Effect of P‐glycoprotein inhibition at the blood–brain barrier on brain distribution of (R)‐[11C]verapamil in elderly vs. young subjects - Bauer, Martin; Wulkersdorfer, Beatrix; Karch, Rudolf; Philippe, Cécile; Jäger, Walter; Stanek, Johann; Wadsak, Wolfgang; Hacker, Marcus; Zeitlinger, Markus; Langer, Oliver (British journal of clinical pharmacology, 2017)
Keywords: Adult; age; Age Factors; Aged; ATP Binding Cassette Transporter, Subfamily B - antagonists & inhibitors; Blood-Brain Barrier - metabolism; blood–brain barrier; Brain - metabolism; Carbon Radioisotopes - metabolism; Drug Interactions; drug–drug interaction; Gray Matter - metabolism; Healthy Volunteers; Humans; Male; PET; Positron-Emission Tomography; P‐glycoprotein; Quinolines - pharmacology; Verapamil - pharmacokinetics; P-glycoprotein; blood-brain barrier; drug-drug interaction; PET; age