The relationship between specialized pro-resolving lipid mediators, morbid obesity and weight loss after bariatric surgery

Obesity and diabetes are associated with chronic inflammation. Specialized pro-resolving lipid mediators (SPMs)—resolvins (Rv), protectins (PD) and maresins (MaR)—actively resolve inflammation. Bariatric surgery achieves remission of diabetes, but mechanisms are unclear. We measured SPMs and proinfl...

Full description

Saved in:
Bibliographic Details
Published inScientific reports Vol. 10; no. 1; p. 20128
Main Authors Schulte, Fabian, Asbeutah, Abdul Aziz, Benotti, Peter N., Wood, G. Craig, Still, Christopher, Bistrian, Bruce R., Hardt, Markus, Welty, Francine K.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 18.11.2020
Subjects
692/308
692/53
Aged
Bariatric Surgery
Biomarkers - blood
Diabetes Mellitus, Type 2 - blood
Dinoprostone - blood
Docosahexaenoic Acids - blood
Eicosanoids - blood
Fatty Acids, Unsaturated - blood
Female
Humanities and Social Sciences
Humans
Leukocyte Count
Lipid Metabolism
Male
Middle Aged
multidisciplinary
Obesity - blood
Obesity, Morbid - blood
Obesity, Morbid - surgery
Science
Science (multidisciplinary)
Urachal Cyst - blood
Weight Loss
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/s41598-020-75353-6

Cover

Abstract Obesity and diabetes are associated with chronic inflammation. Specialized pro-resolving lipid mediators (SPMs)—resolvins (Rv), protectins (PD) and maresins (MaR)—actively resolve inflammation. Bariatric surgery achieves remission of diabetes, but mechanisms are unclear. We measured SPMs and proinflammatory eicosanoid levels using liquid chromatography-tandem mass spectrometry in 29 morbidly obese subjects (13 with diabetes) and 15 nondiabetic, mildly obese subjects. Compared to the mildly obese, the morbidly obese had higher levels of SPMs—RvD3, RvD4 and PD1—and white blood cells (WBC) and platelets. Post-surgery, SPM and platelet levels decreased in morbidly obese nondiabetic subjects but not in diabetic subjects, suggesting continued inflammation. Despite similar weight reductions 1 year after surgery (44.6% vs. 46.6%), 8 diabetes remitters had significant reductions in WBC and platelet counts whereas five non-remitters did not. Remitters had a 58.2% decrease ( p  = 0.03) in 14-HDHA, a maresin pathway marker; non-remitters had an 875.7% increase in 14-HDHA but a 36.9% decrease in MaR1 to a median of 0. In conclusion, higher levels of RvD3, PD1 and their pathway marker, 17-HDHA, are markers of leukocyte activation and inflammation in morbid obesity and diabetes and diminish with weight loss in nondiabetic but not diabetic subjects, possibly representing sustained inflammation in the latter. Lack of diabetes remission after surgically-induced weight loss may be associated with reduced ability to produce MaR1 and sustained inflammation.
AbstractList Obesity and diabetes are associated with chronic inflammation. Specialized pro-resolving lipid mediators (SPMs)—resolvins (Rv), protectins (PD) and maresins (MaR)—actively resolve inflammation. Bariatric surgery achieves remission of diabetes, but mechanisms are unclear. We measured SPMs and proinflammatory eicosanoid levels using liquid chromatography-tandem mass spectrometry in 29 morbidly obese subjects (13 with diabetes) and 15 nondiabetic, mildly obese subjects. Compared to the mildly obese, the morbidly obese had higher levels of SPMs—RvD3, RvD4 and PD1—and white blood cells (WBC) and platelets. Post-surgery, SPM and platelet levels decreased in morbidly obese nondiabetic subjects but not in diabetic subjects, suggesting continued inflammation. Despite similar weight reductions 1 year after surgery (44.6% vs. 46.6%), 8 diabetes remitters had significant reductions in WBC and platelet counts whereas five non-remitters did not. Remitters had a 58.2% decrease ( p  = 0.03) in 14-HDHA, a maresin pathway marker; non-remitters had an 875.7% increase in 14-HDHA but a 36.9% decrease in MaR1 to a median of 0. In conclusion, higher levels of RvD3, PD1 and their pathway marker, 17-HDHA, are markers of leukocyte activation and inflammation in morbid obesity and diabetes and diminish with weight loss in nondiabetic but not diabetic subjects, possibly representing sustained inflammation in the latter. Lack of diabetes remission after surgically-induced weight loss may be associated with reduced ability to produce MaR1 and sustained inflammation.
