Biosynthesized silver nanoparticles protect against hepatic injury induced by murine blood-stage malaria infection

• Published in: Environmental science and pollution research international Vol. 27; no. 15; pp. 17762 - 17769
• Main Authors: Dkhil, Mohamed A., Abdel-Gaber, Rewaida, Alojayri, Ghada, Al-Shaebi, Esam M., Qasem, Mahmood A. A., Murshed, Mutee, Mares, Mohammed M., El-Matbouli, Mansour, Al-Quraishy, Saleh
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2020; Springer Nature B.V
• Subjects: Alanine; Alanine transaminase; Alkaline phosphatase; antimalarials; Antiprotozoal agents; Aquatic Pollution; Aspartate aminotransferase; aspartate transaminase; Atmospheric Protection/Air Quality Control/Air Pollution; biosynthesis; Catalase; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; Environmental Health; Environmental science; Erythrocytes; Glutathione; Hemoglobin; Histology; Indigofera oblongifolia; leaves; Liver; Malaria; Malondialdehyde; mice; Nanoparticles; nanosilver; Nitric oxide; Parasitemia; Plant extracts; pollution; Research Article; Silver; Transmission electron microscopy; Vector-borne diseases; Waste Water Technology; Water Management; Water Pollution Control; Plasmodium; Mice; Silver nanoparticles; Liver injury
• ISSN: 0944-1344; 1614-7499; 1614-7499
• DOI: 10.1007/s11356-020-08280-8

Biosynthesized nanoparticles proposed to have antiplasmodial activities have attracted increasing attention for malaria that considered being one of the foremost hazardous diseases. In this study, Indigofera oblongifolia leaf extracts were used for the synthesis of silver nanoparticles (AgNPs), which were characterized utilizing transmission electron microscopy. We investigated the antiplasmodial and hepatoprotective effects of AgNPs against Plasmodium chabaudi –induced infection in mice. Treatment of the infected mice with 50 mg/kg AgNPs for seven days caused a significant decrease in parasitemia and reduced the histopatholoical changes in the liver, as indicated by Ishak’s histology index. Further, the AgNPs alleviated the oxidative damage in the liver infected with P. chabaudi . This was evidenced by the changed levels of malondialdehyde, nitric oxide, and glutathione, as well as increased catalase activity after treatment with AgNPs. In addition, levels of the liver enzymes alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase were increased after treatment. Moreover, the findings showed the efficiency of AgNPs in improving the infected mice’s erythrocyte counts and hemoglobin content. Generally, our results reported that AgNPs possess antiplasmodial and hepatoprotective properties.