Randomized placebo-controlled dose-ranging and pharmacodynamics study of roxadustat (FG-4592) to treat anemia in nondialysis-dependent chronic kidney disease (NDD-CKD) patients - Besarab, Anatole; Provenzano, Robert; Hertel, Joachim; Zabaneh, Raja; Klaus, Stephen J.; Lee, Tyson; Leong, Robert; Hemmerich, Stefan; Yu, Kin-Hung Peony; Neff, Thomas B. (Nephrology, dialysis, transplantation, 2015)
Keywords: Adolescent; Adult; Aged; Aged, 80 and over; Anemia - drug therapy; Anemia - etiology; Cohort Studies; Dose-Response Relationship, Drug; Erythropoiesis - drug effects; Erythropoietin - metabolism; Female; Glycine - analogs & derivatives; Glycine - therapeutic use; Hemoglobins - metabolism; Hepcidins - metabolism; Humans; Hypoxia-Inducible Factor-Proline Dioxygenases - antagonists & inhibitors; Isoquinolines - therapeutic use; Male; Middle Aged; Original; Prognosis; Renal Dialysis; Renal Insufficiency, Chronic - complications; Single-Blind Method; Young Adult; chronic kidney disease; hepcidin; HIF-PHI; anemia; erythropoietin