Comparison of gastric emptying of a nondigestible capsule to a radio‐labelled meal in healthy and gastroparetic subjects

Summary Background Gastric emptying scintigraphy (GES) using a radio‐labelled meal is used to measure gastric emptying. A nondigestible capsule, SmartPill, records luminal pH, temperature, and pressure during gastrointestinal transit providing a measure of gastric emptying time (GET). Aims To comp...

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Published in	Alimentary pharmacology & therapeutics Vol. 27; no. 2; pp. 186 - 196
Main Authors	KUO, B., McCALLUM, R. W., KOCH, K. L., SITRIN, M. D., WO, J. M., CHEY, W. D., HASLER, W. L., LACKNER, J. M., KATZ, L. A., SEMLER, J. R., WILDING, G. E., PARKMAN, H. P.
Format	Journal Article
Language	English
Published	Oxford, UK Blackwell Publishing Ltd 15.01.2008 Blackwell
Subjects	Adolescent Adult Aged Biological and medical sciences Digestive system Esophageal pH Monitoring - instrumentation Female Gastric Emptying Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal Motility - physiology Gastroparesis - diagnostic imaging Humans Image Interpretation, Computer-Assisted Male Medical sciences Middle Aged Pharmacology. Drug treatments Pressure Prospective Studies Radionuclide Imaging Reproducibility of Results ROC Curve Technetium Tc 99m Sulfur Colloid Time Human Stomach Healthy subject Digestive system Gastric emptying Capsule Comparative study
Online Access	Get full text
ISSN	0269-2813 1365-2036 1365-2036
DOI	10.1111/j.1365-2036.2007.03564.x

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Abstract	Summary Background Gastric emptying scintigraphy (GES) using a radio‐labelled meal is used to measure gastric emptying. A nondigestible capsule, SmartPill, records luminal pH, temperature, and pressure during gastrointestinal transit providing a measure of gastric emptying time (GET). Aims To compare gastric emptying time and GES by assessing their correlation, and to compare GET and GES for discriminating healthy subjects from gastroparetics. Methods Eighty‐seven healthy subjects and 61 gastroparetics enrolled with simultaneous SmartPill and GES. Fasted subjects were ingested capsule and [99mTc]‐SC radio‐labelled meal. Images were obtained every 30 min for 6 h. Gastric emptying time and percentage of meal remaining at 2/4 h were determined for each subject. The sensitivity/specificity and receiver operating characteristic analysis of each measure were determined for each subject. Results Correlation between GET and GES‐4 h was 0.73 and GES‐2 h was 0.63. The diagnostic accuracy from the receiver operating characteristic curve between gastroparetics and healthy subjects was GET = 0.83, GES‐4 h = 0.82 and GES‐2 h = 0.79. The 300‐min cut‐off time for GET gives sensitivity of 0.65 and specificity of 0.87 for diagnosis of gastroparesis. The corresponding sensitivity/specificity for 2 and 4 h standard GES measures were 0.34/0.93 and 0.44/0.93, respectively. Conclusion SmartPill GET correlates with GES and discriminates between healthy and gastroparetic subjects offering a nonradioactive, standardized, ambulatory alternative to scintigraphy.
AbstractList	Summary Background Gastric emptying scintigraphy (GES) using a radio‐labelled meal is used to measure gastric emptying. A nondigestible capsule, SmartPill, records luminal pH, temperature, and pressure during gastrointestinal transit providing a measure of gastric emptying time (GET). Aims To compare gastric emptying time and GES by assessing their correlation, and to compare GET and GES for discriminating healthy subjects from gastroparetics. Methods Eighty‐seven healthy subjects and 61 gastroparetics enrolled with simultaneous SmartPill and GES. Fasted subjects were ingested capsule and [99mTc]‐SC radio‐labelled meal. Images were obtained every 30 min for 6 h. Gastric emptying time and percentage of meal remaining at 2/4 h were determined for each subject. The sensitivity/specificity and receiver operating characteristic analysis of each measure were determined for each subject. Results Correlation between GET and GES‐4 h was 0.73 and GES‐2 h was 0.63. The diagnostic accuracy from the receiver operating characteristic curve between gastroparetics and healthy subjects was GET = 0.83, GES‐4 h = 0.82 and GES‐2 h = 0.79. The 300‐min cut‐off time for GET gives sensitivity of 0.65 and specificity of 0.87 for