Magnetic resonance fingerprinting of the pancreas at 1.5 T and 3.0 T
Magnetic resonance imaging of the pancreas is increasingly used as an important diagnostic modality for characterisation of pancreatic lesions. Pancreatic MRI protocols are mostly qualitative due to time constraints and motion sensitivity. MR Fingerprinting is an innovative acquisition technique tha...
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| Published in | Scientific reports Vol. 10; no. 1; p. 17563 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
16.10.2020
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| Subjects | |
| Online Access | Get full text |
| ISSN | 2045-2322 2045-2322 |
| DOI | 10.1038/s41598-020-74462-6 |
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| Abstract | Magnetic resonance imaging of the pancreas is increasingly used as an important diagnostic modality for characterisation of pancreatic lesions. Pancreatic MRI protocols are mostly qualitative due to time constraints and motion sensitivity. MR Fingerprinting is an innovative acquisition technique that provides qualitative data and quantitative parameter maps from a single free‐breathing acquisition with the potential to reduce exam times. This work investigates the feasibility of MRF parameter mapping for pancreatic imaging in the presence of free-breathing exam. Sixteen healthy participants were prospectively imaged using MRF framework. Regions-of-interest were drawn in multiple solid organs including the pancreas and T
1
and T
2
values determined. MRF T
1
and T
2
mapping was performed successfully in all participants (acquisition time:2.4–3.6 min). Mean pancreatic T
1
values were 37–43% lower than those of the muscle, spleen, and kidney at both 1.5 and 3.0 T. For these organs, the mean pancreatic T
2
values were nearly 40% at 1.5 T and < 12% at 3.0 T. The feasibility of MRF at 1.5 T and 3 T was demonstrated in the pancreas. By enabling fast and free-breathing quantitation, MRF has the potential to add value during the clinical characterisation and grading of pathological conditions, such as pancreatitis or cancer. |
|---|---|
| AbstractList | Magnetic resonance imaging of the pancreas is increasingly used as an important diagnostic modality for characterisation of pancreatic lesions. Pancreatic MRI protocols are mostly qualitative due to time constraints and motion sensitivity. MR Fingerprinting is an innovative acquisition technique that provides qualitative data and quantitative parameter maps from a single free‐breathing acquisition with the potential to reduce exam times. This work investigates the feasibility of MRF parameter mapping for pancreatic imaging in the presence of free-breathing exam. Sixteen healthy participants were prospectively imaged using MRF framework. Regions-of-interest were drawn in multiple solid organs including the pancreas and T1 and T2 values determined. MRF T1 and T2 mapping was performed successfully in all participants (acquisition time:2.4–3.6 min). Mean pancreatic T1 values were 37–43% lower than those of the muscle, spleen, and kidney at both 1.5 and 3.0 T. For these organs, the mean pancreatic T2 values were nearly 40% at 1.5 T and < 12% at 3.0 T. The feasibility of MRF at 1.5 T and 3 T was demonstrated in the pancreas. By enabling fast and free-breathing quantitation, MRF has the potential to add value during the clinical characterisation and grading of pathological conditions, such as pancreatitis or cancer. Magnetic resonance imaging of the pancreas is increasingly used as an important diagnostic modality for characterisation of pancreatic lesions. Pancreatic MRI protocols are mostly qualitative due to time constraints and motion sensitivity. MR Fingerprinting is an innovative acquisition technique that provides qualitative data and quantitative parameter maps from a single free-breathing acquisition with the potential to reduce exam times. This work investigates the feasibility of MRF parameter mapping for pancreatic imaging in the presence of free-breathing exam. Sixteen healthy participants were prospectively imaged using MRF framework. Regions-of-interest were drawn in multiple solid organs including the pancreas and T1 and T2 values determined. MRF T1 and T2 mapping was performed successfully in all participants (acquisition time:2.4-3.6 min). Mean pancreatic T1 values were 37-43% lower than those of the muscle, spleen, and kidney at both 1.5 and 3.0 T. For these organs, the mean pancreatic T2 values were nearly 40% at 1.5 T and < 12% at 3.0 T. The feasibility of MRF at 1.5 T and 3 T was demonstrated in the pancreas. By enabling fast and free-breathing quantitation, MRF has the potential to add value during the clinical characterisation and grading of pathological conditions, such as pancreatitis or cancer.Magnetic resonance imaging of the pancreas is increasingly used as an important diagnostic modality for characterisation of pancreatic lesions. Pancreatic MRI protocols are mostly qualitative due to time constraints and motion sensitivity. MR Fingerprinting is an innovative acquisition technique that provides qualitative data and quantitative parameter maps from a single free-breathing acquisition with the potential to reduce exam times. This work investigates the feasibility of MRF parameter mapping for pancreatic imaging in the presence of free-breathing exam. Sixteen healthy participants were prospectively imaged using MRF framework. Regions-of-interest were drawn in multiple solid organs including the pancreas and T1 and T2 values determined. MRF T1 and T2 mapping was performed successfully in all participants (acquisition time:2.4-3.6 min). Mean pancreatic T1 values were 37-43% lower than those of the muscle, spleen, and kidney at both 1.5 and 3.0 T. For these organs, the mean pancreatic T2 values were nearly 40% at 1.5 T and < 12% at 3.0 T. The feasibility of MRF at 1.5 T and 3 T was demonstrated in the pancreas. By enabling fast and free-breathing quantitation, MRF has the potential to add value during the clinical characterisation and grading of pathological conditions, such