circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan

Circular RNAs (circRNAs) are an emerging class of non-coding RNA molecules that are thought to regulate gene expression and human disease. Despite the observation that circRNAs are known to accumulate in older organisms and have been reported in cellular senescence, their role in aging remains relat...

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Published in	GeroScience Vol. 42; no. 1; pp. 183 - 199
Main Authors	Haque, Shahnaz, Ames, Ryan M., Moore, Karen, Pilling, Luke C., Peters, Luanne L., Bandinelli, Stefania, Ferrucci, Luigi, Harries, Lorna W.
Format	Journal Article
Language	English
Published	Cham Springer International Publishing 01.02.2020
Subjects	Aged Aging - genetics Animals Biomedical and Life Sciences Cell Biology Cellular Senescence - genetics Geriatrics/Gerontology Hand Strength Humans Life Sciences Longevity - genetics Mice MicroRNAs Molecular Medicine Original Original Article Phenotype RNA, Circular Circular RNA Aging phenotypes Senescence Median strain lifespan
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ISSN	2509-2715 2509-2723 2509-2723
DOI	10.1007/s11357-019-00120-z

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Abstract	Circular RNAs (circRNAs) are an emerging class of non-coding RNA molecules that are thought to regulate gene expression and human disease. Despite the observation that circRNAs are known to accumulate in older organisms and have been reported in cellular senescence, their role in aging remains relatively unexplored. Here, we have assessed circRNA expression in aging human blood and followed up age-associated circRNA in relation to human aging phenotypes, mammalian longevity as measured by mouse median strain lifespan and cellular senescence in four different primary human cell types. We found that circRNAs circDEF6 , c ircEP300 , circFOXO3 and circFNDC3B demonstrate associations with parental longevity or hand grip strength in 306 subjects from the InCHIANTI study of aging, and furthermore, circFOXO3 and circEP300 also demonstrate differential expression in one or more human senescent cell types. Finally, four circRNAs tested showed evidence of conservation in mouse. Expression levels of one of these, circPlekhm1 , was nominally associated with lifespan. These data suggest that circRNA may represent a novel class of regulatory RNA involved in the determination of aging phenotypes, which may show future promise as both biomarkers and future therapeutic targets for age-related disease.
AbstractList	Circular RNAs (circRNAs) are an emerging class of non-coding RNA molecules that are thought to regulate gene expression and human disease. Despite the observation that circRNAs are known to accumulate in older organisms and have been reported in cellular senescence, their role in aging remains relatively unexplored. Here, we have assessed circRNA expression in aging human blood and followed up age-associated circRNA in relation to human aging phenotypes, mammalian longevity as measured by mouse median strain lifespan and cellular senescence in four different primary human cell types. We found that circRNAs circDEF6, circEP300, circFOXO3 and circFNDC3B demonstrate associations with parental longevity or hand grip strength in 306 subjects from the InCHIANTI study of aging, and furthermore, circFOXO3 and circEP300 also demonstrate differential expression in one or more human senescent cell types. Finally, four circRNAs tested showed evidence of conservation in mouse. Expression levels of one of these, circPlekhm1, was nominally associated with lifespan. These data suggest that circRNA may represent a novel class of regulatory RNA involved in the determination of aging phenotypes, which may show future promise as both biomarkers and future therapeutic targets for age-related disease.Circular RNAs (circRNAs) are an emerging class of non-coding RNA molecules that are thought to regulate gene expression and human disease. Despite the observation that circRNAs are known to accumulate in older organisms and have been reported in cellular