diagnosis of gastroparesis. The corresponding sensitivity/specificity for 2 and 4 h standard GES measures were 0.34/0.93 and 0.44/0.93, respectively. Conclusion SmartPill GET correlates with GES and discriminates between healthy and gastroparetic subjects offering a nonradioactive, standardized, ambulatory alternative to scintigraphy. Gastric emptying scintigraphy (GES) using a radio-labelled meal is used to measure gastric emptying. A nondigestible capsule, SmartPill, records luminal pH, temperature, and pressure during gastrointestinal transit providing a measure of gastric emptying time (GET). To compare gastric emptying time and GES by assessing their correlation, and to compare GET and GES for discriminating healthy subjects from gastroparetics. Eighty-seven healthy subjects and 61 gastroparetics enrolled with simultaneous SmartPill and GES. Fasted subjects were ingested capsule and [(99m)Tc]-SC radio-labelled meal. Images were obtained every 30 min for 6 h. Gastric emptying time and percentage of meal remaining at 2/4 h were determined for each subject. The sensitivity/specificity and receiver operating characteristic analysis of each measure were determined for each subject. Correlation between GET and GES-4 h was 0.73 and GES-2 h was 0.63. The diagnostic accuracy from the receiver operating characteristic curve between gastroparetics and healthy subjects was GET = 0.83, GES-4 h = 0.82 and GES-2 h = 0.79. The 300-min cut-off time for GET gives sensitivity of 0.65 and specificity of 0.87 for diagnosis of gastroparesis. The corresponding sensitivity/specificity for 2 and 4 h standard GES measures were 0.34/0.93 and 0.44/0.93, respectively. SmartPill GET correlates with GES and discriminates between healthy and gastroparetic subjects offering a nonradioactive, standardized, ambulatory alternative to scintigraphy. Gastric emptying scintigraphy (GES) using a radio-labelled meal is used to measure gastric emptying. A nondigestible capsule, SmartPill, records luminal pH, temperature, and pressure during gastrointestinal transit providing a measure of gastric emptying time (GET).BACKGROUNDGastric emptying scintigraphy (GES) using a radio-labelled meal is used to measure gastric emptying. A nondigestible capsule, SmartPill, records luminal pH, temperature, and pressure during gastrointestinal transit providing a measure of gastric emptying time (GET).To compare gastric emptying time and GES by assessing their correlation, and to compare GET and GES for discriminating healthy subjects from gastroparetics.AIMSTo compare gastric emptying time and GES by assessing their correlation, and to compare GET and GES for discriminating healthy subjects from gastroparetics.Eighty-seven healthy subjects and 61 gastroparetics enrolled with simultaneous SmartPill and GES. Fasted subjects were ingested capsule and [(99m)Tc]-SC radio-labelled meal. Images were obtained every 30 min for 6 h. Gastric emptying time and percentage of meal remaining at 2/4 h were determined for each subject. The sensitivity/specificity and receiver operating characteristic analysis of each measure were determined for each subject.METHODSEighty-seven healthy subjects and 61 gastroparetics enrolled with simultaneous SmartPill and GES. Fasted subjects were ingested capsule and [(99m)Tc]-SC radio-labelled meal. Images were obtained every 30 min for 6 h. Gastric emptying time and percentage of meal remaining at 2/4 h were determined for each subject. The sensitivity/specificity and receiver operating characteristic analysis of each measure were determined for each subject.Correlation between GET and GES-4 h was 0.73 and GES-2 h was 0.63. The diagnostic accuracy from the receiver operating characteristic curve between gastroparetics and healthy subjects was GET = 0.83, GES-4 h = 0.82 and GES-2 h = 0.79. The 300-min cut-off time for GET gives sensitivity of 0.65 and specificity of 0.87 for diagnosis of gastroparesis. The corresponding sensitivity/specificity for 2 and 4 h standard GES measures were 0.34/0.93 and 0.44/0.93, respectively.RESULTSCorrelation between GET and GES-4 h was 0.73 and GES-2 h was 0.63. The diagnostic accuracy from the receiver operating characteristic curve between gastroparetics and healthy subjects was GET = 0.83, GES-4 h = 0.82 and GES-2 h = 0.79. The 300-min cut-off time for GET gives sensitivity of 0.65 and specificity of 0.87 for