Neuroanatomical correlates of olfactory loss in normal aged subjects

► Olfactory loss is associated in normal aged subjects with gray and white matter brain changes. ► DTI shows microstructural changes in superior longitudinal fasciculi and corpus callosum. ► VBM shows GM volume loss in entorhinal and perirhinal olfactory structures. In non-demented older persons, sm...

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Published in	Behavioural brain research Vol. 246; pp. 148 - 153
Main Authors	Segura, Bàrbara, Baggio, Hugo César, Solana, Elisabeth, Palacios, Eva M., Vendrell, Pere, Bargalló, Núria, Junqué, Carme
Format	Journal Article
Language	English
Published	Shannon Elsevier B.V 01.06.2013 Elsevier
Subjects	Aged Aging Anisotropy Behavioral psychophysiology Biological and medical sciences Brain Mapping Cortical thickness Diffusion Magnetic Resonance Imaging DTI Female Fundamental and applied biological sciences. Psychology Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged MRI Nerve Fibers, Myelinated - physiology Neuroanatomy Neuropsychological Tests Olfaction Disorders - pathology Olfactory deficits Olfactory Pathways - pathology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Smell - physiology UPSIT VBM Verbal Learning - physiology VBM UPSIT Cortical thickness MRI DTI Aging Olfactory deficits Human Cerebral cortex Senescence Central nervous system Layer thickness Nuclear magnetic resonance imaging Encephalon Olfaction
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ISSN	0166-4328 1872-7549 1872-7549
DOI	10.1016/j.bbr.2013.02.025

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Abstract	► Olfactory loss is associated in normal aged subjects with gray and white matter brain changes. ► DTI shows microstructural changes in superior longitudinal fasciculi and corpus callosum. ► VBM shows GM volume loss in entorhinal and perirhinal olfactory structures. In non-demented older persons, smell dysfunction, measured premortem, has been associated with postmortem brain degeneration similar to that of Alzheimer's disease. We hypothesized that distinct measures of gray and white matter integrity evaluated through magnetic resonance imaging (MRI) techniques could detect degenerative changes associated with age-related olfactory dysfunction. High-resolution T1-weighted images and diffusion-tensor images (DTI) of 30 clinically healthy subjects aged 51–77 were acquired with a 3-Tesla MRI scanner. Odor identification performance was assessed by means of the University of Pennsylvania Smell Identification Test (UPSIT). UPSIT scores correlated with right amygdalar volume and bilateral perirhinal and entorhinal cortices gray matter volume. Olfactory performance also correlated with postcentral gyrus cortical thickness and with fractional anisotropy and mean diffusivity levels in the splenium of the corpus callosum and the superior longitudinal fasciculi. Our results suggest that age-related olfactory loss is accompanied by diffuse degenerative changes that might correspond to the preclinical stages of neurodegenerative processes.
AbstractList	► Olfactory loss is associated in normal aged subjects with gray and white matter brain changes. ► DTI shows microstructural changes in superior longitudinal fasciculi and corpus callosum. ► VBM shows GM volume loss in entorhinal and perirhinal olfactory structures. In non-demented older persons, smell dysfunction, measured premortem, has been associated with postmortem brain degeneration similar to that of Alzheimer's disease. We hypothesized that distinct measures of gray and white matter integrity evaluated through magnetic resonance imaging (MRI) techniques could detect degenerative changes associated with age-related olfactory dysfunction. High-resolution T1-weighted images and diffusion-tensor images (DTI) of 30 clinically healthy subjects aged 51–77 were acquired with a 3-Tesla MRI scanner. Odor identification performance was assessed by means of the University of Pennsylvania Smell Identification Test (UPSIT). UPSIT scores correlated with right amygdalar volume and bilateral perirhinal and entorhinal cortices gray matter volume. Olfactory performance also correlated with postcentral gyrus cortical thickness and with fractional anisotropy