Polymorphisms of DRD4 and DRD3 and risk of avoidant and obsessive personality traits and disorders
We investigated whether polymorphisms of the dopamine D4 receptor ( DRD4) and polymorphisms of the dopamine D3 receptor ( DRD3) were associated with personality disorder symptomatology rather than with personality traits such as novelty seeking. DNA was obtained from 145 depressed patients in a clin...
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| Published in | Psychiatry research Vol. 119; no. 1; pp. 1 - 10 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Shannon
Elsevier Ireland Ltd
15.07.2003
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0165-1781 1872-7123 |
| DOI | 10.1016/S0165-1781(03)00124-0 |
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| Abstract | We investigated whether polymorphisms of the dopamine D4 receptor (
DRD4) and polymorphisms of the dopamine D3 receptor (
DRD3) were associated with personality disorder symptomatology rather than with personality traits such as novelty seeking. DNA was obtained from 145 depressed patients in a clinical trial. These patients were assessed for the presence of personality disorder symptoms and disorders. The 2-repeat allele of the
DRD4 exon III polymorphism was associated with increased rates of avoidant and obsessive personality disorder symptomatology. The T,T genotype of the
DRD4 −521 C>T polymorphism was also associated with increased rates of avoidant and obsessive personality disorder symptomatology. The Gly9,Gly9 genotype of the
DRD3 Ser9Gly polymorphism was associated with increased rates of obsessive personality disorder symptomatology. None of these three polymorphisms were associated with novelty seeking or other temperament traits on the Temperament and Character Inventory. Our results suggest that genetic polymorphisms of
DRD4 and
DRD3 may well be associated with personality traits, and that conflicting findings to date may arise from the problem of phenotype definition. |
|---|---|
| AbstractList | We investigated whether polymorphisms of the dopamine D4 receptor (DRD4) and polymorphisms of the dopamine D3 receptor (DRD3) were associated with personality disorder symptomatology rather than with personality traits such as novelty seeking. DNA was obtained from 145 depressed patients in a clinical trial. These patients were assessed for the presence of personality disorder symptoms and disorders. The 2-repeat allele of the DRD4 exon III polymorphism was associated with increased rates of avoidant and obsessive personality disorder symptomatology. The T,T genotype of the DRD4 -521 C>T polymorphism was also associated with increased rates of avoidant and obsessive personality disorder symptomatology. The Gly9,Gly9 genotype of the DRD3 Ser9Gly polymorphism was associated with increased rates of obsessive personality disorder symptomatology. None of these three polymorphisms were associated with novelty seeking or other temperament traits on the Temperament and Character Inventory. Our results suggest that genetic polymorphisms of DRD4 and DRD3 may well be associated with personality traits, and that conflicting findings to date may arise from the problem of phenotype definition. We investigated whether polymorphisms of the dopamine D4 receptor ( DRD4) and polymorphisms of the dopamine D3 receptor ( DRD3) were associated with personality disorder symptomatology rather than with personality traits such as novelty seeking. DNA was obtained from 145 depressed patients in a clinical trial. These patients were assessed for the presence of personality disorder symptoms and disorders. The 2-repeat allele of the DRD4 exon III polymorphism was associated with increased rates of avoidant and obsessive personality disorder symptomatology. The T,T genotype of the DRD4 −521 C>T polymorphism was also associated with increased rates of avoidant and obsessive personality disorder symptomatology. The Gly9,Gly9 genotype of the DRD3 Ser9Gly polymorphism was associated with increased rates of obsessive personality disorder symptomatology. None of these three polymorphisms were associated with novelty seeking or other temperament traits on the Temperament and Character Inventory. Our results suggest that genetic polymorphisms of DRD4 and DRD3 may well be associated with personality traits, and that conflicting findings to date may arise from the problem of phenotype definition. We investigated whether polymorphisms of the dopamine D4 receptor (DRD4) and polymorphisms of the dopamine D3 receptor (DRD3) were associated with personality disorder symptomatology rather than with personality traits such as novelty seeking. DNA was obtained from 145 depressed patients in a clinical trial. These patients were assessed for the presence of personality disorder symptoms and disorders. The 2-repeat allele of the DRD4 exon III polymorphism was associated with increased rates of avoidant and obsessive personality disorder symptomatology. The T,T genotype of the DRD4 -521 C>T polymorphism was also associated with increased rates of avoidant and obsessive personality