diagnosis of gastroparesis. The corresponding sensitivity/specificity for 2 and 4 h standard GES measures were 0.34/0.93 and 0.44/0.93, respectively.SmartPill GET correlates with GES and discriminates between healthy and gastroparetic subjects offering a nonradioactive, standardized, ambulatory alternative to scintigraphy.CONCLUSIONSmartPill GET correlates with GES and discriminates between healthy and gastroparetic subjects offering a nonradioactive, standardized, ambulatory alternative to scintigraphy. Background Gastric emptying scintigraphy (GES) using a radio‐labelled meal is used to measure gastric emptying. A nondigestible capsule, SmartPill, records luminal pH, temperature, and pressure during gastrointestinal transit providing a measure of gastric emptying time (GET). Aims To compare gastric emptying time and GES by assessing their correlation, and to compare GET and GES for discriminating healthy subjects from gastroparetics. Methods Eighty‐seven healthy subjects and 61 gastroparetics enrolled with simultaneous SmartPill and GES. Fasted subjects were ingested capsule and [ 99m Tc]‐SC radio‐labelled meal. Images were obtained every 30 min for 6 h. Gastric emptying time and percentage of meal remaining at 2/4 h were determined for each subject. The sensitivity/specificity and receiver operating characteristic analysis of each measure were determined for each subject. Results Correlation between GET and GES‐4 h was 0.73 and GES‐2 h was 0.63. The diagnostic accuracy from the receiver operating characteristic curve between gastroparetics and healthy subjects was GET = 0.83, GES‐4 h = 0.82 and GES‐2 h = 0.79. The 300‐min cut‐off time for GET gives sensitivity of 0.65 and specificity of 0.87 for diagnosis of gastroparesis. The corresponding sensitivity/specificity for 2 and 4 h standard GES measures were 0.34/0.93 and 0.44/0.93, respectively. Conclusion SmartPill GET correlates with GES and discriminates between healthy and gastroparetic subjects offering a nonradioactive, standardized, ambulatory alternative to scintigraphy.
Author	PARKMAN, H. P. WILDING, G. E. WO, J. M. KUO, B. LACKNER, J. M. KOCH, K. L. SEMLER, J. R. McCALLUM, R. W. KATZ, L. A. SITRIN, M. D. CHEY, W. D. HASLER, W. L.
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Keywords	Human Stomach Healthy subject Digestive system Gastric emptying Capsule Comparative study
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References	2002; 16 2004; 127 1988; 29 2005; 100 2004; 16 1987; 92 1984; 87 2007; 132 1993; 10 1989; 6 1997; 112 1985; 80 2000; 95 1994; 69 2003 1985; 89 2003; 200 Gordon SJ (e_1_2_6_9_2) 1987; 92 Faegenburg D (e_1_2_6_13_2) 1985; 80 e_1_2_6_8_2 e_1_2_6_7_2 Rao SS (e_1_2_6_19_2) 2007; 132 e_1_2_6_4_2 Kuo B (e_1_2_6_6_2) 2004; 16 e_1_2_6_3_2 e_1_2_6_5_2 e_1_2_6_12_2 e_1_2_6_2_2 e_1_2_6_10_2 e_1_2_6_11_2 e_1_2_6_16_2 e_1_2_6_17_2 Cassilly DW (e_1_2_6_18_2) 2007; 132 e_1_2_6_14_2 e_1_2_6_15_2
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capsule endoscopy in patients with obscure gastrointestinal bleeding publication-title: Am J Gastroenterol – volume: 69 start-page: 539 year: 1994 end-page: 47 article-title: A new questionnaire for gastroesophageal reflux disease publication-title: Mayo Clin Proc – volume: 6 start-page: 719 year: 1989 end-page: 44 article-title: Gastrointestinal transit of a solid indigestible capsule as measured by radiotelemetry and dual gamma scintigraphy publication-title: Pharm Res – year: 2003 – volume: 10 start-page: 187 year: 1993 end-page: 96 article-title: Upper gastrointestinal pH in seventy‐nine healthy, elderly, North American men and women publication-title: Pharm Res – volume: 200 start-page: 245 year: 2003 article-title: Video capsule endoscopy (VCE) is useful in the evaluation of unexplained abdominal pain (AP) publication-title: Gastroenterology – volume: 29 start-page: 1035 year: 1988 end-page: 41 article-title: Measurement of gastrointestinal pH profiles in normal ambulant subjects publication-title: Gut – volume: 132 start-page: A‐458 issue: 4, Suppl. 2 year: 2007 article-title: A comparative study of SmartPill and radioopaque markers for the assessment of colonic transit time in humans publication-title: Gastroenterology – volume: 127 start-page: 1592 year: 2004 end-page: 622 article-title: AGA technical review on the diagnosis and treatment of gastroparesis publication-title: Gastroenterology – volume: 89 start-page: 392 year: 1985 end-page: 7 article-title: Estimation of gastric residence time of the Heidelberg capsule in humans: effect of varying food composition publication-title: Gastroenterology – volume: 132 start-page: A‐97 issue: 4, Suppl. 