Evaluation of the FAS and FASL Gene changes in women with premature ovarian failure: A case-control study
Background: Premature ovarian failure (POF), is menopause occurring before the age of 40, affecting 1-3% of women worldwide. The risk of POF increases with altered immunological parameters such as FAS and FASL genes, which play a fundamental role in embryogenesis and cellular homeostasis. Objective:...
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| Published in | International journal of reproductive biomedicine (Yazd, Iran) Vol. 20; no. 12; pp. 1007 - 1012 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Iran
Yazd Shahid Sadoughi University of Medical Sciences, Research and Clinical Center for Infertility
01.12.2022
Knowledge E Shahid Sadoughi University of Medical Sciences |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2476-4108 2476-3772 |
| DOI | 10.18502/ijrm.v20i12.12561 |
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| Abstract | Background: Premature ovarian failure (POF), is menopause occurring before the age of 40, affecting 1-3% of women worldwide. The risk of POF increases with altered immunological parameters such as FAS and FASL genes, which play a fundamental role in embryogenesis and cellular homeostasis.
Objective: The study aimed to investigate the potential role of FAS and FASL genes in POF pathogenesis.
Materials and Methods: In this case-control study, the polymorphisms of FAS-670A/G and FASLIVS2nt_124A/G apoptotic genes were analyzed in 51 Iranian women suffering from POF, and 61 healthy controls. Isolation of DNA was done using the salting-out method, and genotypic analysis was performed for all the subjects using the polymerase chain reaction-restriction fragment length polymorphism method.
Results: Our results revealed that homozygous FAS-670A/A and G/G, and heterozygous FAS-670A/G are not significantly different between cases and controls (p = 0.99). Also, in different genotyping models of FASIVS2nt_124, polymorphisms were not related to POF risk (p = 0.23).
Conclusion: There is no statistical association between these polymorphisms and POF risk in women referred to genetic counseling clinics.
Key words: FAS, FASL, Polymorphism, Premature ovarian failure. |
|---|---|
| AbstractList | Background: Premature ovarian failure (POF), is menopause occurring before the age of 40, affecting 1-3% of women worldwide. The risk of POF increases with altered immunological parameters such as FAS and FASL genes, which play a fundamental role in embryogenesis and cellular homeostasis.
Objective: The study aimed to investigate the potential role of FAS and FASL genes in POF pathogenesis.
Materials and Methods: In this case-control study, the polymorphisms of FAS-670A/G and FASLIVS2nt_124A/G apoptotic genes were analyzed in 51 Iranian women suffering from POF, and 61 healthy controls. Isolation of DNA was done using the salting-out method, and genotypic analysis was performed for all the subjects using the polymerase chain reaction-restriction fragment length polymorphism method.
Results: Our results revealed that homozygous FAS-670A/A and G/G, and heterozygous FAS-670A/G are not significantly different between cases and controls (p = 0.99). Also, in different genotyping models of FASIVS2nt_124, polymorphisms were not related to POF risk (p = 0.23).
Conclusion: There is no statistical association between these polymorphisms and POF risk in women referred to genetic counseling clinics.
Key words: FAS, FASL, Polymorphism, Premature ovarian failure. Premature ovarian failure (POF), is menopause occurring before the age of 40, affecting 1-3% of women worldwide. The risk of POF increases with altered immunological parameters such as FAS and FASL genes, which play a fundamental role in embryogenesis and cellular homeostasis.BackgroundPremature ovarian failure (POF), is menopause occurring before the age of 40, affecting 1-3% of women worldwide. The risk of POF increases with altered immunological parameters such as FAS and FASL genes, which play a fundamental role in embryogenesis and cellular homeostasis.The study aimed to investigate the potential role of FAS and FASL genes in POF pathogenesis.ObjectiveThe study aimed to investigate the potential role of FAS and FASL genes in POF pathogenesis.In this case-control study, the polymorphisms of FAS-670A/G and FASLIVS2nt_124A/G apoptotic genes were analyzed in 51 Iranian women suffering from POF, and 61 healthy controls. Isolation of DNA was done using the salting-out method, and genotypic analysis was performed for all the subjects using the polymerase chain reaction-restriction fragment length polymorphism method.Materials and MethodsIn this case-control study, the polymorphisms of FAS-670A/G and FASLIVS2nt_124A/G apoptotic genes were analyzed in 51 Iranian women suffering from POF, and 61 healthy controls. Isolation of DNA was done using the salting-out method, and genotypic analysis was performed for all the subjects using the polymerase chain reaction-restriction fragment length polymorphism method.Our results revealed that homozygous FAS-670A/A and G/G, and heterozygous FAS-670A/G are not significantly different between cases and controls (p = 0.99). Also, in different genotyping models of FASIVS2nt_124, polymorphisms were not related to POF risk (p = 0.23).ResultsOur results revealed that homozygous FAS-670A/A and G/G, and heterozygous FAS-670A/G are not significantly different between cases and controls (p = 0.99). Also, in different genotyping models of FASIVS2nt_124, polymorphisms were not related to POF risk (p = 0.23).There is no statistical association between these polymorphisms and POF risk in women referred to genetic counseling clinics.ConclusionThere is no statistical association between these polymorphisms and POF risk in women referred to genetic counseling clinics. Premature ovarian failure (POF), is menopause occurring before the age of 40, affecting 1-3% of women worldwide. The risk of POF increases with altered immunological parameters such as and genes, which play a fundamental role in embryogenesis and cellular homeostasis. The study aimed to investigate the potential role of and genes in POF pathogenesis. In this case-control study, the polymorphisms of -670A/G and IVS2nt_124A/G apoptotic genes were analyzed in 51 Iranian women suffering from POF, and 61 healthy controls. Isolation of DNA was done using the salting-out method, and genotypic analysis was performed for all the subjects