Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis - Chowdhry, Sudhir; Nazmy, Maiiada H.; Meakin, Paul J.; Dinkova-Kostova, Albena T.; Walsh, Shaun V.; Tsujita, Tadayuki; Dillon, John F.; Ashford, Michael L.J.; Hayes, John D. (Free radical biology & medicine, 2010)
Keywords: Animals; Choline - chemistry; Cyclooxygenase 2 - biosynthesis; Cyclooxygenase 2 - genetics; Disease Progression; Fatty Liver - blood; Fatty Liver - genetics; Fatty Liver - metabolism; Fatty Liver - pathology; Fatty Liver - physiopathology; Food, Formulated; Free radicals; Glutathione; Interleukin-1beta - biosynthesis; Interleukin-1beta - genetics; Liver - metabolism; Liver - pathology; Male; Methionine - chemistry; Methionine- and choline-deficient diet; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration - genetics; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; NF-kappa B - metabolism; NF-κB; Nitric Oxide Synthase Type II - biosynthesis; Nitric Oxide Synthase Type II - genetics; Nonalcoholic steatohepatitis; Nrf2; Oxidative Stress - genetics; Tumor Necrosis Factor-alpha - biosynthesis; Tumor Necrosis Factor-alpha - genetics; NAFLD; TNFα; MPO; NF-κB; RTU; Nonalcoholic steatohepatitis; NRF2; PPAR; RNS; COX2; CYP; GSH; WT; Glutathione; GSSG; L-FABP; NQO1; SREBP; Free radicals; KO; NOS2; TBARS; IL-1β; NASH; MCD; Methionine- and choline-deficient diet; bZIP; GCLC; ROS; Keap1; CNC; GCLM; ADRP