senescence, their role in aging remains relatively unexplored. Here, we have assessed circRNA expression in aging human blood and followed up age-associated circRNA in relation to human aging phenotypes, mammalian longevity as measured by mouse median strain lifespan and cellular senescence in four different primary human cell types. We found that circRNAs circDEF6, circEP300, circFOXO3 and circFNDC3B demonstrate associations with parental longevity or hand grip strength in 306 subjects from the InCHIANTI study of aging, and furthermore, circFOXO3 and circEP300 also demonstrate differential expression in one or more human senescent cell types. Finally, four circRNAs tested showed evidence of conservation in mouse. Expression levels of one of these, circPlekhm1, was nominally associated with lifespan. These data suggest that circRNA may represent a novel class of regulatory RNA involved in the determination of aging phenotypes, which may show future promise as both biomarkers and future therapeutic targets for age-related disease. Circular RNAs (circRNAs) are an emerging class of non-coding RNA molecules that are thought to regulate gene expression and human disease. Despite the observation that circRNAs are known to accumulate in older organisms and have been reported in cellular senescence, their role in aging remains relatively unexplored. Here, we have assessed circRNA expression in aging human blood and followed up age-associated circRNA in relation to human aging phenotypes, mammalian longevity as measured by mouse median strain lifespan and cellular senescence in four different primary human cell types. We found that circRNAs circDEF6 , c ircEP300 , circFOXO3 and circFNDC3B demonstrate associations with parental longevity or hand grip strength in 306 subjects from the InCHIANTI study of aging, and furthermore, circFOXO3 and circEP300 also demonstrate differential expression in one or more human senescent cell types. Finally, four circRNAs tested showed evidence of conservation in mouse. Expression levels of one of these, circPlekhm1 , was nominally associated with lifespan. These data suggest that circRNA may represent a novel class of regulatory RNA involved in the determination of aging phenotypes, which may show future promise as both biomarkers and future therapeutic targets for age-related disease. Circular RNAs (circRNAs) are an emerging class of non-coding RNA molecules that are thought to regulate gene expression and human disease. Despite the observation that circRNAs are known to accumulate in older organisms and have been reported in cellular senescence, their role in aging remains relatively unexplored. Here, we have assessed circRNA expression in aging human blood and followed up age-associated circRNA in relation to human aging phenotypes, mammalian longevity as measured by mouse median strain lifespan and cellular senescence in four different primary human cell types. We found that circRNAs circDEF6, circEP300, circFOXO3 and circFNDC3B demonstrate associations with parental longevity or hand grip strength in 306 subjects from the InCHIANTI study of aging, and furthermore, circFOXO3 and circEP300 also demonstrate differential expression in one or more human senescent cell types. Finally, four circRNAs tested showed evidence of conservation in mouse. Expression levels of one of these, circPlekhm1, was nominally associated with lifespan. These data suggest that circRNA may represent a novel class of regulatory RNA involved in the determination of aging phenotypes, which may show future promise as both biomarkers and future therapeutic targets for age-related disease.
Author	Peters, Luanne L. Haque, Shahnaz Bandinelli, Stefania Ames, Ryan M. Harries, Lorna W. Moore, Karen Pilling, Luke C. Ferrucci, Luigi