Obesity and diabetes are associated with chronic inflammation. Specialized pro-resolving lipid mediators (SPMs)-resolvins (Rv), protectins (PD) and maresins (MaR)-actively resolve inflammation. Bariatric surgery achieves remission of diabetes, but mechanisms are unclear. We measured SPMs and proinflammatory eicosanoid levels using liquid chromatography-tandem mass spectrometry in 29 morbidly obese subjects (13 with diabetes) and 15 nondiabetic, mildly obese subjects. Compared to the mildly obese, the morbidly obese had higher levels of SPMs-RvD3, RvD4 and PD1-and white blood cells (WBC) and platelets. Post-surgery, SPM and platelet levels decreased in morbidly obese nondiabetic subjects but not in diabetic subjects, suggesting continued inflammation. Despite similar weight reductions 1 year after surgery (44.6% vs. 46.6%), 8 diabetes remitters had significant reductions in WBC and platelet counts whereas five non-remitters did not. Remitters had a 58.2% decrease (p = 0.03) in 14-HDHA, a maresin pathway marker; non-remitters had an 875.7% increase in 14-HDHA but a 36.9% decrease in MaR1 to a median of 0. In conclusion, higher levels of RvD3, PD1 and their pathway marker, 17-HDHA, are markers of leukocyte activation and inflammation in morbid obesity and diabetes and diminish with weight loss in nondiabetic but not diabetic subjects, possibly representing sustained inflammation in the latter. Lack of diabetes remission after surgically-induced weight loss may be associated with reduced ability to produce MaR1 and sustained inflammation.Obesity and diabetes are associated with chronic inflammation. Specialized pro-resolving lipid mediators (SPMs)-resolvins (Rv), protectins (PD) and maresins (MaR)-actively resolve inflammation. Bariatric surgery achieves remission of diabetes, but mechanisms are unclear. We measured SPMs and proinflammatory eicosanoid levels using liquid chromatography-tandem mass spectrometry in 29 morbidly obese subjects (13 with diabetes) and 15 nondiabetic, mildly obese subjects. Compared to the mildly obese, the morbidly obese had higher levels of SPMs-RvD3, RvD4 and PD1-and white blood cells (WBC) and platelets. Post-surgery, SPM and platelet levels decreased in morbidly obese nondiabetic subjects but not in diabetic subjects, suggesting continued inflammation. Despite similar weight reductions 1 year after surgery (44.6% vs. 46.6%), 8 diabetes remitters had significant reductions in WBC and platelet counts whereas five non-remitters did not. Remitters had a 58.2% decrease (p = 0.03) in 14-HDHA, a maresin pathway marker; non-remitters had an 875.7% increase in 14-HDHA but a 36.9% decrease in MaR1 to a median of 0. In conclusion, higher levels of RvD3, PD1 and their pathway marker, 17-HDHA, are markers of leukocyte activation and inflammation in morbid obesity and diabetes and diminish with weight loss in nondiabetic but not diabetic subjects, possibly representing sustained inflammation in the latter. Lack of diabetes remission after surgically-induced weight loss may be associated with reduced ability to produce MaR1 and sustained inflammation.
Obesity and diabetes are associated with chronic inflammation. Specialized pro-resolving lipid mediators (SPMs)-resolvins (Rv), protectins (PD) and maresins (MaR)-actively resolve inflammation. Bariatric surgery achieves remission of diabetes, but mechanisms are unclear. We measured SPMs and proinflammatory eicosanoid levels using liquid chromatography-tandem mass spectrometry in 29 morbidly obese subjects (13 with diabetes) and 15 nondiabetic, mildly obese subjects. Compared to the mildly obese, the morbidly obese had higher levels of SPMs-RvD3, RvD4 and PD1-and white blood cells (WBC) and platelets. Post-surgery, SPM and platelet levels decreased in morbidly obese nondiabetic subjects but not in diabetic subjects, suggesting continued inflammation. Despite similar weight reductions 1 year after surgery (44.6% vs. 46.6%), 8 diabetes remitters had significant reductions in WBC and platelet counts whereas five non-remitters did not. Remitters had a 58.2% decrease (p = 0.03) in 14-HDHA, a maresin pathway marker; non-remitters had an 875.7% increase in 14-HDHA but a 36.9% decrease in MaR1 to a median of 0. In conclusion, higher levels of RvD3, PD1 and their pathway marker, 17-HDHA, are markers of leukocyte activation and inflammation in morbid obesity and diabetes and diminish with weight loss in nondiabetic but not diabetic subjects, possibly representing sustained inflammation in the latter. Lack of diabetes remission after surgically-induced weight loss may be associated with reduced ability to produce MaR1 and sustained inflammation.
ArticleNumber 20128
Author Still, Christopher
Asbeutah, Abdul Aziz
Wood, G. Craig
Benotti, Peter N.
Hardt, Markus
Schulte, Fabian
Welty, Francine K.
Bistrian, Bruce R.
Author_xml – sequence: 1
  givenname: Fabian
  surname: Schulte
  fullname: Schulte, Fabian
  organization: Forsyth Institute, Department of Developmental Biology, Harvard School of Dental Medicine
– sequence: 2
  givenname: Abdul Aziz
  surname: Asbeutah
  fullname: Asbeutah, Abdul Aziz
  organization: Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Department of Medicine, University of Tennessee Health Science Center
– sequence: 3
  givenname: Peter N.
  surname: Benotti
  fullname: Benotti, Peter N.
  organization: Geisinger Obesity Institute
– sequence: 4
  givenname: G. Craig
  surname: Wood
  fullname: Wood, G. Craig
  organization: Geisinger Obesity Institute
– sequence: 5
  givenname: Christopher
  surname: Still
  fullname: Still, Christopher
  organization: Geisinger Obesity Institute
– sequence: 6
  givenname: Bruce R.
  surname: Bistrian
  fullname: Bistrian, Bruce R.
  organization: Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
– sequence: 7
  givenname: Markus
  surname: Hardt
  fullname: Hardt, Markus
  organization: Forsyth Institute, Department of Developmental Biology, Harvard School of Dental Medicine
– sequence: 8
  givenname: Francine K.
  surname: Welty
  fullname: Welty, Francine K.
