Comparison of risk of orthostatic hypotension in elderly depressed hypertensive women treated with nortriptyline and thiazides versus elderly depressed normotensive women treated with nortriptyline
This is a nonblind, case-controlled study comparing the risk of orthostatic hypotension (OH) in 2 groups of elderly depressed women: 22 normotensive and 21 hypertensive patients receiving thiazides. Blood pressure measurements and tilt-table tests produced similar results: increased drop in systolic...
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| Published in | The American journal of cardiology Vol. 85; no. 9; pp. 1156 - 1158 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Elsevier Inc
01.05.2000
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0002-9149 1879-1913 |
| DOI | 10.1016/S0002-9149(00)00717-7 |
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| Abstract | This is a nonblind, case-controlled study comparing the risk of orthostatic hypotension (OH) in 2 groups of elderly depressed women: 22 normotensive and 21 hypertensive patients receiving thiazides. Blood pressure measurements and tilt-table tests produced similar results: increased drop in systolic blood pressure (SBP) after standing (p <0.001), with no significant differences between the groups (p = 0.523). There were no changes on diastolic blood pressure (DBP) after standing, or in SBP or DBP at rest. Dizziness was reported by 23 subjects (53.5%) before treatment, and by 16 subjects (38.1%) at week 8. Complaints of dizziness were not associated with OH (Kappa = 0.07). |
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| AbstractList | This is a nonblind, case-controlled study comparing the risk of orthostatic hypotension (OH) in 2 groups of elderly depressed women: 22 normotensive and 21 hypertensive patients receiving thiazides. Blood pressure measurements and tilt-table tests produced similar results: increased drop in systolic blood pressure (SBP) after standing (p <0.001), with no significant differences between the groups (p = 0.523). There were no changes on diastolic blood pressure (DBP) after standing, or in SBP or DBP at rest. Dizziness was reported by 23 subjects (53.5%) before treatment, and by 16 subjects (38.1%) at week 8. Complaints of dizziness were not associated with OH (Kappa = 0.07). This is a nonblind, case-controlled study comparing the risk of orthostatic hypotension (OH) in 2 groups of elderly depressed women: 22 normotensive and 21 hypertensive patients receiving thiazides. Blood pressure measurements and tilt-table tests produced similar results: increased drop in systolic blood pressure (SBP) after standing (p <0.001), with no significant differences between the groups (p = 0.523). There were no changes on diastolic blood pressure (DBP) after standing, or in SBP or DBP at rest. Dizziness was reported by 23 subjects (53.5%) before treatment, and by 16 subjects (38.1%) at week 8. Complaints of dizziness were not associated with OH (Kappa = 0.07).This is a nonblind, case-controlled study comparing the risk of orthostatic hypotension (OH) in 2 groups of elderly depressed women: 22 normotensive and 21 hypertensive patients receiving thiazides. Blood pressure measurements and tilt-table tests produced similar results: increased drop in systolic blood pressure (SBP) after standing (p <0.001), with no significant differences between the groups (p = 0.523). There were no changes on diastolic blood pressure (DBP) after standing, or in SBP or DBP at rest. Dizziness was reported by 23 subjects (53.5%) before treatment, and by 16 subjects (38.1%) at week 8. Complaints of dizziness were not associated with OH (Kappa = 0.07). |
| Author | Scalco, Mônica Z Hachul, Denise T Wajngarten, Maurı́cio Castel, Saulo de Almeida, Osvaldo P Serro-Azul, João |
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| Cites_doi | 10.1136/pgmj.70.830.878 10.1161/01.HYP.19.6.508 10.1001/jama.1983.03340150039023 10.1016/0002-8703(85)90240-6 10.1111/j.1532-5415.1984.tb04178.x 10.1111/j.1532-5415.1989.tb05871.x 10.1192/bjp.149.6.698 10.1192/bjp.134.4.382 10.1111/j.1532-5415.1991.tb03593.x 10.1111/j.1532-5415.1991.tb02869.x 10.1016/S0140-6736(98)00348-1 10.1192/bjp.168.2.164 10.1111/j.1540-8159.1997.tb03904.x 10.1097/00004714-198712000-00008 10.1001/archinte.1992.00400170130024 10.1001/jama.1992.03490080092032 |
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| Keywords | Toxicity Cardiovascular disease Vertigo Diuretic Postural hypotension Antidepressant agent ENT disease Female Psychopathology Diagnosis Human Hypertension Nortriptyline Nervous system diseases Depression Tricyclic compound Medical screening Equilibrium disorder Symptomatology Concomitant disease Chemotherapy Treatment Diseases of the autonomic nervous system Risk factor Antihypertensive agent Combined treatment Thiazide Elderly Comparative study |
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| SubjectTerms | Aged Antidepressive Agents, Tricyclic - adverse effects Antihypertensive agents Biological and medical sciences Blood Pressure - drug effects Cardiovascular system Case-Control Studies Depression - complications Depression - drug therapy Female Humans Hypotension, Orthostatic - chemically induced Medical sciences Middle Aged Nortriptyline - adverse effects Pharmacology. Drug treatments Tilt-Table Test |
| Title | Comparison of risk of orthostatic hypotension in elderly depressed hypertensive women treated with nortriptyline and thiazides versus elderly depressed normotensive women treated with nortriptyline |
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