and mean diffusivity levels in the splenium of the corpus callosum and the superior longitudinal fasciculi. Our results suggest that age-related olfactory loss is accompanied by diffuse degenerative changes that might correspond to the preclinical stages of neurodegenerative processes. In non-demented older persons, smell dysfunction, measured premortem, has been associated with postmortem brain degeneration similar to that of Alzheimer's disease. We hypothesized that distinct measures of gray and white matter integrity evaluated through magnetic resonance imaging (MRI) techniques could detect degenerative changes associated with age-related olfactory dysfunction. High-resolution T1-weighted images and diffusion-tensor images (DTI) of 30 clinically healthy subjects aged 51-77 were acquired with a 3-Tesla MRI scanner. Odor identification performance was assessed by means of the University of Pennsylvania Smell Identification Test (UPSIT). UPSIT scores correlated with right amygdalar volume and bilateral perirhinal and entorhinal cortices gray matter volume. Olfactory performance also correlated with postcentral gyrus cortical thickness and with fractional anisotropy and mean diffusivity levels in the splenium of the corpus callosum and the superior longitudinal fasciculi. Our results suggest that age-related olfactory loss is accompanied by diffuse degenerative changes that might correspond to the preclinical stages of neurodegenerative processes. In non-demented older persons, smell dysfunction, measured premortem, has been associated with postmortem brain degeneration similar to that of Alzheimer's disease. We hypothesized that distinct measures of gray and white matter integrity evaluated through magnetic resonance imaging (MRI) techniques could detect degenerative changes associated with age-related olfactory dysfunction. High-resolution T1-weighted images and diffusion-tensor images (DTI) of 30 clinically healthy subjects aged 51-77 were acquired with a 3-Tesla MRI scanner. Odor identification performance was assessed by means of the University of Pennsylvania Smell Identification Test (UPSIT). UPSIT scores correlated with right amygdalar volume and bilateral perirhinal and entorhinal cortices gray matter volume. Olfactory performance also correlated with postcentral gyrus cortical thickness and with fractional anisotropy and mean diffusivity levels in the splenium of the corpus callosum and the superior longitudinal fasciculi. Our results suggest that age-related olfactory loss is accompanied by diffuse degenerative changes that might correspond to the preclinical stages of neurodegenerative processes.In non-demented older persons, smell dysfunction, measured premortem, has been associated with postmortem brain degeneration similar to that of Alzheimer's disease. We hypothesized that distinct measures of gray and white matter integrity evaluated through magnetic resonance imaging (MRI) techniques could detect degenerative changes associated with age-related olfactory dysfunction. High-resolution T1-weighted images and diffusion-tensor images (DTI) of 30 clinically healthy subjects aged 51-77 were acquired with a 3-Tesla MRI scanner. Odor identification performance was assessed by means of the University of Pennsylvania Smell Identification Test (UPSIT). UPSIT scores correlated with right amygdalar volume and bilateral perirhinal and entorhinal cortices gray matter volume. Olfactory performance also correlated with postcentral gyrus cortical thickness and with fractional anisotropy and mean diffusivity levels in the splenium of the corpus callosum and the superior longitudinal fasciculi. Our results suggest that age-related olfactory loss is accompanied by diffuse degenerative changes that might correspond to the preclinical stages of neurodegenerative processes.
Author	Segura, Bàrbara Junqué, Carme Vendrell, Pere Baggio, Hugo César Solana, Elisabeth Bargalló, Núria Palacios, Eva M.