disorder symptomatology. The Gly9,Gly9 genotype of the DRD3 Ser9Gly polymorphism was associated with increased rates of obsessive personality disorder symptomatology. None of these three polymorphisms were associated with novelty seeking or other temperament traits on the Temperament and Character Inventory. Our results suggest that genetic polymorphisms of DRD4 and DRD3 may well be associated with personality traits, and that conflicting findings to date may arise from the problem of phenotype definition.We investigated whether polymorphisms of the dopamine D4 receptor (DRD4) and polymorphisms of the dopamine D3 receptor (DRD3) were associated with personality disorder symptomatology rather than with personality traits such as novelty seeking. DNA was obtained from 145 depressed patients in a clinical trial. These patients were assessed for the presence of personality disorder symptoms and disorders. The 2-repeat allele of the DRD4 exon III polymorphism was associated with increased rates of avoidant and obsessive personality disorder symptomatology. The T,T genotype of the DRD4 -521 C>T polymorphism was also associated with increased rates of avoidant and obsessive personality disorder symptomatology. The Gly9,Gly9 genotype of the DRD3 Ser9Gly polymorphism was associated with increased rates of obsessive personality disorder symptomatology. None of these three polymorphisms were associated with novelty seeking or other temperament traits on the Temperament and Character Inventory. Our results suggest that genetic polymorphisms of DRD4 and DRD3 may well be associated with personality traits, and that conflicting findings to date may arise from the problem of phenotype definition. |
| Author | Miller, Allison L. Mulder, Roger T. Rogers, Geraldine R. Luty, Suzanne E. Kennedy, Martin A. Joyce, Peter R. |
| Author_xml | – sequence: 1 givenname: Peter R. surname: Joyce fullname: Joyce, Peter R. email: peter.joyce@chmeds.ac.nz organization: Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, P.O. Box 4345, Christchurch, New Zealand – sequence: 2 givenname: Geraldine R. surname: Rogers fullname: Rogers, Geraldine R. organization: Department of Pathology, Christchurch School of Medicine and Health Sciences, P.O. Box 4345, Christchurch, New Zealand – sequence: 3 givenname: Allison L. surname: Miller fullname: Miller, Allison L. organization: Department of Pathology, Christchurch School of Medicine and Health Sciences, P.O. Box 4345, Christchurch, New Zealand – sequence: 4 givenname: Roger T. surname: Mulder fullname: Mulder, Roger T. organization: Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, P.O. Box 4345, Christchurch, New Zealand – sequence: 5 givenname: Suzanne E. surname: Luty fullname: Luty, Suzanne E. organization: Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, P.O. Box 4345, Christchurch, New Zealand – sequence: 6 givenname: Martin A. surname: Kennedy fullname: Kennedy, Martin A. organization: Department of Pathology, Christchurch School of Medicine and Health Sciences, P.O. Box 4345, Christchurch, New Zealand |
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| Keywords | Novelty seeking Avoidant personality Obsessive personality Dopamine 4 receptor Dopamine 3 receptor Mood disorder Human D4 Dopamine receptor Obsessional personality Depression Personality Genetic determinism Temperament Personality disorder D3 Dopamine receptor Sensation seeking Symptomatology Concomitant disease Follow up study Risk factor Genetics Comparative study Novelty Polymorphism |
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| Snippet | We investigated whether polymorphisms of the dopamine D4 receptor (
DRD4) and polymorphisms of the dopamine D3 receptor (
DRD3) were associated with... We investigated whether polymorphisms of the dopamine D4 receptor (DRD4) and polymorphisms of the dopamine D3 receptor (DRD3) were associated with personality... |
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| SubjectTerms | Adult Adult and adolescent clinical studies Alleles Avoidant personality Biological and medical sciences Character Depression Dopamine 3 receptor Dopamine 4 receptor Exons - genetics Exploratory Behavior - physiology Female Fluoxetine - administration & dosage Fluoxetine - therapeutic use Genotype Humans Male Medical sciences Mood disorders Nortriptyline - administration & dosage Nortriptyline - therapeutic use Novelty seeking Obsessive personality Obsessive-Compulsive Disorder - drug therapy Obsessive-Compulsive Disorder - genetics Personality disorders Personality Disorders - drug therapy Personality Disorders - genetics Polymerase Chain Reaction Polymorphism, Genetic - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Dopamine D2 - genetics Receptors, Dopamine D3 Receptors, Dopamine D4 Risk Factors Serotonin Uptake Inhibitors - administration & dosage Serotonin Uptake Inhibitors - therapeutic use Temperament Trinucleotide Repeats - genetics |
| Title | Polymorphisms of DRD4 and DRD3 and risk of avoidant and obsessive personality traits and disorders |
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