  email: fwelty@bidmc.harvard.edu
  organization: Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33208757$$D View this record in MEDLINE/PubMed
BookMark eNp9UctuHCEQRJEjv38gh4hjDhmH4TlziRRZiRPJUi57RwzTs4vFwgQYW-uvN_E6luODudBqqqqbqhN0EGIAhD605KIlrPuSeSv6riGUNEowwRr5Dh1TwkVDGaUHL-ojdJ7zDalH0J63_SE6YoySTgl1jO5XG8AJvCkuhrxxMx6g3AEEnGewznh3DyOeU2wS5OhvXVhj72Y34i2MzpSY8me8jWmonThAdmWHTRjxHbj1pmAfc8ZmKpDwYFLFJ2dxXtIa0u4MvZ-Mz3D-dJ-i1Y_vq8ufzfXvq1-X364by7ksTatoxyiInvUAYpAdk3KoX5k6GCkTcqJCGakI54paOXHCOKOjVbVs5diyU_R1LzsvQ93ZQijJeD0ntzVpp6Nx-v-X4DZ6HW-1kqpqkirw6UkgxT8L5KK3Llvw3gSIS9aUS1rDYJ2o0I8vZz0P-ed3BdA9wKbqTILpGdIS_TdXvc9V11z1Y65aVlL3imRdeQys7uv821S2p-Y6J1TX9U1cUqh2v8V6ALS4uWE
CitedBy_id crossref_primary_10_3389_fcell_2023_1147434
crossref_primary_10_1016_j_phrs_2023_106982
crossref_primary_10_3389_fimmu_2021_704163
crossref_primary_10_1016_j_coemr_2024_100539
crossref_primary_10_1016_j_intimp_2024_112785
crossref_primary_10_1038_s41366_021_01013_y
crossref_primary_10_1016_j_prostaglandins_2023_106718
crossref_primary_10_3390_jcm12185995
crossref_primary_10_1089_ars_2021_0156
crossref_primary_10_3390_biom12030353
crossref_primary_10_3390_ijms241311012
crossref_primary_10_3389_fnut_2021_812119
crossref_primary_10_1016_j_taap_2022_116089
crossref_primary_10_3390_ijerph20196899
crossref_primary_10_1186_s12944_024_02207_9
crossref_primary_10_1016_j_ebiom_2022_103909
crossref_primary_10_1016_j_smim_2022_101597
crossref_primary_10_1016_j_plipres_2022_101165
crossref_primary_10_1186_s12944_021_01507_8
crossref_primary_10_1016_j_bbi_2023_06_018
Cites_doi 10.1038/89759
10.1016/j.soard.2014.06.010
10.2337/db10-0054
10.2174/1568010054022114
10.2337/dc09-9036
10.1371/journal.pone.0107859
10.1096/fj.12-208249
10.1016/j.soard.2014.09.028
10.2337/db12-0828
10.1096/fj.08-125674
10.1074/jbc.M209459200
10.1126/science.1230720
10.4049/jimmunol.1201272
10.1016/j.trsl.2015.06.017
10.1021/cr200246d
10.1096/fj.10-178657
10.1152/ajpcell.00024.2014
10.1074/jbc.M806480200
10.1016/j.clinbiochem.2017.10.010
10.1002/jcla.21920
10.18632/aging.101077
10.4049/jimmunol.1502522
10.1096/fj.201902196R
10.1038/nri2925
10.1038/nature13479
10.1038/s41366-018-0088-z
10.1001/jama.279.18.1477
10.1074/jbc.X112.351437
10.1016/S2213-8587(13)70070-6
10.1056/NEJMoa032804
10.1007/s11695-018-3320-y
10.1001/jama.282.22.2131
10.4049/jimmunol.174.7.4345
10.1002/0471142735.im1426s95
10.1152/ajpheart.00297.2017
10.1186/1472-6947-12-45
10.1038/s41598-018-36679-4
10.1016/j.cmet.2013.10.006
10.1016/j.jasms.2006.09.002
10.1016/j.jacc.2019.04.058
10.1016/j.atherosclerosis.2019.04.213
ContentType Journal Article
Copyright The Author(s) 2020
Copyright_xml – notice: The Author(s) 2020
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
DOI 10.1038/s41598-020-75353-6
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList

CrossRef
MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2045-2322
ExternalDocumentID PMC7674470
33208757
10_1038_s41598_020_75353_6
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: Center for Nutritional Research Charitable Trust
– fundername: ;
GroupedDBID 0R~
3V.
4.4
53G
5VS
7X7
88A
88E
88I
8FE
8FH
8FI
8FJ
AAFWJ
AAJSJ
AAKDD
ABDBF
ABUWG
ACGFS
ACSMW
ACUHS
ADBBV
ADRAZ
AENEX
AEUYN
AFKRA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
DWQXO
EBD
EBLON
EBS
ESX
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
KQ8
LK8
M0L
M1P
M2P
M48
M7P
M~E
NAO
OK1
PIMPY
PQQKQ
PROAC
PSQYO
RNT
RNTTT
RPM
SNYQT
UKHRP
AASML
AAYXX
AFPKN
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
PPXIY
PQGLB
7X8
PJZUB
PUEGO
5PM
ID FETCH-LOGICAL-c446t-172832e5939ee5b68366b052f8ed2356f257a6704472c6f403432dc76f416d13
IEDL.DBID M48
ISSN 2045-2322
IngestDate Thu Aug 21 18:32:55 EDT 2025
Thu Sep 04 23:14:59 EDT 2025
Mon Jul 21 05:36:51 EDT 2025
Thu Apr 24 23:05:33 EDT 2025
Tue Jul 01 02:46:54 EDT 2025
Fri Feb 21 02:37:00 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c446t-172832e5939ee5b68366b052f8ed2356f257a6704472c6f403432dc76f416d13
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/s41598-020-75353-6
PMID 33208757
PQID 2462415385
PQPubID 23479
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_7674470
proquest_miscellaneous_2462415385
pubmed_primary_33208757
crossref_primary_10_1038_s41598_020_75353_6
crossref_citationtrail_10_1038_s41598_020_75353_6
springer_journals_10_1038_s41598_020_75353_6
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2020-11-18
PublicationDateYYYYMMDD 2020-11-18
PublicationDate_xml – month: 11
  year: 2020
  text: 2020-11-18
  day: 18
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Scientific reports
PublicationTitleAbbrev Sci Rep
PublicationTitleAlternate Sci Rep
PublicationYear 2020
Publisher Nature Publishing Group UK
Publisher_xml – name: Nature Publishing Group UK
References Neuhofer (CR38) 2013; 62
Yang, Chiang, Oh, Serhan (CR17) 2011; 95
Kasama (CR9) 2005; 4
Haeggström, Funk (CR8) 2011; 111
Wood (CR15) 2012; 12
Dandona (CR5) 2001; 86
O’Rourke (CR34) 2018; 43