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Cites_doi	10.1006/nimg.2001.0978 10.1038/360339a0 10.1093/brain/awr321 10.1523/JNEUROSCI.5722-07.2008 10.1109/42.906426 10.1111/j.1749-6632.2009.04013.x 10.1093/chemse/bjq028 10.1093/chemse/22.1.39 10.1002/ana.20160 10.1212/WNL.0b013e318227041c 10.1136/jnnp.2006.099721 10.1037/a0018269 10.1007/s00221-009-1999-7 10.1212/WNL.0b013e3181f3db84 10.1001/archpsyc.64.7.802 10.1016/j.neurobiolaging.2008.05.019 10.1016/S0006-8993(02)03137-2 10.1093/brain/awq079 10.1093/brain/awm184 10.1111/j.1532-5415.2008.01826.x 10.1002/hbm.10062 10.1017/S0317167100002389 10.1016/j.neuroimage.2006.02.024 10.1109/42.668698 10.1523/JNEUROSCI.4622-09.2010 10.1002/mds.23208 10.1001/archneur.55.1.84 10.1162/jocn.1993.5.2.162 10.1006/nimg.1998.0395 10.1037/a0020937 10.1073/pnas.200033797 10.1016/j.neurobiolaging.2006.11.014 10.1109/TMI.2006.887364 10.1002/mds.22534 10.1016/j.arr.2003.10.003 10.1002/ana.21291 10.1109/42.796284 10.1002/mds.24892 10.1016/j.brainres.2010.06.003
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Keywords	VBM UPSIT Cortical thickness MRI DTI Aging Olfactory deficits Human Cerebral cortex Senescence Central nervous system Layer thickness Nuclear magnetic resonance imaging Encephalon Olfaction
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References	Kovacs (bib0125) 2004; 3 Christen-Zaech, Kraftsik, Pillevuit, Kiraly, Martins, Khalili (bib0185) 2003; 30 Razani, Chan, Nordin, Murphy (bib0215) 2010; 24 Ibarretxe-Bilbao, Junque, Marti, Valldeoriola, Vendrell, Bargallo (bib0035) 2010; 25 Schubert, Carmichael, Murphy, Klein, Klein, Cruickshanks (bib0030) 2008; 56 Benarroch (bib0130) 2010; 75 Rueckert, Sonoda, Hayes, Hill, Leach, Hawkes (bib0075) 1999; 18 Mesholam, Moberg, Mahr, Doty (bib0005) 1998; 55 Wesson, Levy, Nixon, Wilson (bib0015) 2010; 30 Baba, Kikuchi, Hirayama, Nishio, Hosokai, Kanno (bib0180) 2012; 135 Djordjevic, Jones-Gotman, De Sousa, Chertkow (bib0190) 2008; 29 Wilson, Schneider, Arnold, Tang, Boyle, Bennett (bib0200) 2007; 64 Siderowf, Jennings, Eberly, Oakes, Hawkins, Ascherio (bib0155) 2012; 27 Hummel, Sekinger, Wolf, Pauli, Kobal (bib0210) 1997; 22 Zatorre, Jones-Gotman, Evans, Meyer (bib0115) 1992; 360 Wang, Tian, Huang, Qin, He, Zhou (bib0195) 2002; 951 Bitter, Bruderle, Gudziol, Burmeister, Gaser, Guntinas-Lichius (bib0040) 2010; 1347 Smith, Jenkinson, Johansen-Berg, Rueckert, Nichols, Mackay (bib0065) 2006; 31 Bohnen, Muller (bib0145) 2012 Olofsson, Nordin, Wiens, Hedner, Nilsson, Larsson (bib0205) 2010; 314 Tzourio-Mazoyer, Landeau, Papathanassiou, Crivello, Etard, Delcroix (bib0080) 2002; 15 Ross, Petrovitch, Abbott, Tanner, Popper, Masaki (bib0170) 2008; 63 Sled, Zijdenbos, Evans (bib0085) 1998; 17 Bohnen, Muller, Kotagal, Koeppe, Kilbourn, Albin (bib0140) 2010; 133 Stout, Paulsen, Queller, Solomon, Whitlock, Campbell (bib0150) 2011; 25 Doty (bib0135) 2012; 8 Ponsen, Stoffers, Twisk, Wolters, Berendse (bib0165) 2009; 24 Fischl, Liu, Dale (bib0090) 2001; 20 Ilg, Wohlschlager, Gaser, Liebau, Dauner, Woller (bib0120) 2008; 28 Lezak, Howieson, Loring (bib0220) 2004 Douaud, Smith, Jenkinson, Behrens, Johansen-Berg, Vickers (bib0060) 2007; 130 Saunders-Pullman, Stanley, Wang, San Luciano, Shanker, Hunt (bib0175) 2011; 77 Wilson, Arnold, Schneider, Tang, Bennett (bib0020) 2007; 78 Dale, Fischl, Sereno (bib0100) 1999; 9 Smith (bib0070) 2002; 17 Frasnelli, Lundstrom, Boyle, Djordjevic, Zatorre, Jones-Gotman (bib0010) 2010; 201 Bitter, Gudziol, Burmeister, Mentzel, Guntinas-Lichius, Gaser (bib0045) 2010; 35 Dale, Sereno (bib0110) 1993; 5 Wilson, Arnold, Schneider, Boyle, Buchman, Bennett (bib0025) 2009; 1170 Doty (bib0055) 1995 Ponsen, Stoffers, Booij, van Eck-Smit, Wolters, Berendse (bib0160) 2004; 56 Fischl, Dale (bib0105) 2000; 97 Segonne, Pacheco, Fischl (bib0095) 2007; 26 Lezak (10.1016/j.bbr.2013.02.025_bib0220) 2004 Zatorre (10.1016/j.bbr.2013.02.025_bib0115) 1992; 360 Smith (10.1016/j.bbr.2013.02.025_bib0065) 2006; 31 Dale (10.1016/j.bbr.2013.02.025_bib0110) 1993; 5 Ponsen (10.1016/j.bbr.2013.02.025_bib0160) 2004; 56 Wilson (10.1016/j.bbr.2013.02.025_bib0200) 2007; 64 Saunders-Pullman (10.1016/j.bbr.2013.02.025_bib0175) 2011; 77 Wilson (10.1016/j.bbr.2013.02.025_bib0020) 2007; 78 Olofsson (10.1016/j.bbr.2013.02.025_bib0205) 2010; 314 Sled (10.1016/j.bbr.2013.02.025_bib0085) 1998; 17 Kovacs (10.1016/j.bbr.2013.02.025_bib0125) 2004; 3 Wang (10.1016/j.bbr.2013.02.025_bib0195) 2002; 951 Wilson (10.1016/j.bbr.2013.02.025_bib0025) 2009; 1170 Ibarretxe-Bilbao (10.1016/j.bbr.2013.02.025_bib0035) 2010; 25 Douaud (10.1016/j.bbr.2013.02.025_bib0060) 2007; 130 Wesson (10.1016/j.bbr.2013.02.025_bib0015) 2010; 30 Ponsen (10.1016/j.bbr.2013.02.025_bib0165) 2009; 24 Schubert (10.1016/j.bbr.2013.02.025_bib0030) 2008; 56 Razani (10.1016/j.bbr.2013.02.025_bib0215) 2010; 24 Frasnelli (10.1016/j.bbr.2013.02.025_bib0010) 2010; 201 Bohnen (10.1016/j.bbr.2013.02.025_bib0145) 2012 Djordjevic (10.1016/j.bbr.2013.02.025_bib0190) 2008; 29 Rueckert (10.1016/j.bbr.2013.02.025_bib0075) 1999; 18 Bohnen (10.1016/j.bbr.2013.02.025_bib0140) 2010; 133 Hummel (10.1016/j.bbr.2013.02.025_bib0210) 1997; 22 Dale (10.1016/j.bbr.2013.02.025_bib0100) 1999; 9 Ilg (10.1016/j.bbr.2013.02.025_bib0120) 2008; 28 Doty (10.1016/j.bbr.2013.02.025_bib0055) 1995 Smith (10.1016/j.bbr.2013.02.025_bib0070) 2002; 17 Tzourio-Mazoyer (10.1016/j.bbr.2013.02.025_bib0080) 2002; 15 Christen-Zaech (10.1016/j.bbr.2013.02.025_bib0185) 2003; 30 Bitter (10.1016/j.bbr.2013.02.025_bib0040) 2010; 1347 Ross (10.1016/j.bbr.2013.02.025_bib0170) 2008; 63 Segonne (10.1016/j.bbr.2013.02.025_bib0095) 2007; 26 Doty (10.1016/j.bbr.2013.02.025_bib0135) 2012; 8 Siderowf (10.1016/j.bbr.2013.02.025_bib0155) 2012; 27 Fischl (10.1016/j.bbr.2013.02.025_bib0090) 2001; 20 Fischl (10.1016/j.bbr.2013.02.025_bib0105) 2000; 97 Baba (10.1016/j.bbr.2013.02.025_bib0180) 2012; 135 Bitter (10.1016/j.bbr.2013.02.025_bib0045) 2010; 35 Mesholam (10.1016/j.bbr.2013.02.025_bib0005) 1998; 55 Stout (10.1016/j.bbr.2013.02.025_bib0150) 2011; 25 Benarroch (10.1016/j.bbr.2013.02.025_bib0130) 2010; 75
References_xml	– volume: 20 start-page: 70 year: 2001 end-page: 80 ident: bib0090 article-title: Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex publication-title: IEEE Transactions on Medical Imaging – volume: 78 start-page: 30 year: 2007 end-page: 35 ident: bib0020 article-title: The relationship between cerebral Alzheimer's disease pathology and odour identification in old age publication-title: Journal of Neurology, Neurosurgery and Psychiatry – volume: 15 start-page: 273 year: 2002 end-page: 289 ident: bib0080 article-title: Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain publication-title: Neuroimage – volume: 5 start-page: 162 year: 1993 end-page: 176 ident: bib0110 article-title: Improved localization of cortical activity by combining EEG and MEG with MRI cortical surface reconstruction: a linear approach publication-title: Journal of Cognitive Neuroscience – volume: 56 start-page: 173 year: 2004 end-page: 181 ident: bib0160 article-title: Idiopathic hyposmia as a preclinical sign of Parkinson's disease publication-title: Annals of Neurology – volume: 1347 start-page: 42 year: 2010 end-page: 47 ident: bib0040 article-title: Gray and white matter reduction in hyposmic subjects—a voxel-based morphometry study publication-title: Brain Research – volume: 63 start-page: 167 year: 2008 end-page: 173 ident: bib0170 article-title: Association of olfactory dysfunction with risk for future Parkinson's disease publication-title: Annals of Neurology – volume: 314 start-page: 567 year: 2010 end-page: 577 ident: bib0205 article-title: Odor identification impairment in carriers of ApoE-varepsilon4 is independent of clinical dementia publication-title: Neurobiology of Aging – year: 1995 ident: bib0055 article-title: The Smell Identification Test. Administration Manual – volume: 8 start-page: 329 year: 2012 end-page: 339 ident: bib0135 article-title: Olfactory dysfunction in Parkinson disease publication-title: Nature Reviews Neuroscience – volume: 25 start-page: 1888 year: 2010 end-page: 1894 ident: bib0035 article-title: Olfactory impairment in Parkinson's disease and white matter abnormalities in central olfactory areas: a voxel-based diffusion tensor imaging study publication-title: Movement Disorders – volume: 77 start-page: 319 year: 2011 end-page: 324 ident: bib0175 article-title: Olfactory dysfunction in LRRK2 G2019S mutation carriers publication-title: Neurology – volume: 130 start-page: 2375 year: 2007 end-page: 2386 ident: bib0060 article-title: Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia publication-title: Brain – volume: 133 start-page: 1747 year: 2010 end-page: 1754 ident: bib0140 article-title: Olfactory dysfunction, central cholinergic integrity and cognitive impairment in Parkinson's