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Cites_doi	10.1093/ageing/28.3.283 10.1016/s0531-5565(01)00220-0 10.1111/acel.12499 10.1111/j.1474-9726.2009.00532.x 10.1016/j.arr.2012.01.003 10.1093/gerona/glt061 10.1016/0531-5565(89)90037-5 10.3390/cancers11081067 10.1038/srep15145 10.1016/j.maturitas.2016.07.016 10.1001/jama.281.6.558 10.1038/s41467-017-02183-y 10.1016/j.tig.2011.03.005 10.1016/j.exger.2003.11.011 10.1111/j.1474-9726.2011.00726.x 10.1093/bioinformatics/btt656 10.1093/nar/gkw027 10.1002/cbf.3427 10.3390/cells8060616 10.1007/s11357-011-9256-y 10.1007/978-981-13-1426-1_2 10.1080/15548627.2015.1034419 10.1093/bmb/ldq008 10.1038/nature04844 10.1042/CS20171556 10.1096/fj.201801154R 10.1111/j.1532-5415.2000.tb03873.x 10.1371/journal.pgen.0040024 10.18632/aging.101500 10.4161/auto.4604 10.1016/j.arr.2016.04.009 10.1093/bioinformatics/btp073 10.1016/j.jalz.2013.07.002 10.1186/s12859-016-0881-4 10.1152/japplphysiol.00347.2003 10.1371/journal.pone.0010724 10.1016/j.cmet.2012.02.014 10.1080/15548627.2018.1454810 10.1186/s12943-018-0908-8 10.1186/s12860-017-0147-7 10.1093/gerona/gly071 10.1016/j.bbamcr.2016.07.005 10.1038/srep38907 10.1093/eurheartj/ehw001 10.1093/bioinformatics/btp101 10.1016/j.cub.2004.03.059 10.1093/bioinformatics/btp120 10.1101/cshperspect.a025908 10.1111/j.1474-9726.2009.00478.x 10.1111/jgs.14092 10.1038/nature11928 10.1016/j.cell.2013.05.039 10.1212/WNL.0000000000004516 10.1093/nar/gkt214 10.7554/eLife.31126 10.1007/s11357-019-00100-3 10.3390/genes8120353
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Keywords	Circular RNA Aging phenotypes Senescence Median strain lifespan
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References	Rantanen, Guralnik, Foley, Masaki, Leveille, Curb, White (CR50) 1999; 281 Lopez-Jimenez, Rojas, Andres-Leon (CR39) 2018; 1087 Fuku (CR19) 2016; 92 Latorre, Torregrossa, Wood, Whiteman, Harries (CR33) 2018; 10 Liao, Smyth, Shi (CR37) 2014; 30 Hansen, Chandra, Mitic, Onken, Driscoll, Kenyon (CR23) 2008; 4 Bindea (CR4) 2009; 25 Rantanen, Masaki, He, Ross, Willcox, White (CR51) 2012; 34 Yuan (CR58) 2009; 8 Narici, Maffulli (CR47) 2010; 95 Dutta, Henley, Robine, Langa, Wallace, Melzer (CR14) 2013; 68 Lee (CR34) 2016; 15 Shamir (CR52) 2017; 89 Latorre, Ostler, Faragher, Harries (CR31) 2018; 33 Welle, Brooks, Delehanty, Needler, Bhatt, Shah, Thornton (CR56) 2004; 39 Kapahi, Zid, Harper, Koslover, Sapin, Benzer (CR28) 2004; 14 Flachsbart (CR18) 2017; 8 de Magalhaes, Curado, Church (CR9) 2009; 25 Memczak (CR44) 2013; 495 Du, Yang, Liu, Yang, Dhaliwal, Yang (CR11) 2016; 44 Du (CR12) 2017; 38 Yang, Huang, Petralia, Long, Zhang, Argmann, Zhao, Mobbs, Schadt, Zhu, Tu (CR57) 2015; 5 Noren Hooten, Abdelmohsen, Gorospe, Ejiogu, Zonderman, Evans (CR48) 2010; 5 Lopez-Otin, Blasco, Partridge, Serrano, Kroemer (CR40) 2013; 153 Ferrucci, Bandinelli, Benvenuti, Di Iorio, Macchi, Harris, Guralnik (CR17) 2000; 48 Fabbri (CR16) 2016; 64 CR45 Latorre, Birar, Sheerin, Jeynes, Hooper, Dawe, Melzer, Cox, Faragher, Ostler, Harries (CR30) 2017; 18 Harries (CR25) 2011; 10 CR41 Mahmud, Gomes, Lee, Aimjongjun, Jiramongkol, Yao, Zona, Alasiri, Gong, Yagüe, Lam (CR42) 2019; 11 Pietrocola, Castoldi, Maiuri, Kroemer (CR49) 2018; 14 Mitchell (CR46) 2010; 9 Izuogu, Alhasan, Alafghani, Santibanez-Koref, Elliot, Jackson (CR26) 2016; 17 Doherty (CR10) 2003; 95 Gorospe, Abdelmohsen (CR21) 2011; 27 Gruner, Cortes-Lopez, Cooper, Bauer, Miura (CR22) 2016; 6 Carmeli, Coleman, Reznick (CR6) 2002; 37 Davy (CR8) 2018; 73 Liao, Smyth, Shi (CR36) 2013; 41 Dutta, Henley, Robine, Llewellyn, Langa, Wallace, Melzer (CR15) 2013; 10 Simonsen, Cumming, Finley (CR53) 2007; 3 Li, Li, Liu, Ni, Yao, Xu, Quan, Zhang, Li, Liu, Hu (CR35) 2019; 8 Latorre, Pilling, Lee, Bandinelli, Melzer, Ferrucci, Harries (CR32) 2018; 132 Vijayakumar, Cho (CR55) 2019; 37 Abdelmohsen, Srikantan, Kang, Gorospe (CR1) 2012; 11 Bahar (CR3) 2006; 441 Trapnell, Pachter, Salzberg (CR54) 2009; 25 Kirkland (CR29) 2016; 6 Boulias, Horvitz (CR5) 2012; 15 Jeung (CR27) 2016; 1863 Dutta, Henley, Robine, Langa, Wallace, Melzer (CR13) 2013; 68 Giampaoli (CR20) 1999; 28 CR24 McEwan, Dikic (CR43) 2015; 11 Austad (CR2) 1989; 24 Carmona-Gutierrez, Hughes, Madeo, Ruckenstuhl (CR7) 2016; 32 Liu (CR38) 2018; 17 E Fabbri (120_CR16) 2016; 64 TJ Doherty (120_CR10) 2003; 95 BP Lee (120_CR34) 2016; 15 P Kapahi (120_CR28) 2004; 14 Y Liao (120_CR37) 2014; 30 R Shamir (120_CR52) 2017; 89 T Rantanen (120_CR51) 2012; 34 N Fuku (120_CR19) 