Madjid, Fatemi (CR31) 2013; 40
Serhan (CR11) 2014; 510
Clària, Dalli, Yacoubian, Gao, Serhan (CR41) 2012; 189
Donath, Shoelson (CR4) 2011; 11
Danesh (CR32) 2004; 350
Danesh, Collins, Appleby, Peto (CR33) 1998; 279
Visser, Bouter, McQuillan, Wener, Harris (CR25) 1999; 282
Kumar, Abbas, Aster, Kumar, Abbas, Aster (CR6) 2015
Levy, Clish, Schmidt, Gronert, Serhan (CR12) 2001; 2
Samuelsson (CR7) 2012; 287
Colas, Shinohara, Dalli, Chiang, Serhan (CR16) 2014; 307
Ebrahimi (CR26) 2016; 30
Buse (CR22) 2009; 32
Norris (CR20) 2018; 8
Still (CR23) 2014; 2
Chiappetta (CR28) 2018; 28
Bhatt (CR35) 2019; 74
González-Périz (CR37) 2009; 23
Börgeson (CR44) 2012; 26
Welty, Alfaddagh, Elajami (CR1) 2016; 167
Hellmann, Tang, Kosuri, Bhatnagar, Spite (CR39) 2011; 25
Halade, Kain, Black, Prabhul, Ingle (CR43) 2016; 18
Arismendi (CR27) 2014; 9
Gao (CR2) 2002; 277
Titos (CR40) 2016; 197
Zhang, Gao, Yin, Quon, Ye (CR3) 2008; 283
Tabas, Glass (CR14) 2013; 339
CR21
White, Arita, Taguchi, Kang, Marette (CR45) 2010; 59
Vasundhara (CR42) 2018; 314
Paepegaey (CR29) 2015; 11
Randell (CR24) 2018; 52
Scher, Abramson, Pillinger, Serhan, Ward, Gilroy (CR10) 2010
Careaga (CR30) 2015; 11
Spite, Clària, Serhan (CR13) 2014; 19
Bannenberg (CR36) 2005; 174
Hong (CR18) 2007; 18
Parashar, Schulte, Hardt, Baker (CR19) 2020
M Ebrahimi (75353_CR26) 2016; 30
J Hellmann (75353_CR39) 2011; 25
PJ White (75353_CR45) 2010; 59
CD Still (75353_CR23) 2014; 2
J Danesh (75353_CR33) 1998; 279
GL Bannenberg (75353_CR36) 2005; 174
J Danesh (75353_CR32) 2004; 350
S Chiappetta (75353_CR28) 2018; 28
T Kasama (75353_CR9) 2005; 4
M Visser (75353_CR25) 1999; 282
K Parashar (75353_CR19) 2020
GC Wood (75353_CR15) 2012; 12
E Börgeson (75353_CR44) 2012; 26
J Zhang (75353_CR3) 2008; 283
R Yang (75353_CR17) 2011; 95
E Titos (75353_CR40) 2016; 197
K Vasundhara (75353_CR42) 2018; 314
M Madjid (75353_CR31) 2013; 40
Z Gao (75353_CR2) 2002; 277
E Arismendi (75353_CR27) 2014; 9
JZ Haeggström (75353_CR8) 2011; 111
I Tabas (75353_CR14) 2013; 339
EW Randell (75353_CR24) 2018; 52
M Careaga (75353_CR30) 2015; 11
75353_CR21
A Neuhofer (75353_CR38) 2013; 62
GV Halade (75353_CR43) 2016; 18
PC Norris (75353_CR20) 2018; 8
MY Donath (75353_CR4) 2011; 11
JU Scher (75353_CR10) 2010
V Kumar (75353_CR6) 2015
JB Buse (75353_CR22) 2009; 32
M Spite (75353_CR13) 2014; 19
BD Levy (75353_CR12) 2001; 2
FK Welty (75353_CR1) 2016; 167
DL Bhatt (75353_CR35) 2019; 74
B Samuelsson (75353_CR7) 2012; 287
CN Serhan (75353_CR11) 2014; 510
A González-Périz (75353_CR37) 2009; 23
AC Paepegaey (75353_CR29) 2015; 11
P Dandona (75353_CR5) 2001; 86
S Hong (75353_CR18) 2007; 18
RW O’Rourke (75353_CR34) 2018; 43
J Clària (75353_CR41) 2012; 189
RA Colas (75353_CR16) 2014; 307
References_xml – volume: 2
  start-page: 612
  year: 2001
  end-page: 619
  ident: CR12
  article-title: Lipid mediator class switching during acute inflammation: Signals in resolution
  publication-title: Nat. Immunol.
  doi: 10.1038/89759
– volume: 11
  start-page: 148
  year: 2015
  end-page: 154
  ident: CR29
  article-title: High levels of CRP in morbid obesity: The central role of adipose tissue and lessons for clinical practice before and after bariatric surgery
  publication-title: Surg. Obes. Relat. Dis.
  doi: 10.1016/j.soard.2014.06.010
– volume: 59
  start-page: 3066
  year: 2010
  end-page: 3073
  ident: CR45
  article-title: Transgenic restoration of long-chain n-3 fatty acids in insulin target tissues improves resolution capacity and alleviates obesity-linked inflammation and insulin resistance in high-fat-fed mice
  publication-title: Diabetes
  doi: 10.2337/db10-0054
– volume: 4
  start-page: 273
  year: 2005
  end-page: 279
  ident: CR9
  article-title: Neutrophil-derived cytokines: Potential therapeutic targets in inflammation
  publication-title: Curr. Drug Targets Inflamm. Allergy.
  doi: 10.2174/1568010054022114
– volume: 32
  start-page: 2133
  year: 2009
  end-page: 2135
  ident: CR22
  article-title: How do we define cure of diabetes?
  publication-title: Diabetes Care
  doi: 10.2337/dc09-9036
– volume: 9
  start-page: e107859
  year: 2014
  ident: CR27
  article-title: The systemic inflammome of severe obesity before and after bariatric surgery
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0107859
– volume: 26
  start-page: 4287
  year: 2012
  end-page: 4294
  ident: CR44
  article-title: Lipoxin A attenuates adipose inflammation
  publication-title: FASEB J.
  doi: 10.1096/fj.12-208249
– volume: 11
  start-page: 906
  year: 2015
  end-page: 911
  ident: CR30
  article-title: Inflammation and iron status in bariatric surgery candidates
  publication-title: Surg. Obes. Relat. Dis.
  doi: 10.1016/j.soard.2014.09.028
– volume: 86
  start-page: 3257
  year: 2001
  end-page: 3265
  ident: CR5
  article-title: Insulin inhibits intranuclear nuclear factor κB and stimulates IκB in mononuclear cells in obese subjects: Evidence for an anti-inflammatory effect?
  publication-title: JCEM.