disease publication-title: Brain – volume: 951 start-page: 77 year: 2002 end-page: 81 ident: bib0195 article-title: Olfactory identification and apolipoprotein E epsilon 4 allele in mild cognitive impairment publication-title: Brain Research – volume: 75 start-page: 1104 year: 2010 end-page: 1109 ident: bib0130 article-title: Olfactory system: functional organization and involvement in neurodegenerative disease publication-title: Neurology – volume: 35 start-page: 407 year: 2010 end-page: 415 ident: bib0045 article-title: Anosmia leads to a loss of gray matter in cortical brain areas publication-title: Chemical Senses – volume: 26 start-page: 518 year: 2007 end-page: 529 ident: bib0095 article-title: Geometrically accurate topology-correction of cortical surfaces using nonseparating loops publication-title: IEEE Transactions on Medical Imaging – volume: 29 start-page: 693 year: 2008 end-page: 706 ident: bib0190 article-title: Olfaction in patients with mild cognitive impairment and Alzheimer's disease publication-title: Neurobiology of Aging – volume: 24 start-page: 291 year: 2010 end-page: 299 ident: bib0215 article-title: Semantic networks for odors and colors in Alzheimer's disease publication-title: Neuropsychology – volume: 31 start-page: 1487 year: 2006 end-page: 1505 ident: bib0065 article-title: Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data publication-title: Neuroimage – year: 2004 ident: bib0220 article-title: Neuropsychological Assessment – volume: 3 start-page: 215 year: 2004 end-page: 232 ident: bib0125 article-title: Mechanisms of olfactory dysfunction in aging and neurodegenerative disorders publication-title: Ageing Research Reviews – volume: 135 start-page: 161 year: 2012 end-page: 169 ident: bib0180 article-title: Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease: a 3 year longitudinal study publication-title: Brain – volume: 64 start-page: 802 year: 2007 end-page: 808 ident: bib0200 article-title: Olfactory identification and incidence of mild cognitive impairment in older age publication-title: Archives of General Psychiatry – year: 2012 ident: bib0145 article-title: In vivo neurochemical imaging of olfactory dysfunction in Parkinson's disease publication-title: Journal of Neural Transmission – volume: 30 start-page: 20 year: 2003 end-page: 25 ident: bib0185 article-title: Early olfactory involvement in Alzheimer's disease publication-title: Canadian Journal of Neurological Sciences – volume: 360 start-page: 339 year: 1992 end-page: 340 ident: bib0115 article-title: Functional localization and lateralization of human olfactory cortex publication-title: Nature – volume: 55 start-page: 84 year: 1998 end-page: 90 ident: bib0005 article-title: Olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases publication-title: Archives of Neurology – volume: 9 start-page: 179 year: 1999 end-page: 194 ident: bib0100 article-title: Cortical surface-based analysis: I. Segmentation and surface reconstruction publication-title: Neuroimage – volume: 17 start-page: 87 year: 1998 end-page: 97 ident: bib0085 article-title: A nonparametric method for automatic correction of intensity nonuniformity in MRI data publication-title: IEEE Transactions on Medical Imaging – volume: 97 start-page: 11050 year: 2000 end-page: 11055 ident: bib0105 article-title: Measuring the thickness of the human cerebral cortex from magnetic resonance images publication-title: Proceedings of the National Academy of Sciences of the United States of America – volume: 24 start-page: 1060 year: 2009 end-page: 1065 ident: bib0165 article-title: Hyposmia and executive dysfunction as predictors of future Parkinson's disease: a prospective study publication-title: Movement Disorders – volume: 18 start-page: 712 year: 1999 end-page: 721 ident: bib0075 article-title: Nonrigid registration using free-form deformations: application to breast MR images publication-title: IEEE Transactions on Medical Imaging – volume: 30 start-page: 505 year: 2010 end-page: 514 ident: bib0015 article-title: Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model publication-title: Journal of Neuroscience – volume: 201 start-page: 1 year: 2010 end-page: 11 ident: bib0010 article-title: Neuroanatomical correlates of olfactory performance