2016; 92 E Latorre (120_CR31) 2018; 33 WW Du (120_CR12) 2017; 38 R Bahar (120_CR3) 2006; 441 C Trapnell (120_CR54) 2009; 25 M Hansen (120_CR23) 2008; 4 F Flachsbart (120_CR18) 2017; 8 S Welle (120_CR56) 2004; 39 R Yuan (120_CR58) 2009; 8 120_CR45 OG Izuogu (120_CR26) 2016; 17 E Latorre (120_CR33) 2018; 10 E Latorre (120_CR32) 2018; 132 S Giampaoli (120_CR20) 1999; 28 T Rantanen (120_CR50) 1999; 281 A Dutta (120_CR14) 2013; 68 N Noren Hooten (120_CR48) 2010; 5 K Abdelmohsen (120_CR1) 2012; 11 E Latorre (120_CR30) 2017; 18 Zimam Mahmud (120_CR42) 2019; 11 Ambarish Dutta (120_CR15) 2013; 10 WW Du (120_CR11) 2016; 44 JL Kirkland (120_CR29) 2016; 6 K Boulias (120_CR5) 2012; 15 C Lopez-Otin (120_CR40) 2013; 153 JP de Magalhaes (120_CR9) 2009; 25 L Ferrucci (120_CR17) 2000; 48 E Carmeli (120_CR6) 2002; 37 H Gruner (120_CR22) 2016; 6 SN Austad (120_CR2) 1989; 24 PMC Davy (120_CR8) 2018; 73 A Simonsen (120_CR53) 2007; 3 G Bindea (120_CR4) 2009; 25 H Liu (120_CR38) 2018; 17 A Dutta (120_CR13) 2013; 68 E Lopez-Jimenez (120_CR39) 2018; 1087 MV Narici (120_CR47) 2010; 95 Y Liao (120_CR36) 2013; 41 120_CR24 J Yang (120_CR57) 2015; 5 F Pietrocola (120_CR49) 2018; 14 D Carmona-Gutierrez (120_CR7) 2016; 32 120_CR41 K Vijayakumar (120_CR55) 2019; 37 YJ Jeung (120_CR27) 2016; 1863 DG McEwan (120_CR43) 2015; 11 S Memczak (120_CR44) 2013; 495 Xiaoyue Li (120_CR35) 2019; 8 LW Harries (120_CR25) 2011; 10 JR Mitchell (120_CR46) 2010; 9 M Gorospe (120_CR21) 2011; 27
References_xml	– ident: CR45 – volume: 28 start-page: 283 year: 1999 end-page: 288 ident: CR20 article-title: Hand-grip strength predicts incident disability in non-disabled older men publication-title: Age Ageing doi: 10.1093/ageing/28.3.283 – volume: 37 start-page: 477 year: 2002 end-page: 489 ident: CR6 article-title: The biochemistry of aging muscle publication-title: Exp Gerontol doi: 10.1016/s0531-5565(01)00220-0 – volume: 15 start-page: 903 year: 2016 end-page: 913 ident: CR34 article-title: Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans publication-title: Aging Cell doi: 10.1111/acel.12499 – volume: 9 start-page: 40 year: 2010 end-page: 53 ident: CR46 article-title: Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice publication-title: Aging Cell doi: 10.1111/j.1474-9726.2009.00532.x – volume: 11 start-page: 491 year: 2012 end-page: 500 ident: CR1 article-title: Regulation of senescence by microRNA biogenesis factors publication-title: Ageing Res Rev doi: 10.1016/j.arr.2012.01.003 – volume: 68 start-page: 1409 year: 2013 end-page: 1418 ident: CR13 article-title: Longer lived parents: protective associations with cancer incidence and overall mortality publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/glt061 – volume: 24 start-page: 83 year: 1989 end-page: 92 ident: CR2 article-title: Life extension by dietary restriction in the bowl and doily spider. Frontinella pyramitela publication-title: Exp Gerontol doi: 10.1016/0531-5565(89)90037-5 – volume: 11 start-page: 1067 issue: 8 year: 2019 ident: CR42 article-title: EP300 and SIRT1/6 Co-Regulate Lapatinib Sensitivity Via Modulating FOXO3-Acetylation and Activity in Breast Cancer publication-title: Cancers doi: 10.3390/cancers11081067 – volume: 5 start-page: 15145 year: 2015 ident: CR57 article-title: Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases publication-title: Sci Rep doi: 10.1038/srep15145 – volume: 92 start-page: 110 year: 2016 end-page: 114 ident: CR19 article-title: rs2802292 polymorphism in the FOXO3A gene and exceptional longevity in two ethnically distinct cohorts publication-title: Maturitas doi: 10.1016/j.maturitas.2016.07.016 – volume: 281 start-page: 558 year: 1999 end-page: 560 ident: CR50 article-title: Midlife hand grip strength as a predictor of old age disability publication-title: JAMA doi: 10.1001/jama.281.6.558 – volume: 8 start-page: 2063 year: 2017 ident: CR18 article-title: Identification and characterization of two functional variants in the human longevity gene FOXO3 publication-title: Nat Commun doi: 10.1038/s41467-017-02183-y – volume: 27 start-page: 233 year: 2011 end-page: 241 ident: CR21 