Chelating Polymers for Targeted Decontamination of Actinides: Application of PEI-MP to Hydroxyapatite-Th(IV)

• Published in: International journal of molecular sciences Vol. 23; no. 9; p. 4732
• Main Authors: Fèvre, Jeanne, Leveille, Elena, Jeanson, Aurélie, Santucci-Darmanin, Sabine, Pierrefite-Carle, Valérie, Carle, Georges F., Den Auwer, Christophe, Di Giorgio, Christophe
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.05.2022; MDPI
• Subjects: Biochemistry, Molecular Biology; Biodistribution; Bone cancer; Bones; Chelating agents; Hydroxyapatite; Life Sciences; Ligands; Liver; Lungs; Nuclear power plants; Polymers; Retention; DTPA; actinides; decontamination; PEI-MP; chelating polymers
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms23094732

In case of an incident in the nuclear industry or an act of war or terrorism, the dissemination of plutonium could contaminate the environment and, hence, humans. Human contamination mainly occurs via inhalation and/or wounding (and, less likely, ingestion). In such cases, plutonium, if soluble, reaches circulation, whereas the poorly soluble fraction (such as small colloids) is trapped in alveolar macrophages or remains at the site of wounding. Once in the blood, the plutonium is delivered to the liver and/or to the bone, particularly into its mineral part, mostly composed of hydroxyapatite. Countermeasures against plutonium exist and consist of intravenous injections or inhalation of diethylenetetraminepentaacetate salts. Their effectiveness is, however, mainly confined to the circulating soluble forms of plutonium. Furthermore, the short bioavailability of diethylenetetraminepentaacetate results in its rapid elimination. To overcome these limitations and to provide a complementary approach to this common therapy, we developed polymeric analogs to indirectly target the problematic retention sites. We present herein a first study regarding the decontamination abilities of polyethyleneimine methylcarboxylate (structural diethylenetetraminepentaacetate polymer analog) and polyethyleneimine methylphosphonate (phosphonate polymeric analog) directed against Th(IV), used here as a Pu(IV) surrogate, which was incorporated into hydroxyapatite used as a bone model. Our results suggest that polyethylenimine methylphosphonate could be a good candidate for powerful bone decontamination action.