2 year: 2007 article-title: Simultaneous use of SmartPill pH and pressure capsule, antroduodenal manometry and gastric emptying scintigraphy to assess gastric emptying of digestible and non‐digestible solids publication-title: Gastroenterology – volume: 87 start-page: 895 year: 1984 end-page: 902 article-title: Gastric emptying of solid radiopaque markers: studies in healthy subjects and diabetic patients publication-title: Gastroenterology – volume: 80 start-page: 787 year: 1985 end-page: 9 article-title: Intestinal obstruction caused by ingestion of a Heidelberg capsule: report of a case publication-title: Am J Gastroenterol – volume: 92 start-page: 1410 year: 1987 end-page: 1410 article-title: Measurement of gastric residence time (GRT) by Heidelberg capsule (HC) reproducibility in normal subjects and application in diabetic gastroparesis publication-title: Gastroenterology – ident: e_1_2_6_14_2 doi: 10.1016/S0016-5085(03)81232-5 – ident: e_1_2_6_15_2 doi: 10.1111/j.1572-0241.2005.40722.x – ident: e_1_2_6_17_2 doi: 10.1016/0016-5085(84)90085-4 – ident: e_1_2_6_3_2 doi: 10.1023/A:1018970323716 – ident: e_1_2_6_11_2 doi: 10.1136/gut.29.8.1035 – ident: e_1_2_6_8_2 doi: 10.1023/A:1015998708560 – ident: e_1_2_6_16_2 doi: 10.1007/b97377 – volume: 92 start-page: 1410 year: 1987 ident: e_1_2_6_9_2 article-title: Measurement of gastric residence time (GRT) by Heidelberg capsule (HC) reproducibility in normal subjects and application in diabetic gastroparesis publication-title: Gastroenterology – ident: e_1_2_6_2_2 doi: 10.1053/j.gastro.2004.09.055 – ident: e_1_2_6_5_2 doi: 10.1016/S0016-5085(97)70126-4 – ident: e_1_2_6_12_2 doi: 10.1111/j.1572-0241.2000.02076.x – volume: 132 start-page: A‐458 issue: 4 year: 2007 ident: e_1_2_6_19_2 article-title: A comparative study of SmartPill and radioopaque markers for the assessment of colonic transit time in humans publication-title: Gastroenterology – ident: e_1_2_6_7_2 doi: 10.1016/S0025-6196(12)62245-9 – ident: e_1_2_6_4_2 doi: 10.1046/j.1365-2036.2002.01344.x – volume: 132 start-page: A‐97 issue: 4 year: 2007 ident: e_1_2_6_18_2 article-title: Simultaneous use of SmartPill pH and pressure capsule, antroduodenal manometry and gastric emptying scintigraphy to assess gastric emptying of digestible and non‐digestible solids publication-title: Gastroenterology – ident: e_1_2_6_10_2 doi: 10.1016/0016-5085(85)90342-7 – volume: 16 start-page: 666 year: 2004 ident: e_1_2_6_6_2 article-title: Non‐invasive simultaneous measurement of intra‐luminal pH and pressure: assessment of gastric emptying and upper GI manometry in healthy subjects publication-title: Neurogastroenterology – volume: 80 start-page: 787 year: 1985 ident: e_1_2_6_13_2 article-title: Intestinal obstruction caused by ingestion of a Heidelberg capsule: report of a case publication-title: Am J Gastroenterol
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Snippet	Summary Background Gastric emptying scintigraphy (GES) using a radio‐labelled meal is used to measure gastric emptying. A nondigestible capsule, SmartPill,... Background Gastric emptying scintigraphy (GES) using a radio‐labelled meal is used to measure gastric emptying. A nondigestible capsule, SmartPill, records... Gastric emptying scintigraphy (GES) using a radio-labelled meal is used to measure gastric emptying. A nondigestible capsule, SmartPill, records luminal pH,...
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SubjectTerms	Adolescent Adult Aged Biological and medical sciences Digestive system Esophageal pH Monitoring - instrumentation Female Gastric Emptying Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal Motility - physiology Gastroparesis - diagnostic imaging Humans Image Interpretation, Computer-Assisted Male Medical sciences Middle Aged Pharmacology. Drug treatments Pressure Prospective Studies Radionuclide Imaging Reproducibility of Results ROC Curve Technetium Tc 99m Sulfur Colloid Time
Title	Comparison of gastric emptying of a nondigestible capsule to a radio‐labelled meal in healthy and gastroparetic subjects
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