The lack of target specificity of small molecule anticancer kinase inhibitors is correlated with their ability to damage myocytes in vitro - Hasinoff, Brian B.; Patel, Daywin (Toxicology and applied pharmacology, 2010)
Keywords: 60 APPLIED LIFE SCIENCES; AMINO ACIDS; ANIMAL CELLS; ANIMALS; Animals, Newborn; Anticancer; Antineoplastic Agents - toxicity; Biological and medical sciences; CARBOXYLIC ACIDS; Cardiotoxicity; DAMAGE; Data processing; ENZYMES; HYDROXY ACIDS; In Vitro Techniques; INHIBITION; Kinase; MAMMALS; Medical sciences; Myocyte; Myocytes, Cardiac - cytology; Myocytes, Cardiac - drug effects; ORGANIC ACIDS; ORGANIC COMPOUNDS; PHOSPHORUS-GROUP TRANSFERASES; PHOSPHOTRANSFERASES; Protein Binding; Protein-Serine-Threonine Kinases - antagonists & inhibitors; Protein-Tyrosine Kinases - antagonists & inhibitors; PROTEINS; RATS; Rats, Sprague-Dawley; RODENTS; SERINE; THREONINE; Toxicology; TRANSFERASES; TYROSINE; Tyrosine kinase; VERTEBRATES; Δ% LDH; LDH; Tyrosine kinase; S; Kinase; Cardiotoxicity; Inhibition; 1:1 where x is % (v/v) serum; Anticancer; DF- x; K d; Myocyte; Antineoplastic agent; Targeting; Enzyme; Toxicity; Transferases; Cardiovascular disease; In vitro; Target; Specificity; Heart disease; Inhibitor; Lesion; Small molecule; Protein-tyrosine kinase