publication-title: Experimental Brain Research – volume: 27 start-page: 406 year: 2012 end-page: 412 ident: bib0155 article-title: Impaired olfaction and other prodromal features in the Parkinson at-risk syndrome study publication-title: Movement Disorders – volume: 17 start-page: 143 year: 2002 end-page: 155 ident: bib0070 article-title: Fast robust automated brain extraction publication-title: Human Brain Mapping – volume: 25 start-page: 1 year: 2011 end-page: 14 ident: bib0150 article-title: Neurocognitive signs in prodromal huntington disease publication-title: Neuropsychology – volume: 1170 start-page: 730 year: 2009 end-page: 735 ident: bib0025 article-title: Olfactory impairment in presymptomatic Alzheimer's disease publication-title: Annals of the New York Academy of Sciences – volume: 22 start-page: 39 year: 1997 end-page: 52 ident: bib0210 article-title: ‘Sniffin’ sticks’: olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold publication-title: Chemical Senses – volume: 56 start-page: 1517 year: 2008 end-page: 1521 ident: bib0030 article-title: Olfaction and the 5-year incidence of cognitive impairment in an epidemiological study of older adults publication-title: Journal of the American Geriatrics Society – volume: 28 start-page: 4210 year: 2008 end-page: 4215 ident: bib0120 article-title: Gray matter increase induced by practice correlates with task-specific activation: a combined functional and morphometric magnetic resonance imaging study publication-title: Journal of Neuroscience – volume: 15 start-page: 273 year: 2002 ident: 10.1016/j.bbr.2013.02.025_bib0080 article-title: Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain publication-title: Neuroimage doi: 10.1006/nimg.2001.0978 – volume: 360 start-page: 339 year: 1992 ident: 10.1016/j.bbr.2013.02.025_bib0115 article-title: Functional localization and lateralization of human olfactory cortex publication-title: Nature doi: 10.1038/360339a0 – volume: 135 start-page: 161 year: 2012 ident: 10.1016/j.bbr.2013.02.025_bib0180 article-title: Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease: a 3 year longitudinal study publication-title: Brain doi: 10.1093/brain/awr321 – volume: 28 start-page: 4210 year: 2008 ident: 10.1016/j.bbr.2013.02.025_bib0120 article-title: Gray matter increase induced by practice correlates with task-specific activation: a combined functional and morphometric magnetic resonance imaging study publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.5722-07.2008 – volume: 20 start-page: 70 year: 2001 ident: 10.1016/j.bbr.2013.02.025_bib0090 article-title: Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex publication-title: IEEE Transactions on Medical Imaging doi: 10.1109/42.906426 – volume: 1170 start-page: 730 year: 2009 ident: 10.1016/j.bbr.2013.02.025_bib0025 article-title: Olfactory impairment in presymptomatic Alzheimer's disease publication-title: Annals of the New York Academy of Sciences doi: 10.1111/j.1749-6632.2009.04013.x – volume: 35 start-page: 407 year: 2010 ident: 10.1016/j.bbr.2013.02.025_bib0045 article-title: Anosmia leads to a loss of gray matter in cortical brain areas publication-title: Chemical Senses doi: 10.1093/chemse/bjq028 – volume: 22 start-page: 39 year: 1997 ident: 10.1016/j.bbr.2013.02.025_bib0210 article-title: ‘Sniffin’ sticks’: olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold publication-title: Chemical Senses doi: 10.1093/chemse/22.1.39 – volume: 56 start-page: 173 year: 2004 ident: 10.1016/j.bbr.2013.02.025_bib0160 article-title: Idiopathic hyposmia as a preclinical sign of Parkinson's disease publication-title: Annals of Neurology doi: 10.1002/ana.20160 – volume: 77 start-page: 319 year: 2011 ident: 10.1016/j.bbr.2013.02.025_bib0175 article-title: Olfactory dysfunction in LRRK2 G2019S mutation carriers publication-title: Neurology doi: 10.1212/WNL.0b013e318227041c – volume: 78 start-page: 30 year: 2007 ident: 10.1016/j.bbr.2013.02.025_bib0020 article-title: The relationship between cerebral Alzheimer's disease pathology and odour identification in old age publication-title: Journal of Neurology, Neurosurgery and Psychiatry doi: 10.1136/jnnp.2006.099721 – volume: 24 start-page: 291 year: 2010 ident: 10.1016/j.bbr.2013.02.025_bib0215 