using the polymerase chain reaction-restriction fragment length polymorphism method. Our results revealed that homozygous -670A/A and G/G, and heterozygous -670A/G are not significantly different between cases and controls (p = 0.99). Also, in different genotyping models of IVS2nt_124, polymorphisms were not related to POF risk (p = 0.23). There is no statistical association between these polymorphisms and POF risk in women referred to genetic counseling clinics. Abstract Background: Premature ovarian failure (POF), is menopause occurring before the age of 40, affecting 1-3% of women worldwide. The risk of POF increases with altered immunological parameters such as FAS and FASL genes, which play a fundamental role in embryogenesis and cellular homeostasis. Objective: The study aimed to investigate the potential role of FAS and FASL genes in POF pathogenesis. Materials and Methods: In this case-control study, the polymorphisms of FAS-670A/G and FASLIVS2nt_124A/G apoptotic genes were analyzed in 51 Iranian women suffering from POF, and 61 healthy controls. Isolation of DNA was done using the salting-out method, and genotypic analysis was performed for all the subjects using the polymerase chain reaction-restriction fragment length polymorphism method. Results: Our results revealed that homozygous FAS-670A/A and G/G, and heterozygous FAS-670A/G are not significantly different between cases and controls (p = 0.99). Also, in different genotyping models of FASIVS2nt_124, polymorphisms were not related to POF risk (p = 0.23). Conclusion: There is no statistical association between these polymorphisms and POF risk in women referred to genetic counseling clinics. AbstractBackground:Premature ovarian failure (POF), is menopause occurring before the age of 40, affecting 1-3% of women worldwide. The risk of POF increases with altered immunological parameters such as FAS and FASL genes, which play a fundamental role in embryogenesis and cellular homeostasis.Objective: The study aimed to investigate the potential role of FAS and FASL genes in POF pathogenesis.Materials and Methods: In this case-control study, the polymorphisms of FAS-670A/G and FASLIVS2nt_124A/G apoptotic genes were analyzed in 51 Iranian women suffering from POF, and 61 healthy controls. Isolation of DNA was done using the salting-out method, and genotypic analysis was performed for all the subjects using the polymerase chain reaction-restriction fragment length polymorphism method.Results: Our results revealed that homozygous FAS-670A/A and G/G, and heterozygous FAS-670A/G are not significantly different between cases and controls (p = 0.99). Also, in different genotyping models of FASIVS2nt_124, polymorphisms were not related to POF risk (p = 0.23).Conclusion:There is no statistical association between these polymorphisms and POF risk in women referred to genetic counseling clinics. |
| Author | Mohammadi, Mahnaz Yavari, Shadnaz Fakhteh Tahoori, Mohammad Taher Ghasemi, Nasrin Ashrafzadeh, Hamid Reza Sani, Morteza Bitaraf Akhavansales, Zhima Mosadeghmehrjardi, Alimohammad Montazeri, Fateme |
| AuthorAffiliation | 3 Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 2 Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran 4 Department of Tissue Engineering and Applied Cell Science, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran 6 Animal Science Research Department, Yazd Agricultural and Natural Resources Research and Education Center, Agricultural Research, Education & Extension Organization (AREEO), Yazd, Iran 1 Department of Immunology, Faculty of Medicine, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 5 Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran |
| AuthorAffiliation_xml | – name: 1 Department of Immunology, Faculty of Medicine, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran – name: 5 Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran – name: 3 Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran – name: 4 Department of Tissue Engineering and Applied Cell Science, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran – name: 2 Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran – name: 6 Animal Science Research Department, Yazd Agricultural and Natural Resources Research and Education Center, Agricultural Research, Education & Extension Organization (AREEO), Yazd, Iran |
| Author_xml | – sequence: 1 givenname: Zhima surname: Akhavansales fullname: Akhavansales, Zhima – sequence: 2 givenname: Alimohammad surname: Mosadeghmehrjardi fullname: Mosadeghmehrjardi, Alimohammad – sequence: 3 givenname: Hamid Reza surname: Ashrafzadeh fullname: Ashrafzadeh, Hamid Reza – sequence: 4 givenname: Shadnaz Fakhteh surname: Yavari fullname: Yavari, Shadnaz Fakhteh – sequence: 5 givenname: Mohammad Taher surname: Tahoori fullname: Tahoori, Mohammad Taher – sequence: 6 givenname: Morteza Bitaraf surname: Sani fullname: Sani, Morteza Bitaraf – sequence: 7 givenname: Mahnaz surname: Mohammadi fullname: Mohammadi, Mahnaz – sequence: 8 givenname: Fateme surname: Montazeri fullname: Montazeri, Fateme – sequence: 9 givenname: Nasrin surname: Ghasemi fullname: Ghasemi, Nasrin |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36819201$$D View this record in MEDLINE/PubMed |
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| Keywords | FAS FASL Premature ovarian failure Polymorphism |
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| Snippet | Background: Premature ovarian failure (POF), is menopause occurring before the age of 40, affecting 1-3% of women worldwide. The risk of POF increases with... Premature ovarian failure (POF), is menopause occurring before the age of 40, affecting 1-3% of women worldwide. The risk of POF increases with altered... AbstractBackground:Premature ovarian failure (POF), is menopause occurring before the age of 40, affecting 1-3% of women worldwide. The risk of POF increases... Abstract Background: Premature ovarian failure (POF), is menopause occurring before the age of 40, affecting 1-3% of women worldwide. The risk of POF increases... |
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| SubjectTerms | fas, fasl, polymorphism, premature ovarian failure Genetic counseling Menopause Original Ovaries Reproductive health Womens health |
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| Title | Evaluation of the FAS and FASL Gene changes in women with premature ovarian failure: A case-control study |
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