article-title: MicroRegulators come of age in senescence publication-title: Trends Genet doi: 10.1016/j.tig.2011.03.005 – volume: 39 start-page: 369 year: 2004 end-page: 377 ident: CR56 article-title: Skeletal muscle gene expression profiles in 20-29 year old and 65-71 year old women publication-title: Exp Gerontol doi: 10.1016/j.exger.2003.11.011 – volume: 10 start-page: 868 year: 2011 end-page: 878 ident: CR25 article-title: Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing publication-title: Aging Cell doi: 10.1111/j.1474-9726.2011.00726.x – volume: 30 start-page: 923 year: 2014 end-page: 930 ident: CR37 article-title: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt656 – volume: 44 start-page: 2846 year: 2016 end-page: 2858 ident: CR11 article-title: Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkw027 – volume: 37 start-page: 452 year: 2019 end-page: 458 ident: CR55 article-title: Autophagy: An evolutionarily conserved process in the maintenance of stem cells and aging publication-title: Cell Biochem Funct doi: 10.1002/cbf.3427 – volume: 8 start-page: 616 issue: 6 year: 2019 ident: CR35 article-title: Circular RNA circ-FoxO3 Inhibits Myoblast Cells Differentiation publication-title: Cells doi: 10.3390/cells8060616 – volume: 34 start-page: 563 year: 2012 end-page: 570 ident: CR51 article-title: Midlife muscle strength and human longevity up to age 100 years: a 44-year prospective study among a decedent cohort publication-title: Age (Dordr) doi: 10.1007/s11357-011-9256-y – volume: 1087 start-page: 17 year: 2018 end-page: 33 ident: CR39 article-title: RNA sequencing and Prediction Tools for Circular RNAs Analysis publication-title: Adv Exp Med Biol doi: 10.1007/978-981-13-1426-1_2 – volume: 11 start-page: 720 year: 2015 end-page: 722 ident: CR43 article-title: PLEKHM1: Adapting to life at the lysosome publication-title: Autophagy doi: 10.1080/15548627.2015.1034419 – volume: 95 start-page: 139 year: 2010 end-page: 159 ident: CR47 article-title: Sarcopenia: characteristics, mechanisms and functional significance publication-title: Br Med Bull doi: 10.1093/bmb/ldq008 – volume: 441 start-page: 1011 year: 2006 end-page: 1014 ident: CR3 article-title: Increased cell-to-cell variation in gene expression in ageing mouse heart publication-title: Nature doi: 10.1038/nature04844 – volume: 132 start-page: 313 year: 2018 end-page: 325 ident: CR32 article-title: The VEGFA156b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease publication-title: Clin Sci (Lond) doi: 10.1042/CS20171556 – volume: 33 start-page: 1086 year: 2018 end-page: 1097 ident: CR31 article-title: FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence publication-title: FASEB J doi: 10.1096/fj.201801154R – volume: 48 start-page: 1618 year: 2000 end-page: 1625 ident: CR17 article-title: Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI study publication-title: J Am Geriatr Soc doi: 10.1111/j.1532-5415.2000.tb03873.x – volume: 4 start-page: e24 year: 2008 ident: CR23 article-title: A role for autophagy in the extension of lifespan by dietary restriction in C. elegans publication-title: PLoS Genet doi: 10.1371/journal.pgen.0040024 – volume: 10 start-page: 1666 year: 2018 end-page: 1681 ident: CR33 article-title: Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2 publication-title: Aging (Albany NY) doi: 10.18632/aging.101500 – volume: 3 start-page: 499 year: 2007 end-page: 501 ident: CR53 article-title: Linking lysosomal trafficking defects with changes in aging and stress response in Drosophila publication-title: Autophagy doi: 10.4161/auto.4604 – volume: 32 start-page: 2 year: 2016 end-page: 12 ident: CR7 article-title: The Crucial impact of lysosomes in aging and longevity publication-title: Ageing Res Rev doi: 10.1016/j.arr.2016.04.009 – volume: 25 start-page: 875 year: 2009 end-page: 881 ident: CR9 article-title: Meta-analysis of age-related gene expression profiles identifies common signatures of aging publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp073 – volume: 10 start-page: S315 year: 2013 end-page: S322 ident: CR15 article-title: Aging children of long-lived parents experience slower cognitive decline publication-title: Alzheimer's & Dementia doi: 10.1016/j.jalz.2013.07.002 – volume: 17 start-page: 31 year: 2016 ident: CR26 article-title: PTESFinder: a computational method to identify post-transcriptional exon shuffling (PTES) events publication-title: BMC Bioinformatics doi: 10.1186/s12859-016-0881-4 – volume: 95 start-page: 1717 year: 2003 end-page: 1727 ident: CR10 article-title: Invited review: aging and sarcopenia publication-title: J Appl Physiol doi: 10.1152/japplphysiol.00347.2003 – volume: 5 start-page: e10724 year: 2010 ident: CR48 article-title: microRNA expression patterns reveal differential expression of target genes with age publication-title: PLoS One doi: 10.1371/journal.pone.0010724 – volume: 15 start-page: 439 year: 2012 end-page: 450 ident: CR5 article-title: The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO publication-title: Cell Metab doi: 10.1016/j.cmet.2012.02.014 – volume: 14 start-page: 1162 year: 2018 end-page: 1163 ident: CR49 article-title: Aspirin-another caloric-restriction mimetic publication-title: Autophagy doi: 10.1080/15548627.2018.1454810 – volume: 17 start-page: 161 year: 2018 ident: CR38 article-title: Invasion-related circular RNA circFNDC3B inhibits bladder cancer progression through the miR-1178-3p/G3BP2/SRC/FAK axis publication-title: Mol Cancer doi: 10.1186/s12943-018-0908-8 – volume: 18 start-page: 31 year: 2017 ident: CR30 article-title: Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence publication-title: BMC Cell Biol doi: 10.1186/s12860-017-0147-7 – volume: 73 start-page: 1448 year: 2018 end-page: 1452 ident: CR8 article-title: Minimal shortening of leukocyte telomere length across age groups in a cross-sectional study for carriers of a longevity-associated FOXO3 allele publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/gly071 – volume: 1863 start-page: 2584 year: 2016 end-page: 2593 ident: CR27 article-title: Shikonin induces apoptosis of lung cancer cells via activation of FOXO3a/EGR1/SIRT1 signaling antagonized by p300 Biochim publication-title: Biophys Acta doi: 10.1016/j.bbamcr.2016.07.005 – volume: 6 start-page: 38907 year: 2016 ident: CR22 article-title: CircRNA accumulation in the aging mouse brain publication-title: Sci Rep doi: 10.1038/srep38907 – volume: 38 start-page: 1402 year: 2017 end-page: 1412 ident: CR12 article-title: Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses publication-title: Eur Heart J doi: 10.1093/eurheartj/ehw001 – volume: 25 start-page: 1091 year: 2009 end-page: 1093 ident: CR4 article-title: ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp101 – volume: 14 start-page: 885 year: 2004 end-page: 890 ident: CR28 article-title: Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway publication-title: Curr Biol doi: 10.1016/j.cub.2004.03.059 – volume: 25 start-page: 1105 year: 2009 end-page: 1111 ident: CR54 article-title: TopHat: discovering splice junctions with RNA-Seq publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp120 – volume: 6 start-page: a025908 year: 2016 ident: CR29 article-title: Translating the science of aging into therapeutic interventions publication-title: Cold Spring Harb Perspect Med doi: 10.1101/cshperspect.a025908 – volume: 8 start-page: 277 year: 2009 end-page: 287 ident: CR58 article-title: Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels publication-title: Aging Cell doi: 10.1111/j.1474-9726.2009.00478.x – volume: 64 start-page: 965 year: 2016 end-page: 972 ident: CR16 article-title: Association between accelerated multimorbidity and age-related cognitive decline in older Baltimore longitudinal study of aging participants without dementia publication-title: J Am Geriatr Soc doi: 10.1111/jgs.14092 – volume: 495 start-page: 333 year: 2013 end-page: 338 ident: CR44 article-title: Circular RNAs are a large class of animal RNAs with regulatory potency publication-title: Nature doi: 10.1038/nature11928 – volume: 68 start-page: 1409 year: 2013 end-page: 1418 ident: CR14 article-title: Longer lived parents: protective associations with cancer incidence