– volume: 62
  start-page: 1945
  year: 2013
  end-page: 1956
  ident: CR38
  article-title: Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation
  publication-title: Diabetes
  doi: 10.2337/db12-0828
– volume: 23
  start-page: 1946
  year: 2009
  end-page: 1957
  ident: CR37
  article-title: Obesity-induced insulin resistance and hepatic steatosis are alleviated by ω-3 fatty acids: A role for resolvins and protectins
  publication-title: FASEB J.
  doi: 10.1096/fj.08-125674
– volume: 277
  start-page: 48115
  year: 2002
  end-page: 48121
  ident: CR2
  article-title: Serine phosphorylation of insulin receptor substrate 1 by inhibitor κB kinase complex
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M209459200
– volume: 339
  start-page: 166
  year: 2013
  end-page: 172
  ident: CR14
  article-title: Anti-Inflammatory therapy in chronic disease: Challenges and opportunities
  publication-title: Science
  doi: 10.1126/science.1230720
– volume: 189
  start-page: 2597
  year: 2012
  end-page: 2605
  ident: CR41
  article-title: Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1201272
– volume: 167
  start-page: 257
  year: 2016
  end-page: 280
  ident: CR1
  article-title: Targeting inflammation in metabolic syndrome
  publication-title: Transl. Res.
  doi: 10.1016/j.trsl.2015.06.017
– volume: 111
  start-page: 5866
  year: 2011
  end-page: 5898
  ident: CR8
  article-title: Lipoxygenase and leukotriene pathways: Biochemistry, biology, and roles in disease
  publication-title: Chem. Rev.
  doi: 10.1021/cr200246d
– volume: 25
  start-page: 2399
  year: 2011
  end-page: 2407
  ident: CR39
  article-title: Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice
  publication-title: FASEB J.
  doi: 10.1096/fj.10-178657
– volume: 307
  start-page: C39
  year: 2014
  end-page: 54
  ident: CR16
  article-title: Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00024.2014
– volume: 283
  start-page: 35375
  year: 2008
  end-page: 35382
  ident: CR3
  article-title: S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-α signaling through IKK2
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M806480200
– ident: CR21
– volume: 52
  start-page: 13
  year: 2018
  end-page: 19
  ident: CR24
  article-title: Pre-operative and post-operative changes in CRP and other biomarkers sensitive to inflammatory status in patients with severe obesity undergoing laparoscopic sleeve gastrectomy
  publication-title: Clin. Biochem.
  doi: 10.1016/j.clinbiochem.2017.10.010
– volume: 30
  start-page: 672
  year: 2016
  end-page: 676
  ident: CR26
  article-title: Association of serum hs-CRP levels with the presence of obesity, diabetes mellitus, and other cardiovascular risk factors
  publication-title: J. Clin. Lab. Anal.
  doi: 10.1002/jcla.21920
– volume: 18
  start-page: 2611
  year: 2016
  end-page: 2634
  ident: CR43
  article-title: Aging dysregulates D- and E-series resolvings to modulate cardiosplenic and cardiorenal network following myocardial infarction
  publication-title: Aging.
  doi: 10.18632/aging.101077
– volume: 197
  start-page: 3360
  year: 2016
  end-page: 3370
  ident: CR40
  article-title: Signaling and immunoresolving actions of resolvin D1 in inflamed human visceral adipose tissue
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1502522
– year: 2020
  ident: CR19
  article-title: Sex-mediated elevation of the specialized pro-resolving lipid mediator levels in a Sjögren's syndrome mouse model
  publication-title: FASEB J.
  doi: 10.1096/fj.201902196R
– volume: 11
  start-page: 98
  year: 2011
  end-page: 107
  ident: CR4
  article-title: Type 2 diabetes as an inflammatory disease
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri2925
– volume: 510
  start-page: 92
  year: 2014
  end-page: 101
  ident: CR11
  article-title: Pro-resolving lipid mediators are leads for resolution physiology
  publication-title: Nature
  doi: 10.1038/nature13479
– year: 2010
  ident: CR10
  article-title: Neutrophils I
  publication-title: Fundamentals of Inflammation
– volume: 43
  start-page: 285
  year: 2018
  end-page: 296
  ident: CR34
  article-title: Serum biomarkers of inflammation and adiposity in the LABS cohort: Associations with metabolic disease and surgical outcomes
  publication-title: Int. J. Obes.
  doi: 10.1038/s41366-018-0088-z
– start-page: 69
  year: 2015
  end-page: 111
  ident: CR6
  article-title: Inflammation and repair
  publication-title: Robbins and Cotran Pathologic Basis of Disease
– volume: 279
  start-page: 1477
  year: 1998
  end-page: 1482
  ident: CR33
  article-title: Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: Meta-analyses of prospective studies
  publication-title: JAMA
  doi: 10.1001/jama.279.18.1477
– volume: 287
  start-page: 10070
  year: 2012
  end-page: 10080
  ident: CR7
  article-title: Role of basic science in the development of new medicines: Examples from the eicosanoid field
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.X112.351437
– volume: 2
  start-page: 38
  year: 2014
  end-page: 45
  ident: CR23
  article-title: A probability score for preoperative prediction of type 2 diabetes remission following RYGB surgery
  publication-title: Lancet Diabetes Endocrinol.
  doi: 10.1016/S2213-8587(13)70070-6
– volume: 350
  start-page: 1387
  year: 2004
  end-page: 1397
  ident: CR32
  article-title: C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa032804
– volume: 40
  start-page: 17
  year: 2013
  end-page: 29
  ident: CR31
  article-title: Components of the complete blood count as risk predictors for coronary heart disease: In-depth review and update
  publication-title: Tex. Heart Inst. J.