article-title: Semantic networks for odors and colors in Alzheimer's disease publication-title: Neuropsychology doi: 10.1037/a0018269 – volume: 201 start-page: 1 year: 2010 ident: 10.1016/j.bbr.2013.02.025_bib0010 article-title: Neuroanatomical correlates of olfactory performance publication-title: Experimental Brain Research doi: 10.1007/s00221-009-1999-7 – volume: 75 start-page: 1104 year: 2010 ident: 10.1016/j.bbr.2013.02.025_bib0130 article-title: Olfactory system: functional organization and involvement in neurodegenerative disease publication-title: Neurology doi: 10.1212/WNL.0b013e3181f3db84 – volume: 64 start-page: 802 year: 2007 ident: 10.1016/j.bbr.2013.02.025_bib0200 article-title: Olfactory identification and incidence of mild cognitive impairment in older age publication-title: Archives of General Psychiatry doi: 10.1001/archpsyc.64.7.802 – volume: 314 start-page: 567 year: 2010 ident: 10.1016/j.bbr.2013.02.025_bib0205 article-title: Odor identification impairment in carriers of ApoE-varepsilon4 is independent of clinical dementia publication-title: Neurobiology of Aging doi: 10.1016/j.neurobiolaging.2008.05.019 – volume: 951 start-page: 77 year: 2002 ident: 10.1016/j.bbr.2013.02.025_bib0195 article-title: Olfactory identification and apolipoprotein E epsilon 4 allele in mild cognitive impairment publication-title: Brain Research doi: 10.1016/S0006-8993(02)03137-2 – volume: 133 start-page: 1747 year: 2010 ident: 10.1016/j.bbr.2013.02.025_bib0140 article-title: Olfactory dysfunction, central cholinergic integrity and cognitive impairment in Parkinson's disease publication-title: Brain doi: 10.1093/brain/awq079 – volume: 130 start-page: 2375 year: 2007 ident: 10.1016/j.bbr.2013.02.025_bib0060 article-title: Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia publication-title: Brain doi: 10.1093/brain/awm184 – volume: 56 start-page: 1517 year: 2008 ident: 10.1016/j.bbr.2013.02.025_bib0030 article-title: Olfaction and the 5-year incidence of cognitive impairment in an epidemiological study of older adults publication-title: Journal of the American Geriatrics Society doi: 10.1111/j.1532-5415.2008.01826.x – volume: 17 start-page: 143 year: 2002 ident: 10.1016/j.bbr.2013.02.025_bib0070 article-title: Fast robust automated brain extraction publication-title: Human Brain Mapping doi: 10.1002/hbm.10062 – volume: 30 start-page: 20 year: 2003 ident: 10.1016/j.bbr.2013.02.025_bib0185 article-title: Early olfactory involvement in Alzheimer's disease publication-title: Canadian Journal of Neurological Sciences doi: 10.1017/S0317167100002389 – volume: 31 start-page: 1487 year: 2006 ident: 10.1016/j.bbr.2013.02.025_bib0065 article-title: Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data publication-title: Neuroimage doi: 10.1016/j.neuroimage.2006.02.024 – volume: 17 start-page: 87 year: 1998 ident: 10.1016/j.bbr.2013.02.025_bib0085 article-title: A nonparametric method for automatic correction of intensity nonuniformity in MRI data publication-title: IEEE Transactions on Medical Imaging doi: 10.1109/42.668698 – volume: 30 start-page: 505 year: 2010 ident: 10.1016/j.bbr.2013.02.025_bib0015 article-title: Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.4622-09.2010 – volume: 25 start-page: 1888 year: 2010 ident: 10.1016/j.bbr.2013.02.025_bib0035 article-title: Olfactory impairment in Parkinson's disease and white matter abnormalities in central olfactory areas: a voxel-based diffusion tensor imaging study publication-title: Movement Disorders doi: 10.1002/mds.23208 – volume: 55 start-page: 84 year: 1998 ident: 10.1016/j.bbr.2013.02.025_bib0005 article-title: Olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases publication-title: Archives of Neurology doi: 10.1001/archneur.55.1.84 – volume: 5 start-page: 162 year: 1993 ident: 10.1016/j.bbr.2013.02.025_bib0110 article-title: Improved localization of cortical activity by combining EEG and MEG with MRI cortical surface reconstruction: a linear approach publication-title: Journal of Cognitive Neuroscience doi: 10.1162/jocn.1993.5.2.162 – volume: 9 start-page: 179 year: 1999 ident: 10.1016/j.bbr.2013.02.025_bib0100 article-title: Cortical surface-based analysis: I. Segmentation and surface reconstruction publication-title: Neuroimage