as pancreatitis or cancer. Magnetic resonance imaging of the pancreas is increasingly used as an important diagnostic modality for characterisation of pancreatic lesions. Pancreatic MRI protocols are mostly qualitative due to time constraints and motion sensitivity. MR Fingerprinting is an innovative acquisition technique that provides qualitative data and quantitative parameter maps from a single free‐breathing acquisition with the potential to reduce exam times. This work investigates the feasibility of MRF parameter mapping for pancreatic imaging in the presence of free-breathing exam. Sixteen healthy participants were prospectively imaged using MRF framework. Regions-of-interest were drawn in multiple solid organs including the pancreas and T 1 and T 2 values determined. MRF T 1 and T 2 mapping was performed successfully in all participants (acquisition time:2.4–3.6 min). Mean pancreatic T 1 values were 37–43% lower than those of the muscle, spleen, and kidney at both 1.5 and 3.0 T. For these organs, the mean pancreatic T 2 values were nearly 40% at 1.5 T and < 12% at 3.0 T. The feasibility of MRF at 1.5 T and 3 T was demonstrated in the pancreas. By enabling fast and free-breathing quantitation, MRF has the potential to add value during the clinical characterisation and grading of pathological conditions, such as pancreatitis or cancer. Magnetic resonance imaging of the pancreas is increasingly used as an important diagnostic modality for characterisation of pancreatic lesions. Pancreatic MRI protocols are mostly qualitative due to time constraints and motion sensitivity. MR Fingerprinting is an innovative acquisition technique that provides qualitative data and quantitative parameter maps from a single free-breathing acquisition with the potential to reduce exam times. This work investigates the feasibility of MRF parameter mapping for pancreatic imaging in the presence of free-breathing exam. Sixteen healthy participants were prospectively imaged using MRF framework. Regions-of-interest were drawn in multiple solid organs including the pancreas and T and T values determined. MRF T and T mapping was performed successfully in all participants (acquisition time:2.4-3.6 min). Mean pancreatic T values were 37-43% lower than those of the muscle, spleen, and kidney at both 1.5 and 3.0 T. For these organs, the mean pancreatic T values were nearly 40% at 1.5 T and < 12% at 3.0 T. The feasibility of MRF at 1.5 T and 3 T was demonstrated in the pancreas. By enabling fast and free-breathing quantitation, MRF has the potential to add value during the clinical characterisation and grading of pathological conditions, such as pancreatitis or cancer. |
| ArticleNumber | 17563 |
| Author | Sala, Evis Gilbert, Fiona J. McLean, Mary A. Graves, Martin J. Schulte, Rolf F. Beer, Lucian Brindle, Kevin M. Buonincontri, Guido Kessler, Dimitri A. Kaggie, Joshua D. Serrao, Eva M. Gallagher, Ferdia A. Carmo, Bruno Godfrey, Edmund |
| Author_xml | – sequence: 1 givenname: Eva M. surname: Serrao fullname: Serrao, Eva M. organization: Department of Radiology, University of Cambridge, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cancer Research UK – sequence: 2 givenname: Dimitri A. surname: Kessler fullname: Kessler, Dimitri A. organization: Department of Radiology, University of Cambridge, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust – sequence: 3 givenname: Bruno surname: Carmo fullname: Carmo, Bruno organization: Department of Radiology, University of Cambridge, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust – sequence: 4 givenname: Lucian surname: Beer fullname: Beer, Lucian organization: Department of Radiology, University of Cambridge, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust – sequence: 5 givenname: Kevin M. surname: Brindle fullname: Brindle, Kevin M. organization: Cancer Research UK – sequence: 6 givenname: Guido surname: Buonincontri fullname: Buonincontri, Guido organization: IMAGO7 Foundation – sequence: 7 givenname: Ferdia A. surname: Gallagher fullname: Gallagher, Ferdia A. organization: Department of Radiology, University of Cambridge, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cancer Research UK – sequence: 8 givenname: Fiona J. surname: Gilbert fullname: Gilbert, Fiona J. organization: Department of Radiology, University of Cambridge, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cancer Research UK – sequence: 9 givenname: Edmund surname: Godfrey fullname: Godfrey, Edmund organization: Department of Radiology, University of Cambridge – sequence: 10 givenname: Martin J. surname: Graves fullname: Graves, Martin J. organization: Department of Radiology, University of Cambridge, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust – sequence: 11 givenname: Mary A. surname: McLean fullname: McLean, Mary A. organization: Department of Radiology, University of Cambridge, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cancer Research UK – sequence: 12 givenname: Evis surname: Sala fullname: Sala, Evis organization: Department of Radiology, University of Cambridge, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cancer Research UK – sequence: 13 givenname: Rolf F. surname: Schulte fullname: Schulte, Rolf F. organization: GE Healthcare – sequence: 14 givenname: Joshua D. surname: Kaggie fullname: Kaggie, Joshua D. email: jk636@cam.ac.uk organization: Department of Radiology, University of Cambridge, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust |
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| SubjectTerms | 692/308/53/2421 692/700/1421 Adult Algorithms Female Humanities and Social Sciences Humans Image Processing, Computer-Assisted - methods Magnetic Resonance Imaging Male Motion multidisciplinary Pancreas - diagnostic imaging Pattern Recognition, Automated Phantoms, Imaging Prospective Studies Respiration Science Science (multidisciplinary) |
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| Title | Magnetic resonance fingerprinting of the pancreas at 1.5 T and 3.0 T |
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