– volume: 28
  start-page: 3028
  year: 2018
  end-page: 3040
  ident: CR28
  article-title: The impact of obesity and metabolic surgery on chronic inflammation
  publication-title: Obes. Surg.
  doi: 10.1007/s11695-018-3320-y
– volume: 282
  start-page: 2131
  year: 1999
  end-page: 2135
  ident: CR25
  article-title: Elevated C-reactive protein levels in overweight and obese adults
  publication-title: JAMA
  doi: 10.1001/jama.282.22.2131
– volume: 174
  start-page: 4345
  year: 2005
  end-page: 4355
  ident: CR36
  article-title: Molecular circuits of resolution: Formation and actions of resolvins and protectins
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.174.7.4345
– volume: 95
  start-page: 1
  year: 2011
  end-page: 26
  ident: CR17
  article-title: Metabolomics-lipidomics of eicosanoids and docosanoids generated by phagocytes
  publication-title: Curr. Protoc. Immunol.
  doi: 10.1002/0471142735.im1426s95
– volume: 314
  start-page: H-160
  year: 2018
  end-page: H-169
  ident: CR42
  article-title: Excess ω-6 fatty acids influx in aging drives metabolic dysregulation, electrocardiographic alterations, and low-grade chronic inflammation
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.00297.2017
– volume: 12
  start-page: 45
  year: 2012
  ident: CR15
  article-title: An electronic health record-enabled obesity database
  publication-title: BMC Med Dec. Mak. Inform.
  doi: 10.1186/1472-6947-12-45
– volume: 8
  start-page: 18050
  year: 2018
  ident: CR20
  article-title: Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: A methodological validation
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-36679-4
– volume: 19
  start-page: 21
  year: 2014
  end-page: 36
  ident: CR13
  article-title: Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2013.10.006
– volume: 18
  start-page: 128
  year: 2007
  end-page: 144
  ident: CR18
  article-title: Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms
  publication-title: J. Am. Soc. Mass. Spectrom.
  doi: 10.1016/j.jasms.2006.09.002
– volume: 74
  start-page: 261
  year: 2019
  end-page: 263
  ident: CR35
  article-title: Cardiovascular biomarkers after metabolic surgery versus medical therapy for diabetes
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2019.04.058
– volume: 307
  start-page: C39
  year: 2014
  ident: 75353_CR16
  publication-title: Am. J. Physiol. Cell Physiol.
  doi: 10.1152/ajpcell.00024.2014
– volume: 12
  start-page: 45
  year: 2012
  ident: 75353_CR15
  publication-title: BMC Med Dec. Mak. Inform.
  doi: 10.1186/1472-6947-12-45
– volume: 9
  start-page: e107859
  year: 2014
  ident: 75353_CR27
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0107859
– volume: 287
  start-page: 10070
  year: 2012
  ident: 75353_CR7
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.X112.351437
– year: 2020
  ident: 75353_CR19
  publication-title: FASEB J.
  doi: 10.1096/fj.201902196R
– volume: 52
  start-page: 13
  year: 2018
  ident: 75353_CR24
  publication-title: Clin. Biochem.
  doi: 10.1016/j.clinbiochem.2017.10.010
– volume: 197
  start-page: 3360
  year: 2016
  ident: 75353_CR40
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1502522
– volume: 4
  start-page: 273
  year: 2005
  ident: 75353_CR9
  publication-title: Curr. Drug Targets Inflamm. Allergy.
  doi: 10.2174/1568010054022114
– volume: 40
  start-page: 17
  year: 2013
  ident: 75353_CR31
  publication-title: Tex. Heart Inst. J.
– volume: 174
  start-page: 4345
  year: 2005
  ident: 75353_CR36
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.174.7.4345
– volume: 59
  start-page: 3066
  year: 2010
  ident: 75353_CR45
  publication-title: Diabetes
  doi: 10.2337/db10-0054
– volume: 30
  start-page: 672
  year: 2016
  ident: 75353_CR26
  publication-title: J. Clin. Lab. Anal.
  doi: 10.1002/jcla.21920
– volume: 95
  start-page: 1
  year: 2011
  ident: 75353_CR17
  publication-title: Curr. Protoc. Immunol.
  doi: 10.1002/0471142735.im1426s95
– volume: 283
  start-page: 35375
  year: 2008
  ident: 75353_CR3
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M806480200
– ident: 75353_CR21
  doi: 10.1016/j.atherosclerosis.2019.04.213
– volume: 19
  start-page: 21
  year: 2014
  ident: 75353_CR13
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2013.10.006
– volume: 282
  start-page: 2131
  year: 1999
  ident: 75353_CR25
  publication-title: JAMA
  doi: 10.1001/jama.282.22.2131
– volume: 11
  start-page: 98
  year: 2011
  ident: 75353_CR4
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri2925
– volume: 86
  start-page: 3257
  year: 2001
  ident: 75353_CR5
  publication-title: JCEM.