doi: 10.1006/nimg.1998.0395 – year: 1995 ident: 10.1016/j.bbr.2013.02.025_bib0055 – volume: 8 start-page: 329 year: 2012 ident: 10.1016/j.bbr.2013.02.025_bib0135 article-title: Olfactory dysfunction in Parkinson disease publication-title: Nature Reviews Neuroscience – volume: 25 start-page: 1 issue: 1 year: 2011 ident: 10.1016/j.bbr.2013.02.025_bib0150 article-title: Neurocognitive signs in prodromal huntington disease publication-title: Neuropsychology doi: 10.1037/a0020937 – volume: 97 start-page: 11050 year: 2000 ident: 10.1016/j.bbr.2013.02.025_bib0105 article-title: Measuring the thickness of the human cerebral cortex from magnetic resonance images publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.200033797 – volume: 29 start-page: 693 year: 2008 ident: 10.1016/j.bbr.2013.02.025_bib0190 article-title: Olfaction in patients with mild cognitive impairment and Alzheimer's disease publication-title: Neurobiology of Aging doi: 10.1016/j.neurobiolaging.2006.11.014 – year: 2004 ident: 10.1016/j.bbr.2013.02.025_bib0220 – volume: 26 start-page: 518 year: 2007 ident: 10.1016/j.bbr.2013.02.025_bib0095 article-title: Geometrically accurate topology-correction of cortical surfaces using nonseparating loops publication-title: IEEE Transactions on Medical Imaging doi: 10.1109/TMI.2006.887364 – volume: 24 start-page: 1060 year: 2009 ident: 10.1016/j.bbr.2013.02.025_bib0165 article-title: Hyposmia and executive dysfunction as predictors of future Parkinson's disease: a prospective study publication-title: Movement Disorders doi: 10.1002/mds.22534 – volume: 3 start-page: 215 year: 2004 ident: 10.1016/j.bbr.2013.02.025_bib0125 article-title: Mechanisms of olfactory dysfunction in aging and neurodegenerative disorders publication-title: Ageing Research Reviews doi: 10.1016/j.arr.2003.10.003 – volume: 63 start-page: 167 year: 2008 ident: 10.1016/j.bbr.2013.02.025_bib0170 article-title: Association of olfactory dysfunction with risk for future Parkinson's disease publication-title: Annals of Neurology doi: 10.1002/ana.21291 – volume: 18 start-page: 712 year: 1999 ident: 10.1016/j.bbr.2013.02.025_bib0075 article-title: Nonrigid registration using free-form deformations: application to breast MR images publication-title: IEEE Transactions on Medical Imaging doi: 10.1109/42.796284 – volume: 27 start-page: 406 year: 2012 ident: 10.1016/j.bbr.2013.02.025_bib0155 article-title: Impaired olfaction and other prodromal features in the Parkinson at-risk syndrome study publication-title: Movement Disorders doi: 10.1002/mds.24892 – year: 2012 ident: 10.1016/j.bbr.2013.02.025_bib0145 article-title: In vivo neurochemical imaging of olfactory dysfunction in Parkinson's disease publication-title: Journal of Neural Transmission – volume: 1347 start-page: 42 issue: 6 year: 2010 ident: 10.1016/j.bbr.2013.02.025_bib0040 article-title: Gray and white matter reduction in hyposmic subjects—a voxel-based morphometry study publication-title: Brain Research doi: 10.1016/j.brainres.2010.06.003
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Snippet	► Olfactory loss is associated in normal aged subjects with gray and white matter brain changes. ► DTI shows microstructural changes in superior longitudinal... In non-demented older persons, smell dysfunction, measured premortem, has been associated with postmortem brain degeneration similar to that of Alzheimer's...
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SubjectTerms	Aged Aging Anisotropy Behavioral psychophysiology Biological and medical sciences Brain Mapping Cortical thickness Diffusion Magnetic Resonance Imaging DTI Female Fundamental and applied biological sciences. Psychology Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged MRI Nerve Fibers, Myelinated - physiology Neuroanatomy Neuropsychological Tests Olfaction Disorders - pathology Olfactory deficits Olfactory Pathways - pathology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Smell - physiology UPSIT VBM Verbal Learning - physiology
Title	Neuroanatomical correlates of olfactory loss in normal aged subjects
URI	https://dx.doi.org/10.1016/j.bbr.2013.02.025 https://www.ncbi.nlm.nih.gov/pubmed/23458742 https://www.proquest.com/docview/1338389796
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