Uterine cavity matrix metalloproteinases and cytokines in patients with leiomyoma, adenomyosis or endometrial polyp
Objective: To determine whether leiomyoma, adenomyosis and endometrial polyps are associated with changes in uterine cavity matrix metalloproteinases (MMP-2 and MMP-9) and cytokines. Study design: Uterine cavity irrigation was performed in women with leiomyoma, adenomyosis and endometrial polyps, an...
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| Published in | European journal of obstetrics & gynecology and reproductive biology Vol. 111; no. 2; pp. 197 - 203 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Shannon
Elsevier Ireland Ltd
10.12.2003
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0301-2115 1872-7654 |
| DOI | 10.1016/S0301-2115(03)00244-6 |
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| Abstract | Objective: To determine whether leiomyoma, adenomyosis and endometrial polyps are associated with changes in uterine cavity matrix metalloproteinases (MMP-2 and MMP-9) and cytokines.
Study design: Uterine cavity irrigation was performed in women with leiomyoma, adenomyosis and endometrial polyps, and in women with a normal uterus. MMP-2 and MMP-9 were assayed in the uterine washings by gelatin zymography. For individual subjects, the total MMP level was obtained by adding the semi-quantitative scores of band densities related to gelatinases in the zymograms. Interleukin-1beta (IL-1β), tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ) and transforming growth factor-beta1 (TGF-β1) were measured using enzyme-linked immunosorbant assay (ELISA) kits.
Results: The uterine cavity of patients with leiomyoma, adenomyosis and endometrital polyps had significantly higher MMP scores than controls. Although the mean IL-1β levels were elevated in uteri harboring a pathology compared with the normal uteri, the cytokine was significantly elevated only in the adenomyotic group. Significantly elevated levels of IFN-γ were found in uteri with leiomyoma and endometrial polyps. Uterine washings from leiomyoma and adenomyosis contained significantly elevated mean levels of TGF-β1 compared with controls, while TNF-α was significantly higher only in leiomyoma. When uterine cytokine levels were compared in relation to individual MMP levels a significant relationship was found between TGF-β1 and elevated levels of MMP-9 and total MMPs in leiomyoma. A significant relationship was also found between IL-1β and elevated levels of MMP-2, MMP-9 and total MMPs in the endometrial polyp group.
Conclusion: The uterine cavity in leiomyoma, adenomyosis and endometrial polyps contains elevated levels of MMPs and cytokines compared with the normal uterus. In some pathologies elevated cytokines are associated with elevated MMPs. |
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| AbstractList | To determine whether leiomyoma, adenomyosis and endometrial polyps are associated with changes in uterine cavity matrix metalloproteinases (MMP-2 and MMP-9) and cytokines.OBJECTIVETo determine whether leiomyoma, adenomyosis and endometrial polyps are associated with changes in uterine cavity matrix metalloproteinases (MMP-2 and MMP-9) and cytokines.Uterine cavity irrigation was performed in women with leiomyoma, adenomyosis and endometrial polyps, and in women with a normal uterus. MMP-2 and MMP-9 were assayed in the uterine washings by gelatin zymography. For individual subjects, the total MMP level was obtained by adding the semi-quantitative scores of band densities related to gelatinases in the zymograms. Interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma) and transforming growth factor-beta1 (TGF-beta1) were measured using enzyme-linked immunosorbant assay (ELISA) kits.STUDY DESIGNUterine cavity irrigation was performed in women with leiomyoma, adenomyosis and endometrial polyps, and in women with a normal uterus. MMP-2 and MMP-9 were assayed in the uterine washings by gelatin zymography. For individual subjects, the total MMP level was obtained by adding the semi-quantitative scores of band densities related to gelatinases in the zymograms. Interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma) and transforming growth factor-beta1 (TGF-beta1) were measured using enzyme-linked immunosorbant assay (ELISA) kits.The uterine cavity of patients with leiomyoma, adenomyosis and endometrial polyps had significantly higher MMP scores than controls. Although the mean IL-1beta levels were elevated in uteri harboring a pathology compared with the normal uteri, the cytokine