– volume: 2
  start-page: 38
  year: 2014
  ident: 75353_CR23
  publication-title: Lancet Diabetes Endocrinol.
  doi: 10.1016/S2213-8587(13)70070-6
– volume: 26
  start-page: 4287
  year: 2012
  ident: 75353_CR44
  publication-title: FASEB J.
  doi: 10.1096/fj.12-208249
– volume: 339
  start-page: 166
  year: 2013
  ident: 75353_CR14
  publication-title: Science
  doi: 10.1126/science.1230720
– volume: 11
  start-page: 148
  year: 2015
  ident: 75353_CR29
  publication-title: Surg. Obes. Relat. Dis.
  doi: 10.1016/j.soard.2014.06.010
– volume: 32
  start-page: 2133
  year: 2009
  ident: 75353_CR22
  publication-title: Diabetes Care
  doi: 10.2337/dc09-9036
– volume: 2
  start-page: 612
  year: 2001
  ident: 75353_CR12
  publication-title: Nat. Immunol.
  doi: 10.1038/89759
– volume: 277
  start-page: 48115
  year: 2002
  ident: 75353_CR2
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M209459200
– volume: 8
  start-page: 18050
  year: 2018
  ident: 75353_CR20
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-36679-4
– volume: 350
  start-page: 1387
  year: 2004
  ident: 75353_CR32
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa032804
– volume: 18
  start-page: 128
  year: 2007
  ident: 75353_CR18
  publication-title: J. Am. Soc. Mass. Spectrom.
  doi: 10.1016/j.jasms.2006.09.002
– volume: 43
  start-page: 285
  year: 2018
  ident: 75353_CR34
  publication-title: Int. J. Obes.
  doi: 10.1038/s41366-018-0088-z
– volume: 62
  start-page: 1945
  year: 2013
  ident: 75353_CR38
  publication-title: Diabetes
  doi: 10.2337/db12-0828
– volume: 25
  start-page: 2399
  year: 2011
  ident: 75353_CR39
  publication-title: FASEB J.
  doi: 10.1096/fj.10-178657
– volume: 11
  start-page: 906
  year: 2015
  ident: 75353_CR30
  publication-title: Surg. Obes. Relat. Dis.
  doi: 10.1016/j.soard.2014.09.028
– volume: 279
  start-page: 1477
  year: 1998
  ident: 75353_CR33
  publication-title: JAMA
  doi: 10.1001/jama.279.18.1477
– volume: 23
  start-page: 1946
  year: 2009
  ident: 75353_CR37
  publication-title: FASEB J.
  doi: 10.1096/fj.08-125674
– volume: 111
  start-page: 5866
  year: 2011
  ident: 75353_CR8
  publication-title: Chem. Rev.
  doi: 10.1021/cr200246d
– volume: 28
  start-page: 3028
  year: 2018
  ident: 75353_CR28
  publication-title: Obes. Surg.
  doi: 10.1007/s11695-018-3320-y
– volume: 167
  start-page: 257
  year: 2016
  ident: 75353_CR1
  publication-title: Transl. Res.
  doi: 10.1016/j.trsl.2015.06.017
– volume: 510
  start-page: 92
  year: 2014
  ident: 75353_CR11
  publication-title: Nature
  doi: 10.1038/nature13479
– volume-title: Fundamentals of Inflammation
  year: 2010
  ident: 75353_CR10
– volume: 189
  start-page: 2597
  year: 2012
  ident: 75353_CR41
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1201272
– volume: 74
  start-page: 261
  year: 2019
  ident: 75353_CR35
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2019.04.058
– volume: 314
  start-page: H-160
  year: 2018
  ident: 75353_CR42
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.00297.2017
– volume: 18
  start-page: 2611
  year: 2016
  ident: 75353_CR43
  publication-title: Aging.
  doi: 10.18632/aging.101077
– start-page: 69
  volume-title: Robbins and Cotran Pathologic Basis of Disease
  year: 2015
  ident: 75353_CR6
SSID ssj0000529419
Score 2.4295514
Snippet Obesity and diabetes are associated with chronic inflammation. Specialized pro-resolving lipid mediators (SPMs)—resolvins (Rv), protectins (PD) and maresins...
Obesity and diabetes are associated with chronic inflammation. Specialized pro-resolving lipid mediators (SPMs)-resolvins (Rv), protectins (PD) and maresins...
SourceID pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 20128
SubjectTerms 692/308
692/53
Aged
Bariatric Surgery
Biomarkers - blood
Diabetes Mellitus, Type 2 - blood
Dinoprostone - blood
Docosahexaenoic Acids - blood
Eicosanoids - blood
Fatty Acids, Unsaturated - blood
Female
Humanities and Social Sciences
Humans
Leukocyte Count
Lipid Metabolism
Male
Middle Aged
multidisciplinary