and overall mortality the journals of gerontology series a publication-title: Biol sci med sci doi: 10.1093/gerona/glt061 – ident: CR41 – ident: CR24 – volume: 153 start-page: 1194 year: 2013 end-page: 1217 ident: CR40 article-title: The hallmarks of aging publication-title: Cell doi: 10.1016/j.cell.2013.05.039 – volume: 89 start-page: 1676 year: 2017 end-page: 1683 ident: CR52 article-title: Analysis of blood-based gene expression in idiopathic Parkinson disease publication-title: Neurology doi: 10.1212/WNL.0000000000004516 – volume: 41 start-page: e108 year: 2013 ident: CR36 article-title: The subread aligner: fast, accurate and scalable read mapping by seed-and-vote publication-title: Nucleic Acids Res doi: 10.1093/nar/gkt214 – volume: 28 start-page: 283 year: 1999 ident: 120_CR20 publication-title: Age Ageing doi: 10.1093/ageing/28.3.283 – volume: 8 start-page: 616 issue: 6 year: 2019 ident: 120_CR35 publication-title: Cells doi: 10.3390/cells8060616 – volume: 34 start-page: 563 year: 2012 ident: 120_CR51 publication-title: Age (Dordr) doi: 10.1007/s11357-011-9256-y – volume: 441 start-page: 1011 year: 2006 ident: 120_CR3 publication-title: Nature doi: 10.1038/nature04844 – volume: 33 start-page: 1086 year: 2018 ident: 120_CR31 publication-title: FASEB J doi: 10.1096/fj.201801154R – volume: 27 start-page: 233 year: 2011 ident: 120_CR21 publication-title: Trends Genet doi: 10.1016/j.tig.2011.03.005 – volume: 10 start-page: 1666 year: 2018 ident: 120_CR33 publication-title: Aging (Albany NY) doi: 10.18632/aging.101500 – ident: 120_CR45 doi: 10.7554/eLife.31126 – volume: 25 start-page: 1091 year: 2009 ident: 120_CR4 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp101 – volume: 14 start-page: 885 year: 2004 ident: 120_CR28 publication-title: Curr Biol doi: 10.1016/j.cub.2004.03.059 – volume: 5 start-page: e10724 year: 2010 ident: 120_CR48 publication-title: PLoS One doi: 10.1371/journal.pone.0010724 – volume: 95 start-page: 1717 year: 2003 ident: 120_CR10 publication-title: J Appl Physiol doi: 10.1152/japplphysiol.00347.2003 – volume: 92 start-page: 110 year: 2016 ident: 120_CR19 publication-title: Maturitas doi: 10.1016/j.maturitas.2016.07.016 – volume: 15 start-page: 903 year: 2016 ident: 120_CR34 publication-title: Aging Cell doi: 10.1111/acel.12499 – volume: 11 start-page: 720 year: 2015 ident: 120_CR43 publication-title: Autophagy doi: 10.1080/15548627.2015.1034419 – volume: 281 start-page: 558 year: 1999 ident: 120_CR50 publication-title: JAMA doi: 10.1001/jama.281.6.558 – volume: 64 start-page: 965 year: 2016 ident: 120_CR16 publication-title: J Am Geriatr Soc doi: 10.1111/jgs.14092 – ident: 120_CR41 doi: 10.1007/s11357-019-00100-3 – volume: 11 start-page: 1067 issue: 8 year: 2019 ident: 120_CR42 publication-title: Cancers doi: 10.3390/cancers11081067 – volume: 10 start-page: S315 year: 2013 ident: 120_CR15 publication-title: Alzheimer's & Dementia doi: 10.1016/j.jalz.2013.07.002 – volume: 18 start-page: 31 year: 2017 ident: 120_CR30 publication-title: BMC Cell Biol doi: 10.1186/s12860-017-0147-7 – volume: 68 start-page: 1409 year: 2013 ident: 120_CR13 publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/glt061 – volume: 89 start-page: 1676 year: 2017 ident: 120_CR52 publication-title: Neurology doi: 10.1212/WNL.0000000000004516 – volume: 24 start-page: 83 year: 1989 ident: 120_CR2 publication-title: Exp Gerontol doi: 10.1016/0531-5565(89)90037-5 – volume: 11 start-page: 491 year: 2012 ident: 120_CR1 publication-title: Ageing Res Rev doi: 10.1016/j.arr.2012.01.003 – volume: 6 start-page: 38907 year: 2016 ident: 120_CR22 publication-title: Sci Rep doi: 10.1038/srep38907 – volume: 41 start-page: e108 year: 2013 ident: 120_CR36 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkt214 – volume: 10 start-page: 868 year: 2011 ident: 120_CR25 publication-title: Aging Cell doi: 10.1111/j.1474-9726.2011.00726.x – volume: 153 start-page: 1194 year: 2013 ident: 120_CR40 publication-title: Cell doi: 10.1016/j.cell.2013.05.039 – ident: 120_CR24 doi: 10.3390/genes8120353 – volume: 38 start-page: 1402 year: 2017 ident: 120_CR12 publication-title: Eur Heart J doi: 10.1093/eurheartj/ehw001 – volume: 14 start-page: 1162 year: 2018 ident: 120_CR49 publication-title: Autophagy doi: 10.1080/15548627.2018.1454810 – volume: 495 start-page: 333 year: 2013 ident: 120_CR44 publication-title: Nature doi: 10.1038/nature11928 – volume: 9 start-page: 40 year: 2010 ident: 120_CR46 publication-title: Aging Cell doi: 10.1111/j.1474-9726.2009.00532.x – volume: 37 start-page: 477 year: 2002 ident: 120_CR6 publication-title: Exp Gerontol doi: 10.1016/s0531-5565(01)00220-0 – volume: 25 start-page: 875 year: 2009 ident: 120_CR9 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp073 – volume: 48 start-page: 1618 year: 2000 ident: 120_CR17 publication-title: J Am Geriatr Soc doi: 10.1111/j.1532-5415.2000.tb03873.x – volume: 3 start-page: 499 year: 2007 ident: 120_CR53 publication-title: Autophagy doi: 10.4161/auto.4604 – volume: 30 start-page: 923 year: 2014 ident: 120_CR37 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt656 – volume: 1863 start-page: 2584 year: 2016 ident: 120_CR27 publication-title: Biophys Acta doi: 10.1016/j.bbamcr.2016.07.005 – volume: 25 start-page: 1105 year: 2009 ident: 120_CR54 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp120 – volume: 6 start-page: a025908 year: 2016 ident: 120_CR29 publication-title: Cold Spring Harb Perspect Med doi: 10.1101/cshperspect.a025908 – volume: 73 start-page: 1448 year: 2018 ident: 120_CR8 publication-title: J Gerontol A Biol Sci Med Sci doi: 10.1093/gerona/gly071 – volume: 95 start-page: 139 year: 2010 ident: 120_CR47 publication-title: Br Med Bull doi: 10.1093/bmb/ldq008 – volume: 44 start-page: 2846 year: 2016 ident: 120_CR11 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkw027 – volume: 5 start-page: 15145 year: 2015 ident: 120_CR57 publication-title: Sci Rep doi: 10.1038/srep15145 – volume: 17 start-page: 31 year: 2016 ident: 120_CR26 publication-title: BMC Bioinformatics doi: 10.1186/s12859-016-0881-4 – volume: 1087 start-page: 17 year: 2018 ident: 120_CR39 publication-title: Adv Exp Med Biol doi: 10.1007/978-981-13-1426-1_2 – volume: 132 start-page: 313 year: 2018 ident: 120_CR32 publication-title: Clin Sci (Lond) doi: 10.1042/CS20171556 – volume: 39 start-page: 369 year: 2004 ident: 120_CR56 publication-title: Exp Gerontol doi: 10.1016/j.exger.2003.11.011 – volume: 68 start-page: 1409 year: 2013 ident: 120_CR14 publication-title: Biol sci med sci doi: 10.1093/gerona/glt061 – volume: 8 start-page: 277 year: 2009 ident: 120_CR58 publication-title: Aging Cell doi: 10.1111/j.1474-9726.2009.00478.x – volume: 8 start-page: 2063 year: 2017 ident: 120_CR18 publication-title: Nat Commun doi: 10.1038/s41467-017-02183-y – volume: 32 start-page: 2 year: 2016 ident: 120_CR7 publication-title: Ageing Res Rev doi: 10.1016/j.arr.2016.04.009 – volume: 17 start-page: 161 year: 2018 ident: 120_CR38 publication-title: Mol Cancer doi: 10.1186/s12943-018-0908-8 – volume: 15 start-page: 439 year: 2012 ident: 120_CR5 publication-title: Cell Metab doi: 10.1016/j.cmet.2012.02.014 – volume: 4 start-page: e24 year: 2008 ident: 120_CR23 publication-title: PLoS Genet doi: 10.1371/journal.pgen.0040024 – volume: 37 start-page: 452 year: 2019 ident: 120_CR55 publication-title: Cell Biochem Funct doi: 10.1002/cbf.3427
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Snippet	Circular RNAs (circRNAs) are an emerging class of non-coding RNA molecules that are thought to regulate gene expression and human disease. Despite the...
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SubjectTerms	Aged Aging - genetics Animals Biomedical and Life Sciences Cell Biology Cellular Senescence - genetics Geriatrics/Gerontology Hand Strength Humans Life Sciences Longevity - genetics Mice MicroRNAs Molecular Medicine Original Original Article Phenotype RNA, Circular
Title	circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan
URI	https://link.springer.com/article/10.1007/s11357-019-00120-z https://www.ncbi.nlm.nih.gov/pubmed/31811527 https://www.proquest.com/docview/2322737511 https://pubmed.ncbi.nlm.nih.gov/PMC7031184
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