was significantly elevated only in the adenomyotic group. Significantly elevated levels of IFN-gamma were found in uteri with leiomyoma and endometrial polyps. Uterine washings from leiomyoma and adenomyosis contained significantly elevated mean levels of TGF-beta1 compared with controls, while TNF-alpha was significantly higher only in leiomyoma. When uterine cytokine levels were compared in relation to individual MMP levels a significant relationship was found between TGF-beta1 and elevated levels of MMP-9 and total MMPs in leiomyoma. A significant relationship was also found between IL-1beta and elevated levels of MMP-2, MMP-9 and total MMPs in the endometrial polyp group.RESULTSThe uterine cavity of patients with leiomyoma, adenomyosis and endometrial polyps had significantly higher MMP scores than controls. Although the mean IL-1beta levels were elevated in uteri harboring a pathology compared with the normal uteri, the cytokine was significantly elevated only in the adenomyotic group. Significantly elevated levels of IFN-gamma were found in uteri with leiomyoma and endometrial polyps. Uterine washings from leiomyoma and adenomyosis contained significantly elevated mean levels of TGF-beta1 compared with controls, while TNF-alpha was significantly higher only in leiomyoma. When uterine cytokine levels were compared in relation to individual MMP levels a significant relationship was found between TGF-beta1 and elevated levels of MMP-9 and total MMPs in leiomyoma. A significant relationship was also found between IL-1beta and elevated levels of MMP-2, MMP-9 and total MMPs in the endometrial polyp group.The uterine cavity in leiomyoma, adenomyosis and endometrial polyps contains elevated levels of MMPs and cytokines compared with the normal uterus. In some pathologies elevated cytokines are associated with elevated MMPs.CONCLUSIONThe uterine cavity in leiomyoma, adenomyosis and endometrial polyps contains elevated levels of MMPs and cytokines compared with the normal uterus. In some pathologies elevated cytokines are associated with elevated MMPs. Objective: To determine whether leiomyoma, adenomyosis and endometrial polyps are associated with changes in uterine cavity matrix metalloproteinases (MMP-2 and MMP-9) and cytokines. Study design: Uterine cavity irrigation was performed in women with leiomyoma, adenomyosis and endometrial polyps, and in women with a normal uterus. MMP-2 and MMP-9 were assayed in the uterine washings by gelatin zymography. For individual subjects, the total MMP level was obtained by adding the semi-quantitative scores of band densities related to gelatinases in the zymograms. Interleukin-1beta (IL-1β), tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ) and transforming growth factor-beta1 (TGF-β1) were measured using enzyme-linked immunosorbant assay (ELISA) kits. Results: The uterine cavity of patients with leiomyoma, adenomyosis and endometrital polyps had significantly higher MMP scores than controls. Although the mean IL-1β levels were elevated in uteri harboring a pathology compared with the normal uteri, the cytokine was significantly elevated only in the adenomyotic group. Significantly elevated levels of IFN-γ were found in uteri with leiomyoma and endometrial polyps. Uterine washings from leiomyoma and adenomyosis contained significantly elevated mean levels of TGF-β1 compared with controls, while TNF-α was significantly higher only in leiomyoma. When uterine cytokine levels were compared in relation to individual MMP levels a significant relationship was found between TGF-β1 and elevated levels of MMP-9 and total MMPs in leiomyoma. A significant relationship was also found between IL-1β and elevated levels of MMP-2, MMP-9 and total MMPs in the endometrial polyp group. Conclusion: The uterine cavity in leiomyoma, adenomyosis and endometrial polyps contains elevated levels of MMPs and cytokines compared with the normal uterus. In some pathologies elevated cytokines are associated with elevated MMPs. To determine whether leiomyoma, adenomyosis and endometrial polyps are associated with changes in uterine cavity matrix metalloproteinases (MMP-2 and MMP-9) and cytokines. Uterine cavity irrigation was performed in women with leiomyoma, adenomyosis and endometrial polyps, and in women with a normal uterus. MMP-2 and MMP-9 were assayed in the uterine washings by gelatin zymography. For individual subjects, the total MMP level was obtained by adding the semi-quantitative scores of band densities related to gelatinases in the zymograms. Interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma) and transforming growth factor-beta1 (TGF-beta1) were measured using enzyme-linked immunosorbant assay (ELISA) kits. The uterine cavity of patients with leiomyoma, adenomyosis and endometrial polyps had significantly higher MMP scores than controls. Although the mean IL-1beta levels were elevated in uteri harboring a pathology compared with the normal uteri, the cytokine was significantly elevated only in the adenomyotic group. Significantly elevated levels of IFN-gamma were found in uteri with leiomyoma and endometrial polyps. Uterine washings from leiomyoma and adenomyosis contained significantly elevated mean levels of TGF-beta1 compared with controls, while TNF-alpha was significantly higher only in leiomyoma. When uterine cytokine levels were compared in relation to individual MMP levels a significant relationship was found between TGF-beta1 and elevated levels of MMP-9 and total MMPs in leiomyoma. A significant relationship was also found between IL-1beta and elevated levels of MMP-2, MMP-9 and total MMPs in the endometrial polyp group. The uterine cavity in leiomyoma, adenomyosis and endometrial polyps contains elevated levels of MMPs and cytokines compared with the normal uterus. In some pathologies elevated cytokines are associated with elevated MMPs. |
| Author | Otani, Tetsuo Wilkinson, David Inagaki, Noboru Ung, Linh Lopata, Alex |
| Author_xml | – sequence: 1 givenname: Noboru surname: Inagaki fullname: Inagaki, Noboru email: noboruinagaki@hotmail.com organization: Reproductive Biology Research, Department of Obstetrics and Gynaecology, Royal Women’s Hospital, University of Melbourne, Melbourne, Vic. 3053, Australia – sequence: 2 givenname: Linh surname: Ung fullname: Ung, Linh organization: Reproductive Biology Research, Department of Obstetrics and Gynaecology, Royal Women’s Hospital, University of Melbourne, Melbourne, Vic. 3053, Australia – sequence: 3 givenname: Tetsuo surname: Otani fullname: Otani, Tetsuo organization: Otani Women’s Clinic, Kobe, Japan – sequence: 4 givenname: David surname: Wilkinson fullname: Wilkinson, David organization: Reproductive Services, Department of Obstetrics and Gynaecology, Royal Women’s Hospital 132, Grattan Street, Carlton, Vic. 3053, Australia – sequence: 5 givenname: Alex surname: Lopata fullname: Lopata, Alex email: alexader@unimelb.edu.au organization: Reproductive Biology Research, Department of Obstetrics and Gynaecology, Royal Women’s Hospital, University of Melbourne, Melbourne, Vic. 3053, Australia |
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| Keywords | Matrix metalloproteinase-9 Leiomyoma Uterine cavity Cytokines Uterine lavage Matrix metalloproteinase-2 Endometrial polyp Adenomyosis Human Statistical analysis Pathophysiology Enzyme Cytokine Metalloendopeptidases Endometriosis Smooth muscle Gelatinase B Female genital diseases Gelatinase A Peptidases Preimplantation diagnosis Matrix metalloproteinase-2; Matrix metalloproteinase-9; Leiomyoma; Endometrial polyp; Adenomyosis Cavity Uterus Uterine diseases Hydrolases Female Benign neoplasm Endometrium Polyp Uterine cavity; Uterine massages Cytokines |
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| Snippet | Objective: To determine whether leiomyoma, adenomyosis and endometrial polyps are associated with changes in uterine cavity matrix metalloproteinases (MMP-2... To determine whether leiomyoma, adenomyosis and endometrial polyps are associated with changes in uterine cavity matrix metalloproteinases (MMP-2 and MMP-9)... |
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| SubjectTerms | Adenomyosis Biological and medical sciences Cytokines Cytokines - analysis Endometrial Neoplasms - metabolism Endometrial polyp Endometriosis - metabolism Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Interferon-gamma - analysis Interleukin-1 - analysis Leiomyoma Leiomyoma - metabolism Matrix Metalloproteinase 2 - analysis Matrix Metalloproteinase 9 - analysis Matrix metalloproteinase-2 Matrix metalloproteinase-9 Matrix Metalloproteinases - analysis Medical sciences Non tumoral diseases Polyps - metabolism Transforming Growth Factor beta - analysis Transforming Growth Factor beta1 Tumor Necrosis Factor-alpha - analysis Uterine cavity Uterine Diseases - metabolism Uterine lavage Uterine Neoplasms - metabolism Uterus - chemistry Uterus - enzymology |
| Title | Uterine cavity matrix metalloproteinases and cytokines in patients with leiomyoma, adenomyosis or endometrial polyp |
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