Obesity - blood
Obesity, Morbid - blood
Obesity, Morbid - surgery
Science
Science (multidisciplinary)
Urachal Cyst - blood
Weight Loss
SummonAdditionalLinks – databaseName: Springer Nature HAS Fully OA
  dbid: AAJSJ
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1La9wwEB7SDYVeQtJX3EdQobdG1JZkSXtcSkPYQy9NITchSzIxbO1lvaE0vz4j2V7YpAR6M7YkZI0eM5qZ7wP4jEZVqfAcoa4Wnop57ah2VlDrS7SwLVfapWiLH_Lyl1hel9cHwKZcmBS0nyAt0zY9RYd97fGgiclgaOyggl1yKp_BoVa4_c7gcLFY_lzublai70oU8zFDJuf6H5X3T6FHquXjCMkHbtJ0-lwcw9GoNpLF0NETOAjtS3g-EEn-fQV3KG2ymeLabpo1GeOvSD_wyzd3wRPsAEXrulvFSwSyataNJylzJDLunJPf3abCN91AFUBs68mfdHFKVvgPJLGJkwpt64TqT_ohofo1XF18v_p2SUdWBerQ9NvSSEjFWSjnfB5CWUnNpaxwzGodPOOlrHERW6lyIRRzshZ5TD31TuFjIX3B38Cs7dpwCkQzK2xVMO-9E6j2VYrllbDKo9mlsPEMimmQjRsRxyPxxcokzzfXZhCMQcGYJBgjM_iyq7Me8DaeLP1pkp3BZRF9HbYN3W1vmJBRN-G6zODtIMtde5yzhOOfgdqT8q5AhNze_9I2Nwl6O0IfCZVncD7NBzOu-f6Jbr77v-Lv4QWLczUGG-oPMNtubsNHVH221dk41-8BFKn_tg
  priority: 102
  providerName: Springer Nature
Title The relationship between specialized pro-resolving lipid mediators, morbid obesity and weight loss after bariatric surgery
URI https://link.springer.com/article/10.1038/s41598-020-75353-6
https://www.ncbi.nlm.nih.gov/pubmed/33208757
https://www.proquest.com/docview/2462415385
https://pubmed.ncbi.nlm.nih.gov/PMC7674470
Volume 10
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEB7yoCWX0vTpPhYVemvUriVZsg8hLEtC2EMvTSA3YUs2Mbj2dr2hTX59R5K9sE3IoTdjS7asmWFmNI8P4DM6VYlCPUJNJSwVWWVoanJBc5ugh51zlRqfbfFdnl-KxVVytQMj3NGwgf2Drp3Dk7pcNV___Lo9QYE_DiXj6bcelZArFENHCI3vhFO5C_s-XuRS-QZzP_T6ZpmIs6F25uGpB_CUc-b7vG-rqnv25_00yn9iqV5FnT2HZ4NtSWaBGQ5hp2xfwJOANnn7Eu6QJchqTH67rpdkSNIifQChr-9KS3ABFF3wrnEnDaSpl7UlvrzEwfIckZ_dqsA7XcATIHlryW9_ukoa_AfiIcdJgQ64b_1P-lB1_Qouzk4v5ud0gF6gBv3DNXWoVZyVScazskwKmXIpC9y-Ki0t44msUNJzqaZCKGZkJaauPtUahZextDF_DXtt15ZvgaQsF3kRM2utEWgbFopNC5Eri76ZwpdHEI-brM3QltyhYzTah8d5qgONNNJIexppGcGXzZxlaMrx6OhPI-00yo4LiORt2d30mgnpDBieJhG8CbTcvG9kggjUFpU3A1xf7u0nbX3t-3O7_khCTSM4GvlBj3z9yDLf_feH3sMBcxzskhPTD7C3Xt2UH9FUWhcT2J_NFj8WE9idy_nEHzhMvEz8BU7qFHc
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Nb9QwEB2VIkQviO8GKBiJG7VIbMf2HlFFtYXS0yL1Zjm2o0ZaktVmK0R_PWMnWWkpqsQtSuzI8diZGc_MewAf0KkqFeoR6mrhqZjVjmpnBbW-RA_bcqVdyra4kPMf4utlebkHbKqFSUn7CdIy_aan7LBPPSqaWAyGzg4a2CWn8h7c1xH8PQZo5cn2XCVGrkQxG-tjcq7_0XVXB90yLG_nR_4VJE265_QxPBqNRvJ5GOYT2AvtU3gw0Ej-fgY3KGuynrLarpoVGbOvSD-wyzc3wRMcAEXfulvGIwSybFaNJ6luJPLtHJOf3brCO91AFEBs68mvdGxKlvgNJHGJkwo964TpT_qhnPo5LE6_LE7mdORUoA4dvw2NdFSchXLGZyGUldRcygrnrNbBM17KGrewlSoXQjEna5HHwlPvFF4W0hf8Bey3XRsOgWhmha0K5r13Ao2-SrG8ElZ5dLoUvjyDYppk40a88Uh7sTQp7s21GQRjUDAmCcbIDD5u-6wGtI07W7-fZGdwU8RIh21Dd90bJmS0TLguM3g5yHL7Ps5ZQvHPQO1IedsgAm7vPmmbqwS8HYGPhMozOJ7Wgxl3fH_HMF_9X_N38HC--H5uzs8uvr2GAxbXbUw71G9gf7O-DkdoBG2qt2nV_wEAmAFZ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1La9wwEB7SlJZeSt91nyr01qixJVnSHsu2S_og9JBCbkKWZGLY2st6Q0h-fUeyvbBNCfRmbMnIGskzn2bmG4D3CKpKhXqEulp4Kma1o9pZQa0vEWFbrrRL0RbH8uiX-HZanu6BnHJhUtB-orRMv-kpOuywR0UTk8EQ7KCBXXIqP658fQtua1SJEXTN5Xx7thK9V6KYjTkyOdf_6L6rh64Zl9djJP9ylCb9s3gA90fDkXwahvoQ9kL7CO4MpSQvH8MVypusp8i2s2ZFxggs0g8V5pur4AkOgCK-7pbxGIEsm1XjScodiTV3Dsjvbl3hnW4oFkBs68lFOjolS_wGkuqJkwrRdeL1J_2QUv0EThZfTuZHdKyrQB2Cvw2NJak4C-WMz0IoK6m5lBXOWa2DZ7yUNW5jK1UuhGJO1iKPyafeKbwspC_4U9hvuzY8B6KZFbYqmPfeCTT8KsXySljlEXgpfHkGxTTJxo2c47H0xdIk3zfXZhCMQcGYJBgjM_iw7bMaGDdubP1ukp3BjRG9HbYN3XlvmJDROuG6zODZIMvt-zhnick_A7Uj5W2DSLq9-6RtzhL5diQ_EirP4GBaD2bc9f0Nw3zxf83fwt2fnxfmx9fj7y_hHovLNkYe6lewv1mfh9doB22qN2nR_wGjBwJi
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+relationship+between+specialized+pro-resolving+lipid+mediators%2C+morbid+obesity+and+weight+loss+after+bariatric+surgery&rft.jtitle=Scientific+reports&rft.au=Schulte%2C+Fabian&rft.au=Asbeutah%2C+Abdul+Aziz&rft.au=Benotti%2C+Peter+N.&rft.au=Wood%2C+G.+Craig&rft.date=2020-11-18&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2045-2322&rft.volume=10&rft_id=info:doi/10.1038%2Fs41598-020-75353-6&rft_id=info%3Apmid%2F33208757&rft.externalDocID=PMC7674470
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon