validated in order to reach this condition. Background: Evidence is growing regarding the ability of platelet-rich plasma (PRP) injections to enhance functional capacity and alleviate pain in knee osteoarthritis (OA). However, heterogeneity in common practice regarding PRP preparation and biological content makes the initiation of this activity in a hospital complex. The aim of this study was to document the efficacy of a single PRP injection to treat knee OA and validate a routine care procedure. Methods: Fifty-seven patients with symptomatic knee OA received a single injection of large volume of very pure PRP. They were assessed at baseline and after one, three and six months, by measuring Knee Injury and Osteoarthritis Score (KOOS), Observed Pain after a 50-foot walk test and Visual Analog Scale (VAS) assessments. Magnetic Resonance Imaging (MRI) analysis was performed at baseline and six months after the procedure. The objective was to recover 50% of responders three months after the procedure using OMERACT-OARSI criteria. Results: A single administration of high volume pure PRP provided significant clinical benefit for 84.2% of the responders, three months after the procedure. The KOOS total score significantly increased from 43.5 ± 14.3 to 66.4 ± 21.7 six months after the procedure ( p < 0.001). Pain also significantly decreased from 37.5 ± 25.1 to 12.9 ± 20.9 ( p < 0.001). No difference was observed on MRI parameters. Conclusion: A single injection of large volume of very pure PRP is associated with significant functional improvement and pain relief, allowing initiation of daily PRP injection within our hospital. Evidence is growing regarding the ability of platelet-rich plasma (PRP) injections to enhance functional capacity and alleviate pain in knee osteoarthritis (OA). However, heterogeneity in common practice regarding PRP preparation and biological content makes the initiation of this activity in a hospital complex. The aim of this study was to document the efficacy of a single PRP injection to treat knee OA and validate a routine care procedure.BACKGROUNDEvidence is growing regarding the ability of platelet-rich plasma (PRP) injections to enhance functional capacity and alleviate pain in knee osteoarthritis (OA). However, heterogeneity in common practice regarding PRP preparation and biological content makes the initiation of this activity in a hospital complex. The aim of this study was to document the efficacy of a single PRP injection to treat knee OA and validate a routine care procedure.Fifty-seven patients with symptomatic knee OA received a single injection of large volume of very pure PRP. They were assessed at baseline and after one, three and six months, by measuring Knee Injury and Osteoarthritis Score (KOOS), Observed Pain after a 50-foot walk test and Visual Analog Scale (VAS) assessments. Magnetic Resonance Imaging (MRI) analysis was performed at baseline and six months after the procedure. The objective was to recover 50% of responders three months after the procedure using OMERACT-OARSI criteria.METHODSFifty-seven patients with symptomatic knee OA received a single injection of large volume of very pure PRP. They were assessed at baseline and after one, three and six months, by measuring Knee Injury and Osteoarthritis Score (KOOS), Observed Pain after a 50-foot walk test and Visual Analog Scale (VAS) assessments. Magnetic Resonance Imaging (MRI) analysis was performed at baseline and six months after the procedure. The objective was to recover 50% of responders three months after the procedure using OMERACT-OARSI criteria.A single administration of high volume pure PRP provided significant clinical benefit for 84.2% of the responders, three months after the procedure. The KOOS total score significantly increased from 43.5 ± 14.3 to 66.4 ± 21.7 six months after the procedure (p < 0.001). Pain also significantly decreased from 37.5 ± 25.1 to 12.9 ± 20.9 (p < 0.001). No difference was observed on MRI parameters.RESULTSA single administration of high volume pure PRP provided significant clinical benefit for 84.2% of the responders, three months after the procedure. The KOOS total score significantly increased from 43.5 ± 14.3 to 66.4 ± 21.7 six months after the procedure (p < 0.001). Pain also significantly decreased from 37.5 ± 25.1 to 12.9 ± 20.9 (p < 0.001). No difference was observed on MRI parameters.A single injection of large volume of very pure PRP is associated with significant functional improvement and pain relief, allowing initiation of daily PRP injection within our hospital.CONCLUSIONA single injection of large volume of very pure PRP is associated with significant functional improvement and pain relief, allowing initiation of daily PRP injection within our hospital. |
| Author | Charpin, Caroline Benmenni, Annie Raffray, Marie Dehaut, Francois-Xavier Giorgi, Roch Arniaud, Denis Magalon, Jeremy Guillibert, Caroline El Ghobeira, Georges |
| AuthorAffiliation | 4 Aix Marseille Univ, APHM, INSERM, IRD, SESSTIM, Sciences Economiques et Sociales de la Santé & Traitement de l’Information Médicale, Hop Timone, BioSTIC, Biostatistique et Technologies de l’Information et de la Communication, 13005 Marseille, France; Roch.GIORGI@ap-hm.fr 1 Rheumatology Department, Hôpital Saint Joseph, 13008 Marseille, France; cguillibert@hopital-saint-joseph.fr (C.G.); ccharpin@hopital-saint-joseph.fr (C.C.); mraffray@hopital-saint-joseph.fr (M.R.); anbenmenni@hopital-saint-joseph.fr (A.B.); darniaud@hopital-saint-joseph.fr (D.A.) 3 Physical Therapy Department, Hôpital Saint Joseph, 13008 Marseille, France; gelghobeira@hopital-saint-joseph.fr 5 Cell Therapy Department, Hôpital de la Conception, AP-HM, INSERM CIC BT 1409, 13005 Marseille, France 2 Radiology Department, Hôpital Saint Joseph, 13008 Marseille, France; fxdehaut@hopital-saint-joseph.fr |
| AuthorAffiliation_xml | – name: 5 Cell Therapy Department, Hôpital de la Conception, AP-HM, INSERM CIC BT 1409, 13005 Marseille, France – name: 1 Rheumatology Department, Hôpital Saint Joseph, 13008 Marseille, France; cguillibert@hopital-saint-joseph.fr (C.G.); ccharpin@hopital-saint-joseph.fr (C.C.); mraffray@hopital-saint-joseph.fr (M.R.); anbenmenni@hopital-saint-joseph.fr (A.B.); darniaud@hopital-saint-joseph.fr (D.A.) – name: 3 Physical Therapy Department, Hôpital Saint Joseph, 13008 Marseille, France; gelghobeira@hopital-saint-joseph.fr – name: 4 Aix Marseille Univ, APHM, INSERM, IRD, SESSTIM, Sciences Economiques et Sociales de la Santé & Traitement de l’Information Médicale, Hop Timone, BioSTIC, Biostatistique et Technologies de l’Information et de la Communication, 13005 Marseille, France; Roch.GIORGI@ap-hm.fr – name: 2 Radiology Department, Hôpital Saint Joseph, 13008 Marseille, France; fxdehaut@hopital-saint-joseph.fr |
| Author_xml | – sequence: 1 givenname: Caroline surname: Guillibert fullname: Guillibert, Caroline – sequence: 2 givenname: Caroline surname: Charpin fullname: Charpin, Caroline – sequence: 3 givenname: Marie surname: Raffray fullname: Raffray, Marie – sequence: 4 givenname: Annie surname: Benmenni fullname: Benmenni, Annie – sequence: 5 givenname: Francois-Xavier surname: Dehaut fullname: Dehaut, Francois-Xavier – sequence: 6 givenname: Georges surname: El Ghobeira fullname: El Ghobeira, Georges – sequence: 7 givenname: Roch surname: Giorgi fullname: Giorgi, Roch – sequence: 8 givenname: Jeremy orcidid: 0000-0003-1494-7011 surname: Magalon fullname: Magalon, Jeremy – sequence: 9 givenname: Denis surname: Arniaud fullname: Arniaud, Denis |
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| Keywords | growth factors knee arthrosis PRP |
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| Snippet | Background: Evidence is growing regarding the ability of platelet-rich plasma (PRP) injections to enhance functional capacity and alleviate pain in knee... Evidence is growing regarding the ability of platelet-rich plasma (PRP) injections to enhance functional capacity and alleviate pain in knee osteoarthritis... Among them, platelet-rich plasma (PRP) is defined as an autologous plasma suspension of platelets, characterized by a platelet concentration higher than in... |
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| SubjectTerms | Arthritis Blood platelets Growth factors Life Sciences Pain Patients |
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| Title | Single Injection of High Volume of Autologous Pure PRP Provides a Significant Improvement in Knee Osteoarthritis: A Prospective Routine Care Study |
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